Catalog No.
Product Name
Application
Product Information
Citations
- Acoziborole (SCYX-7158) is an effective, safe and orally active treatment for human african trypanosomiasis (HAT). In the T. b. brucei S427 strain, the MIC value for SCYX-7158 is 0.6 ?g/mL.
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semi-synthetic antimalarial
Artemisone (Artemifone) is a potent and semi-synthetic antimalarial, inhibits P. falciparum strains, with a mean IC50 of 0.83 nM. - Piperazine Citrate is an organic compound that consists of a six-membered ring, containting two nitrogen atoms at opposite positions in the ring; first introduced in 1953 as an Anthelmintic.
- Buparvaquone is a hydroxynaphthoquinone antiprotozoal drug related to parvaquone and atovaquone.
- GNF179 metabolite is the metabolite of GNF179, which is an optimized 8,8-dimethyl IP analog that exhibited the potency(4.8 nM against the multidrug resistant strain W2) in vitro metabolic stability and in vivo oral bioavailability.
- Artefenomel (OZ439) is a synthetic antimalarial agent with the artemisinin pharmacophore. Artefenomel (OZ439) is a long-acting artemisinin-related agent.
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Androgen receptor antagonist
Nilutamide (Nilandron) is a non-steroidal anti-androgen drug proposed in the treatment of metastatic prostatic carcinoma. - Cipargamin (NITD609) is an potent antimalarial compound, with IC50 of appr 1 nM against P. falciparum.
- Carbendazim is a broad-spectrum benzimidazole fungicide which can be used to control a broad range of diseases on arable crops, fruits, vegetables, ornamentals and medicinal herbs.
- Fexinidazole is a 5-nitroimidazole drug currently in clinical development for the treatment of human sleeping sickness (human African trypanosomiasis [HAT]), caused by infection with species of the protozoan parasite Trypanosoma brucei.
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asparaginyl endopeptidases inhibitors
RR-11a analog is a potent and selective inhibitors of asparaginyl endopeptidases (AE) (Legumain), with IC50 values of 4.5 nM, 4.5 nM and 31 nM for AE1 in Trichomonas Vaginalis, AE in Ixodes ricinus and AE in Schistosoma mansoni, respectively. -
Protein synthesis inhibitor
Blasticidin S is a nucleoside antibiotic isolated from Streptomyces griseochromogenes. Blasticidin S is a potent inhibitor of protein synthesis in both prokaryotic and eukaryotic cells. - Cycloguanil hydrochloride, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes.
- Albendazole sulfoxide D3 is deuterium labeled Albendazole sulfoxide, which is a broad-spectrum anthelmintic.
- N-Desethyl amodiaquine dihydrochloride is the major biologically active metabolite of Amodiaquine. N-Desethyl amodiaquine dihydrochloride is an antiparasitic agent.
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Cruzain inhibitor
Cruzain-IN-1 is a covalent and reversible Cruzain inhibitor, with an IC50 of 10 nM. - Tilbroquinol is an antiprotozoal agent effective against amoebiasis. It has also been used against Vibrio cholerae.
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strigolactone (SL) antagonist
Soporidine is a strigolactone (SL) antagonist and inhibitor of germination in their biological assays. It binds AtHTL and specifically interferes with SL signaling. -
cell permeable TgPrxII inhibitor
Conoidin A is a cell permeable inhibitor of T. gondii enzyme peroxiredoxin II (TgPrxII). -
anti-inflammatory agent
Cepharanthine is an alkaloid derived from Stephania cepharantha Hayata, with possesses anti-inflammatory and antioxidative activities. -
broad-spectrum seed treatment nematicide
Tioxazafen is a disubstituted oxadiazole and a broad-spectrum seed treatment nematicide. Tioxazafen is designed to provide consistent broad-spectrum control of nematodes in corn, soy, and cotton. -
anti-infective agent
Tizoxanide is the active metabolite of Nitazoxanide, which is a thiazolide anti-infective compound against anaerobic bacteria, protozoa, and a range of viruses. Tizoxanide has anti-HIV-1 activities. -
Sulfaquinoxaline is a veterinary antimicrobial agent effective against a broad spectrum of Gram-negative and Gram-positive bacteria. It is commonly used for the prevention and treatment of coccidiosis and bacterial infections in livestock and poultry.
