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LY-411575

Catalog No.: A11176

Gamma secretase inhibitor

LY-411575

LY-411575 Chemical Structure

CAS NO. 209984-57-6

LY-411575 is a selective, cell permeable, small molecule gamma secretase inhibitor.

Availability: In stock Shipped in 7-10 Days

Package Price Qty
5 mg
$65.00
10 mg
$110.00
50 mg
$430.00
100 mg
$665.00
10mM * 1mL in DMSO
$100.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Wojciech J Szlachcic, .et al. SARS-CoV-2 infects an in vitro model of the human developing pancreas through endocytosis, iScience, 2022, Jul 15;25(7) PMID: 35756892
  • Zhang ZH, .et al. Notch signaling suppresses CD14+ monocytes cells activity in patients with chronic hepatitis C, APMIS, 2019, Jul 5 PMID: 31274210
  • Bo Pang, .et al. Elevated Notch1 enhances interleukin-22 production by CD4+ T cells via aryl hydrocarbon receptor in patients with lung adenocarcinoma, Biosci Rep, 2018, Dec 21; 38(6): BSR20181922 PMID: 30473538
  • Shuo Li, .et al. Notch signaling pathway suppresses CD8+ T cells activity in patients with lung adenocarcinoma, Int Immunopharmacol, 2018, Oct;63:129-136 PMID: 30086535
  • Jiang BC, .et al. Notch Signaling Regulates Circulating T Helper 22 Cells in Patients with Chronic Hepatitis C, Viral Immunol, 2017, Sep;30(7):522-532 PMID: 28410452

Biological Activity

LY-411575 is a selective, cell permeable, small molecule gamma secretase inhibitor.

Targets
γ secretase (membrane-based) (HEK293 cells expressing either APP or NδE) γ secretase (cell-based) (HEK293 cells expressing either APP or NδE) Notch S3 cleavage (HEK293 cells expressing either APP or NδE)
0.078 nM0.082 nM0.39 nM
In vitro (25°C) DMSO 94 mg/mL (196.04 mM)
Water Insoluble
Ethanol 13 mg/mL (27.11 mM)
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.86 mL 104.28 mL 208.56 mL
0.5 mM 4.17 mL 20.86 mL 41.71 mL
1 mM 2.09 mL 10.43 mL 20.86 mL
5 mM 0.42 mL 2.09 mL 4.17 mL

*The above data is based on the productmolecular weight 479.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11176
Actions Inhibitor
CAS No. 209984-57-6
Formula C26H23F2N3O4
M. Wt 479.48
Purity >98%
Synonyms LY411575
SMILES C[[email protected]@H](C(=O)N[[email protected]]1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)[[email protected]](C4=CC(=CC(=C4)F)F)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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