Catalog No.
Product Name
Application
Product Information
Citations
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Antibiotic
A-39183A is a potent antibiotic that exerts significant cytotoxic effects on HeLa cells, demonstrated by an IC50 value of 1.8 μM. This compound's mechanism of action may offer valuable insights into antimicrobial properties and cellular response pathways. A-39183A is suitable for research applications focused on studying antibiotic resistance and cell viability in cancer models. -
Antibiotic
Baquiloprim is an antibiotic that selectively inhibits bacterial dihydrofolate reductases. It demonstrates in vitro bacteriostatic activity against a variety of both Gram-negative and Gram-positive bacteria. Baquiloprim is utilized in research applications focused on understanding bacterial resistance and the mechanisms of folate metabolism in microbial pathogens. -
Antitumor Antibiotic
Alcindoromycin is an anthracycline antitumor antibiotic that exerts its effects primarily through the inhibition of topoisomerase II and intercalation into DNA. This compound demonstrates significant cytotoxic activity against various cancer cell lines, making it a valuable tool in cancer research. Alcindoromycin is utilized to investigate the mechanisms of chemoresistance and to evaluate potential therapeutic strategies for various malignancies. -
Antibiotic
Albomycin δ1 is a selective antibiotic that targets bacterial ribosomes, demonstrating bactericidal activity through covalent binding to 70S ribosomes and irreversible inhibition of peptidyl transferase. With an MIC of 0.0625 μg/mL against Streptococcus pneumoniae, this compound shows potential for research into infections caused by S. pneumoniae and Staphylococcus aureus. Its unique mechanism of action makes Albomycin δ1 a valuable tool in the study of ribosome-targeted therapeutics. -
Bacterial Inhibitor
LL-BM123α is a bacterial inhibitor derived from Nocardia sp., with a primary mechanism of action targeting Gram-negative bacteria. This compound demonstrates moderate antimicrobial activity, making it a valuable tool in research focused on bacterial infections and antibiotic resistance. LL-BM123α can be utilized in studies aimed at understanding the efficacy of novel antibiotics and developing strategies for overcoming bacterial resistance. -
Antibiotic
Actagardin is a tetracyclic lantibiotic that effectively targets Gram-positive bacteria by inhibiting peptidoglycan synthesis. This compound is characterized by its unique macrocyclic structure, formed through thioether bridges. Actagardin is utilized in research for its antibiotic properties, providing insights into bacterial resistance mechanisms and potential therapeutic applications. -
Cephalosporin Antibiotic
Cephradine sodium is a broad-spectrum cephalosporin antibiotic that demonstrates efficacy against both gram-positive and gram-negative bacteria, including penicillinase-producing strains. Its primary mechanism involves disrupting bacterial cell wall synthesis, leading to cell lysis and death. This reagent is utilized extensively in research focusing on genitourinary, gastrointestinal, and respiratory tract infections, as well as infections of the skin and soft tissues. Additionally, Cephradine sodium has been shown to inhibit TOPK, providing a potential therapeutic avenue for managing solar-ultraviolet induced skin inflammation. -
Antibiotic
PTZ601 is an antibiotic that targets gram-positive bacteria, effectively inhibiting strains such as Vancomycin-resistant Enterococcus faecium (VREF) and Methicillin-resistant Staphylococcus aureus (MRSA). This compound demonstrates significant antimicrobial activity in infected mouse models, making it a valuable tool for research in bacterial resistance and therapeutic development. Its application in preclinical studies may provide insights into potential treatments for resistant bacterial infections. -
Tetracycline Antibiotic
Demeclocycline calcium is a tetracycline antibiotic that primarily inhibits protein synthesis by binding to the 30S ribosomal subunit, preventing the attachment of aminoacyl tRNA. This compound exhibits a broad spectrum of antibacterial activity, making it useful in the treatment of various bacterial infections. Demeclocycline calcium is frequently utilized in research applications to study bacterial resistance and protein synthesis mechanisms. -
Antibiotic
Teicoplanin A2-3 is an antibiotic that primarily targets Gram-positive bacteria, including both aerobic and anaerobic strains. It exhibits potent antibacterial activity by inhibiting cell wall synthesis, making it effective in treating various infections caused by susceptible microorganisms. This reagent is valuable for research applications focused on antibiotic resistance, microbial pathogenesis, and the development of novel antibacterial therapies. -
