LY-411575

Catalog No.: A11176
Gamma secretase inhibitor

LY-411575 is a selective, cell permeable, small molecule gamma secretase inhibitor.

Grouped product items
Size Price Stock Qty
2mg
$30.00
In stock
5mg
$55.00
In stock
10mg
$100.00
In stock
25mg
$215.00
In stock
50mg
$425.00
In stock
100mg
$630.00
In stock
10mM * 1mL in DMSO
$55.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500

Important Notice: For research use only. We do not sell to patients.

Adooq Products cited in reputable paper
Adooq's LY-411575 has been cited by 6 publications
  • Haiwen Yu, .et al. , Immunol Invest, 2023, Feb;52(2):241-255 PMID: 36562737
  • Wojciech J Szlachcic, .et al. , iScience, 2022, Jul 15;25(7) PMID: 35756892
  • Zhang ZH, .et al. , APMIS, 2019, Jul 5 PMID: 31274210
  • Bo Pang, .et al. , Biosci Rep, 2018, Dec 21; 38(6): BSR20181922 PMID: 30473538
  • Shuo Li, .et al. , Int Immunopharmacol, 2018, Oct;63:129-136 PMID: 30086535
  • Jiang BC, .et al. , Viral Immunol, 2017, Sep;30(7):522-532 PMID: 28410452
  • Biological Activity
    Discription

    LY-411575 is a selective, cell permeable, small molecule gamma secretase inhibitor.

    Targets
    Target Value
    Cell Research
    Cell Line Type Value Description References
    Product Information
    Catalog Num A11176
    Formula C26H23F2N3O4
    Molecular Weight 479.48
    CAS Number 209984-57-6
    SMILES C[C@@H](C(=O)N[C@H]1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)[C@H](C4=CC(=CC(=C4)F)F)O
    Synonyms LY411575
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 94 mg/mL (196.04 mM)
    Water Insoluble
    Ethanol 13 mg/mL (27.11 mM)
    In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 20.86 mL 104.28 mL 208.56 mL
    0.5 mM 4.17 mL 20.86 mL 41.71 mL
    1 mM 2.09 mL 10.43 mL 20.86 mL
    5 mM 0.42 mL 2.09 mL 4.17 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

    • Mass

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      Molecular Weight

    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

    • C1

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