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Catalog No.
Product Name
Application
Product Information
Citations
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RSV replication inhibitor
RSV604 R enantiomer is the R-enantiomer of RSV604. RSV604 is an inhibitor of respiratory syncytial virus (RSV) replication. R-enantiomer is less active against RSV. -
Cruzain inhibitor
Cruzain-IN-1 is a covalent and reversible Cruzain inhibitor, with an IC50 of 10 nM. -
β-lactamase inhibitor
Zidebactam sodium salt (WCK-5107 sodium salt) is a potent β-lactamase inhibitor. Zidebactam also is a penicillin-binding protein2 (PBP2) inhibitor with an IC50 of 0.26 μg/mL. -
Topoisomerase inhibitor
Zabofloxacin hydrochloride (DW-224a) is a novel fluoronaphthyridone quinolone that is considered a potent antibacterial candidate for clinical trials. -
efflux pump inhibitor
PAβN dihydrochloride (MC-207110 dihydrochloride) is an efflux pump inhibitor. -
SDHI Inhibitor
Boscalid is a succinate dehydrogenase inhibitor that exhibits significant antifungal activity. By binding to the ubiquinone-binding site of mitochondrial complex II in fungi, Boscalid disrupts ATP production and aerobic respiration, effectively controlling a range of plant fungal diseases, such as gray mold, sclerotinia rot, and powdery mildew. In addition to its agricultural applications, research indicates that Boscalid induces apoptosis and alters lipid metabolism while causing mitochondrial dysfunction, oxidative stress, and ROS accumulation in zebrafish models. Furthermore, it demonstrates chronic toxicity and impacts foraging behavior in honeybees, alongside exhibiting genotoxic and cytotoxic effects in cellular systems. -
Bacterial Inhibitor
Citrinin is a mycotoxin known for its role as a bacterial inhibitor. It exhibits a range of biological activities, including the regulation of immune cell populations, induction of apoptosis and autophagy in immune cells, and modulation of toll-like receptor expression and cytokine production. Citrinin also induces oxidative stress, leading to apoptosis in oocytes, while low doses demonstrate neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. This compound's diverse mechanisms make it a valuable reagent for research in immunology, neurobiology, and antibacterial applications. -
IMPDH Inhibitor
Mycophenolic acid sodium is a potent uncompetitive inhibitor of inosine monophosphate dehydrogenase (IMPDH), with an EC50 of 0.24 µM. This compound exhibits antiviral activity against various RNA viruses, including influenza, alongside its immunosuppressive properties. Additionally, Mycophenolic acid sodium demonstrates antiangiogenic and antitumor effects, making it valuable for research in immunology, virology, and cancer therapy. -
Virus Protease Inhibitor
Anthraquinone acts primarily as a viral protease inhibitor, exhibiting multifaceted biological activities including anticancer, anti-inflammatory, diuretic, anti-arthritic, antifungal, antibacterial, antimalarial, and antioxidant properties. This compound plays a crucial role in plant metabolism by impacting the electron transport chain, thereby inhibiting energy transfer during photosynthesis. Additionally, anthraquinone intercalates into DNA and inhibits topoisomerase II, leading to cell death through apoptosis. This diverse profile supports its applications in various fields of chemical and biological research. -
Fungal Inhibitor
Mancozeb is a potent fungicide that operates primarily by inhibiting fungal growth in a variety of agricultural products, including cereals, vegetables, fruits, and ornamental plants. In addition to its antifungal properties, Mancozeb has been shown to activate the Keap1/Nrf2 signaling pathway, leading to liver damage in mice. It alters cellular metabolism through the upregulation of lactate dehydrogenase and cytochrome c, resulting in induced apoptotic pathways, particularly in ovarian cells. This compound is of significant interest in studies related to reproductive toxicity and cellular metabolism. -
HIV Protease Inhibitor
Indinavir is a selective inhibitor of HIV-1 protease, displaying a Ki value of 0.54 nM, making it a potent antiviral agent. In addition to its primary role in HIV treatment, Indinavir has demonstrated anticancer properties by inhibiting matrix metalloproteinases (MMPs) and promoting anti-angiogenic effects, alongside inducing apoptosis in cancer cells. Furthermore, Indinavir has shown inhibitory activity against the SARS-CoV 3CL protease, expanding its potential applications in viral research. -
Bacterial/Fungal Inhibitor, Preservative Agent
