Shop By
Catalog No.
Product Name
Application
Product Information
Citations
-
Bacterial Inhibitor
LolCDE-IN-2 is a potent inhibitor of the LolCDE protein complex, targeting bacterial lipid transport. It demonstrates significant antibacterial activity against E. coli MG1655, with a minimum inhibitory concentration (MIC) of 2 μg/ml. This compound is valuable for research applications focused on bacterial pathogenesis and antibiotic resistance mechanisms. -
Bacterial Inhibitor
Enterocin K1 is a ribosomally synthesized peptide that functions as a bacteriocin, specifically targeting Enterococcus faecalis through the Eep protein on the bacterial membrane. This compound exhibits significant antibacterial activity against vancomycin-resistant Enterococcus (VRE). Enterocin K1 is primarily utilized in research focusing on VRE infections and the mechanisms of microbial resistance, making it a valuable tool in the development of novel therapeutic strategies. -
β-Lactamase Inhibitor
Metallo β-lactamase ligand 1 is an established class B β-lactamase inhibitor that targets metallo-β-lactamases, enzymes responsible for antibiotic resistance. This compound exhibits significant antibacterial activity, making it a useful tool in combating infections caused by β-lactamase-producing bacteria. It is particularly valuable in research focused on developing new antimicrobial strategies and understanding the mechanism of β-lactamase-mediated resistance. -
Bacterial Inhibitor
Fmoc-Tpi-OH is a biologically active amino acid that functions as a building block for the synthesis of antimicrobial peptide mimetics. Its unique structure allows for the development of compounds with potential antibacterial properties. This reagent is essential for research applications focused on peptide chemistry, drug design, and the exploration of new antimicrobial therapies. -
Bacterial Inhibitor
Isopsoralenoside is a benzofuran glycoside derived from Psoralea corylifolia, functioning primarily as a bacterial inhibitor. This compound exhibits estrogen-like activity, promotes osteoblastic proliferation, and demonstrates antitumor effects. Isopsoralenoside's antibacterial properties make it a valuable tool for research applications aimed at exploring microbial inhibition and associated biological processes. -
Bacterial Inhibitor
Bixafen is a pyrazole fungicide that acts as a succinate dehydrogenase inhibitor, effectively targeting and inhibiting bacterial pathogens in cereal crops. Its broad-spectrum activity makes it a valuable tool in agricultural research, helping to elucidate mechanisms of pathogen resistance and manage crop health. Bixafen's specific inhibition of succinate dehydrogenase contributes to its efficacy in various fungicidal applications. -
Bacterial Division Inhibitor
Divin, a bacterial division inhibitor, acts as a potent chelator of iron, leading to a bacteriostatic effect against both Gram-negative and Gram-positive bacteria. This compound disrupts the assembly of late division proteins, interferes with peptidoglycan remodeling at the division site, and inhibits cytoplasmic compartmentalization. Divin is valuable for research applications focused on understanding bacterial cell division mechanisms and developing new antibacterial strategies. -
Bacterial Inhibitor
Licoricone is a flavonoid derived from licorice that serves as a bacterial inhibitor. It demonstrates significant anti-Helicobacter pylori activity against both clarithromycin- and amoxicillin-resistant strains, as well as four clarithromycin- and amoxicillin-sensitive strains. This compound is valuable for research focusing on bacterial resistance and studies aimed at developing new therapeutic strategies against H. pylori infections. -
Bacterial Inhibitor
Nornidulin is a depsidone derived from Aspergillus nidulans, exhibiting significant antibacterial activity against Mycobacterium tuberculosis and Mycobacterium ranoe, as well as antifungal effects against Trichophyton tonsurans and Microsporum audouini. Additionally, it demonstrates potent inhibition of methicillin-resistant Staphylococcus aureus (MRSA) with a minimum inhibitory concentration (MIC) of 2 μg/mL. Furthermore, Nornidulin displays cytotoxicity in MOLT-3 cells with an IC50 value of 35.7 μM, while exhibiting lower toxicity against HuCCA-1, HepG2, and A549 cell lines. -
β-lactamase Inhibitor
Brobactam sodium is a potent synthetic β-lactamase inhibitor that effectively targets various β-lactamase enzymes. This compound exhibits broad-spectrum antibacterial activity, making it a valuable tool for enhancing the efficacy of β-lactam antibiotics. Brobactam sodium is primarily utilized in research applications aimed at understanding antibiotic resistance mechanisms and developing new therapeutic strategies against resistant bacterial strains. -
