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Catalog No.
Product Name
Application
Product Information
Citations
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Fungal Inhibitor
Sakuranetin is a cherry flavonoid phytoalexin that acts as a potent fungal inhibitor. It exhibits strong antifungal properties, along with notable anti-inflammatory and antioxidative activities. Additionally, Sakuranetin has demonstrated efficacy in ameliorating LPS-induced acute lung injury, making it a valuable compound for research in inflammation and respiratory disorders. -
Tropone Derivatives; Tyrosinase Inhibitor; Virus Inhibitor; Funga Inhibitor
Tropolone is a seven-membered non-benzenoid aromatic compound recognized for its role as a tyrosinase inhibitor, exhibiting an IC50 value of 0.4 μM. This compound demonstrates significant anti-viral and anti-fungal properties, making it effective in a variety of therapeutic applications. Additionally, Tropolone shows enhanced effects when used in conjunction with nucleos(t)ide analogs. Its potential for research in osteosarcoma emphasizes its importance in the exploration of new treatments. -
Antifungal Antibiotic/Complex III Inhibitor
Myxothiazol is an antifungal antibiotic that acts as an inhibitor of mitochondrial electron transport chain complex III (bc1 complex). It demonstrates potent antifungal activity against various yeasts and fungi, exhibiting effective growth inhibition at concentrations ranging from 0.01 to 3 μg/ml. This compound is valuable for research applications focused on mitochondrial function and the mechanisms of antifungal resistance. -
β-1,3-Glucan Inhibitor
Ibrexafungerp is an orally active β-1,3-glucan synthesis inhibitor with demonstrated antifungal properties. Its mechanism targets the cell wall biosynthesis pathway of fungi, making it valuable in research on Candida and Aspergillus infections. This compound is a promising candidate for studies focused on antifungal resistance and the development of new antifungal therapies. -
Antibacterial Agent/eEF2K Inhibitor
Cefatrizine is a broad-spectrum cephalosporin antibiotic that primarily targets bacterial infections while also acting as an eEF2K inhibitor. This compound exhibits anti-proliferative activity in human breast cancer cells, inducing endoplasmic reticulum stress and subsequent cell death. Cefatrizine is a valuable reagent for research applications in understanding mechanisms of cancer therapy and exploring antibacterial efficacy. -
Ras Inhibitor
(-)-Rasfonin is a natural fungal secondary metabolite that acts as an inhibitor of small G protein Ras. It exhibits significant biological activities, including the induction of apoptosis, necrosis, and autophagy in ACHN cells, a renal carcinoma cell line. This compound is instrumental for research focused on cellular death pathways and therapeutic strategies targeting Ras-mediated signaling in cancer. -
Superoxide Anion Inhibitor
Tanzawaic acid B is a potent inhibitor of superoxide anion production, derived from the fungal source Penicillium citrinum. This compound has been demonstrated to mitigate oxidative stress by targeting superoxide radicals, making it valuable for research in oxidative damage and related pathologies. Its biological activity provides a useful tool for studying the effects of reactive oxygen species in various cellular models. -
HIV-1 RT Inhibitor
Apricitabine is a selective inhibitor of HIV-1 reverse transcriptase (RT) with a Ki value of 0.08 μM. It also exerts inhibitory effects on DNA polymerases α, β, and γ, with corresponding Ki values of 300 μM, 12 μM, and 112.25 μM. Demonstrating significant antiretroviral efficacy and favorable tolerability, Apricitabine shows a reduced potential for resistance development in patients with antiretroviral-naive HIV infection. This compound is applicable for research in the mechanisms of HIV-1 replication and antiviral drug development. -
DENV Inhibitor
DENV-IN-4 is a potent inhibitor of Dengue Virus (DENV), exhibiting an EC50 value of 4.79 µM in Vero cells with a selectivity index greater than 20.9. This compound effectively reduces the expression levels of DENV2 in a concentration-dependent manner and inhibits RNA-dependent RNA polymerase (RdRp) enzymatic activity. DENV-IN-4 is valuable for research applications focused on understanding DENV pathogenesis and developing antiviral therapies. -
DNA Synthesis/HSV/HIV-1 Inhibitor
16,16-Dimethyl prostaglandin A1 is a prostaglandin analog that primarily inhibits DNA synthesis. It demonstrates significant antiviral activity by reducing viral replication in both herpes simplex virus (HSV) and HIV-1 infection models. This compound serves as a valuable tool for research focused on cancer biology and viral pathogenesis. -
DENV/ZIKV Inhibitor
