Catalog No.
Product Name
Application
Product Information
Citations
-
β-lactamase inhibitor
Zidebactam sodium salt (WCK-5107 sodium salt) is a potent β-lactamase inhibitor. Zidebactam also is a penicillin-binding protein2 (PBP2) inhibitor with an IC50 of 0.26 μg/mL. -
Topoisomerase inhibitor
Zabofloxacin hydrochloride (DW-224a) is a novel fluoronaphthyridone quinolone that is considered a potent antibacterial candidate for clinical trials. - Tilbroquinol is an antiprotozoal agent effective against amoebiasis. It has also been used against Vibrio cholerae.
-
efflux pump inhibitor
PAβN dihydrochloride (MC-207110 dihydrochloride) is an efflux pump inhibitor. -
Apoptosis Inducer
Hirsutine, an indole alkaloid derived from Uncaria rhynchophylla, serves as an apoptosis inducer with notable anti-cancer properties. It effectively triggers apoptotic pathways while demonstrating significant inhibitory effects against Dengue virus, all with low cytotoxicity. This compound is valuable for research in cancer biology and virology, enabling studies on apoptotic mechanisms and antiviral strategies. -
Antibiotic
Tylvalosin is a macrolide antibiotic that exhibits broad-spectrum antimicrobial activity. Primarily utilized as an antiviral agent, Tylvalosin is effective in studying Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infection. This compound also induces apoptosis and possesses anti-inflammatory properties, helping to mitigate oxidative stress and acute lung injury by inhibiting NF-κB activation. Its diverse biological activities make Tylvalosin valuable for research in infectious diseases and inflammation. -
SDHI Inhibitor
Boscalid is a succinate dehydrogenase inhibitor that exhibits significant antifungal activity. By binding to the ubiquinone-binding site of mitochondrial complex II in fungi, Boscalid disrupts ATP production and aerobic respiration, effectively controlling a range of plant fungal diseases, such as gray mold, sclerotinia rot, and powdery mildew. In addition to its agricultural applications, research indicates that Boscalid induces apoptosis and alters lipid metabolism while causing mitochondrial dysfunction, oxidative stress, and ROS accumulation in zebrafish models. Furthermore, it demonstrates chronic toxicity and impacts foraging behavior in honeybees, alongside exhibiting genotoxic and cytotoxic effects in cellular systems. -
Antimicrobial Peptide
Protegrin-1 is an antimicrobial peptide that exhibits potent antibacterial activity by activating ERK, COX2, and NFκB pathways, while inhibiting apoptosis and nitric oxide production. It demonstrates significant bactericidal effects against various pathogens, including Staphylococcus aureus, Enterococcus faecium, Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae, with minimal inhibitory concentrations ranging from 10 to 20 µM. Additionally, Protegrin-1 shows antiviral activity against the dengue virus NS2B-NS3 and possesses anti-inflammatory properties, making it a valuable tool in the research of inflammatory diseases and infections. -
Antibiotic
Tylvalosin tartrate is a broad-spectrum macrolide antibiotic primarily targeting bacterial infections. This compound exhibits significant antimicrobial activity and is effective in studying Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infections. Additionally, Tylvalosin tartrate induces apoptosis, demonstrates anti-inflammatory properties, relieves oxidative stress, and mitigates acute lung injury by inhibiting NF-κB activation. It serves as a valuable tool for research into viral pathogenesis and cellular responses. -
Antimicrobial Agent
Dipyrithione is a potent antimicrobial agent primarily targeting fungal pathogens. It exhibits significant antifungal and antiproliferative activities, inducing apoptosis and G1 phase cell cycle arrest. Additionally, Dipyrithione demonstrates anti-inflammatory effects in vivo and exhibits anti-tumor potential. This compound is of particular interest for research applications related to dermatophytosis and other fungal infections. -
Bacterial Inhibitor
Citrinin is a mycotoxin known for its role as a bacterial inhibitor. It exhibits a range of biological activities, including the regulation of immune cell populations, induction of apoptosis and autophagy in immune cells, and modulation of toll-like receptor expression and cytokine production. Citrinin also induces oxidative stress, leading to apoptosis in oocytes, while low doses demonstrate neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. This compound's diverse mechanisms make it a valuable reagent for research in immunology, neurobiology, and antibacterial applications. -
Macrocyclic Ellagitannin