Bacterial Inhibitor
3-CPs is a serotype capsular polysaccharide that inhibits antibody-mediated bacterial killing. By interfering with the immune response, it effectively reduces the phagocytosis of encapsulated bacteria. This compound is valuable for studying bacterial pathogenesis and the mechanisms of immune evasion. 3-CPs can inform research on vaccine development and therapeutic strategies aimed at combating encapsulated bacterial infections. -
Heat-inactivated Bacterial Luciferases Inhibitor
2-Nonanone is a ketone compound that inhibits the DnaKJE-ClpB bichaperone-dependent refolding of heat-inactivated bacterial luciferases. By interacting with hydrophobic segments of heat-inactivated substrates, it competes with chaperones such as IbpAB. This compound is valuable for research into bacterial infections and the mechanisms of chaperone-mediated protein refolding. -
Parasite Inhibitor
Hydroxymetronidazole, a metabolite of Metronidazole, functions primarily as an inhibitor of parasitic infections. This nitroimidazole derivative exhibits significant antibacterial and antiprotozoal activities, making it valuable in research applications related to bacterial and protozoal diseases. It is particularly useful for studying conditions such as swine dysentery, as well as genital trichomoniasis in cattle, contributing to a better understanding of these veterinary health issues. -
Bacterial Inhibitor
Ethyl Orsellinate is a lichen-derived metabolite and a derivative of lecanoric acid, primarily acting as a bacterial inhibitor. It exhibits notable antiproliferative and antitumor activities, making it useful in cancer research. The compound demonstrates significant cytotoxicity against A. salina, with an LC50 of 495 μM, indicating its potential as a bioactive agent in the study of microbial and tumor biology. -
Bacterial Inhibitor
EcMetAP1-IN-1 is a selective inhibitor of Escherichia coli methionine aminopeptidase 1 (MetAP1), a key enzyme involved in protein maturation. By obstructing the enzymatic activity of MetAP1, this compound effectively disrupts bacterial growth and protein synthesis, making it a valuable tool for research focused on bacterial infections and antibiotic development. Its specificity towards MetAP1 further positions EcMetAP1-IN-1 as a potential candidate for studying the mechanistic roles of methionine aminopeptidases in pathogenic bacteria. -
Bacterial Inhibitor
Urolithin M6 is a polyphenolic compound primarily recognized for its role as a bacterial inhibitor. This metabolite, synthesized through intestinal microbial metabolism, exhibits potential antioxidant properties and may function as an analogue to tannic acid compounds. Urolithin M6's production in humans necessitates the presence of specific bacterial 3-dehydroxylase activity, unveiling a novel pathway for its biotransformation. The metabolic profile of Urolithin M6 can aid in stratifying individuals for research aimed at elucidating its implications in health and disease. -
Bacterial Inhibitor
Methyl octanoate acts as a bacterial inhibitor and is recognized for its role in antimicrobial activity. This compound has applications in food preservation and can be studied for its effects on microbial growth inhibition. Additionally, it serves as a volatile aroma component in various beverages, including persimmon wine, making it of interest in both food science and microbiology research. -
Bacterial Inhibitor
NSC-79887 is a potent nucleoside hydrolase inhibitor that demonstrates significant activity against Bacillus anthracis. This compound serves as a promising candidate for biological testing and further development aimed at countering bacterial infections. Additionally, its pharmacokinetic profile suggests that all physicochemical parameters fall within acceptable ranges, indicating potential suitability for human use. -
Bacterial Inhibitor
Surgumycin is a bacterial inhibitor that exhibits notable antimicrobial activity. Its mechanism involves disrupting essential cellular processes in bacteria, making it a valuable tool for studying bacterial infections and resistance mechanisms. Surgumycin is particularly useful in research applications focused on antibiotic development and the exploration of microbial pathogenesis. -
Bacterial Inhibitor
LL-BM123α is a bacterial inhibitor derived from Nocardia sp., with a primary mechanism of action targeting Gram-negative bacteria. This compound demonstrates moderate antimicrobial activity, making it a valuable tool in research focused on bacterial infections and antibiotic resistance. LL-BM123α can be utilized in studies aimed at understanding the efficacy of novel antibiotics and developing strategies for overcoming bacterial resistance. -
Antibacterial, Biofilm Formation Inhibitor
