Catalog No.
Product Name
Application
Product Information
Citations
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Polysaccharide
Curdlan, a bacterial polysaccharide, is composed of a glucose homopolymer linked by β-1,3-glycosidic bonds. It interacts with Dectin-1, a C-type lectin receptor, triggering immune responses in mast cells and enhancing dendritic cell functions relevant to tumor immunity. Curdlan is of significant interest in research focused on cancer therapies and the modulation of immune-inflammatory conditions. -
Non-digestible Polysaccharide
β-D-Glucan is a natural non-digestible polysaccharide that primarily targets recognition receptors such as Dectin-1 and Toll-like receptors. It exhibits high biocompatibility and can be readily internalized by murine and human macrophages, facilitating targeted delivery. This molecule serves as an effective enteric delivery vehicle for probiotics, making it valuable for research applications in immunology and microbiome studies. -
Benzylisoquinoline Alkaloid
Papaveraldine is a benzylisoquinoline alkaloid known for its antispasmodic effects and ability to provide protection against histamine-induced bronchospasm in animal models. Additionally, it is utilized in formulations targeting melanin production, making it valuable for studies related to hair pigmentation and treatment of grey hair. Its biological activity positions it as a potential candidate for further research into respiratory health and cosmetic applications. -
Natural Products
Embramine hydrochloride is a monoethanolamine compound that functions primarily as an antihistamine and anticholinergic agent. It effectively inhibits histamine receptors and blocks acetylcholine action, making it valuable in studies related to allergic responses and neurotransmission. This reagent is commonly utilized in research focused on understanding various natural products and their pharmacological effects. -
Natural Product
Onitin is a natural product derived from Onychium siliculosum that functions as a non-competitive antagonist of histamine. It effectively blocks the peristaltic reflex in guinea-pig ileum and inhibits the responses of both guinea-pig ileum and tracheal muscle to histamine. Its mechanism of action makes it valuable for research into gastrointestinal motility and respiratory responses mediated by histamine signaling. -
Flavonoid
Pongamol is a flavonoid that targets PTPase-1B and intestinal α-Glycosidase with an IC50 of 75 μM and 103.5 μM, respectively. This compound exhibits anti-inflammatory properties by reducing the release of cytokines such as IL-1β and TNF-α while also reversing the nuclear translocation of NF-κB. Additionally, Pongamol promotes glucose uptake through GLUT4 upregulation, inhibits epithelial-mesenchymal transition via the FAK/Akt-mTOR pathway, and demonstrates neuroprotective effects in models of Alzheimer's disease by alleviating oxidative stress and restoring autophagy. Pongamol is valuable for research applications in Alzheimer's disease, type 2 diabetes, and non-small cell lung cancer. -
Sesquiterpenoid Hormone
Juvenile hormone B 3 (mixture of diastereomers) is a sesquiterpenoid hormone primarily targeting juvenile hormone receptors Met and Gce. This compound exhibits anti-metamorphic activity by modulating the expression of Kr-h1 through direct receptor interaction. Juvenile hormone B 3 is utilized in research focused on insect lethality and developmental regulation, providing insights into hormonal control in insects such as Drosophila melanogaster. -
Toxic Indole Alkaloid
Humantenine is a highly toxic indole alkaloid derived from Gelsemium elegans. It specifically targets RNA m6A modification regulatory proteins, including ALKBH5 and METTL, where it binds stably through hydrogen bonding and hydrophobic interactions. This binding disrupts m6A methylation levels of target genes, leading to impaired expression of intestinal epithelial cell tight junction and cytoskeleton-related genes, ultimately resulting in intestinal barrier dysfunction and substantial cytotoxicity. In animal studies, Humantenine exhibits an intraperitoneal LD50 of less than 1 mg/kg in mice. Its metabolism varies across species, with notable demethylation, dehydrogenation, and oxidation observed in liver microsomes of humans, pigs, goats, and rats. -
Carcinogenic Natural Compound
