Methyltetrazine-Ph-PEG4-azide is a PEG-based linker specifically designed for the synthesis of PROTACs, functioning as a vital component in targeted protein degradation strategies. This compound features a Tetrazine moiety that enables inverse electron-demand Diels-Alder reactions (iEDDA) with TCO-containing partners, enhancing the efficiency of linkage in complex biomolecular assemblies. Additionally, the azide functionality facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) and can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN derivatives. This dual reactivity expands its utility in bioconjugation and chemical biology applications.
Methyltetrazine-Ph-PEG4-azide is a PEG-based linker specifically designed for the synthesis of PROTACs, functioning as a vital component in targeted protein degradation strategies. This compound features a Tetrazine moiety that enables inverse electron-demand Diels-Alder reactions (iEDDA) with TCO-containing partners, enhancing the efficiency of linkage in complex biomolecular assemblies. Additionally, the azide functionality facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) and can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN derivatives. This dual reactivity expands its utility in bioconjugation and chemical biology applications.
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