Majoranaquinone is a potent antibacterial agent that targets various bacterial strains, demonstrating significant inhibitory effects against four Staphylococcus species, one Moraxella species, and one Enterococcus species. Additionally, it exhibits substantial efflux pump inhibitory activity in Escherichia coli ATCC 25922. Majoranaquinone also effectively inhibits biofilm formation in both E. coli ATCC 25922 and E. coli K-12 AG100, making it a valuable reagent for research applications focused on combating bacterial infections and biofilm-related challenges. -
Bacterial Inhibitor
Lauryl-LF 11 is an N-terminally acylated analogue of LF11 that acts as a bacterial inhibitor. This peptide demonstrates significant antibacterial activity, making it a valuable tool for research in microbiology and infectious diseases. It can be utilized in studies focused on the mechanisms of bacterial resistance and the development of novel antimicrobial agents. -
Bacterial Inhibitor
Citreamicin alpha is a potent bacterial inhibitor demonstrated to exhibit significant antimicrobial activity against a range of Gram-positive cocci. In vitro studies reveal that MIC values for Staphylococci range from 0.12-4.0 μg/ml, and for Streptococcus pyogenes, they range from 0.03-0.12 μg/ml. While Citreamicin alpha shows superior efficacy compared to ampicillin, amoxicillin, and ceftriaxone, it exhibits comparable effects to vancomycin. Its effectiveness against various strains makes it a valuable reagent for research in antibiotic development and resistance studies. -
Beta-Lactamase Inhibitor
β-Lactamase-IN-2 is a beta-lactamase inhibitor that targets and inhibits the activity of beta-lactamase enzymes. This compound exhibits significant anti-microbial and anti-bacterial properties, making it useful in overcoming antibiotic resistance. Its application extends to research focused on enhancing the efficacy of beta-lactam antibiotics in clinical settings. -
β-lactamase Inhibitor
Enmetazobactam iodide is an extended-spectrum β-lactamase inhibitor that targets various β-lactamase enzymes produced by resistant Gram-negative bacteria. This compound effectively enhances the efficacy of β-lactam antibiotics, making it a valuable tool in combating antibiotic resistance. Research applications include studying antibiotic resistance mechanisms and developing novel therapeutic strategies against multidrug-resistant infections. -
Bacterial Inhibitor
MT0703 is an aminothiazolyl glycyl cephalosporin that targets bacterial pathogens, exhibiting potent anti-Pseudomonas activity. This compound is studied for its potential in understanding bacterial resistance mechanisms and developing novel therapeutic strategies. Its structure, featuring a 1,5-dihydroxy-4-pyridone-2-carbonyl group, enhances its efficacy against a range of bacterial infections. -
ATPase/Bacterial Inhibitor
Dihydronovobiocin is a bacterial inhibitor that targets ATPase activity by binding to the GyrB subunit of DNA gyrase. This compound is useful for investigating the interactions between coumarin antibiotics, such as Novobiocin, Chlorobiocin, and Coumermycin, and their effects on DNA gyrase function. Dihydronovobiocin also has potential applications in the study of bacterial infections, facilitating research into the mechanisms of antibiotic action and resistance. -
Bacterial Inhibitor
(4-Aminobenzyl)phosphonic acid is a bioactive compound that acts as a bacterial inhibitor. It exhibits notable antibacterial and potential anticancer activities, making it useful in various research applications, particularly in the synthesis of new compounds aimed at inhibiting bacterial growth. Its unique structural properties enable effective interaction with biological targets, facilitating the exploration of novel therapeutic strategies. -
Bacterial Inhibitor
MGB-BP-3 is a bacterial inhibitor that targets multi-resistant Gram-positive pathogens. This antibiotic exhibits potent activity across a variety of clinically relevant bacterial strains, making it a valuable tool for studies focused on combating antibiotic resistance. Its broad-spectrum efficacy supports research applications in antibiotic development and microbiology. -
Bacterial Inhibitor
Gramicidin C is a polypeptide antibiotic with a primary mechanism of action as a bacterial inhibitor. It disrupts bacterial cell membrane function, resulting in increased permeability that leads to cell lysis. This compound is widely utilized in microbiology research to study bacterial resistance mechanisms and to investigate antibiotic efficacy against various gram-positive and gram-negative bacteria. -
Bacterial Inhibitor
