Catalog No.
Product Name
Application
Product Information
Citations
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Parasite Inhibitor
Anti-parasitic agent 3 is a potent inhibitor targeting resistant parasites, exhibiting significant anti-parasitic activity. This compound is essential for research applications focused on parasitic infections and the development of effective treatments. Its mechanism of action provides valuable insights into overcoming resistance in various parasitic species. -
Parasite Inhibitor
SSJ-183 is a parasite inhibitor with notable antimalarial activity. It functions by modulating both the efficacy and pharmacokinetic properties relevant to antimalarial treatment. Studies have demonstrated its potential in antimalarial research, positioning SSJ-183 as a significant candidate for the development of new combination therapies targeting malaria. -
Parasite Inhibitor
GSK932121 is a selective antimalarial agent that targets the electron transport chain of Plasmodium falciparum by inhibiting cytochrome bc1 (complex III). This compound disrupts the parasite's metabolic processes, demonstrating significant activity against malaria. Due to its efficient five-step synthesis process, GSK932121 can be produced at kilogram scale, making it suitable for extensive clinical research applications. -
Parasite Inhibitor
MMV674850 is a potent inhibitor targeting asexual stage parasites, exhibiting IC50 values of 2.7 and 4.5 nM. This compound preferentially affects early-stage gametocytes, with an IC50 of 4.5 ± 3.6 nM, while late-stage gametocytes display an IC50 of 28.7 ± 0.2 nM. MMV674850 serves as a valuable tool for research focused on malaria and parasite biology, particularly in investigating gametocyte development and inhibition strategies. -
Antileishmanial Agent
Antileishmanial agent-3 is a potent inhibitor targeting Leishmania major, demonstrating significant growth-inhibitory activity. This compound is valuable for investigating leishmaniasis and exploring potential therapeutic strategies against this parasitic infection. Its mechanism of action makes it a useful tool in antileishmanial research applications. -
Parasite Inhibitor
PfPKG-IN-1 is an imidazole-based inhibitor targeting Plasmodium falciparum cGMP-dependent protein kinase (PfPKG). This compound exhibits significant biological activity by interfering with the function of PfPKG, an essential enzyme in the life cycle of the malaria parasite. PfPKG-IN-1 is utilized in research applications aimed at developing effective antimalarial therapies and understanding the molecular mechanisms of parasite survival and replication. -
Parasite Inhibitor
6-Benzylthioinosine acts as a potent inhibitor of parasite growth, demonstrating significant antileukemic activity by enhancing cytotoxic effects against acute myeloid leukemia cells. It operates by modulating cellular metabolism and influencing signaling pathways, particularly when used in combination with metformin. This compound is valuable for research applications focused on leukemia treatment and understanding metabolic regulation in cancer. -
Parasite Inhibitor
Antileishmanial agent-2 is a potent inhibitor targeting Leishmania parasites, demonstrating submicromolar antileishmanial activity with an IC50 value of 0.29 μM. This compound exhibits a high selectivity index, indicating minimal toxicity to mammalian cells. It is suitable for research applications focused on the development of therapies for leishmaniasis and related parasitic infections. -
Parasite Inhibitor
(+)-Isopulegol functions primarily as a parasite inhibitor, derived from the terpenoid constituents of Mentha canadensis L. It exhibits phagostimulatory effects on adult pests, particularly S. granarius and T. confusum, acting as a feeding attractant for adult T. confusum and larvae of T. granarium. This compound is valuable for research applications in pest control and management strategies targeting stored product insects. -
Antileishmanial Agent
LC-61 is a potent antileishmanial agent that exhibits significant efficacy with an IC50 value of 0.076 µM against intracellular Leishmania infantum. This compound is crucial for research in parasitology and can be utilized in studies focusing on leishmaniasis treatment and drug development. Its high potency makes it a valuable tool for investigating the mechanisms of action and therapeutic strategies against leishmanial infections. -
Anti-parasite Agent
