Epoxyazadiradione is a limonoid derived from the fruits of the neem tree (Azadirachta indica) that targets macrophage migration inhibitory factor (MIF). It exhibits non-competitive inhibition of the tautomerase activity of both human MIF (huMIF) and MIF from malaria parasites, specifically Plasmodium falciparum (PfMIF) and Plasmodium yoelii (PyMIF), with a Ki value ranging from 2.11 to 5.23 μM. This compound demonstrates potential in modulating proinflammatory responses associated with MIF in both human and malaria contexts, making it a valuable tool for research into anti-parasitic strategies and inflammatory diseases.
Epoxyazadiradione is a limonoid derived from the fruits of the neem tree (Azadirachta indica) that targets macrophage migration inhibitory factor (MIF). It exhibits non-competitive inhibition of the tautomerase activity of both human MIF (huMIF) and MIF from malaria parasites, specifically Plasmodium falciparum (PfMIF) and Plasmodium yoelii (PyMIF), with a Ki value ranging from 2.11 to 5.23 μM. This compound demonstrates potential in modulating proinflammatory responses associated with MIF in both human and malaria contexts, making it a valuable tool for research into anti-parasitic strategies and inflammatory diseases.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