Oenothein B is a dimeric macrocyclic ellagitannin known for its potent inhibition of poly(ADP-ribose) glycohydrolase. It exhibits a range of biological activities, including antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor effects. This compound serves as a valuable tool in research applications focusing on cellular stress responses, inflammation, and cancer therapeutics. -
IMPDH Inhibitor
Mycophenolic acid sodium is a potent uncompetitive inhibitor of inosine monophosphate dehydrogenase (IMPDH), with an EC50 of 0.24 µM. This compound exhibits antiviral activity against various RNA viruses, including influenza, alongside its immunosuppressive properties. Additionally, Mycophenolic acid sodium demonstrates antiangiogenic and antitumor effects, making it valuable for research in immunology, virology, and cancer therapy. -
Anti-bacterial Agent
Pinosylvin is a stilbenoid toxin derived from the heartwood of Pinus species, exhibiting significant anti-bacterial activity. As a resveratrol analogue, it has been shown to induce apoptosis and autophagy in leukemia cells, making it a valuable agent for research in cancer therapy and infectious disease studies. Its unique properties position Pinosylvin as a promising candidate for further exploration in the development of anti-microbial and anti-cancer compounds. -
Virus Protease Inhibitor
Anthraquinone acts primarily as a viral protease inhibitor, exhibiting multifaceted biological activities including anticancer, anti-inflammatory, diuretic, anti-arthritic, antifungal, antibacterial, antimalarial, and antioxidant properties. This compound plays a crucial role in plant metabolism by impacting the electron transport chain, thereby inhibiting energy transfer during photosynthesis. Additionally, anthraquinone intercalates into DNA and inhibits topoisomerase II, leading to cell death through apoptosis. This diverse profile supports its applications in various fields of chemical and biological research. -
Antibiotic
Maduramicin ammonium is a potent antibiotic derived from the actinomycete Actinomadura rubra, primarily functioning as an anticoccidial agent. It effectively targets Eimeria spp., including E. adenoeides, E. gallopavonis, and E. dispersa, making it valuable in the treatment of coccidiosis. Additionally, Maduramicin ammonium has been shown to induce apoptosis in chicken myocardial cells through both intrinsic and extrinsic pathways, underscoring its utility in biological research involving cell viability and apoptosis mechanisms. -
Antitumor Antibiotic
Neocarzinostatin (solution) is a potent antitumor antibiotic that primarily targets double-stranded DNA through the recognition of DNA bulges, leading to the induction of double strand breaks (DSBs). This mechanism initiates apoptosis in cancer cells, making Neocarzinostatin an important reagent for studying DNA damage response and cancer biology. It exhibits potential in the treatment of EpCAM-positive cancers, providing a valuable tool for researchers investigating therapeutic strategies in oncology. -
Fungal Inhibitor
Mancozeb is a potent fungicide that operates primarily by inhibiting fungal growth in a variety of agricultural products, including cereals, vegetables, fruits, and ornamental plants. In addition to its antifungal properties, Mancozeb has been shown to activate the Keap1/Nrf2 signaling pathway, leading to liver damage in mice. It alters cellular metabolism through the upregulation of lactate dehydrogenase and cytochrome c, resulting in induced apoptotic pathways, particularly in ovarian cells. This compound is of significant interest in studies related to reproductive toxicity and cellular metabolism. -
Antioxidant Agent
Clovamide is a natural phenolic compound that functions as a potent antioxidant agent. It effectively scavenges reactive oxygen species (ROS) and oxygen radicals, demonstrating significant anti-inflammatory and neuroprotective properties. Additionally, Clovamide exhibits antimicrobial activity against human pathogens such as influenza A subtype H5N1, Trypanosoma evansi, and Helicobacter pylori, making it valuable for various biological research applications. -
Antibacterial Agent
5-Fluoroindole is a fluorinated indole derivative that serves as an antibacterial agent. It has been shown to induce reactive oxygen species (ROS) accumulation and initiate apoptosis in bacterial cells. 5-Fluoroindole effectively inhibits the growth of pan-susceptible Mycobacterium tuberculosis H37Rv strains and demonstrates significant bactericidal activity against Pseudomonas syringae pv. actinidiae, with an EC50 of 15.34 µg/mL. This compound is valuable for research focused on tuberculosis and bacterial infections in kiwifruit. Additionally, its fluorinated structure makes it suitable for protein labeling applications. -
Apoptosis Inducer