ELQ-316 is an endochinlike quinolone compound that serves as an anti-parasitic agent. It exhibits significant efficacy against both acute and chronic experimental toxoplasmosis, making it a valuable tool in parasitology research. This compound's mechanism of action targets essential pathways in the parasite, providing insights into potential therapeutic strategies for Toxoplasma infections. -
Parasite
Doramectin monosaccharide, an acid degradation product of Doramectin, targets glutamate- and GABA-gated chloride channels in nematodes, enhancing their opening and resulting in effective anthelminthic activity. This compound is useful for studying the pharmacodynamics of anthelmintics and exploring mechanisms of resistance in parasitic infection research. Its significance lies in its role in understanding the biochemical pathways involved in nematode neuromuscular function and development. -
Parasite
Trimethacarb is a carbamate insecticide that primarily targets the nervous system of parasites. It inhibits key cholinesterase enzymes, leading to accumulation of acetylcholine and subsequent paralysis of target organisms. This compound is commonly utilized in research settings to study pest control methods and the biochemical mechanisms underlying insecticide action against various parasites. -
Parasite Inhibitor
SLU-10906 is a potent inhibitor targeting the protozoan parasite Cryptosporidium. Demonstrating significant efficacy in a cell-based infection model with an EC50 of 0.19 μM, SLU-10906 is non-cytotoxic, making it a valuable tool for investigating cryptosporidiosis. Its oral bioavailability further enhances its potential for preclinical studies and therapeutic exploration. -
Anti-parasite Agent
MED6-189 is an anti-parasitic agent that disrupts apicoplast function and vesicular trafficking in Plasmodium falciparum, with an inhibitory concentration (IC50) of less than 50 nM. This kalihinol analog specifically targets the apicoplast, a vital non-photosynthetic plastid in Apicomplexa parasites essential for isoprenoid synthesis. Its primary biological activity makes it an important tool for research in malaria treatment and the development of anti-parasitic strategies. -
Anti-Parasite Agent
NEU617 is an anti-parasite agent that targets the proliferation of human African trypanosomiasis (HAT) pathogens. It effectively inhibits Trypanosoma brucei with an EC50 of 42 nM and shows activity against T. cruzi with an EC50 of 1.8 μM. This compound is a derivative of Lapatinib, providing a novel approach for research applications focused on parasitic infections and potential treatment strategies. -
Parasite
Vinclozolin M2 is an active metabolite of vinclozolin, primarily functioning as an antagonist of the mineralocorticoid receptor (IC50 = 1,400 nM) and the androgen receptor (IC50 = 0.17 nM). This compound is obtained through esterase activity and decarboxylation processes in C. elegans and human liver microsomes. Vinclozolin M2 exhibits significant biological activity, making it useful for investigating receptor-mediated signaling pathways and studying endocrine disruption in parasitic and mammalian systems. -
Parasite Inhibitor
Carbonic anhydrase inhibitor 27 is a targeted antitrypanosomal agent that inhibits carbonic anhydrase activity, impacting parasite viability. This compound effectively reduces parasitic load in the bloodstream and enhances the survival rate of infected murine models. It is valuable for research applications focused on the treatment of parasitic infections such as Trypanosomiasis. -
Anti-Parasite Agent
Hynapene B is an effective anti-parasitic agent that targets Eimeria tenella. With a minimum inhibitory concentration (MIC) of 34.7 μM, it demonstrates significant biological activity in inhibiting the growth and development of this protozoan parasite. This compound is suitable for research applications focusing on the control of coccidiosis and other parasitic infections. -
Parasite
Japonilure is a synthetic chemical compound known for its role as a pheromone that attracts specific parasitic insects. It exhibits key biological activity in pest management by disrupting the life cycle of targeted insect populations. Research applications include exploring its potential as a biocontrol agent in agriculture and studying its behavioral effects on insect hosts. -
Parasite
Eprinomectin B1b is a member of the avermectin family, primarily targeting parasites. It exhibits potent anthelmintic and insecticidal properties, making it a valuable reagent in research applications focused on parasite control and management. Eprinomectin B1b is utilized in studies investigating its effects on helminths and arthropod pests, contributing to the development of effective treatment strategies in agricultural and veterinary settings. -