Antiviral agent 36 is a potent inhibitor of dengue virus (DENV) and Zika virus (ZIKV), demonstrating effective antiviral activity. It inhibits viral replication with EC50 values of 100 nM for ZIKV-FLR, 90 nM for ZIKV-HN16, 210 nM for DENV-2, and 120 nM for DENV-3. This compound serves as a valuable tool for research focused on the therapeutic development and understanding of DENV and ZIKV infections. -
DENV Inhibitor
DENV-IN-7 is a flavone analog that functions as a dengue virus (DENV) inhibitor, demonstrating an EC50 value of 70 nM. This compound exhibits low toxicity to normal cells while maintaining effective antiviral activity against DENV. It is suitable for research applications focused on the development of therapeutics for dengue virus infections. -
Bacterial DNA Gyrase/Topo IV Inhibitor
GC-072 is a selective inhibitor of bacterial DNA gyrase and Topoisomerase IV, demonstrating potent antibacterial activity. This 4-oxoquinolizine antibiotic exhibits efficacy against a wide range of bacterial strains, including Gram-positive, Gram-negative, and multidrug-resistant organisms. Importantly, GC-072 does not interfere with human topoisomerases I and II, making it a suitable candidate for studying bacterial infections. Its bactericidal action against Burkholderia pseudomallei is significant, as it supports dose-dependent survival rates in mice during lethal inhalational models, highlighting its potential in melioidosis research. -
HIV-1 Reverse Transcriptase Inhibitor
R82913 (9-Cl-TIBO) is a selective inhibitor of HIV-1 reverse transcriptase, demonstrating significant antiviral activity against both RNA and DNA templates crucial for viral replication. This compound effectively inhibits the replication of various HIV-1 strains in CEM cells, with a median IC50 value of 0.15 μM. It serves as a valuable reagent for research applications focused on HIV therapy development and reverse transcriptase inhibition studies. -
Bacterial DNA Gyrase B Inhibitor
DNA Gyrase-IN-3 is a specific inhibitor of bacterial DNA gyrase B, exhibiting IC50 values ranging from 5.41 to 15.64 µM against E. coli DNA gyrase. This compound demonstrates significant anti-tubercular and antibacterial activity, making it a valuable tool for microbial research. Its mechanism of action is relevant in studies aimed at developing new antibacterial agents targeting bacterial DNA replication and transcription processes. -
Bacterial Inhibitor
CI-990 (PD-131112) is a selective inhibitor of bacterial DNA gyrase, targeting key enzymes involved in DNA replication and repair. It exhibits potent antibacterial activity and is especially relevant for studying Enterococcal infections, including endocarditis and sepsis. This compound can serve as a valuable tool in microbiological research to understand bacterial resistance mechanisms and develop therapeutic strategies. -
Dengue Viral Replication Inhibitor
DENV-IN-2 is a potent inhibitor of dengue viral replication, demonstrating exceptional activity against all four serotypes of the dengue virus. With an EC50 ranging from 0.013 to 0.029 nM, it shows remarkable efficacy in suppressing viral activity. This compound is valuable for research applications targeting dengue virus pathogenesis and developing antiviral strategies. -
Bacterial Transcription Inhibitor
CUHK242 is a selective bacterial transcription inhibitor that effectively disrupts RNA synthesis within bacterial cells. It demonstrates a minimum inhibitory concentration (MIC) of 2 μg/mL against the B. subtilis reporter strain BS2019 and exhibits antimicrobial activity against Staphylococcus aureus. This compound is useful for research applications focused on understanding bacterial gene expression and studying the mechanisms of antibiotic resistance. -
DENV Inhibitor
DENV-IN-6 is a powerful inhibitor of dengue virus (DENV) serotypes I-IV, exhibiting effective antiviral activity with EC50 values of 17.5, 13.20, 6.8, and 11.41 μM, respectively, for the inhibition of viral replication. Additionally, DENV-IN-6 demonstrates notable activity against HIV-1 IIIB, with an EC50 of 0.0181 µM and a cytotoxicity (CC50) of 64.92 µM. This compound serves as a valuable tool for research into antiviral therapies targeting DENV and HIV-1. -
HIV Inhibitor
Fozivudine tidoxil is an orally active HIV inhibitor designed as a thioether lipid-zidovudine (ZDV) conjugate. This compound exhibits potent anti-HIV activity by incorporating into the newly synthesized DNA strand during viral replication, leading to irreversible binding to viral reverse transcriptase and disruption of the reverse transcription process. In addition to its antiviral properties, Fozivudine tidoxil is also a versatile click chemistry reagent, capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with suitable alkyne or DBCO/BCN-containing molecules, making it valuable for chemical biology applications. -
