LY-411575

Catalog No.: A11176

Gamma secretase inhibitor

LY-411575

LY-411575 Chemical Structure

CAS NO. 209984-57-6

LY-411575 is a selective, cell permeable, small molecule gamma secretase inhibitor.

Availability: In stock Shipped in 7-10 Days

Package Price Qty
5 mg

Regular Price: $90.00

Special Price $81.00

10 mg

Regular Price: $160.00

Special Price $144.00

50 mg

Regular Price: $580.00

Special Price $522.00

100 mg

Regular Price: $960.00

Special Price $864.00

10mM * 1mL in DMSO

Regular Price: $120.00

Special Price $108.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

LY-411575 is a selective, cell permeable, small molecule gamma secretase inhibitor.

Targets
γ secretase (membrane-based) (HEK293 cells expressing either APP or NδE) γ secretase (cell-based) (HEK293 cells expressing either APP or NδE) Notch S3 cleavage (HEK293 cells expressing either APP or NδE)
0.078 nM0.082 nM0.39 nM
In vitro (25°C) DMSO 95 mg/mL (198.13 mM)
Water <1 mg/mL (<1 mM)
Ethanol 95 mg/mL (198.13 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.86 mL 104.28 mL 208.56 mL
0.5 mM 4.17 mL 20.86 mL 41.71 mL
1 mM 2.09 mL 10.43 mL 20.86 mL
5 mM 0.42 mL 2.09 mL 4.17 mL

*The above data is based on the productmolecular weight 479.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A11176
Actions Inhibitor
M. Wt 479.48
Formula C26H23F2N3O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 209984-57-6
Synonyms LY411575
SMILES C[[email protected]@H](C(=O)N[[email protected]]1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)[[email protected]](C4=CC(=CC(=C4)F)F)O

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