Antileishmanial Agent
Antileishmanial agent-34 is an aurone that exhibits potent antileishmanial activity, specifically targeting Leishmania species. This compound demonstrates efficacy against both extracellular forms of Leishmania major, Leishmania donovani, Leishmania infantum, and Leishmania enriettii, as well as intracellular forms of Leishmania donovani, with an IC50 value of less than 2 µg/mL. Antileishmanial agent-34 is a valuable tool for research focused on leishmaniasis and the development of new therapeutic strategies against this infectious disease. -
Parasite
Isonicotinaldehyde 2-pyridin is an antileishmanial compound targeting Leishmania species, particularly effective against the promastigotes of L. amazonensis and L. braziliensis. Its primary mechanism involves the enhancement of reactive oxygen species (ROS) production, leading to disruption of mitochondrial function in parasites. Notably, Isonicotinaldehyde 2-pyridin exhibits low toxicity to mouse macrophages, making it a promising candidate for further pharmacological studies in the treatment of leishmaniasis. -
Parasite Inhibitor
MMV665852 is an antischistosomal agent that targets Schistosoma mansoni, inhibiting worm viability in vitro. This compound has demonstrated efficacy in reducing worm burden in murine models of schistosomiasis, making it a valuable tool for research in parasitic disease treatment and prevention. -
Anti-Parasite Agent
Hynapene A is an anti-parasitic agent that targets Eimeria tenella, a coccidian parasite responsible for avian coccidiosis. This compound has a minimum inhibitory concentration (MIC) of 123 μM, demonstrating significant efficacy against the parasite. Hynapene A is useful in research applications aimed at understanding coccidiosis and developing effective treatments for parasitic infections in poultry. -
Anti-parasite Agent
Norselic acid B is a natural compound known for its anti-parasitic properties, primarily targeting the Leishmania parasite. Isolated from the Antarctic sponge Crella sp., norselic acid B exhibits significant biological activity against these pathogens, making it a valuable reagent for research applications focusing on Leishmaniasis and related parasitic diseases. Its unique origin and efficacy position it as a promising candidate for further investigation in the field of parasitology. -
Parasite
Z3-Dodecenyl E2-butenoate is a female sex pheromone synthesized by the sweet potato weevil, Cylas formicarius. This compound is utilized in baiting and trapping male weevils, facilitating effective population management in agricultural settings while minimizing reliance on chemical insecticides. Its application contributes to sustainable pest control strategies. -
Parasite
Butocarboxim is an effective insecticide and acaricide that targets a variety of parasites. Its primary mechanism involves the disruption of neurotransmission in target organisms, leading to paralysis and subsequent mortality. This compound serves crucial roles in agricultural and public health research, particularly in studies focused on pest control strategies and the management of vector-borne diseases. -
Anti-Parasite Agent
Hynapene C is an anti-parasitic agent that specifically inhibits Eimeria tenella, a protozoan parasite responsible for coccidiosis in poultry. It demonstrates a minimum inhibitory concentration (MIC) of 34.7 μM, highlighting its potent efficacy against this pathogen. Hynapene C is valuable for research applications focused on developing treatments for coccidiosis and studying parasite biology. -
Anti-Parasite Agent
DB-766 is an anti-parasitic agent that targets Trypanosoma cruzi, the causative agent of Chagas disease. It demonstrates significant efficacy in reducing parasite load in both blood and cardiac tissues, making it a valuable compound for research in parasitology and potential therapeutic applications against leishmaniasis. This agent facilitates the investigation of novel treatments for parasitic infections. -
Antileishmanial Compound
Colchicoside is a bioactive tropolone alkaloid recognized for its antileishmanial activity. This compound effectively targets Leishmania parasites, demonstrating potential in the treatment of leishmaniasis. Its biological properties make it a valuable tool for research focused on parasitic infections and the development of antileishmanial therapies. -