Falcarindiol is an orally active polyacetylenic oxylipin that functions as an apoptosis inducer by activating PPARγ and enhancing the expression of the cholesterol transporter ABCA1 in cells. This compound exhibits significant biological activities, including anti-inflammatory, antifungal, anticancer, and antidiabetic effects. Additionally, as a click chemistry reagent, Falcarindiol contains an alkyne group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules, making it valuable for various research applications. -
Antibiotic
Levofloxacin hydrochloride is a fluoroquinolone antibiotic that primarily targets DNA gyrase and topoisomerase IV, leading to the inhibition of bacterial DNA replication and subsequent apoptosis. This compound exhibits broad-spectrum antibacterial activity against both Gram-positive and Gram-negative pathogens, making it suitable for research on infectious diseases, including tuberculosis and chronic periodontitis. Additionally, Levofloxacin hydrochloride demonstrates anticancer effects against lung cancer, along with potential anti-acnegenic, anxiogenic, and analgesic properties. Its effects on sleep duration in murine models further support its utility in various biomedical research applications. -
Apoptosis Inducer
δ-Cadinene is a sesquiterpene primarily known for its role as an apoptosis inducer. It exhibits significant antiproliferative and pro-apoptotic effects specifically in human ovarian cancer (OVCAR-3) cells. Additionally, δ-Cadinene demonstrates broad-spectrum bioactivity, including trichomonacidal, antimicrobial, antifungal, and anticancer properties, making it a valuable compound for various research applications in cancer biology and infectious disease studies. -
HIV Protease Inhibitor
Indinavir is a selective inhibitor of HIV-1 protease, displaying a Ki value of 0.54 nM, making it a potent antiviral agent. In addition to its primary role in HIV treatment, Indinavir has demonstrated anticancer properties by inhibiting matrix metalloproteinases (MMPs) and promoting anti-angiogenic effects, alongside inducing apoptosis in cancer cells. Furthermore, Indinavir has shown inhibitory activity against the SARS-CoV 3CL protease, expanding its potential applications in viral research. -
Bacterial/Fungal Inhibitor, Preservative Agent
Methylisothiazolinone is a potent bacterial and fungal inhibitor with significant applications as a preservative agent. It activates matrix metalloproteinases (MMPs) in human bronchial epithelial cells, leading to apoptosis and an inflammatory response. Additionally, this compound is linked to the exacerbation of atopic dermatitis in mice through the disruption of Th2/Th17-related immune responses. Furthermore, Methylisothiazolinone has been shown to induce mitochondrial damage in the endothelium of rat cerebral blood vessels, highlighting its potential impact on vascular health. -
Antibiotic
Narasin is a cationic ionophore antibiotic that effectively targets various microbial pathogens and acts as a coccidiostat agent. Its biological activity includes the inhibition of NF-κB signaling, leading to the induction of apoptosis in tumor cells. Narasin also exhibits antimicrobial, antiviral, and anticancer properties, specifically inhibiting tumor metastasis and the growth of ERα-positive breast cancer cells by inactivating the TGF-β/SMAD3 and IL-6/STAT3 signaling pathways, making it a valuable tool for cancer research and therapeutic applications. -
Bacterial Inhibitor
Oligomycin B is an antibiotic derived from marine Streptomyces, primarily acting as an inhibitor of ATP synthase in eukaryotic cells. Its mechanism of action leads to a decrease in ATP production, resulting in cellular stress and the induction of apoptosis. Oligomycin B is widely utilized in research focused on mitochondrial function, energy metabolism, and apoptosis-related studies. -
Bacterial Inhibitor
Lactoferrin (17-41) acetate is a peptide derived from residues 17-41 of bovine lactoferrin, primarily functioning as a bacterial inhibitor. It exhibits potent antimicrobial activity against various microorganisms, including Gram-positive and Gram-negative bacteria, viruses, protozoa, and fungi. In addition to its antimicrobial properties, Lactoferrin (17-41) acetate also demonstrates antitumor activities, making it a valuable reagent in studies related to infection control and cancer research. -
Apoptosis Inducer
Damnacanthal is an anthraquinone that primarily functions as an apoptosis inducer through selective inhibition of p56lck tyrosine kinase activity. Demonstrating significant anticancer properties, Damnacanthal effectively inhibits p56lck autophosphorylation and the phosphorylation of exogenous substrates, with IC50 values of 46 nM and 220 nM, respectively. Additionally, Damnacanthal exhibits antinociceptive and anti-inflammatory effects in murine models, along with antifungal activity against Candida albicans. This compound is valuable for research into cancer biology and related therapeutic pathways. -