Methylisothiazolinone is a potent bacterial and fungal inhibitor with significant applications as a preservative agent. It activates matrix metalloproteinases (MMPs) in human bronchial epithelial cells, leading to apoptosis and an inflammatory response. Additionally, this compound is linked to the exacerbation of atopic dermatitis in mice through the disruption of Th2/Th17-related immune responses. Furthermore, Methylisothiazolinone has been shown to induce mitochondrial damage in the endothelium of rat cerebral blood vessels, highlighting its potential impact on vascular health. -
Bacterial Inhibitor
Oligomycin B is an antibiotic derived from marine Streptomyces, primarily acting as an inhibitor of ATP synthase in eukaryotic cells. Its mechanism of action leads to a decrease in ATP production, resulting in cellular stress and the induction of apoptosis. Oligomycin B is widely utilized in research focused on mitochondrial function, energy metabolism, and apoptosis-related studies. -
Bacterial Inhibitor
Lactoferrin (17-41) acetate is a peptide derived from residues 17-41 of bovine lactoferrin, primarily functioning as a bacterial inhibitor. It exhibits potent antimicrobial activity against various microorganisms, including Gram-positive and Gram-negative bacteria, viruses, protozoa, and fungi. In addition to its antimicrobial properties, Lactoferrin (17-41) acetate also demonstrates antitumor activities, making it a valuable reagent in studies related to infection control and cancer research. -
Parasite Inhibitor
Gallinamide A TFA is a potent inhibitor of cathepsin L (CatL), with an IC50 of 17.6 pM. This peptide demonstrates significant antiviral activity by inhibiting SARS-CoV-2 infection, with an EC50 of 28 nM. Additionally, Gallinamide A TFA effectively inhibits Plasmodium falciparum, exhibiting an IC50 of 50 nM, making it a valuable reagent for research into parasitic infections and viral therapies. -
Bacterial Transcription Inhibitor
GKL003 is a bacterial transcription inhibitor that targets the interaction interface of RNA polymerase (RNAP) and the sigma factor, with a Ki value of 5.79 nM. By specifically binding to the RNAP β' clamp helix region at the σA factor binding site, GKL003 disrupts the formation of the RNAP holoenzyme and inhibits bacterial transcription initiation complexes. This compound effectively inhibits the growth of both Gram-positive and Gram-negative bacterial strains, including those that are drug-resistant, making it a valuable tool for research applications in microbiology and antibiotic resistance studies. -
RSV Polymerase Inhibitor
JNJ-8003 is a highly potent, orally active non-nucleoside inhibitor of respiratory syncytial virus (RSV) polymerase, exhibiting an IC50 of 0.29 nM. It specifically targets the L protein of the polymerase complex, effectively blocking the transcription and replication of the viral genome by inhibiting RNA-dependent RNA polymerase (RdRp) activity, with an IC50 of 0.67 nM. In vitro studies demonstrate subnanomolar efficacy, and it has shown significant effectiveness in mouse and neonatal lamb models. JNJ-8003 is a valuable reagent for investigating RSV biology and developing antiviral therapies. -
HBV Inhibitor
Bersacapavir is an HBV capsid assembly modulator that targets hepatitis B virus (HBV) replication. It exhibits a dual mechanism of action by forming complete genome-free empty capsids and inhibiting the de novo synthesis of covalently closed circular DNA (cccDNA). This compound is valuable for research applications focusing on HBV infection and the development of antiviral therapies. -
DENV Polymerase Inhibitor
NITD-2 is a selective inhibitor of dengue virus (DENV) polymerase, specifically targeting the RNA-dependent RNA polymerase (RdRp) to impede RNA elongation. This compound exhibits potent antiviral activity against DENV, making it a valuable tool for research focused on understanding dengue virus replication and developing therapeutic strategies. Its limited ability to penetrate cell membranes can be an important consideration for in vitro experimental design. -
HBV RNase H Inhibitor
β-Thujaplicinol is a potent inhibitor of hepatitis B virus (HBV) ribonuclease H, showing inhibitory effects on HBV genotypes D and H with IC50 values of 5.9 and 2.3 μM, respectively. Its primary mechanism involves disrupting the enzymatic activity of HBV RNase H, making it a valuable tool for researching HBV replication and pathogenesis. This compound is suitable for studies focused on antiviral development and the therapeutic targeting of HBV. -
HBV inhibitor
ALG-000184 is an orally bioavailable inhibitor targeting hepatitis B virus (HBV). It functions as a prodrug to ALG-001075 and effectively reduces HBV DNA production in liver cells. This compound is intended for research applications in chronic hepatitis B studies, facilitating investigations into therapeutic strategies against HBV infection.