Inhibitor of Parasite Motility and Invasion
TachypleginA-2 is a small-molecule inhibitor that targets parasite motility and invasion. It effectively induces a mobility shift in TgMLC1, an essential light chain involved in cellular movement. This compound is useful for research investigating the mechanisms of parasitic behavior and the development of potential therapeutic strategies against parasitic infections. -
Antileishmanial Drug
1,3-Linolein-2-Olein is a triglyceride that serves as an effective antileishmanial agent. This compound demonstrates potent inhibitory activity against Leishmania promastigotes, with an IC50 of 0.079 µg/ml, and also effectively suppresses the growth of amastigotes, showing an IC50 of 40.03 µg/ml. Its biological activity makes it a valuable tool for research in the development of treatments for leishmaniasis. -
Parasite
Dieugenol is a neolignan with notable antiprotozoal activity, specifically targeting parasitic infections. It exhibits inhibitory effects on T. cruzi, exhibiting IC50 values of 15.1 μM against amastigotes and 11.5 μM against trypomastigotes, while demonstrating antioxidative properties by scavenging superoxide anions and inhibiting thiobarbituric acid reactive substances (TBARS) formation. Although Dieugenol disrupts the plasma membrane integrity of T. cruzi trypomastigotes at a concentration of 15 μM, it shows cytotoxicity to NCTC L-929 fibroblasts with a CC50 value of 58.2 μM, indicating its potential for further investigation in parasitic disease research. -
Parasite Inhibitor
Bitipazone is a potent cysteine ester derivative that serves as an effective anticoccidial agent. It demonstrates significant efficacy against coccidian parasites in animal models, including rabbits and turkeys, with good tolerability observed at concentrations below 90 ppm in feed. Pharmacokinetic studies indicate that Bitipazone is slowly eliminated from the blood and organs, making it a valuable compound for research in parasitology and veterinary medicine. -
Antiparasite Agent
Parvaquone is an antiparasite agent that targets Theileria parva. It demonstrates potent in vitro activity with an ED50 of 0.006 mg/L, effectively reducing the proportion of schizont-infected cells. This compound is primarily used in research related to East Coast fever, enabling investigations into the pathology and treatment of Theileria parva infections. -
Parasite
Tetromycin B is a potent cysteine protease inhibitor, demonstrating Ki values of 0.62, 1.42, 32.5, and 1.59 μM against rhodesain, falcipain-2, cathepsin L, and cathepsin B, respectively. This compound effectively inhibits the growth of Trypanosoma brucei in vitro with an IC50 of 30.87 μM. Additionally, Tetromycin B exhibits cytotoxic effects on HEK293T kidney cells and J774.1 macrophages, with IC50 values of 71.77 μM and 20.2 μM, respectively, highlighting its potential utility in research applications targeting parasitic infections. -
Parasite Inhibitor
AB 3217-B is a parasite inhibitor that targets mite species with potent anti-mite activity. This compound demonstrates efficacy in disrupting the life cycle of parasites, making it valuable for research related to pest control and parasitology. Its ability to inhibit mite proliferation positions it as a potential candidate for further studies aimed at developing effective treatments against parasitic infestations. -
Parasite Inhibitor
Anti-Trypanosoma cruzi agent-5 is a potent inhibitor of Trypanosoma cruzi, the causative agent of Chagas disease. This compound demonstrates significant antiparasitic activity, inhibiting the proliferation of the parasite in vitro. It is suitable for research applications investigating the mechanisms of Chagas disease and potential therapeutic strategies. -
Parasite Inhibitor
RS 49676 is an N-substituted imidazole compound that acts as a potent inhibitor against endogenous amoebae, displaying an ED50 of less than 0.1 ng/mL. It demonstrates significant biological activity in vivo, notably prolonging the average survival time of mice infected with Trypanosoma cruzi to over 11 weeks when administered at a dose of 100 mg/kg per day via subcutaneous injection. This compound is valuable for research applications involving parasitic infections and host-pathogen interactions. -
Parasite Tyrosyl-tRNA Synthetase Inhibitor