Anhydroerythromycin A is a bacterial inhibitor derived from the degradation of the macrolide antibiotic erythromycin. It exhibits antimicrobial activity against Staphylococcus aureus and Bacillus cereus, with minimum inhibitory concentrations of 12.5 µg/ml and 6.25 µg/ml, respectively. Additionally, Anhydroerythromycin A inhibits steroid 6β-hydroxylase activity linked to the cytochrome P450 isoform CYP3A in human liver microsomes, making it a valuable tool for studying bacterial resistance and metabolic pathways. -
Bacterial Inhibitor
Cefsulodin is a bacterial inhibitor primarily targeting Pseudomonas aeruginosa. It exhibits potent antimicrobial activity against penicillin-susceptible and gentamicin-sensitive strains, demonstrating effectiveness comparable to gentamicin and debendazole. However, Cefsulodin's efficacy is reduced against penicillin-resistant strains of P. aeruginosa, particularly those also resistant to gentamicin. The compound shows a similar minimum inhibitory concentration for P. aeruginosa maltofila when compared to penicillin, gentamicin, and debendazole, while Pseudomonas cepacia strains typically present moderate resistance to Cefsulodin. Its applications include evaluating bacterial resistance mechanisms and antibiotic efficacy in clinical microbiology. -
Parasite Inhibitor
Asimilobine is an aporphine isoquinoline alkaloid derived from Magnolia obovata. This compound acts as a dopamine biosynthesis inhibitor and a serotonergic receptor antagonist, making it a valuable reagent for studying neurotransmitter pathways. Asimilobine exhibits significant antimalarial and anti-cancer activities, highlighting its potential applications in parasitology and oncology research. -
Bacterial Inhibitor
Ampicillin is a broad-spectrum beta-lactam antibiotic that targets bacterial cell wall synthesis by inhibiting penicillin-binding proteins. It is effective against a wide range of gram-positive and gram-negative bacteria, making it a valuable reagent in microbiological research and antibiotic susceptibility testing. Ampicillin is commonly used to study bacterial resistance mechanisms and is also employed in molecular biology for the selection of recombinant plasmids in cloning applications. -
SPT Inhibitor
Myriocin is a potent serine palmitoyltransferase (SPT) inhibitor derived from various fungal species such as Myriococcum albomyces, Isaria sinclairi, and Mycelia sterilia. By inhibiting SPT, Myriocin plays a crucial role in the disruption of de novo sphingolipid synthesis. It has demonstrated significant antiviral activity, effectively suppressing the replication of both the subgenomic HCV-1b replicon and the JFH-1 strain of genotype 2a infectious HCV, with an IC50 of 3.5 μg/mL. This compound is valuable for research into sphingolipid metabolism and hepatitis C virus infection mechanisms. -
SARS-CoV-2 Inhibitor
TFMU-ADPr is a selective reporter substrate that targets the SARS-CoV-2 Macro1 protein, displaying an IC50 of 0.59 μM. This compound emits fluorescence at 502 nm (or 495 nm) upon enzymatic hydrolysis by Poly(ADP-ribose) Glycohydrolase (PARG) and ADP-ribosylhydrolase 3. TFMU-ADPr binds to the ADPr-binding site of Macro1, providing a robust method for assessing the activity of poly(ADP-ribose) hydrolases. Its applications extend to evaluating small-molecule inhibitors under in vitro conditions, investigating ADP-ribosyl catabolic enzyme mechanisms, and detecting PAR hydrolase activity in whole-cell lysates, making it a valuable tool for COVID-19-related research. -
Bacterial Inhibitor
Resazurin sodium is a non-toxic, stable redox indicator that targets bacterial activity through its membrane-permeable properties. It serves as a vital tool for assessing cell viability, proliferation, and toxicity in various cell types, including human, plant, animal, bacterial, and fungal cells. Upon reduction, Resazurin sodium transforms into Resorufin, a highly fluorescent compound, enabling sensitive detection and quantification of cellular processes under fluorescent microscopy or spectrophotometry. -
SARS-CoV Inhibitor
Direct Violet 1 is an azo dye that functions as an inhibitor of the spike protein-ACE2 interaction in SARS-CoV-2, exhibiting IC50 values ranging from 1.47 to 2.63 μM. This compound serves as a valuable tool for investigating viral entry mechanisms and studying protein-protein interactions related to SARS-CoV-2. Its application may extend to antiviral research and the development of therapeutic strategies targeting COVID-19. -
Bacterial Inhibitor
4-Methylherniarin, a coumarin derivative, exhibits antibacterial activity by effectively inhibiting both gram-positive and gram-negative bacterial strains. It demonstrates significant antimicrobial efficacy against B. subtilis and S. sonnei, with IC50 values of 11.76 μg/ml and 13.47 μg/ml, respectively. This compound serves as a valuable tool for research applications focused on combating bacterial infections and elucidating mechanisms of action in microbial resistance. -