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Dengue Virus Protease Inhibitor
SP-471P is a potent inhibitor of the dengue virus (DENV) protease, exhibiting EC50 values of 5.9 μM, 1.4 μM, 5.1 μM, and 1.7 μM against DENV1, DENV2, DENV3, and DENV4, respectively, with a CC50 exceeding 100 μM. This compound effectively reduces DENV viral RNA synthesis, making it a valuable tool for research in dengue virus biology and antiviral therapeutic development. -
HCV Inhibitor
TTP-8307 is a potent HCV inhibitor that disrupts the replication of various rhino- and enteroviruses. It specifically inhibits coxsackievirus B3 (CVB3) with an EC50 value of 1.2 μM, alongside poliovirus, by interfering with viral RNA synthesis. The compound exerts its antiviral effects through interaction with oxysterol-binding protein (OSBP), making it a valuable tool for research in virology and antiviral drug development. -
HBV Replication Inhibitor
AT-130 is a phenylpropenamide derivative that serves as a potent non-nucleoside inhibitor of hepatitis B virus (HBV) replication. It effectively inhibits viral DNA synthesis, exhibiting an EC50 of 0.13 μM against both wild-type and mutant strains of HBV. AT-130 demonstrates significant anti-HBV activity in hepatoma cell lines, making it a valuable tool for research focused on HBV infection and treatment strategies. -
Bacterial Inhibitor
Mequindox is an antimicrobial agent that functions as a bacterial inhibitor by selectively targeting and inhibiting DNA synthesis. This compound demonstrates significant genotoxic and carcinogenic effects in murine models, making it a valuable tool for studying bacterial resistance mechanisms and the potential impacts of antimicrobial agents on genetic material. Its applications extend to research on the safety and efficacy of antimicrobial treatments in various biological systems. -
Bacterial Inhibitor
Silver sulfadiazine is a sulfonamide antibiotic that functions as a bacterial inhibitor through dual mechanisms. The sulfa moiety inhibits bacterial folate absorption, thereby disrupting essential DNA synthesis. Additionally, silver ions released from silver sulfadiazine bind to and disrupt DNA structures, preventing bacterial DNA replication. This compound is widely used in research applications focusing on bacterial growth inhibition and antimicrobial studies. -
HBV Inhibitor
HBV-IN-4 is a phthalazinone derivative that functions as a potent inhibitor of HBV DNA replication, exhibiting an IC50 value of 14 nM. This compound effectively induces the formation of genome-free capsids, demonstrating substantial anti-HBV activity. Its applications include research into therapeutic strategies for hepatitis B virus infections. -
HSV Inhibitor
Denotivir is an orally active antiviral agent targeting herpes simplex virus (HSV) and varicella-zoster virus (VZV). It exhibits significant inhibition of viral proliferation and demonstrates anti-cancer properties, influencing the growth of various cancer cell lines. Additionally, Denotivir plays a role in immunosuppression by inhibiting the generation of pro-inflammatory cytokines such as TNF-α, IL-1, and IL-6, making it relevant for research in virology and oncology. -
HEVA71/PTP1B Inhibitor
Prunin is a potent inhibitor of human enterovirus A71 (HEVA71) and demonstrates strong inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), with an IC50 value of 5.5 μM. This compound has significant potential for research applications in virology and metabolic disease studies, particularly in elucidating the roles of HEVA71 and PTP1B in cellular signaling pathways and disease mechanisms. -
Bacterial Inhibitor
Fenvalerate is a highly effective bacterial inhibitor, primarily functioning as a protein phosphatase 2B (calcineurin) inhibitor, with an IC50 of 2-4 nM for PP2B-Aα. As a pyrethroid ester, it exhibits significant insecticidal and acaricidal properties. This compound is utilized in various research applications to study protein phosphatase signaling pathways and to explore potential therapeutic targets in bacterial infections. -
Calcineurin Phosphatase Inhibitor
Dibefurin is a potent inhibitor of calcineurin phosphatase, a critical regulator of calcium-dependent signaling pathways. This fungal metabolite has demonstrated significant biological activity in various cellular processes, making it a valuable tool for studying immune response and neuronal signaling. Its application extends to research focused on autoimmune diseases and neurodegenerative disorders, where calcineurin activity plays a pivotal role. -
