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- Wojciech J Szlachcic, .et al. SARS-CoV-2 infects an in vitro model of the human developing pancreas through endocytosis, iScience, 2022, Jul 15;25(7) PMID: 35756892
- Zhang ZH, .et al. Notch signaling suppresses CD14+ monocytes cells activity in patients with chronic hepatitis C, APMIS, 2019, Jul 5 PMID: 31274210
- Bo Pang, .et al. Elevated Notch1 enhances interleukin-22 production by CD4+ T cells via aryl hydrocarbon receptor in patients with lung adenocarcinoma, Biosci Rep, 2018, Dec 21; 38(6): BSR20181922 PMID: 30473538
- Shuo Li, .et al. Notch signaling pathway suppresses CD8+ T cells activity in patients with lung adenocarcinoma, Int Immunopharmacol, 2018, Oct;63:129-136 PMID: 30086535
- Jiang BC, .et al. Notch Signaling Regulates Circulating T Helper 22 Cells in Patients with Chronic Hepatitis C, Viral Immunol, 2017, Sep;30(7):522-532 PMID: 28410452
Biological Activity
LY-411575 is a selective, cell permeable, small molecule gamma secretase inhibitor.
Targets
| γ secretase (membrane-based) (HEK293 cells expressing either APP or NδE) | γ secretase (cell-based) (HEK293 cells expressing either APP or NδE) | Notch S3 cleavage (HEK293 cells expressing either APP or NδE) | ||
| 0.078 nM | 0.082 nM | 0.39 nM |
| In vitro (25°C) | DMSO | 94 mg/mL (196.04 mM) | |
| Water | Insoluble | ||
| Ethanol | 13 mg/mL (27.11 mM) | ||
| In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.86 mL | 104.28 mL | 208.56 mL |
| 0.5 mM | 4.17 mL | 20.86 mL | 41.71 mL |
| 1 mM | 2.09 mL | 10.43 mL | 20.86 mL |
| 5 mM | 0.42 mL | 2.09 mL | 4.17 mL |
*The above data is based on the productmolecular weight 479.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11176 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 209984-57-6 |
| Formula | C26H23F2N3O4 |
| M. Wt | 479.48 |
| Purity | >98% |
| Synonyms | LY411575 |
| SMILES | C[[email protected]@H](C(=O)N[[email protected]]1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)[[email protected]](C4=CC(=CC(=C4)F)F)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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