ML471 is an orally active inhibitor of parasite tyrosyl-tRNA synthetase (PfTyrRS), which is essential for protein synthesis in Plasmodium species. This compound exhibits potent activity against malaria by selectively targeting PfTyrRS, providing valuable insights into the treatment of malaria infections. It is a useful tool for researchers investigating novel antimalarial strategies and exploring the role of tRNA synthetases in parasitic biology. -
Antileishmanial Agent
Sitamaquine hydrochloride is an antileishmanial agent that targets mitochondrial complex II (succinate dehydrogenase). This orally active 8-aminoquinoline analog exhibits potent biological activity by rapidly accumulating in the acidic compartments of Leishmania spp., particularly in acidocalcisomes. It is utilized in research applications focused on understanding leishmaniasis and developing effective treatments against this parasitic infection. -
Parasite Inhibitor
(Rac)-ACT-451840 is a parasite inhibitor with significant antimalarial properties. It demonstrates effective antimalarial activity against P. berghei-infected mice, achieving an ED90 of 13 mg/kg and showing inhibitory effects at higher doses. In humanized immunodeficient mouse models infected with P. falciparum, the compound has an ED90 of 3.7 mg/kg. (Rac)-ACT-451840 is structurally similar to artemisinin and offers a rapid onset of action, although it necessitates repeated high dosing for optimal efficacy. -
Parasite
Aurachin B is a quinoline derivative that exerts its effects through inhibition of parasitic growth. This alkaloid displays significant antimalarial activity by interfering with the metabolism of Plasmodium species. It serves as a valuable tool for investigating therapeutic strategies against malaria and other parasitic infections. -
Parasite
Indoxacarb is an oxathiazole insecticide that targets a variety of insect pests by disrupting neuronal sodium channel activity, leading to paralysis and death. It is utilized in forest pest management, demonstrating significant toxicity toward the predatory stink bug Podisus distinctus, with a lethal concentration (LC50) of 2.62 g L-1. Exposure to Indoxacarb markedly decreases the survival rate of P. distinctus to 40.7% and diminishes its respiration rate from 18.45 to 14.41 μL CO2 h-1, along with reducing food intake. Furthermore, treated individuals exhibit hyperexcitation, indicating profound impacts on their physiological responses. -
Parasite
Acequinocyl is a naphthoquinone acaricide that acts on parasites, specifically targeting mite populations. It is utilized in agricultural formulations for effective control of these pests. Acequinocyl is suitable for various research applications, including studies in agricultural science and forensic analysis related to pest management in cannabis. -
Anti-Parasite Agent
Jietacin B is an anti-parasitic agent with demonstrated efficacy against nematodes. It effectively eliminates Burs helenchus lignicolus at a concentration of 0.25 μg/mL. This compound is a valuable tool for research applications focused on nematode resistance and parasitic control. -
Parasite
Diacetylcercosporin is a perylenequinone produced by the fungi Cercospora and Septoria, primarily targeting parasites. It demonstrates potent inhibitory activity against Plasmodium falciparum, with IC50 values of 2.75 μM for the D6 clone and 1.94 μM for the W2 strain, as well as against Leishmania donovani at an IC50 of 3.1 μM. Additionally, Diacetylcercosporin exhibits significant cytotoxic effects on various human cancer cell lines, including SK-MEL, KB, BT549, and SKOV3, with IC50 values ranging from 4.8 to 8.7 μM. This reagent also acts as a phytotoxin, inhibiting the growth of crops such as lettuce and bentgrass at a concentration of 1.62 mM. -
Parasite
Vamidothion is an organophosphorus compound that targets pests through its insecticidal and acaricidal properties. It exhibits biological activity against a range of insects and mites, facilitating the formation of phosphate adducts with tyrosine residues when degraded by human serum albumin. The resulting metabolites can be characterized using liquid chromatography quadrupole-Orbitrap mass spectrometry, making Vamidothion useful in forensic toxicology for investigating organophosphorus poisoning cases. -
Parasite
Karsil is a chemical compound utilized as an agricultural pesticide, specifically designed to target parasitic organisms. Its primary mechanism involves disrupting the biological processes of pests, leading to their mortality. Karsil is effective in controlling a variety of parasites, making it a valuable tool in agricultural research and pest management applications.
