Catalog No.
Product Name
Application
Product Information
Citations
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Parasite Inhibitor
WRR-483 is an irreversible cysteine protease inhibitor targeting cruzain, demonstrating potent trypanocidal activity against Trypanosoma cruzi. This compound effectively inhibits the proliferation of the parasite in cell culture and shows significant efficacy in eradicating parasitic infection in acute Chagas disease mouse models. Its pH-dependent high affinity makes WRR-483 a promising candidate for research applications focused on combating Chagas disease. -
Antileishmanial Agent
Antileishmanial agent-28 is an effective antileishmanial compound that targets Leishmania parasites. It exhibits potent biological activity, demonstrating EC50 values of 1.5 μM against L. donovani, 13 μM against L. amazonensis, and 18 μM against J774A.1 macrophages. This reagent is applicable in research related to leishmaniasis treatment and offers insights into therapeutic strategies against this disease. -
Parasite
Spinosyn D aglycone is an active compound derived from the insecticide Spinosyn D, targeting various parasitic organisms. This compound demonstrates a reduced toxicity profile, as it is not lethal to H. virescens (tobacco budworm) neonate larvae, exhibiting an LC50 greater than 64 ppm. Its unique properties make Spinosyn D aglycone useful in studies focused on pest control and resistance mechanisms in agricultural research. -
Parasite Inhibitor
Betulonic acid, a naturally occurring triterpene, primarily targets parasite inhibition. It demonstrates significant antiparasitic activity along with anti-tumor and anti-inflammatory properties. Research applications include studies on its efficacy against various parasites, as well as exploration in cancer and inflammatory disease models. -
Parasite Inhibitor
Methylene blue trihydrate is an inhibitor of guanylyl cyclase (sGC), monoamine oxidase A (MAO-A), and nitric oxide synthase (NOS). This compound exhibits a range of biological activities including antinociceptive, antimalarial, antidepressant, and anxiolytic effects. Methylene blue trihydrate is utilized in research applications related to methemoglobinemias, neurodegenerative disorders, and treatment of ifosfamide-induced encephalopathy. Additionally, it serves as a dye in various medical procedures, highlighting its versatility in scientific investigations. -
Parasites Inhibitor
Dehydroemetine is an orally active antiparasitic agent that targets and inhibits parasites, particularly Entamoeba histolytica. It exhibits key biological activity in combating parasitic infections and is used in research applications related to various parasitic diseases, including visceral leishmaniasis. -
Parasite Inhibitor
Trans-4-Methylcyclohexanamine is a key intermediate utilized in the development of inhibitors targeting Trypanosoma cruzi enzymes. This compound demonstrates significant biological activity against the parasite, making it a valuable tool for research in parasitology and drug discovery. Its applications extend to the exploration of therapeutic options for parasitic infections, particularly Chagas disease. -
Parasite Inhibitor
Diazinon is an irreversible acetylcholinesterase (AChE) inhibitor with primary applications in pest control as an insecticide. By inhibiting AChE, Diazinon leads to the accumulation of acetylcholine, resulting in overstimulation of acetylcholine receptors and disruption of nervous system function. Additionally, Diazinon generates reactive oxygen species (ROS), contributing to oxidative stress across various biological tissues. This compound is predominantly utilized in agricultural settings but may also hold implications for human and animal health research. -
Parasite Inhibitor
Licoflavone B is a flavonoid derived from Glycyrrhiza inflata, acting as a specific inhibitor of Schistosoma mansoni ATPase and ADPase, with IC50 values of 23.78 µM and 31.50 µM, respectively. This compound demonstrates significant anti-schistosomiasis activity, making it a valuable tool for researchers investigating therapeutic strategies against schistosomiasis. Its mechanism of action and inhibition of key enzymatic pathways underline its potential in parasitic disease research. -
Parasite Inhibitor
Aklomide (2-Chloro-4-nitrobenzamide) is a potent coccidiostat that targets protozoan parasites. Its primary biological activity involves inhibiting the growth and reproduction of coccidia, making it effective in preventing and controlling coccidiosis in poultry, particularly in chickens. Aklomide is valuable for researchers investigating parasite biology and developing strategies for managing coccidial infections. -