Antibiotic
Nonactin is a macrotetrolide antibiotic that functions primarily as a mitochondrial uncoupler. It exhibits antibacterial, insecticidal, and acaricidal properties by acting as an ionophore for monovalent cations such as K+ and NH4+. Additionally, Nonactin inhibits the surface expression of endogenous HSP60 and can induce apoptosis in β-catenin mutant tumor cells, demonstrating its potential for anti-tumor applications. This compound is valuable for research in antibiotic resistance and cancer biology. -
Antibiotic
Quinocetone is an orally active antibiotic that targets various pathogenic microorganisms, making it effective as an animal feed additive to enhance meat production in livestock and poultry. It demonstrates antibacterial activity while also exhibiting tissue-specific toxicity, notably in the liver and lymphocytes. Quinocetone induces autophagy through the ATF6/DAPK1 pathway and activates the NF-κB and iNOS pathways, resulting in cell apoptosis and hepatocyte vacuolar degeneration. Furthermore, it can inhibit the Nrf2/HO-1 pathway and promote the production of reactive oxygen species (ROS), contributing to oxidative stress and DNA damage. -
Antibiotic
Pyoluteorin is an antibiotic with a primary mechanism of inhibiting Oomycete fungi, specifically targeting the plant pathogen Pythium ultimum. This compound effectively suppresses diseases caused by this pathogen in plants. Additionally, Pyoluteorin has been shown to induce apoptosis in human triple-negative breast cancer MDA-MB-231 cells in vitro, making it a valuable reagent for research in human triple-negative breast cancer. -
Antibiotic
2,4-Diacetylphloroglucinol is a polyketide antibiotic that primarily targets a range of pathogenic organisms. This compound demonstrates broad-spectrum antimicrobial activity, effective against bacteria, fungi, oomycetes, and nematodes. Additionally, 2,4-Diacetylphloroglucinol is known to inhibit plant pathogens and can influence root development in tomato seedlings, making it valuable for agricultural research and pathogen control studies. -
Antifungal Potentiator
Polygodial is a sesquiterpene known for its role as an antifungal potentiator. It exhibits significant anti-hyperalgesic properties, making it a valuable compound in research focused on pain modulation and fungal infections. Polygodial has potential applications in developing therapeutic strategies targeting antifungal resistance and enhancing pain relief mechanisms. -
Fluxapyroxad Metabolite
M700F048 is a primary metabolite of the fungicide Fluxapyroxad, targeting the inhibition of succinate dehydrogenase in fungal respiration. This compound is essential for studying the metabolic pathways and environmental behavior of Fluxapyroxad. It has significant applications in toxicological research and understanding the efficacy and degradation of fungicides in agricultural settings. -
Fungicide
Propiconazole is a triazole compound primarily used as a fungicide, targeting fungal sterol biosynthesis by inhibiting the enzyme lanosterol demethylase. Its biological activity is characterized by effective control over various fungal pathogens in agricultural applications. However, it has been identified as a hepatotoxicant and hepatocarcinogen in experimental models, with reported adverse effects on reproduction and development in animals. This information is critical for researchers in toxicology and agricultural sciences assessing the safety and efficacy of fungicidal agents. -
Triazole Fungicide
Difenoconazole is a triazole fungicide that acts as a sterol demethylation inhibitor. It selectively binds to the heme group of fungal cytochrome P450 51, disrupting mycelial growth and inhibiting spore germination. This compound is utilized in research applications focused on pathogenic fungi, offering insights into fungal growth mechanisms and resistance management strategies. -
Antibiotic
Tigecycline mesylate is a broad-spectrum glycylcycline antibiotic that targets bacterial protein synthesis. It exhibits significant inhibitory activity against various Gram-positive and Gram-negative bacteria, with a mean inhibitory concentration (MIC) for E. coli (MG1655 strain) of approximately 125 ng/mL. For Acinetobacter baumannii, the MIC50 and MIC90 values are 1 mg/L and 2 mg/L, respectively, making it valuable for research focused on antibiotic resistance and infection control. -
HIV NNRTI
(Rac)-Efavirenz is a non-nucleoside reverse transcriptase inhibitor (NNRTI) targeting HIV-1. It demonstrates significant antiviral activity with a Ki of 2.93 nM for the inhibition of the wild-type HIV-1 reverse transcriptase and an IC95 of 1.5 nM against HIV-1 replication in cultured cells. This compound is suitable for research applications focusing on HIV-1 therapy and the development of antiretroviral drugs. -