HIV-1 Inhibitor
HIV-1 Inhibitor-43 is a selective inhibitor targeting the HIV-1 virus. It demonstrates potent efficacy with an EC50 of 21.3 nM for Y188L mutants, 6.2 nM for K103N-Y181C, and under 0.7 nM for both K103N and Y181C strains. This compound effectively reduces HIV-1 RNA levels and protein p24 expression, making it a valuable tool for research in HIV pathogenesis and therapeutic development. -
DENV/HIV-1 Inhibitor
DENV-IN-5 is a potent inhibitor targeting both dengue virus (DENV) and HIV-1 replication. It demonstrates effective antiviral activity with half-maximal effective concentration (EC50) values of 1.47, 9.23, 7.08, and 8.91 μM against DENV serotypes I to IV, respectively. Additionally, DENV-IN-5 inhibits the HIV-1 IIIB strain with an EC50 of 0.1512 μM. This compound is valuable for research focused on viral infections and the development of antiviral therapies. -
Bacterial DNA Gyrase B Inhibitor
DNA Gyrase-IN-2 is a potent inhibitor of bacterial DNA gyrase B, demonstrating IC50 values of 3.29-10.49 µM for Escherichia coli and 4.41-5.61 µM for Mycobacterium tuberculosis. This compound exhibits significant anti-tubercular and antibacterial activity, making it valuable for research focused on bacterial replication and antibiotic development. Its specific targeting of DNA gyrase B positions it as a promising candidate for further investigation in treating bacterial infections. -
HIV/HBV Inhibitor
L-2'-Fd4C is an L-nucleoside analogue that acts as an inhibitor of both human immunodeficiency virus (HIV) and hepatitis B virus (HBV). This compound exhibits potent antiviral activity, making it valuable for research focused on the treatment and understanding of these viral infections. Its unique mechanism of action may provide insights into the development of novel therapeutic strategies against HIV and HBV. -
DENV NS5 RdRp Inhibitor
3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate) is a nucleotide analog that serves as a potent inhibitor of DENV NS5 RNA-dependent RNA polymerase (RdRp). Functioning as a chain terminator, it effectively suppresses RNA synthesis, making it a valuable tool in virology research. With an IC50 of 0.02 μM against DENV NS5 RdRp, this compound is crucial for studies focusing on antiviral mechanisms and the development of therapeutic strategies targeting dengue virus infections. -
HIV-1 Inhibitor
SJP-L-5 is an HIV-1 capsid dissociation inhibitor that targets the HIV-1 viral capsid, preventing its normal function. It demonstrates significant inhibitory activity against various HIV-1 strains, with an EC50 ranging from 0.16 to 0.97 μg/mL. By effectively blocking the entry of HIV-1 viral DNA into the nucleus, SJP-L-5 offers valuable potential for applications in HIV-1 infection research and development of antiviral therapies. -
HIV-Ⅰ Inhibitor
HIV-IN-6 is an inhibitor of HIV-1 viral replication, specifically targeting Src family kinases (SFKs) that associate with the viral Nef protein, including Hck. This compound has demonstrated significant antiviral activity by disrupting the functional interactions necessary for viral pathogenesis. Its application in research includes the study of HIV infection mechanisms and the exploration of novel therapeutic strategies against HIV-1. -
BTK/MNK Dual Inhibitor
QL-X-138 is a selective dual inhibitor of Bruton's tyrosine kinase (BTK) and MAPK-interacting kinase (MNK), demonstrating potent covalent binding to BTK and non-covalent binding to MNK. It exhibits IC50 values of 9.4 nM for BTK, and 107.4 nM and 26 nM for MNK1 and MNK2, respectively. Additionally, QL-X-138 displays antiviral activity against dengue virus serotype 2, with an IC50 of 3.5 μM. This compound is valuable for research involving B-cell malignancies and related therapeutic investigations. -
Bacterial Inhibitor
Ethionamide is a second-line anti-tuberculosis agent that acts primarily by inhibiting the synthesis of mycolic acids in Mycobacterium tuberculosis. This compound demonstrates significant antibacterial activity and is effective when administered orally. Ethionamide is utilized in research applications focused on tuberculosis treatment resistance mechanisms and the development of novel therapeutics against mycobacterial infections. -
Bacterial Inhibitor
Fleroxacin is a broad-spectrum fluoroquinolone antibiotic that targets bacterial DNA gyrase and topoisomerase IV, inhibiting bacterial DNA replication and transcription. This compound exhibits potent antibacterial activity against a wide range of gram-negative and some gram-positive bacteria. Fleroxacin is suitable for research applications focused on the elucidation of bacterial resistance mechanisms and the development of novel antimicrobial therapies. -