Antibiotic
Malioxamycin is an antibiotic that targets Gram-negative bacteria by inhibiting peptidoglycan synthesis in bacterial cell walls. This mechanism disrupts bacterial cell wall integrity, leading to the formation of spheroplasts and subsequently causing cell lysis. Malioxamycin is applicable in research related to antibiotic resistance and bacterial cell wall biology. -
Antibiotic
Desotamide is a cyclic hexapeptide antibiotic that targets bacterial cell membrane integrity. It demonstrates potent activity against Staphylococcus aureus, Streptococcus pneumoniae, and methicillin-resistant Staphylococcus epidermidis (MRSE), with minimum inhibitory concentrations of 16, 12.5, and 32 μg/mL, respectively. This compound is useful for research applications related to antibiotic activity and resistance mechanisms in pathogenic bacteria. -
Antibiotic
Teicoplanin A3-1 is a glycopeptide antibiotic that targets Gram-positive bacteria. It is a degradation product of teicoplanins A2-1 to 5, showcasing broad-spectrum antibacterial activity. This compound is pivotal in research applications involving the effectiveness of glycopeptide antibiotics against resistant bacterial strains. -
Antibacterial, Biofilm Formation Inhibitor
Majoranaquinone is a potent antibacterial agent that targets various bacterial strains, demonstrating significant inhibitory effects against four Staphylococcus species, one Moraxella species, and one Enterococcus species. Additionally, it exhibits substantial efflux pump inhibitory activity in Escherichia coli ATCC 25922. Majoranaquinone also effectively inhibits biofilm formation in both E. coli ATCC 25922 and E. coli K-12 AG100, making it a valuable reagent for research applications focused on combating bacterial infections and biofilm-related challenges. -
Antibiotic
Antibacterial agent 159 is a broad-spectrum antibiotic that targets bacterial infections. It exhibits efficacy against impetigo and Clostridium difficile infections (CDI), demonstrating complete absence of recurrence for CDI while preserving the integrity of beneficial gut microbiota. This compound is valuable for research applications focusing on antibiotic resistance and the management of C. difficile-associated diseases. -
Antibiotic Peptide
BMAP-28 is an antibiotic peptide that acts as an inducer of the mitochondrial permeability transition pore. It triggers cell death by promoting the opening of this pore, making it a valuable tool for studying microbial infections and cancer mechanisms. Researchers can utilize BMAP-28 to explore its potential therapeutic applications and the underlying processes involved in cell apoptosis. -
Antibacterial Metabolite
Monomethylsulochrin is a potent antibacterial metabolite derived from the endophytic fungus Aspergillus fumigatus, isolated from the leaves of Albizia lucidior. This compound demonstrates significant antibacterial activity against Staphylococcus aureus, with a minimum inhibitory concentration (MIC) of 31.25 μg/mL. Monomethylsulochrin serves as a valuable tool for research applications focused on exploring novel antimicrobial agents and mechanisms of bacterial resistance. -
Bacterial Inhibitor
Lauryl-LF 11 is an N-terminally acylated analogue of LF11 that acts as a bacterial inhibitor. This peptide demonstrates significant antibacterial activity, making it a valuable tool for research in microbiology and infectious diseases. It can be utilized in studies focused on the mechanisms of bacterial resistance and the development of novel antimicrobial agents. -
Antibacterial Agent
FK-041 is an orally active cephalosporin antibiotic that targets penicillin-binding proteins (PBPs) to exert its antibacterial effects. It demonstrates broad-spectrum activity against a variety of pathogens, including both Gram-positive and Gram-negative bacteria as well as anaerobes. Additionally, FK-041 shows efficacy against certain drug-resistant strains, such as penicillin-resistant Streptococcus pneumoniae. This reagent is valuable for research focused on infectious diseases and the development of new antibacterial therapies. -
Bacterial Inhibitor
Citreamicin alpha is a potent bacterial inhibitor demonstrated to exhibit significant antimicrobial activity against a range of Gram-positive cocci. In vitro studies reveal that MIC values for Staphylococci range from 0.12-4.0 μg/ml, and for Streptococcus pyogenes, they range from 0.03-0.12 μg/ml. While Citreamicin alpha shows superior efficacy compared to ampicillin, amoxicillin, and ceftriaxone, it exhibits comparable effects to vancomycin. Its effectiveness against various strains makes it a valuable reagent for research in antibiotic development and resistance studies. -