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Antihelminthic Agent
Niclosamide (BAY2353) is an orally active antihelminthic agent used in parasitic infection research. Niclosamide is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells. Niclosamide has biological activities against cancer, inhibits DNA replication in Vero E6 cells. -
Apoptosis Inducer
Sanguinarine chloride is a benzophenanthridine alkaloid that functions as an apoptosis inducer primarily through the generation of reactive oxygen species (ROS). This compound is known to activate key signaling pathways, specifically JNK and NF-κB, facilitating programmed cell death. Sanguinarine chloride is widely utilized in cancer research and studies investigating apoptotic mechanisms. -
Fluorescent Dye
Acridine Orange base is a cell-permeable fluorescent dye primarily utilized for staining nucleic acids in various organisms, including bacteria, parasites, and viruses. This dye exhibits distinct fluorescence characteristics; it emits green light when bound to double-stranded DNA (Ex=488 nm, Em=520-524 nm) and red light when associated with single-stranded DNA or RNA (Ex=457 nm, Em=630-644 nm). Acridine Orange base is particularly valuable in fluorescence microscopy for distinguishing human cells under acidic conditions (pH=3.5) and is widely employed in cell cycle assays. -
Photobase Reagent
Malachite Green Carbinol Base acts as a photobase reagent, capable of releasing hydroxide ions (OH-) upon ultraviolet light irradiation. This reaction facilitates a progressive shift in pH levels, allowing for precise pH regulation in experimental settings. When exposed to high-intensity UV light (500 W, 50 W/cm), the solution transitions rapidly from colorless to deep green, which can be utilized for applications in photochemistry and environmental monitoring. -
Parasite Inhibitor
Dihydroartemisinic acid, a biosynthetic precursor to the antimalarial compound Artemisinin, functions primarily as a parasite inhibitor. This compound demonstrates potent activity against malaria-causing Plasmodium species, making it valuable for research in malaria treatment and drug development. Its role in synthesizing Artemisinin positions it as an important reagent for studies focusing on antimalarial therapies. -
Parasite Inhibitor
Pervicoside B is a glycoside C derived from the sea cucumber Neothyone gibbosa, exhibiting potent antiparasitic activity as it effectively inhibits Leishmania mexicana promastigotes at concentrations of 5-10 μg/mL. Additionally, Pervicoside B displays significant antifungal properties against Aspergillus niger, with minimum inhibitory concentration (MIC) values ranging from 4.65 to 16.7 μg/mL. This compound holds promise for research applications focused on addressing parasitic infections and fungal diseases. -
Parasite
Aspyrone is a polyketide fungal metabolite primarily targeting various parasites. Exhibiting broad-spectrum biological activity, it demonstrates antifungal efficacy against 13 fungi at a concentration of 20 μg/mL and is effective against a range of 21 bacteria in a disc assay at 100 μg per disc. Additionally, Aspyrone shows potent nematocidal activity against Pratylenchus penetrans at concentrations ranging from 10 to 1,000 mg/L, making it a valuable compound for research in both parasitology and microbiology. -
Parasite Inhibitor
5,7,3',4'-Tetramethoxyflavone is a polymethoxyflavone that acts as a potent inhibitor of parasitic activity. Isolated from M. exotica, this compound demonstrates a range of bioactivities, including antifungal, antimalarial, antimycobacterial, and anti-inflammatory effects. Additionally, 5,7,3',4'-Tetramethoxyflavone exerts chondroprotective effects through modulation of β-catenin signaling, making it a valuable tool for research in both parasitology and inflammatory conditions. -
Parasite Inhibitor
Isopimpinellin acts as a potent inhibitor of parasitic activity. Isolated from Glomerella cingulata, this orally active compound prevents DNA adduct formation and inhibits skin tumor initiation induced by 7,12-dimethylbenz[a]anthracene. Additionally, Isopimpinellin demonstrates significant anti-leishmania activity, making it a valuable reagent for studies in parasitology and cancer research. -
Parasite Inhibitor
CpCDPK1/TgCDPK1-IN-1 is a potent dual inhibitor of CpCDPK1 and TgCDPK1, demonstrating IC50 values of 10 nM and 5.0 nM, respectively. In addition, it shows inhibitory activity against Abl and Src kinases with IC50 values of 75 nM and 65 nM. This compound is suitable for research applications related to toxoplasmosis, providing valuable insights into the therapeutic targeting of these pathways. -
Antileishmanial Agent
Antileishmanial agent-36 is an indole-dihydropyrimidinone derivative that targets Leishmania species, demonstrating significant anti-leishmanial activity. This compound induces mitochondrial dysfunction through the generation of reactive oxygen species (ROS), leading to apoptosis in infected cells. It exhibits potent lethality against L. donovani with an IC50 value of 4.54 µM, while displaying low cytotoxicity towards J774.1 macrophages. Antileishmanial agent-36 is suitable for research applications focused on visceral leishmaniasis (VL) and parasite burden clearance. -
Parasite Inhibitor
Quinacrine acetate is a potent modulator of the cGAS-STING-TBK1 signaling pathway, exhibiting notable immune stimulatory activity. This compound has been investigated for its therapeutic potential in enhancing anti-tumor immunity and improving the efficacy of cancer immunotherapies by addressing the immunogenicity challenges faced by various tumors. Quinacrine acetate also represents a promising approach to mitigate the limitations associated with immune checkpoint inhibitors in cancer treatment. -
Parasite Inhibitor
Gallinamide A TFA is a potent inhibitor of cathepsin L (CatL), with an IC50 of 17.6 pM. This peptide demonstrates significant antiviral activity by inhibiting SARS-CoV-2 infection, with an EC50 of 28 nM. Additionally, Gallinamide A TFA effectively inhibits Plasmodium falciparum, exhibiting an IC50 of 50 nM, making it a valuable reagent for research into parasitic infections and viral therapies. -
Anti-parasite Agent
D-Arabinose functions as an anti-parasitic agent with a notable capability to inhibit the growth of Caenorhabditis elegans, exhibiting an IC50 of 7.5 mM. This compound effectively penetrates the blood-brain barrier and selectively interferes with the metabolism of D-ribose and D-fructose. Additionally, D-Arabinose demonstrates antibacterial properties by inhibiting biofilm synthesis and activates the ACSS2-PPARγ/TFEB-CRTC1 axis via the lysosomal AXIN-LKB1-AMPK pathway, contributing to its antidepressant-like effects. D-Arabinose serves as the ring-opened form of the aldopentose D-arabinose. -
Antileishmanial Agent
PT4 is an antileishmanial agent specifically effective against cutaneous leishmaniasis. It exhibits significant activity against both Leishmania species, with IC50 values of 125.18 µM for L. amazonensis and 233.18 µM for L. braziliensis. PT4 induces a reduction in mitochondrial membrane potential and elevates reactive oxygen species production, resulting in parasite lethality. Additionally, PT4 demonstrates potent in vivo anti-inflammatory properties, making it a valuable tool for research in leishmaniasis and related inflammatory conditions.