Dengue Protease Inhibitor
Carbonic anhydrase inhibitor 16 is a potent dengue protease inhibitor that targets human carbonic anhydrases I and II, exhibiting inhibitory constants (Ki) of 28.5 nM and 2.2 nM, respectively. This compound demonstrates significant biological activity in hindering dengue virus replication by disrupting protease function. It may be utilized in research applications aimed at elucidating mechanisms of dengue virus pathogenesis and developing antiviral therapeutics. -
Bacterial Inhibitor
Procodazole is a potent bacterial inhibitor that enhances immune response, offering protection against various viral and bacterial infections. In addition to its broad-spectrum antibacterial effects, Procodazole demonstrates antiparasitic activity and serves as a carbonic anhydrase inhibitor, contributing to its antitumor properties. This compound is suitable for research applications focused on infectious diseases and cancer biology. -
HIV Inhibitor
ZL0580 is an HIV inhibitor that functions by selectively binding to the BD1 domain of BRD4, leading to epigenetic suppression of the virus. This compound effectively inhibits Tat transactivation and transcription elongation while promoting a repressive chromatin structure at the HIV promoter. ZL0580 is valuable for research applications focused on HIV therapies and the mechanisms of viral transcription regulation. -
FgGpmk1 Inhibitor
FgGpmk1-IN-1 is a selective inhibitor of the Fusarium graminearum mitogen-activated protein kinase (FgGpmk1), exhibiting an EC50 value of 3.46 μg/mL. This compound is valuable for investigating the biological role of FgGpmk1 in fungal pathogenesis and offers potential applications in the study of plant-fungal interactions. Researchers can utilize FgGpmk1-IN-1 to explore therapeutic strategies against Fusarium-related diseases. -
Bacterial Inhibitor
Aniline-MPB-amino-C3-PBD is a cytotoxic agent targeting bacterial cells through minor-groove binding of DNA. This sequence-selective compound serves as an effective payload for antibody-drug conjugates (ADCs), enhancing their therapeutic efficacy. Its antimicrobial properties make it a valuable tool for research in bacterial inhibition and related applications. -
Bacterial Inhibitor
Py-MPB-amino-C3-PBD is a cytotoxic agent that functions as a bacterial inhibitor. This compound serves as a payload for antibody-drug conjugates (ADCs) and exhibits significant antimicrobial activity. Its unique structure, characterized by a non-alkylating group, makes it a valuable tool for research applications aimed at targeting bacterial infections and developing therapeutics in the field of microbiology. -
Clk1 Inhibitor
CLK1-IN-2 is a potent and metabolically stable inhibitor of CLK1, exhibiting a selectivity for its target with an IC50 value of 1.7 nM. This compound is valuable for research applications focusing on tumor biology, Duchenne muscular dystrophy, and viral infections, including HIV-1 and influenza. CLK1-IN-2 facilitates the study of cellular mechanisms and therapeutic interventions related to these diseases. -
CLK Inhibitor
KH-CB19 is a selective inhibitor of CLK (cdc2-like kinase) with an IC50 of 19.7 nM for CLK1 and 530 nM for CLK3. This compound exhibits antiviral properties, demonstrated by its ability to hinder influenza virus replication, with an IC50 value of 13.6 μM. KH-CB19 serves as a valuable tool for research into CLK-related pathways and antiviral drug development. -
SARS-CoV-2 Inhibitor
SARS-CoV-2 nsp14-IN-3 is an inhibitor of the SARS-CoV-2 N7-Methyltransferase, demonstrating an IC50 value of 3.5 μM. This compound is designed to interfere with the viral methylation process, which is crucial for viral replication and evasion of host immune responses. It serves as a valuable tool in antiviral research and the development of therapeutic strategies targeting SARS-CoV-2. -
SARS-CoV Inhibitor
SARS-CoV-2-IN-7 is a potent inhibitor of the SARS-CoV virus, demonstrating significant antiviral activity with an IC50 value of 844 nM in SARS-CoV-2-infected Vero E6 cells. This compound is primarily utilized in research applications aimed at understanding viral replication processes and developing effective therapeutics against SARS-CoV-2. Its efficacy makes it a valuable tool for studying COVID-19 and potential antiviral strategies. -
SARS-CoV Inhibitor
Bonducellpin D is a furanoditerpenoid lactone that acts as an inhibitor of SARS-CoV and MERS-CoV main proteases (Mpro). With Ki values of 467.11 nM and 284.86 nM for SARS-CoV and MERS-CoV, respectively, it demonstrates broad-spectrum antiviral activity. Additionally, Bonducellpin D exhibits moderate anti-cancer activity in vitro, making it a valuable compound for research into both viral inhibition and cancer therapeutics.
