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Catalog No.
Product Name
Application
Product Information
Citations
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HIV/HBV Inhibitor
L-Fd4A is an adenine derivative that inhibits both human immunodeficiency virus (HIV) and hepatitis B virus (HBV) with effective concentrations (EC50) of 1.5 μM and 1.7 μM, respectively. This compound demonstrates promising antiviral activity while exhibiting low cytotoxicity, making it suitable for research applications in studying HIV and HBV inhibition mechanisms. -
Nematode Growth Inhibitor
5-(4-Methoxyphenyl)oxazole is a nematode growth inhibitor that targets Caenorhabditis elegans, effectively interfering with hatching and growth processes. This compound, derived from fungal culture broth, exhibits potential in studying nematode biology and assessing the efficacy of nematicidal agents. Its application in research provides valuable insights into nematode management and development. -
FREP1 Inhibitor
P-orlandin is a specific inhibitor of FREP1, a protein that mediates the binding of Plasmodium gametocytes and ookinetes. This fungal metabolite demonstrates potent activity in blocking Plasmodium falciparum infections in mosquito vectors, making it a valuable tool for research in malaria transmission and vector control studies. Its unique mode of action offers insights into potential strategies for disrupting the lifecycle of malaria parasites. -
HCV/HIV Inhibitor
C5A is a microbicidal peptide that targets and inhibits both hepatitis C virus (HCV) and human immunodeficiency virus (HIV). By disrupting the membrane integrity of the HIV virion and affecting the conical capsid core that encases the viral genome, C5A significantly reduces the infectivity of a wide range of HIV isolates in various primary target cells in vitro. Additionally, studies have demonstrated that C5A offers protective effects in mice against vaginal and rectal challenges with HIV, highlighting its potential utility in antiviral research applications. -
COVID-19 Inhibitor
RBT-9 is a COVID-19 inhibitor that targets viral replication and inflammation pathways. It has demonstrated efficacy in preventing the progression to severe COVID-19 and associated organ failure. Furthermore, RBT-9 exhibits antiviral activity against various enveloped viruses, including influenza, hepatitis C virus (HCV), dengue, and yellow fever, making it a valuable tool for research in viral pathogenesis and therapeutic intervention. -
Bacterial Inhibitor
Pyrroxamycin is a novel antibiotic with a primary mechanism targeting Gram-positive bacteria and dermatophytes. Derived from the fermentation of Streptomyces, it exhibits potent antibacterial activity. This compound has potential applications in pharmaceutical research for the development of new antimicrobials, particularly against resistant bacterial strains. Detailed analysis of its chemical structure was performed using X-ray crystallography and 13C NMR spectroscopy, elucidating its physicochemical properties and enhancing its utility in microbiological studies. -
Quorum Sensing Inhibitor
Aculene D is a quorum sensing inhibitor derived from fungal metabolites that targets the signaling mechanisms in bacteria. It effectively reduces violacein production in Chromobacterium violaceum CV026 cultures induced by N-hexanoyl-L-homoserine lactone (C6-HSL) at sub-inhibitory concentrations. This compound is valuable for research exploring bacterial communication and the modulation of biofilm formation, with potential applications in combating antibiotic resistance and developing new antimicrobial strategies. -
Bacterial Inhibitor
β-Lactamase-IN-6 is a potent inhibitor of β-Lactamase enzymes, which play a crucial role in bacterial resistance to β-lactam antibiotics. This compound demonstrates significant antibacterial activity by preventing the enzymatic breakdown of β-lactam antibiotics, thereby enhancing their effectiveness against resistant bacterial strains. β-Lactamase-IN-6 serves as a valuable tool in microbiological research and antibiotic development, providing insights into combating bacterial infections and resistance mechanisms. -
Bacterial Inhibitor
(R)-Gyramide A hydrochloride is a bacterial DNA gyrase inhibitor that effectively disrupts DNA supercoiling, exhibiting an IC50 of 3.3 µM. This compound demonstrates significant antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, and Salmonella enterica, with minimum inhibitory concentrations ranging from 10 to 80 µM. Notably, (R)-Gyramide A hydrochloride does not inhibit topoisomerase IV, making it a valuable tool for studying bacterial mechanisms and antibiotic resistance. -
Bacterial Inhibitor
Acrisorcin is a topical anti-infective compound that functions primarily as a bacterial inhibitor. It exhibits potent fungicidal properties, making it valuable for research into antifungal therapies and the understanding of bacterial resistance mechanisms. Its efficacy in mitigating fungal infections supports its application in various microbiological studies and therapeutic evaluations. -