Bacterial Inhibitor
Nitrofurazone is a nitro-aromatic antibacterial compound primarily targeting bacterial DNA and RNA synthesis. It exhibits broad-spectrum activity against both Gram-positive and Gram-negative bacteria, making it suitable for a variety of microbiological research applications. Nitrofurazone is often utilized in studies assessing antimicrobial resistance and the efficacy of antibiotic treatments. -
Bacterial Inhibitor
Teicoplanin is a glycopeptide antibiotic primarily targeting Gram-positive bacteria, demonstrating potent activity against methicillin-resistant Staphylococcus aureus (MRSA) and Enterococcus aureus. In addition to its antibacterial properties, teicoplanin exhibits antiviral effects against HIV-1, SARS-CoV-1, and SARS-CoV-2. This versatile compound is utilized in research related to bacterial resistance and viral infections, making it a valuable tool for studying antimicrobial efficacy and therapeutic interventions. -
Bacterial Inhibitor
Tobramycin is a broad-spectrum aminoglycoside antibiotic that primarily targets bacterial protein synthesis by binding to the 30S ribosomal subunit. It exhibits significant antibacterial activity against a variety of Gram-negative and some Gram-positive bacteria. Tobramycin is particularly effective in research applications focused on infections caused by Pseudomonas aeruginosa, including studies related to pneumonia. Its efficacy makes it a valuable reagent in microbial pathogenesis and antibiotic resistance research. -
Bacterial Inhibitor
Ampicillin sodium is a broad-spectrum beta-lactam antibiotic that targets bacterial cell wall synthesis. It is effective against a wide range of gram-positive and gram-negative bacteria, making it a valuable reagent for microbiological research. Ampicillin sodium is commonly used in cell culture and for selecting genetically modified organisms, as well as in the study of bacterial resistance mechanisms. Its ability to inhibit bacterial growth supports investigations into antibiotic efficacy and microbial interactions. -
Bacterial Inhibitor
Cefoperazone is a semisynthetic cephalosporin that functions as a bacterial inhibitor by interfering with cell wall synthesis. It exhibits a broad spectrum of antibacterial activity against both Gram-positive and Gram-negative bacteria. This reagent is commonly employed in microbiological research to study bacterial infections and assess the efficacy of antimicrobial agents. -
Bacterial Inhibitor
Erdosteine functions as a bacterial inhibitor by inhibiting lipopolysaccharide (LPS)-induced activation of NF-κB. This compound exhibits muco-modulatory, anti-bacterial, anti-inflammatory, and antioxidant properties. Erdosteine is primarily utilized in research applications focused on respiratory disorders and inflammation, supporting the study of therapeutic interventions in these areas. -
Bacterial Inhibitor
Erianin is a bacterial inhibitor that exhibits potent anticancer properties by inhibiting indoleamine 2,3-dioxygenase (IDO). This activity contributes to its ability to suppress tumor angiogenesis, making it a valuable compound in cancer research. Erianin's dual role as an antipyretic and analgesic further broadens its potential applications in therapeutic studies. -
HIV Inhibitor
Sennoside A is an anthraquinone glycoside derived from the senna plant (Cassia angustifolia) that exhibits inhibitory activity against HIV-1. This compound demonstrates an IC50 value of 3.8 μM in preventing HIV-1 replication and effectively inhibits HIV-1 reverse transcriptase-related DNA polymerase and ribonuclease H, with IC50 values of 1.9 μM and 5.3 μM, respectively. Sennoside A serves as a valuable tool in antiviral research, particularly in studies of HIV-1 replication mechanisms and potential therapeutic interventions. -
Bacterial Inhibitor
Allicin (diallyl thiosulfinate) is a potent bacterial inhibitor derived from garlic extracts, primarily responsible for the antimicrobial properties of garlic. It demonstrates significant antimicrobial activity against a wide range of microorganisms, including antibiotic-resistant strains, making it a valuable reagent for research in microbiology and pharmacology. Allicin is commonly utilized in studies investigating natural antibacterial compounds and their mechanisms of action. -
Bacterial Inhibitor
Evoxine, also known as Haplophytin B, is a bacterial inhibitor that selectively targets CO2-induced immunosuppression. It demonstrates significant antimicrobial activity, particularly against common pathogens such as Escherichia coli, Bacillus subtilis, and Staphylococcus aureus, as evidenced by its performance in minimum inhibitory concentration (MIC) assays. Evoxine also inhibits the expression of pro-inflammatory cytokines such as interleukin-6 and chemokine CCL2 in human THP-1 macrophages, indicating its potential utility in therapeutic applications and crude drug preparations, particularly in the context of traditional medicine in West Africa. -
