MAPK - ERK5

XMD8-92 is a potent and selective BMK1/ERK5 inhibitor .

BAY885 is a novel ERK5 inhibitor.

XMD17-109 is a novel, specific inhibitor of ERK-5 with an EC50 value of 4.2 uM in HEK293 cells.

ERK5-IN-1 exhibits potent inhibition of ERK5 with cellular EC50 values of 0.19 uM and enzymatic IC50 values of 0.087 uM and of LRRK2[G2019S] with enzymatic IC50 values of 0.026uM.

ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively.

AX-15836 is a potent and selective ERK5 inhibitor with an IC50 of 8 nM.