Parasite Inhibitor
8-Deoxygartanin, a prenylated xanthone derived from Garcinia mangostana, serves as a selective inhibitor of butyrylcholinesterase (BChE). This compound demonstrates significant antiplasmodial activity, with an IC50 value of 11.8 μM against the W2 strain of Plasmodium falciparum. Additionally, 8-Deoxygartanin inhibits NF-κB (p65) activation, displaying an IC50 of 11.3 μM, making it a valuable reagent for research in parasitic infections and inflammation pathways. -
Parasite Inhibitor
Dibenzosuberol is an effective inhibitor of Trypanosoma thiol reductase (TryR), showing significant biological activity against the parasite T. brucei with an EC50 value of 51.3 μM. This compound serves as a crucial intermediate in the synthesis of various compounds aimed at treating parasitic infections. Its properties make it valuable for research applications targeting trypanosomiasis and related diseases. -
Parasite Inhibitor
ACT-451840 is a potent oral inhibitor specifically targeting Plasmodium falciparum, including both sensitive and resistant strains. This compound demonstrates significant activity against all asexual blood stages of the parasite, characterized by a rapid onset of action. ACT-451840 exhibits a mechanism of action akin to that of artemisinin derivatives, effectively facilitating the elimination of the malaria pathogen. It serves as a valuable research tool for studies related to malaria treatment and resistance. -
Parasite Inhibitor
2',4'-Dihydroxy-6'-Methoxyacetophenone is a phenolic acetophenone that acts as a parasite inhibitor, derived from Artemisia annua. This compound serves as an effective analog of Artemisinin, making it valuable in malaria research. Its properties contribute to the understanding of parasite biology and the development of potential therapeutic strategies against malaria. -
Anti-parasite Agent
Bithionol (sulfoxide) is an anti-parasitic agent that exhibits mutagenic activity. It is primarily used in research on parasitic infections, including paragonimiasis, fluke infections, and cestode infestations. Bithionol (sulfoxide) serves as a valuable tool for investigating treatment options and understanding the mechanisms of parasitic disease pathways. -
Parasite Inhibitor
Nepodin is a quinone oxidoreductase (PfNDH2) inhibitor derived from Rumex crispus. It exhibits significant antidiabetic and antimalarial activities by stimulating the translocation of GLUT4 to the plasma membrane via AMPK activation. This compound serves as a valuable tool for research into metabolic disorders and parasitic infections, facilitating studies on glucose metabolism and potential therapeutic interventions. -
Parasite
Epoxyazadiradione is a limonoid derived from the fruits of the neem tree (Azadirachta indica) that targets macrophage migration inhibitory factor (MIF). It exhibits non-competitive inhibition of the tautomerase activity of both human MIF (huMIF) and MIF from malaria parasites, specifically Plasmodium falciparum (PfMIF) and Plasmodium yoelii (PyMIF), with a Ki value ranging from 2.11 to 5.23 μM. This compound demonstrates potential in modulating proinflammatory responses associated with MIF in both human and malaria contexts, making it a valuable tool for research into anti-parasitic strategies and inflammatory diseases. -
Parasite Inhibitor
Guanfu base H (Atisinium chloride) is a diterpenoid alkaloid derived from Aconitum coreanum, functioning primarily as a parasite inhibitor. It exhibits significant antiplasmodial activity against the malarial Plasmodium falciparum strains TM4/8.2 (wild type) and K1CB1, exhibiting IC50 values of 4 µM and 3.6 µM, respectively. This compound is a valuable tool for research in malaria treatment and drug development. -
Parasite Inhibitor
1R-cis-Permethrin is a potent insecticide with neurotoxic properties that primarily targets sodium channels in neuronal membranes. By prolonging the activation state of these channels, it disrupts normal neuronal function, resulting in paralysis and death of target pests. This compound is utilized extensively in research for studying the mechanisms of insect neurotoxicity and developing pest control strategies. -
Parasite Inhibitor