Parasite Inhibitor
Gallinamide A TFA is a potent inhibitor of cathepsin L (CatL), with an IC50 of 17.6 pM. This peptide demonstrates significant antiviral activity by inhibiting SARS-CoV-2 infection, with an EC50 of 28 nM. Additionally, Gallinamide A TFA effectively inhibits Plasmodium falciparum, exhibiting an IC50 of 50 nM, making it a valuable reagent for research into parasitic infections and viral therapies. -
Anti-parasite Agent
D-Arabinose functions as an anti-parasitic agent with a notable capability to inhibit the growth of Caenorhabditis elegans, exhibiting an IC50 of 7.5 mM. This compound effectively penetrates the blood-brain barrier and selectively interferes with the metabolism of D-ribose and D-fructose. Additionally, D-Arabinose demonstrates antibacterial properties by inhibiting biofilm synthesis and activates the ACSS2-PPARγ/TFEB-CRTC1 axis via the lysosomal AXIN-LKB1-AMPK pathway, contributing to its antidepressant-like effects. D-Arabinose serves as the ring-opened form of the aldopentose D-arabinose. -
PPAR-γ Activator
Glabrone, a PPAR-γ activator derived from the roots of Glycyrrhiza glabra, demonstrates notable ligand binding activity to this nuclear receptor. In addition to its role as a specific probe substrate for UGT1A9, Glabrone's metabolites inhibit neuraminidase, thus preventing influenza virus release. This compound is suitable for research applications focused on herb-drug interactions and the evaluation of anti-influenza viral activity. -
Antibiotic
nTZDpa is a partial agonist of PPARG and functions as an antibiotic. It exhibits significant antibacterial activity, particularly against both growing and persistent strains of Staphylococcus aureus, through the mechanism of lipid bilayer disruption. This compound is valuable for research applications focused on antibiotic resistance and the exploration of novel therapeutic strategies against bacterial infections. -
Antibacterial Agent/Growth-promoting Agent
Quindoxin is an antibacterial agent that acts by disrupting bacterial cell function. It demonstrates significant growth-promoting activity, particularly in livestock, and has been shown to exhibit dose-dependent mutagenicity against Salmonella typhimurium strains TA98 and TA100. Additionally, Quindoxin is associated with potential DNA damage, highlighting its relevance in studies related to genotoxicity and carcinogenicity. -
Bacterial Transcription Inhibitor
GKL003 is a bacterial transcription inhibitor that targets the interaction interface of RNA polymerase (RNAP) and the sigma factor, with a Ki value of 5.79 nM. By specifically binding to the RNAP β' clamp helix region at the σA factor binding site, GKL003 disrupts the formation of the RNAP holoenzyme and inhibits bacterial transcription initiation complexes. This compound effectively inhibits the growth of both Gram-positive and Gram-negative bacterial strains, including those that are drug-resistant, making it a valuable tool for research applications in microbiology and antibiotic resistance studies. -
FXR Antagonist
(-)-(E)-Guggulsterone is a natural stereoisomer of Guggulsterone that functions as a Farnesoid X Receptor (FXR) antagonist with an IC50 of 24.06 μM. This compound exhibits significant hypolipidemic effects and demonstrates the ability to suppress dengue virus (DENV) replication by enhancing antiviral interferon responses through the activation of Nrf2 and upregulation of HO-1 expression. Additionally, (-)-(E)-Guggulsterone displays antibacterial properties against various strains, including Bacillus subtilis, Staphylococcus aureus, and Pseudomonas aeruginosa, as well as offering cardiac protective and antioxidant benefits in rat models. -
Antibiotic
CPPD-Q is an antimicrobial agent that primarily targets bacterial pathogens. It demonstrates potent antibacterial activity with an EC50 value of 6.98 mg/L against Vibrio fischeri. Additionally, CPPD-Q exhibits insecticidal properties in Caenorhabditis elegans, where it induces the generation of reactive oxygen species (ROS) in the intestines at concentrations of 1 or 10 µg/mL. This compound is suitable for research applications focused on antimicrobial resistance and the mechanisms of insecticidal action. -
Antiviral Agent
Onradivir is an orally active antiviral agent that specifically targets the PB2 subunit of influenza A virus RNA polymerase, exhibiting an IC50 of 0.562 nM. By inhibiting cap binding, Onradivir effectively suppresses viral replication, lowers viral titers, and mitigates influenza A virus infection. In preclinical studies, Onradivir demonstrated enhanced survival rates in mice infected with influenza A virus and significantly reduced viral loads. This compound is valuable for researching influenza A virus infections and developing potential therapeutic strategies.