Antibiotic
CK0683A is a novel biaminourea antibiotic that targets bacterial plaque formation. Demonstrating significant antiplaque effects, this compound has shown efficacy in experimental mouse models of dental disease. In a 12-week study, CK0683A was evaluated in beagles for its potential to reduce plaque and gingivitis while assessing safety and staining potential. The canine model is relevant, as the onset and progression of periodontal disease in dogs parallels that in humans, making CK0683A a promising candidate for further research in periodontal treatment. -
Antibiotic
Aztreonam (lysine) is a monocyclic beta-lactam antibiotic that specifically targets penicillin-binding protein 3 (PBP-3). It exhibits potent activity against Gram-negative aerobic bacteria, making it an important reagent for studies involving bacterial resistance and the development of antimicrobial therapies. This compound is particularly relevant in research focused on combating infections caused by resistant strains and understanding the mechanisms of beta-lactam antibiotics. -
Antibiotic/Antimicrobial Peptide
Aurein 2.4 is an antibiotic antimicrobial peptide that primarily targets Gram-positive bacteria. It exhibits potent antibacterial activity, making it a valuable reagent for research focused on antimicrobial resistance and the development of novel antibacterial therapies. Its unique mechanism of disrupting bacterial membranes positions Aurein 2.4 as a relevant tool in studies investigating the efficacy of peptide-based antibiotics. -
Antibiotic
Cefmenoxime is a semisynthetic cephalosporin antibiotic targeting bacterial cell wall synthesis. It exhibits broad-spectrum antibacterial activity against a wide variety of gram-positive and gram-negative bacteria. This compound is primarily applied in microbiological research and antibiotic susceptibility studies. -
Anti-HSV Agent
Acyclovir monophosphate is a potent anti-herpes simplex virus (HSV) agent that inhibits viral DNA polymerase, effectively blocking DNA synthesis and terminating viral DNA chain elongation. In addition to its antiviral properties, Acyclovir monophosphate has demonstrated antitumor activity. This compound is valuable for research focused on virology and cancer therapeutic applications. -
Antibiotic
N-Formylfortimicin A is an aminoglycoside antibiotic that targets bacterial ribosomes to inhibit protein synthesis. It demonstrates broad-spectrum antibacterial activity, effectively inhibiting both Gram-positive and Gram-negative bacteria, such as Escherichia coli with a minimum inhibitory concentration (MIC) of 12.5-50 μg/mL. This compound is a promising candidate for research focused on bacterial infections and related diseases. -
Antibiotic
Arbekacin is an aminoglycoside antibiotic that targets bacterial protein synthesis, inhibiting the growth of both Gram-positive and Gram-negative bacteria. It demonstrates broad-spectrum antimicrobial activity, making it a valuable tool in the study of bacterial infections and resistance mechanisms. Arbekacin is utilized in research applications aimed at understanding antibiotic efficacy and developing new therapeutic strategies. -
Fluorescent Substrate
4-MUNANA is a highly selective fluorescent substrate for influenza virus neuraminidase (NA), undergoing an irreversible enzymatic reaction that releases fluorescent 4-methylumbelliferone (4-MU). The fluorescence intensity of 4-MU provides a quantitative measure of NA activity, making 4-MUNANA a valuable tool in influenza research. Applications include screening for neuraminidase inhibitors, creating new anti-influenza therapies, and investigating the infection mechanisms of influenza viruses. -
Fluorescence probe
BTP9-Neu5Ac is a fluorescence probe that targets neuraminidase (NA) sialidase activity in influenza viruses. It enables the visualization of intracellular Golgi localization of viral NA activity, providing insights into the enzyme's function within the viral life cycle. BTP9-Neu5Ac is essential for precise and temporal monitoring of key enzymatic activities, facilitating the study of viral pathogenesis and therapeutic intervention strategies. -
Recombinant Bacterial Clones Chromogenic Substrate
X-GalNAc is a chromogenic substrate that specifically targets N-acetyl-β-galactosidase. This reagent is utilized in molecular biology to detect the presence of cloned DNA inserts in bacterial colonies cultured on agar plates. The enzymatic hydrolysis of X-GalNAc results in a distinct color change, facilitating easy identification of recombinant bacterial clones in various genetic research applications. -
SARS-CoV-2 Inhibitor