Albendazole sulfone is a metabolism-derived compound of Albendazole, primarily targeting parasitic infections. It demonstrates significant anti-parasitic activity against Echinococcus multilocularis metacestodes, making it a valuable reagent for research focused on parasitic diseases and treatment efficacy. Its application extends to studies concerning drug resistance and therapeutic approaches in veterinary and human medicine. -
Parasite Inhibitor
Clofentezine is a potent growth inhibitor with primary activity against acarine pests, specifically targeting mites. This compound effectively disrupts the developmental stages of parasites, making it valuable for research applications in pest control and agricultural science. Its mechanism of action makes clofentezine an important reagent for studying mite population dynamics and developing strategies for management in agricultural settings. -
Parasite Inhibitor
Laetanine is a noraporphine alkaloid derived from Litsea laeta, known for its potent antiplasmodial activity. This compound is also present in the leaf extracts of Phoebe tavoyana (Meissn) Hook. Laetanine is primarily utilized in research applications targeting parasite inhibition, offering potential insights into therapeutic strategies against malaria and related diseases. -
Parasite Inhibitor
Cratoxylone is a potent antiplasmodial agent isolated from the bark of Cratoxylum cochinchinense. It exhibits activity against malaria-causing parasites, making it a valuable tool in the study of parasitic infections. Its biological properties may facilitate research into novel treatments for malaria and enhance understanding of parasite biology. -
Anti-parasite Agent
DHQZ 36 is a potent inhibitor of retrograde trafficking, targeting intracellular mechanisms to combat parasitic infections. It demonstrates significant anti-parasitic activity, effectively inhibiting Leishmania amazonensis infection in macrophages with an EC50 of 13.63 μM. This compound is valuable for research applications focused on parasitology and the development of anti-parasitic therapies. -
Parasite Inhibitor
2-Benzoxazolinone is an anti-leishmanial compound that exhibits an LC50 of 40 μg/mL against Leishmania donovani. This small molecule serves as a versatile building block in chemical synthesis. Additionally, 1,3-Benzoxazol-2(3H)-one derivatives demonstrate significant antimicrobial activity against various Gram-positive and Gram-negative bacteria, as well as yeasts. Certain derivatives have also been identified as effective anti-quorum sensing agents, making them valuable for research applications in microbiology and infectious disease studies. -
Anti-parasite Agent
6-Hydroxyindazole is an anti-parasite agent that demonstrates efficacy against intracellular amastigotes of Leishmania amazonensis, with an EC50 value of 128.9 μM. This compound is valuable for research focused on leishmaniasis and related parasitic infections, providing insights into potential therapeutic approaches. -
Parasite Inhibitor
4′-Hydroxy-2′-methylacetophenone acts as a parasite inhibitor, demonstrating significant ciliate toxicity. This compound effectively inhibits the growth of Tetrahymena pyriformis, with an IC50 value of 0.65 mM. It is a valuable reagent for studies focused on parasitic biology and potential therapeutic applications targeting ciliate organisms. -
Parasite Inhibitor
Fenbendazole analog-1 is an antiparasitic compound that functions by inhibiting rat brain tubulin polymerization. This analog demonstrates significant activity against the protozoa Giardia lamblia and Entamoeba histolytica, as well as the helminth Trichinella spiralis. It serves as a valuable tool for studies focused on parasitic infections and tubulin-targeting therapies. -
Parasite Inhibitor
Dodecamethylpentasiloxane acts as a parasite inhibitor, showcasing insecticidal properties specifically against bed bugs. This siloxane compound is utilized in various applications due to its effectiveness in pest management and control. Its unique chemical structure allows it to disrupt the physiological processes of target organisms, making it a valuable reagent in research focused on overcoming insect infestations. -
Parasite Inhibitor
Arprinocid, a purine analog, selectively targets and inhibits the growth of the parasite Toxoplasma gondii in murine models. Its unique mechanism of action interferes with nucleotide metabolism, thereby exhibiting significant antiparasitic activity. This compound is valuable for research applications focused on the pathogenesis and treatment of Toxoplasmosis. -
Parasite Inhibitor