IMPase Inhibitor
L-671776 is a non-competitive inhibitor of inositol monophosphatase (IMPase), a critical enzyme in the phosphoinositide signaling pathway. This compound, derived from the fungal strain ATCC 20928B, exhibits significant potential for modulating inositol levels and can be utilized in studies investigating mood disorders, neurodegenerative diseases, and other conditions linked to inositol metabolism. Its application in biochemical research can help elucidate the role of IMPase in cellular signaling processes. -
PTP1B Inhibitor
Deoxyfunicone is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B), demonstrating an IC50 value of 24.3 µM through direct active site binding. This secondary fungal metabolite exhibits notable anti-inflammatory properties, making it a valuable tool for research into metabolic regulation and the treatment of inflammatory diseases. Its mechanism of action positions it as a significant compound for studies focused on diabetes and obesity-related conditions. -
HIV Integrase Inhibitor
Equisetin is an N-methylserine-derived acyl tetramic acid that functions as a potent HIV integrase inhibitor. It specifically interferes with the activity of HIV-1 integrase and demonstrates notable inhibition of 11β-HSD1 and Dnp-stimulated ATPase, with an IC50 of approximately 8 nmol per mg of protein. Additionally, Equisetin exhibits significant antibacterial properties, anti-inflammatory effects, and potential benefits in managing lipid-associated disorders while also showcasing cytotoxic activity. This compound is valuable for research applications focused on HIV treatment and the exploration of antimicrobial and anti-inflammatory mechanisms. -
HSV-1 Inhibitor
Gallic aldehyde, also known as 3,4,5-trihydroxybenzaldehyde, targets herpes simplex virus type 1 (HSV-1) through its potent antiviral properties. This phenolic aldehyde exhibits notable anti-HSV-1 activity while also functioning as an effective antioxidant. Additionally, gallic aldehyde inhibits the gelatinolytic activity and expression of matrix metalloproteinase-9 (MMP-9), as well as the activation of ERK1/2, p38, and JNK signaling pathways. Its antibacterial effects are further demonstrated against Oenococcus oeni VF, making it a valuable reagent for diverse biological research applications. -
SARS-CoV PLpro Inhibitor
4'-O-Methylbavachalcone is a prenylated flavonoid that acts as an inhibitor of the SARS-CoV papain-like protease (PLpro), displaying an IC50 value of 10.1 μM and a Ki of 4.6 μM. This compound has demonstrated the ability to inhibit poly (ADP-ribose) polymerase-mediated cell death and reduce cerebral infarct volume. Additionally, it modulates SUCNR1 activity and interferes with ERK1/2 signaling pathways, affecting cardiomyocyte hypertrophy. 4'-O-Methylbavachalcone is applicable in research focused on ischemic stroke, SARS-CoV, and cardiovascular diseases. -
Parasite Inhibitor
CpCDPK1/TgCDPK1-IN-1 is a potent dual inhibitor of CpCDPK1 and TgCDPK1, demonstrating IC50 values of 10 nM and 5.0 nM, respectively. In addition, it shows inhibitory activity against Abl and Src kinases with IC50 values of 75 nM and 65 nM. This compound is suitable for research applications related to toxoplasmosis, providing valuable insights into the therapeutic targeting of these pathways. -
HIV Protease Inhibitor
Indinavir sulfate ethanolate is a selective inhibitor of HIV-1 protease, demonstrating a potent Ki of 0.54 nM for the target enzyme. Beyond its antiviral activity, this compound has shown potential in anticancer research through the inhibition of MMPs-2 activation, anti-angiogenic effects, and promotion of apoptosis. Additionally, Indinavir sulfate ethanolate acts as an inhibitor of the SARS-CoV 3CLpro enzyme, highlighting its diverse biological activity and relevance in multiple research applications. -
HBV Inhibitor
Alisol F 24-acetate is a triterpenoid compound that targets Hepatitis B Virus (HBV) by inhibiting the secretion of HBV surface antigens HBsAg and HBeAg, with respective IC50 values of 7.7 µM and 5.1 µM. This compound also exhibits proapoptotic activity, making it a valuable agent for cancer research applications. Its role in regulating viral antigen secretion positions it as a potential therapeutic candidate in HBV-related studies. -
Nucleoside Reverse Transcriptase Inhibitor