Bacterial Inhibitor
3,3'-Di-O-methylellagic acid is a bacterial inhibitor derived from Euphorbia adenochlora. It selectively inhibits the development of acid-fastness in mycobacteria without affecting their growth rates. Additionally, this compound exhibits hepatoprotective properties, likely attributed to its antioxidative effects, making it valuable for research in microbial resistance and liver health. -
HIV Inhibitor
Gomisin G is a lignan derived from Schisandra chinensis that acts as an anti-HIV agent with an EC50 of 0.006 μg/mL. It exhibits anti-liver cancer and anti-inflammatory properties while utilizing an AKT-cyclin D1 dependent mechanism to target triple-negative breast cancer cells by inhibiting phosphorylation rather than promoting apoptosis. Additionally, Gomisin G leads to G1 phase cell cycle arrest and inhibition of AKT phosphorylation. This compound is suitable for research applications focusing on HIV and various cancer types, including breast and liver cancers. -
HIV Protease Inhibitor
Ganoderic acid B is a triterpene derived from the medicinal mushroom Ganoderma lucidum, functioning as an inhibitor of HIV protease. This compound exhibits moderate inhibitory activity against HIV-1 protease, with an IC50 value of 170 μM, making it a potential candidate for research into antiviral therapies. Additionally, ganoderic acid B has demonstrated the ability to inhibit Epstein-Barr virus (EBV) antigen activation and may serve as a telomerase inhibitor, highlighting its broad potential in virology and cancer research applications. -
Bacterial Inhibitor
Methyl Paraben is a bacterial inhibitor primarily used as a preservative in various applications due to its stability and non-volatility. It has been shown to enhance histamine release and modulate cellular immune responses, in addition to blocking sodium channels. Its properties make it valuable for studies exploring microbial inhibition and the mechanisms of ischemia-reperfusion injury. -
Bacterial Inhibitor
Enrofloxacin is a potent bacterial inhibitor belonging to the fluoroquinolone class. It exhibits an MIC90 value of 0.312 μg/mL against Mycoplasma bovis, demonstrating its effectiveness in combating bacterial infections. This compound is widely utilized in research applications focused on antibiotic resistance, microbiology, and the study of bacterial pathogens. -
Bacterial Inhibitor
Florfenicol is a broad-spectrum antibacterial agent that exerts its effects primarily through inhibition of bacterial protein synthesis. This orally active compound demonstrates additional properties, including anti-inflammatory, pro-apoptotic, and immunomodulatory functions. Florfenicol is commonly utilized in research focused on bacterial infections and the modulation of immune responses. -
Bacterial Inhibitor
Furaltadone hydrochloride is an orally active antibacterial agent targeting bacterial infections. It exhibits in vitro inhibitory effects on Staphylococcus and can be utilized in the study of intestinal Salmonella infections. Additionally, Furaltadone demonstrates potential inhibitory effects on allergic reactions, making it a valuable tool for research in microbiology and immunology. -
Bacterial Inhibitor
Penicillin G sodium salt is a β-lactam antibiotic that inhibits bacterial cell wall synthesis by targeting penicillin-binding proteins. It demonstrates broad-spectrum antibacterial activity against various Gram-positive and some Gram-negative organisms. This reagent is commonly used in microbiological studies to evaluate susceptibility patterns and in the development of antibiotic resistance models. -
Bacterial Inhibitor
Piperacillin sodium is a semisynthetic β-lactam antibiotic that targets penicillin-binding proteins, exhibiting potent bactericidal activity against a broad range of Gram-negative bacteria and select Gram-positive strains. This compound is widely utilized in pharmaceutical research to study bacterial infections and antibiotic resistance. Piperacillin sodium is frequently employed in combination with the β-lactamase inhibitor Tazobactam to enhance its efficacy against resistant bacterial strains. -
Bacterial Inhibitor
Ribostamycin sulfate is a broad-spectrum bacterial inhibitor that targets protein synthesis by binding to the 30S and 50S ribosomal subunits. Additionally, it inhibits the chaperone activity of protein disulfide isomerase (PDI). This reagent is primarily utilized in pharmacokinetic studies and investigations of nephrotoxicity, making it valuable in the evaluation of antimicrobial efficacy and safety profiles.