Bacterial Inhibitor
CID21480113 is an inhibitor targeting bacterial pathways, specifically effective against dapsone-resistant strains of leprosy. This compound demonstrates significant antibacterial activity, making it a valuable tool for research in microbial resistance and infectious disease studies. Its ability to combat resistant bacteria positions CID21480113 as a relevant reagent for investigations into alternative therapies for leprosy. -
Bacterial Inhibitor
o-Cymen-5-ol acts as a broad-spectrum antimicrobial agent targeting various bacterial and fungal pathogens. It demonstrates effective minimum inhibitory concentrations (MICs) against organisms such as Streptococcus mutans and Candida albicans. Notably, o-Cymen-5-ol exhibits synergistic effects when combined with zinc, enhancing its antimicrobial activity against oral pathogens by inhibiting glycolysis. Studies indicate a more pronounced antibacterial effect in formulations such as toothpaste compared to placebo. This compound is valuable for research applications in microbiology and dental health. -
Bacterial Inhibitor
Strinoline is a bacterial inhibitor that targets and disrupts bacterial cell function. This compound exhibits significant antibacterial activity, making it a valuable tool for research in the field of microbiology. Strinoline can be utilized to study bacterial resistance mechanisms and the efficacy of antibiotic therapies. -
Bacterial IMPDH Inhibitor
IMPDH-IN-1 is a selective inhibitor of bacterial inosine 5'-monophosphate dehydrogenase (IMPDH), targeting the catalytic domain of the enzyme. This compound demonstrates potent inhibitory activity against IMPDH from key bacterial pathogens, including Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli. It serves as a valuable tool for research into bacterial metabolism and the development of novel antimicrobial therapies. -
Bacterial Inhibitor
4-Hydroxysphinganine (C17 base) is a bacterial inhibitor that plays a critical role in membrane structure for various organisms, including fungi, plants, and bacteria. It is essential for maintaining membrane integrity, regulating cellular growth, and facilitating the heat stress response in yeast. Additionally, 4-Hydroxysphinganine acts as a precursor for the synthesis of key lipid mediators, such as PHS 1-phosphate and inositol phosphorylceramide. Its properties also support keratinocyte differentiation, making it relevant for applications in dermatology and cosmetic research. -
Bacterial Inhibitor
Sarothralin G is a potent antibacterial compound derived from Hypericum japonicum Thunb. It exhibits exceptional activity against Gram-positive bacteria, including Staphylococcus aureus, Bacillus subtilis, and Nocardia species. With its unique phenolic and aromatic acid structure, Sarothralin G demonstrates superior antibacterial efficacy compared to related compounds such as Sarothralen A, B and Saroaspidin A, B, C. This compound is valuable for research in antibiotic development and the study of bacterial resistance mechanisms. -
AgrA Quorum-sensing Inhibitor
Apicidin D2 is a specific inhibitor of the accessory gene regulator A (AgrA), which plays a pivotal role in bacterial quorum sensing. This fungal metabolite demonstrates notable anti-virulence properties by effectively suppressing AgrA activation in Staphylococcus aureus, including methicillin-resistant strains (MRSA), without exhibiting biocidal effects. Apicidin D2 is a valuable reagent for research focused on understanding MRSA infections and developing strategies to combat quorum-sensing related pathogenicity. -
Bacterial Inhibitor
INF55 is a multidrug resistance pump inhibitor targeting bacterial efflux mechanisms. By inhibiting the NoA pump, INF55 enhances the antibacterial efficacy of compounds such as berberine, reducing their efflux and overcoming bacterial resistance. Structural variants of INF55 demonstrate diverse NoA inhibitory activities, which can influence the antibacterial effectiveness of their respective heterocomplexes. This versatility makes INF55 and its derivatives valuable tools in the study and development of novel antimicrobial strategies. -
Bacterial Inhibitor
Racemomycin B is a potent bacterial inhibitor derived from Streptomyces lavendulae OP-2, characterized as a streptothricin antibiotic with three β-lysine groups. It demonstrates significant antimicrobial activity against plant pathogenic microorganisms, effectively inhibiting the root growth of Brassica rapa L. at a concentration of 50 ppm. Racemomycin B exhibits a minimum inhibitory concentration (MIC) of 0.4 μg/ml against Pseudomonas syringae pv. tabaci IFO-3508 and a MIC range of 0.1-2.0 μg/ml against various strains of Fusarium oxysporum. The biological efficacy of this compound is enhanced by the increasing number of β-lysine groups, making it a valuable tool for agricultural research. -