D-Phenothrin is a synthetic pyrethroid classified as a Type II insecticide, primarily targeting insect nervous systems. It exhibits potent insecticidal activity against a variety of pests, including mosquitoes and human lice, making it valuable in both agricultural and veterinary settings. This compound is extensively utilized for pest control in crops and animal husbandry, contributing to effective vector management and enhancing public health. -
Parasite Inhibitor
Tectol is a farnesyltransferase inhibitor, effectively targeting the enzyme in both human and Trypanosoma brucei systems. With IC50 values of 2.09 μM and 1.73 μM respectively, Tectol demonstrates potent antitumor activity against human leukemia cell lines HL60 and CEM. In addition, it exhibits significant inhibitory effects on the drug-resistant strain of Plasmodium falciparum (FcB1), with an IC50 of 3.44 μM, making it a valuable tool for researching parasitic and cancer biology. -
PfGSK3/PfPK6 Inhibitor
PfGSK3/PfPK6-IN-1 is a selective inhibitor targeting PfGSK3 and PfPK6, with IC50 values of 97 nM and 8 nM, respectively. This compound effectively inhibits the proliferation of blood-stage Plasmodium falciparum 3D7 parasites, making it a valuable tool for malaria research. Additionally, PfGSK3/PfPK6-IN-1 exhibits low cytotoxicity in hepatocyte cultures at concentrations up to 200 nM, with a significant reduction in cell viability observed at 2 μM. Its dual action enhances its potential in studying malaria-related mechanisms and potential therapeutic strategies. -
Antiparasite Agent
13,21-Dihydroeurycomanone is a natural compound derived from the root of Eurycoma longifolia, known for its antiparasitic properties. It displays significant activity against Plasmodium falciparum and Toxoplasma gondii, making it a valuable candidate for research on antiparasitic therapies. Its role in inhibiting these pathogens provides insights for the development of new treatments for malaria and toxoplasmosis. -
Parasite Inhibitor
Melarsonyl, also known as Melarsonic acid, is an anthelmintic agent that targets and inhibits parasitic organisms. It exhibits potent activity against a variety of parasites, making it valuable in research aimed at understanding and combating parasitic infections. This compound is utilized in the study of helminthic diseases and other related areas in parasitology. -
Parasite Inhibitor
Piperazine adipate is an effective anthelmintic agent that targets parasitic worms in mammals. Its broad-spectrum activity makes it suitable for treating various helminth infections, thereby providing significant therapeutic benefits in veterinary and clinical settings. This compound is utilized in research to explore mechanisms of helminth resistance and to develop novel treatment protocols against parasitic infections. -
Antileishmanial Agent
Niazinin is a thiocarbamate glycoside that serves as an antileishmanial agent with an IC50 value of 5.25 μM. It demonstrates potent leishmanicidal activity and exhibits binding affinity to the target protein 3CL protease. Additionally, Niazinin possesses anti-inflammatory and antipyretic properties, making it a valuable compound for research in tropical diseases and inflammatory conditions. -
Antileishmanial Agent
Phylloflavan is an antileishmanial agent that targets intracellular pathways, exhibiting an EC50 of 3.2 nM in RAW 264.7 cells. Additionally, Phylloflavan demonstrates the ability to inhibit the cytopathic effect of encephalomyocarditis virus in L929 fibroblast cells at a concentration of 38 U/mL. This compound is relevant for research applications focused on leishmaniasis and viral infections. -
Parasite
Triazophos is a potent non-systemic insecticide and acaricide that functions as an acetylcholinesterase (AChE) inhibitor. By covalently and irreversibly binding to the acetylcholine binding site, Triazophos effectively disrupts the hydrolysis of acetylcholine, resulting in increased neuroexcitability. This compound demonstrates efficacy against a broad spectrum of soil insects and mites, including aphids, thrips, and spider mites, making it valuable for crop protection in various agricultural settings, such as ornamentals, cotton, rice, maize, soybeans, oil palms, olives, and coffee. -
Parasite Inhibitor
Phosalone is an organophosphate insecticide that primarily targets acetylcholinesterase, leading to the inhibition of neurotransmission in parasites. Its potent biological activity makes it effective in controlling a wide range of insect pests. Phosalone is utilized in entomological research and in studies focusing on pest management strategies and the biochemical pathways of insecticide resistance. -