Stavudine sodium is a nucleoside reverse transcriptase inhibitor (NRTI) primarily utilized for its efficacy against HIV-1 and HIV-2. This compound demonstrates the ability to inhibit mitochondrial DNA replication, reduce NLRP3 inflammasome activation, and modulate the autophagy of Amyloid-β, contributing to its therapeutic potential. Additionally, Stavudine sodium is associated with inducing apoptosis in targeted cells, making it a valuable tool in HIV research and related cellular studies. -
HSV Inhibitor
Acyclovir hydrochloride is an antiviral agent that specifically targets herpes simplex virus (HSV) replication. It exhibits significant antiherpetic activity, with IC50 values of 0.85 μM for HSV-1 and 0.86 μM for HSV-2. In addition to its antiviral effects, Acyclovir hydrochloride can induce cell cycle disruption and promote apoptosis in infected cells. This compound is also utilized in the context of bacterial infection prevention during induction therapy for acute leukemia. -
Bacterial Inhibitor
(Z)-Methyl tetradec-9-enoate functions as a bacterial inhibitor, primarily exerting its cytotoxic effects in human prostate cancer LNCaP cells through the induction of apoptosis and necrosis. Isolated from S. repens fruit extract, this compound also demonstrates antifungal activity, effectively inhibiting the germination of Candida albicans with a minimum inhibitory concentration (MIC) of 9 μM in vivo. Its applications extend to studies in both cancer research and microbiology, making it a valuable reagent for understanding cellular processes and developing therapeutic strategies. -
CYP51 Inhibitor
Antifungal agent 136 is an irreversible inhibitor of fungal lanosterol 14α-demethylase (CYP51). It demonstrates potent antifungal activity against drug-resistant strains of Candida albicans and effectively downregulates IL-6 expression. This compound holds potential for research applications in the fields of fungal infection and inflammatory diseases. -
Fungal Inhibitor
Filipin III is a pentaene macrolide antifungal antibiotic featuring a 28-membered ring, primarily derived from various Streptomyces species including S. filipinensis, S. avermitilis, and S. miharaensis. This compound targets membrane sterols, leading to significant alterations in membrane structure, which disrupts fungal cell integrity. Filipin III is widely utilized in research to study fungal infections and to explore mechanisms of antifungal resistance. -
Actin Polymerization Inhibitor
Latrunculin B is an actin polymerization inhibitor commonly derived from marine algae. It modulates the electrophysiological properties of pulmonary veins and has been shown to reduce stretch-induced arrhythmias. Additionally, Latrunculin B exhibits antifungal and antiprotozoal activities, making it a valuable reagent for research in cell biology and pharmacology. -
Fungal Inhibitor
Phenazine-1-carboxylic acid functions as a potent antifungal agent, targeting fungal pathogens effectively. In addition to its antifungal properties, it demonstrates anticancer activity by promoting apoptosis in cancer cells through the modulation of reactive oxygen species (ROS) generation. Phenazine-1-carboxylic acid also influences cytokine expression, upregulating IL-8 and ICAM-1 while inhibiting RANTES and MCP-1 release, indicating potential immunomodulatory effects. This compound is valuable for research in anti-infection strategies, cancer therapy, and immune response modulation. -
Fungal Inhibitor
Sakuranetin is a cherry flavonoid phytoalexin that acts as a potent fungal inhibitor. It exhibits strong antifungal properties, along with notable anti-inflammatory and antioxidative activities. Additionally, Sakuranetin has demonstrated efficacy in ameliorating LPS-induced acute lung injury, making it a valuable compound for research in inflammation and respiratory disorders. -
Tropone Derivatives; Tyrosinase Inhibitor; Virus Inhibitor; Funga Inhibitor
Tropolone is a seven-membered non-benzenoid aromatic compound recognized for its role as a tyrosinase inhibitor, exhibiting an IC50 value of 0.4 μM. This compound demonstrates significant anti-viral and anti-fungal properties, making it effective in a variety of therapeutic applications. Additionally, Tropolone shows enhanced effects when used in conjunction with nucleos(t)ide analogs. Its potential for research in osteosarcoma emphasizes its importance in the exploration of new treatments.