Bacterial Inhibitor
(R,R)-Ethambutol is a bacterial inhibitor primarily targeting Mycobacterium tuberculosis, exhibiting significant antituberculosis activity. It is commonly utilized in combination therapies to enhance the therapeutic efficacy against tuberculosis. Additionally, (R,R)-Ethambutol demonstrates effectiveness in inhibiting infections caused by Mycobacterium avium complex and Mycobacterium kansasii, making it a valuable reagent for research in mycobacterial infections. -
Bacterial Inhibitor
Fenvalerate-d6 is a deuterium-labeled derivative of Fenvalerate, primarily targeting bacterial inhibition. This compound exhibits potent antibacterial activity, making it valuable for research applications focused on elucidating bacterial resistance mechanisms and evaluating the efficacy of antibacterial agents. Its isotopic labeling enables tracking and quantification in metabolic studies and pharmacokinetic investigations. -
Bacterial Inhibitor
(E/Z)-Aureusidin is a flavonoid compound that functions as a bacterial inhibitor through its antioxidant properties. It effectively inhibits the production of reactive oxygen species, thereby reducing cellular damage and inflammation by lowering the expression of inflammatory factors. Additionally, (E/Z)-Aureusidin exhibits broad-spectrum antimicrobial activity, highlighting its potential applications in combating bacterial infections and studying inflammatory responses. -
Bacterial Inhibitor
AGS1286 sodium, an organosulfur compound, functions as a bacterial inhibitor by targeting enzymatic activities and metabolic pathways influenced by sulfur-containing compounds. This reagent is utilized in research to examine the regulatory effects on bacterial growth and gene expression, making it valuable for studies in microbiology and metabolic regulation. Its unique structural features provide insights into the role of sulfur in microbial dynamics and enzymatic processes. -
Bacterial Inhibitor
VCC234718 is a selective inhibitor of inosine monophosphate dehydrogenase (GuaB2), effectively targeting Mycobacterium tuberculosis (Mtb) to inhibit its growth. With a K value of 100 nM, VCC234718 exhibits non-competitive inhibition involving both IMP and NAD+, demonstrating its ability to disrupt enzymatic function through direct interactions with these metabolites. This compound is valuable for studying mycobacterial infections and developing new treatments for tuberculosis. -
Bacterial Inhibitor
Antitubercular agent-47 (compound 5C) is a potent bacterial inhibitor specifically targeting Mycobacterium tuberculosis. It demonstrates significant efficacy against drug-sensitive (DS), multidrug-resistant (MDR), and extensively drug-resistant (XDR) clinical isolates. This compound is valuable for research applications focused on tuberculosis treatment and drug resistance mechanisms. -
LasB Inhibitor, Antibacterial Activity
Elastase LasB-IN-1 is a selective inhibitor of elastase LasB, exhibiting a potent IC50 value of 76 nM. This compound demonstrates significant antibacterial activity, making it an important tool for research applications focused on bacterial infections. Its specificity for LasB facilitates investigations into the role of elastolytic enzymes in microbial pathogenesis. -
Bacterial Inhibitor
Antibacterial agent 149 is a potent laccase inhibitor that exhibits significant antibacterial properties. This compound is particularly effective against bacterial pathogens and has demonstrated high fungicidal activity, making it a valuable tool for studying rice sheath blight and related diseases. Its mechanism of action and specificity enhance its utility in researching bacterial inhibition and plant pathogenic interactions. -
Bacterial Inhibitor
15-Methylhexadeca Sphinganine is an iso-branched sphingolipid that acts as a bacterial inhibitor. It is identified as a component of ceramide-containing phospholipids in bacterial cell membranes. This compound is valuable for research applications focused on understanding bacterial lipid metabolism and exploring potential therapeutic strategies against bacterial infections. -
Bacterial Inhibitor
Chevalone B is a bacterial inhibitor derived from the marine sponge-associated fungus Aspergillus similanensis. It exhibits antimicrobial activity against both Gram-positive and Gram-negative bacteria, as well as Candida albicans and multidrug-resistant environmental strains. Its potential applications in antimicrobial research highlight its significance in the development of novel therapeutic agents. -
Bacterial Ribosome Inhibitor
Capreomycin IA is a bactericidal agent that inhibits bacterial ribosomes, primarily affecting mycobacterial species. By blocking the translocation of peptidyl-transfer RNA from the A to the P site, Capreomycin IA effectively interrupts protein synthesis. This compound demonstrates significant antimicrobial activity against Mycobacterium tuberculosis and is useful for research applications related to tuberculosis and other mycobacterial infections. -
