LDN193189

Catalog No.: A11205

ALK inhibitor

LDN193189

LDN193189 Chemical Structure

CAS NO. 1062368-24-4

LDN193189 is a highly potent small molecule BMP inhibitor that inhibits BMP type I receptors ALK2 (IC50: 5 nM), ALK3 (IC50: 30 nM) and ALK6 (TGFβ1/BMP signaling) and subsequent SMAD phosphorylation.

Availability: In stock

Package Price Qty
2 mg

Regular Price: $40.00

Special Price $32.00

5 mg

Regular Price: $70.00

Special Price $56.00

25 mg

Regular Price: $140.00

Special Price $112.00

50 mg

Regular Price: $240.00

Special Price $192.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Details

LDN193189 is a highly potent small molecule BMP inhibitor that inhibits BMP type I receptors ALK2 (IC50: 5 nM), ALK3 (IC50: 30 nM) and ALK6 (TGFβ1/BMP signaling) and subsequent SMAD phosphorylation.
Targets
ALK2 (C2C12 cells) ALK3 (C2C12 cells)
5 nM30 nM
In vitro (25°C) DMSO 0.01 mg/mL (<1 mM)
Water 0.01 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo Saline 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.6 mL 123.01 mL 246.01 mL
0.5 mM 4.92 mL 24.6 mL 49.2 mL
1 mM 2.46 mL 12.3 mL 24.6 mL
5 mM 0.49 mL 2.46 mL 4.92 mL

*The above data is based on the productmolecular weight 406.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

Catalog Num A11205
Actions Inhibitor
M. Wt 406.48
Formula C25H22N6
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1062368-24-4
Synonyms LDN-193189
SMILES C1CN(CCN1)C2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC6=CC=CC=C56)N=C3

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