Parasite Inhibitor
trans-Permethrin is a synthetic pyrethroid that primarily targets the nervous system of insects, functioning as a potent insecticide and neurotoxin. Its primary biological activity involves disrupting sodium channel function, leading to paralysis and death in targeted pest populations. This compound is widely used in research applications aimed at understanding insecticide resistance mechanisms and developing novel pest control strategies. -
Parasite
22,23-Dihydroavermectin B1a aglycon is a hydrolysis-derived degradation product of ivermectin that targets parasitic nematodes. This compound effectively inhibits the larval development of nematodes without inducing paralysis, making it useful for studying nematode biology and potential therapeutic applications. Its specific mechanism of action contributes to research in parasitology and the development of antiparasitic agents. -
Antiparasite Agent
Ile-AMS is an antiparasitic agent that exerts its activity against Plasmodium falciparum, with an ABS IC50 value of 1.19 nM. This compound is essential for studying malaria pathogenesis and can aid in the development of effective therapeutic strategies. Its potent inhibition of P. falciparum makes it a valuable tool in malaria research and drug discovery efforts. -
Parasite Inhibitor
Bitoscanate, also known as p-Phenylene diisothiocyanate, primarily acts as a parasite inhibitor. It demonstrates significant activity against hookworms, making it valuable in the therapeutic management of parasitic infections. Its biological properties facilitate research applications focused on developing effective treatments for helminthic diseases. -
Aniti-parasite Agent
epi-Ivermectin B1a is a significant derivative of Ivermectin, functioning as an anti-parasitic agent. This compound serves as a valuable tool for researching internal and external parasites, particularly in cattle. Its role in understanding the efficacy and safety of ivermectin-based formulations enhances its relevance in parasitology studies. -
Parasite Inhibitor
CWHM-1552 is a potent inhibitor of Plasmodium falciparum, demonstrating IC50 values of 51 nM and 53 nM against the 3D7 and Dd2 strains, respectively. This compound exhibits significant efficacy in oral administration and is designed for research applications focused on malaria treatment and parasite biology. CWHM-1552 serves as a valuable tool for studying antimalarial mechanisms and developing novel therapeutic strategies. -
Antileishmanial Agent
Trypaflavin is an acridine derivative recognized for its antileishmanial activity. It exerts its effects by targeting germ cells and inducing chromosomal aberrations in unfertilized oocytes, resulting in increased rates of genetic instability. Notably, Trypaflavin demonstrates significant toxicity toward Leishmania, leading to immediate lysis of leptomonads. This compound serves as a valuable tool in the study of leishmaniasis and related cellular processes. -
Parasite Inhibitor
Anticancer agent 140 is a compound designed as a parasite inhibitor, exhibiting significant potential for anticancer and antiparasitic activities. This reagent targets specific cellular pathways, making it valuable for research in cancer biology and parasitology. Its effectiveness in inhibiting parasite proliferation underscores its relevance in drug discovery and development for related diseases. -
Parasite Inhibitor
Mirincamycin hydrochloride is a potent inhibitor of malaria, specifically targeting the early liver stages of Plasmodium. This compound demonstrates protective effects, effectively preventing the progression of the parasite during its initial infection phase. However, it is important to note that Mirincamycin does not eliminate dormant liver stages, as observed in studies utilizing a rhesus monkey model. This characteristic limits its applicability in certain therapeutic scenarios against malaria. -
Parasite Inhibitor
Allylpyrocatechol is a parasite inhibitor known for its antimalarial activity. This compound has been validated for its efficacy both in vitro and in vivo, demonstrating significant potential in combating malaria. Additionally, structure-activity relationship analyses of its analogs have been conducted, providing insights into the mechanisms underlying its biological effects. Its application in research can contribute to the development of novel antimalarial therapies.