Bacterial Inhibitor
Timcodar mesylate is a bacterial efflux pump inhibitor that targets multidrug-resistant strains by directly inhibiting ethidium bromide efflux in Staphylococcus aureus. This compound enhances the effectiveness of antibiotic treatments by reducing the minimum inhibitory concentration required against Gram-positive pathogens, including Staphylococcus aureus, Enterococcus, and Streptococcus pneumoniae. Timcodar mesylate serves as a valuable tool in microbial resistance studies and antibiotic synergy research. -
Bacterial Inhibitor
Anti-MRSA agent 24 is a potent antimicrobial compound specifically targeting methicillin-resistant Staphylococcus aureus (MRSA), with particular efficacy against penicillin-resistant strains. This reagent demonstrates significant antibacterial activity, making it essential for research applications focused on combating resistant bacterial infections and studying mechanisms of antibiotic resistance. -
Bacterial Inhibitor
Streptovitacin A is a potent antibacterial agent derived from microorganisms, designed to inhibit a wide range of bacterial strains and demonstrate antiproliferative effects on tumor cells. Its primary mechanism involves interference with essential bacterial processes, making it a valuable tool in microbiological research and cancer studies. Researchers can utilize Streptovitacin A to explore bacterial resistance mechanisms and evaluate its therapeutic potential in oncology. -
Antibacterial Inhibitor
HA5 is an antibacterial inhibitor that targets biofilm formation in Streptococcus mutans. It demonstrates a potent inhibitory effect with an IC50 value of 6.42 μM, selectively disrupting biofilm structure without impacting bacterial growth. Additionally, HA5 reduces glucan production and extracellular DNA levels, making it a valuable tool for studying bacterial pathogenesis and potential therapeutic interventions in dental caries research. -
Bacterial Inhibitor
7-O-Methylaloeresin A is a 5-methylchromone glycoside isolated from Commiphora socotrana, acting primarily as a bacterial inhibitor. It demonstrates significant antimicrobial activity against methicillin-resistant Staphylococcus aureus (NCTC 11994) and Salmonella typhimurium (ATCC 1255), with minimum inhibitory concentrations (MIC) of 0.72 mM and 0.18 mM, respectively. Additionally, 7-O-Methylaloeresin A exhibits antioxidant properties, with IC50 values of 0.026 mM for the DPPH assay and 0.021 mM for the 2-deoxyribose degradation assay, making it useful in studies related to microbial resistance and oxidative stress. -
Bacterial Inhibitor
1,4,6-Trihydroxy-5-methoxy-7-prenylxanthone is a bacterial inhibitor derived from the genus Garcinia. This compound exhibits significant antimicrobial activity against Staphylococcus aureus and Bacillus cereus, with minimum inhibitory concentration (MIC) values of 128 μg/mL and 200 μg/mL, respectively. It serves as a valuable tool in research applications aimed at understanding bacterial resistance and developing new antimicrobial therapies. -
Bacterial Inhibitor
Urease-IN-1 is a specific urease inhibitor, demonstrated by an IC50 value of 2.21 ± 0.45 µM. This compound is primarily used for research into bacterial inhibition and is relevant for studies investigating the role of urease in microbial metabolism and pathogenesis. Further applications may include exploring its potential in controlling microbial infections associated with urease-producing bacteria. -
Bacterial Inhibitor
CysHHC10 is a synthetic antimicrobial peptide that acts as a bacterial inhibitor by disrupting the integrity of microbial membranes. This compound demonstrates potent antibacterial activity against a range of both Gram-positive and Gram-negative bacteria, with minimum inhibitory concentrations (MIC) of 10.1 mM for E. coli, 20.2 mM for P. aeruginosa, 2.5 mM for S. aureus, and 1.3 mM for S. epidermidis. CysHHC10 is valuable for research applications focused on combating bacterial infections and studying microbial resistance mechanisms. -
Bacterial Inhibitor
SCH-538415 is an acyl carrier protein synthase inhibitor that disrupts bacterial cell functions by targeting the AcpS enzyme. It demonstrates significant antibacterial activity, specifically against Staphylococcus aureus, with an IC50 value of 4.19 μM in enzymatic assays. This compound is valuable for research focused on bacterial inhibition mechanisms and the development of new antimicrobial agents. -
Bacterial Inhibitor
(±)-Heraclenol is a coumarin compound known for its antibacterial properties. Isolated from the fruits of Angelica lucida, it demonstrates effective inhibition against various bacterial strains. This compound is utilized in research applications focused on understanding bacterial resistance mechanisms and exploring novel antimicrobial agents. -
Bacterial Inhibitor