TFMU-ADPr is a selective reporter substrate that targets the SARS-CoV-2 Macro1 protein, displaying an IC50 of 0.59 μM. This compound emits fluorescence at 502 nm (or 495 nm) upon enzymatic hydrolysis by Poly(ADP-ribose) Glycohydrolase (PARG) and ADP-ribosylhydrolase 3. TFMU-ADPr binds to the ADPr-binding site of Macro1, providing a robust method for assessing the activity of poly(ADP-ribose) hydrolases. Its applications extend to evaluating small-molecule inhibitors under in vitro conditions, investigating ADP-ribosyl catabolic enzyme mechanisms, and detecting PAR hydrolase activity in whole-cell lysates, making it a valuable tool for COVID-19-related research. -
Bacterial Inhibitor
Resazurin sodium is a non-toxic, stable redox indicator that targets bacterial activity through its membrane-permeable properties. It serves as a vital tool for assessing cell viability, proliferation, and toxicity in various cell types, including human, plant, animal, bacterial, and fungal cells. Upon reduction, Resazurin sodium transforms into Resorufin, a highly fluorescent compound, enabling sensitive detection and quantification of cellular processes under fluorescent microscopy or spectrophotometry. -
SARS-CoV Inhibitor
Direct Violet 1 is an azo dye that functions as an inhibitor of the spike protein-ACE2 interaction in SARS-CoV-2, exhibiting IC50 values ranging from 1.47 to 2.63 μM. This compound serves as a valuable tool for investigating viral entry mechanisms and studying protein-protein interactions related to SARS-CoV-2. Its application may extend to antiviral research and the development of therapeutic strategies targeting COVID-19. -
Antibacterial Agent
ANS ammonium is a potent antibacterial agent that also serves as a textile dye. It functions as a fluorescence probe, enabling the detection of various biological interactions. Additionally, ANS ammonium is known to inhibit the binding of triiodothyronine to thyroxine binding globulin, making it useful in radioimmunoassays for triiodothyronine analysis. -
Antiviral Agent
Brilliant Black BN is an azo dye with a notable application as an antiviral agent. It effectively inhibits the interaction between enterovirus 71 (EV71) and its uncoating factor, cyclophilin A, demonstrating significant potential in the treatment of viral infections. This compound serves as a valuable tool for research focused on antiviral mechanisms and infectious disease studies. -
Bacterial Inhibitor
4-Methylherniarin, a coumarin derivative, exhibits antibacterial activity by effectively inhibiting both gram-positive and gram-negative bacterial strains. It demonstrates significant antimicrobial efficacy against B. subtilis and S. sonnei, with IC50 values of 11.76 μg/ml and 13.47 μg/ml, respectively. This compound serves as a valuable tool for research applications focused on combating bacterial infections and elucidating mechanisms of action in microbial resistance. -
Antibiotic Agent
Polyketomycin is a tetracyclic quinone glycoside antibiotic derived from Streptomyces sp. or Streptomyces diastatochromogenes, targeting Gram-positive bacteria with a minimal inhibitory concentration (MIC) of less than 0.2 µg/mL. This compound exhibits notable antibacterial, anticancer, and antimalarial activities, making it a valuable tool in microbiological and pharmacological research. Its diverse biological applications support investigations in antibiotic efficacy, cancer treatment, and antimalarial drug development. -
Antitumor Antibiotic
Sandramycin is a cyclic depsipeptide antibiotic with a primary mechanism of action as an antitumor agent. It exhibits potent DNA intercalation and binding, functioning effectively as a cytotoxin in antibody-drug conjugates (ADCs). Sandramycin demonstrates significant activity against Gram-positive bacteria and is recognized for its strong antitumor efficacy, making it a valuable reagent for cancer research and the development of targeted therapies. -
Dengue Protease Inhibitor
Carbonic anhydrase inhibitor 16 is a potent dengue protease inhibitor that targets human carbonic anhydrases I and II, exhibiting inhibitory constants (Ki) of 28.5 nM and 2.2 nM, respectively. This compound demonstrates significant biological activity in hindering dengue virus replication by disrupting protease function. It may be utilized in research applications aimed at elucidating mechanisms of dengue virus pathogenesis and developing antiviral therapeutics. -
Bacterial Inhibitor
Procodazole is a potent bacterial inhibitor that enhances immune response, offering protection against various viral and bacterial infections. In addition to its broad-spectrum antibacterial effects, Procodazole demonstrates antiparasitic activity and serves as a carbonic anhydrase inhibitor, contributing to its antitumor properties. This compound is suitable for research applications focused on infectious diseases and cancer biology. -