Pyrithione sodium primarily targets bacterial inhibition and exhibits antimicrobial properties. This compound is commonly utilized in research applications related to skin microbiome studies and the development of anti-fungal and anti-bacterial treatments. While it is noted for its effectiveness in inhibiting bacterial growth, its limited skin penetration should be considered in experimental designs. -
Bacterial Biofilm Inhibitor
Antibacterial synergist 1 (compound 20P) is an effective bacterial biofilm inhibitor. It specifically inhibits the production of pyocyanin and biofilm formation in Pseudomonas aeruginosa with IC50 values of 8.6 μM and 4.5 μM, respectively. This compound is valuable for researching therapeutic strategies against P. aeruginosa infections, particularly in the context of chronic infections characterized by biofilm development. -
Bacterial Inhibitor
Eupatarone, also known as Caleprunin B, is a bacterial inhibitor derived from Calea platylepis. This compound exhibits significant antibacterial activity, making it a valuable tool in research focused on combating bacterial infections. Its ability to inhibit bacterial growth positions Eupatarone as an important reagent in microbiological studies and drug discovery efforts targeting antibiotic resistance. -
Bacterial Inhibitor
Bombinin-Like Peptide (BLP-1) is an antimicrobial peptide derived from Bombina species, primarily functioning as a bacterial inhibitor. This peptide exhibits potent activity against a range of bacterial strains, making it a valuable tool for research in antimicrobial resistance and the development of new therapeutic agents. Its unique mechanism and efficacy position it as an important candidate for studies focused on infection control and peptide-based drug design. -
Bacterial Inhibitor
Antimicrobial agent-21 is a potent bacterial inhibitor that demonstrates significant activity against both gram-positive and gram-negative bacteria. This compound serves as a valuable tool in microbiological research and antibiotic development, aiding in the study of bacterial resistance mechanisms and the efficacy of new antimicrobial strategies. Its broad-spectrum activity makes it applicable in various experimental settings focused on understanding bacterial pathogenesis and treatment. -
Bacterial Inhibitor
Carbendazim mixture with flusilazole is a potent bacterial inhibitor utilized in the management of sooty mold, particularly attributable to Botrytis narcissicola. This fungicide combination demonstrates efficacy in diminishing lesion size and alleviating secondary sooty mold symptoms, especially when employed alongside other fungicides. In field trials conducted in regions such as Cambridgeshire and Lincolnshire, the application of this mixture significantly controlled sooty mold and enhanced bulb production by employing a strategic spray program that alternated fungicides with varying modes of action. This research emphasizes the importance of selecting appropriate fungicides and methodologies to optimize disease management while minimizing the required applications. -
Bacterial Inhibitor
Cellocidin is a bacterial inhibitor that targets the α-ketoglutarate-succinate system in Xanthomonas species. This agricultural antibiotic demonstrates preventive activity against rice bacterial leaf blight, offering a valuable tool for managing bacterial infections in crop production. Its mechanism of action makes it an essential reagent for research into plant-pathogen interactions and the development of sustainable agricultural practices. -
Bacterial Inhibitor
Phentolamine acetate is a bacterial inhibitor that targets and disrupts the growth of specific bacterial strains, including Staphylococcus aureus. This compound exhibits notable anti-inflammatory and anticancer properties, highlighting its potential for diverse biological applications. Its significant in vitro activity makes it a valuable tool for researchers studying bacterial infections and inflammation-related disorders. -
Bacterial Inhibitor
Ethionamide hydrochloride is an antituberculosis agent that acts as a bacterial inhibitor. It disrupts mycobacterial cell wall synthesis by inhibiting fatty acid synthesis, leading to potential bacteriostatic or bactericidal effects based on concentration and microorganism susceptibility. Ethionamide hydrochloride forms an adduct with NAD+, which is crucial for its antimicrobial activity. This compound is primarily utilized in research for understanding tuberculosis treatment and the mechanisms of drug resistance in Mycobacterium tuberculosis. -
DGK Inhibitor
Cochlioquinone A is a potent diacylglycerol kinase (DGK) inhibitor, exhibiting ATP-competitive properties with a Ki value of 3.1 μM. Isolated from the fungal species Drechslera sacchari, Cochlioquinone A serves as a valuable tool for studying DGK's role in cellular signaling pathways. Its inhibitory effects on DGK activity make it pertinent for research in lipid signaling and related biological processes.