Nucleoside Antibiotic
Dealanylascamycin is a nucleoside antibiotic that functions as a carbonic anhydrase (CA) inhibitor, exhibiting Ki values of 167, 65.2, 234, and 143 nM for human CA isoforms I, II, IV, and IX, respectively. This compound demonstrates broad-spectrum antibacterial activity, notably effective against pathogens such as Xanthomonas citri with a minimum inhibitory concentration (MIC) of 0.4 μg/mL. Additionally, Dealanylascamycin displays significant cytotoxicity, making it a substance of interest for various biological research applications, particularly in the study of antimicrobial effects and CA inhibition. -
HIV Inhibitor
ZL0580 is an HIV inhibitor that functions by selectively binding to the BD1 domain of BRD4, leading to epigenetic suppression of the virus. This compound effectively inhibits Tat transactivation and transcription elongation while promoting a repressive chromatin structure at the HIV promoter. ZL0580 is valuable for research applications focused on HIV therapies and the mechanisms of viral transcription regulation. -
HIV-1 LRA
UMB-136 is a bromodomain inhibitor targeting HIV-1 latency. It serves as a promising latency-reversing agent (LRA) for the eradication of HIV-1, effectively reactivating the virus in various cell models. UMB-136 enhances HIV-1 transcription and promotes viral production by facilitating the release of P-TEFb, thereby contributing to research in HIV treatment strategies. -
FgGpmk1 Inhibitor
FgGpmk1-IN-1 is a selective inhibitor of the Fusarium graminearum mitogen-activated protein kinase (FgGpmk1), exhibiting an EC50 value of 3.46 μg/mL. This compound is valuable for investigating the biological role of FgGpmk1 in fungal pathogenesis and offers potential applications in the study of plant-fungal interactions. Researchers can utilize FgGpmk1-IN-1 to explore therapeutic strategies against Fusarium-related diseases. -
Heterocyclic Compound
Indazole, a heterocyclic aromatic compound, exhibits significant biological activity through its diverse derivatives. These derivatives are known for their anti-inflammatory, antibacterial, anti-HIV, antiarrhythmic, antifungal, and antitumor properties. Indazole and its derivatives are valuable tools for research into cancer, neurological disorders, cardiovascular diseases, and gastrointestinal diseases, highlighting their potential in various therapeutic applications. -
Antibiotic
Luisol A is an anthraquinone antibiotic analog derived from an aromatic tetraol, recognized as a major metabolite of Streptomyces, a marine actinomycete. This compound exhibits significant antibacterial activity, making it a valuable tool in the study of antibiotic mechanisms and resistance. Its application in research aids in the exploration of novel antimicrobial agents and their effects on various bacterial strains. -
Bacterial Inhibitor
Aniline-MPB-amino-C3-PBD is a cytotoxic agent targeting bacterial cells through minor-groove binding of DNA. This sequence-selective compound serves as an effective payload for antibody-drug conjugates (ADCs), enhancing their therapeutic efficacy. Its antimicrobial properties make it a valuable tool for research in bacterial inhibition and related applications. -
Antibiotic
Agrochelin is an alkaloid antibiotic with cytotoxic properties, derived from the fermentation of marine Agrobacterium species. This compound exhibits significant cytotoxic activity against various tumor cell lines, making it a valuable tool in cancer research. Agrochelin's mechanism of action may provide insights into antibiotic efficacy and the development of novel therapeutic strategies for oncological applications. -
Bacterial Inhibitor
Py-MPB-amino-C3-PBD is a cytotoxic agent that functions as a bacterial inhibitor. This compound serves as a payload for antibody-drug conjugates (ADCs) and exhibits significant antimicrobial activity. Its unique structure, characterized by a non-alkylating group, makes it a valuable tool for research applications aimed at targeting bacterial infections and developing therapeutics in the field of microbiology. -
Phytoestrogen
3,7-Dihydroxyflavone is a flavonoid phytoestrogen that modulates estrogen receptors, making it a valuable compound for research in hormonal signaling pathways. It serves as an inhibitor of the human progesterone metabolizing enzyme AKR1C1 and fungal 17β-hydroxysteroid dehydrogenase, demonstrating redox inhibitory activity with IC50 values of 0.6 μM and 6.0 μM, respectively. Additionally, 3,7-Dihydroxyflavone exhibits fluorescence properties, acting as a binding substrate for human serum albumin with specific excitation and emission wavelengths, rendering it useful for biochemical assays and studies related to protein binding interactions.