1-Hydroxyanthraquinone is a naturally occurring anthraquinone compound known for its oral bioactivity, primarily derived from plants such as Tabebuia avellanedae. This compound has been identified to have carcinogenic properties, making it relevant for studies focusing on cancer research and toxicology. Its biological activities indicate potential insights into the mechanisms of carcinogenesis and the evaluation of plant-derived compounds in cancer biology. -
Tetrasaccharide
Nystose is a tetrasaccharide composed of two fructose units linked through beta (1→2) bonds to the fructosyl portion of sucrose. It demonstrates significant prebiotic properties, along with immunomodulatory and metabolism-regulating activities. Additionally, Nystose has been shown to enhance bone mineralization by activating the Wnt/β-catenin signaling pathway, making it a valuable compound for studies in nutrition and metabolic health. -
Natural Product
Poricoic acid A is a natural product derived from Poria cocos, exhibiting oral bioactivity as an anti-tumor agent. This compound plays a significant role in attenuating renal fibrosis by modulating the Gas6/Axl-NFκB/Nrf2 signaling pathway and activating AMPK while inhibiting Smad3, thus reducing fibroblast activation and abnormal extracellular matrix remodeling. Additionally, Poricoic acid A, in conjunction with Melatonin, has been shown to mitigate oxidative stress and inflammation, improving renal function and decreasing serum creatinine and urea levels in rodent models of ischemia-reperfusion injury. This highlights its potential in renal protection and cancer research applications. -
Bioactive Alkaloid
Aristolochic acid B is a bioactive alkaloid that primarily targets DNA through adduct formation. This compound demonstrates mutagenic properties and poses a higher carcinogenic risk in vivo compared to aristolochic acid I. It is widely utilized in research applications focused on understanding carcinogenesis and the molecular mechanisms of DNA damage. -
Alkaloid
1-Prenyl-2-methoxy-6-formyl-8-hydroxy-9H-carbazole is a carbazole alkaloid that demonstrates significant anti-inflammatory and antimicrobial properties. This compound effectively inhibits the production of pro-inflammatory cytokines, including TNF-α and IL-6. With IC50 values of 10.9 μM against Bacillus cereus and 95 μM against Staphylococcus aureus, it serves as a valuable tool for studies of inflammatory and infectious diseases. As a naturally derived substance from Murraya koenigii, it has potential applications in drug discovery and therapeutic development. -
Natural Product
Luteolin 7-diglucuronide is a natural product derived from the flavonoid classes, primarily found in Aloysia triphylla and Verbena officinalis. This compound exhibits potent antioxidant activity and has been shown to contribute to various biological effects, including anti-inflammatory and neuroprotective properties. Its applications in research encompass studies on plant-derived compounds, pharmacological investigations, and the exploration of its potential health benefits. -
Flavonoid
Isovitexin 2''-O-arabinoside is a flavonoid that primarily targets various biological pathways associated with plant metabolism. This compound demonstrates significant antioxidant activity, making it useful in research related to oxidative stress and cellular signaling. Its applications extend to studies on the health benefits of phytochemicals, as well as investigations into plant physiology and biochemistry. -
Natural Product
7,8-Dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one, also known as 7,8,4'-Trihydroxyisoflavone, is a natural product with potential antioxidant properties. This compound exhibits the ability to scavenge free radicals and may have beneficial effects in various biological systems. Its applications in research include studies on oxidative stress, cellular signaling pathways, and evaluation of its role in disease prevention. -
Prenylated Flavonoid
Parvisoflavone B is a prenylated flavonoid that selectively inhibits protein tyrosine phosphatase 1B (PTP1B) with an IC50 of 42.6 μM and α-glucosidase with an IC50 of 12.19 μM. This compound is derived from the root bark of Erythrina mildbraedii and exhibits significant biological activity relevant to metabolic disorders. Parvisoflavone B is utilized in research exploring mechanisms related to type 2 diabetes and obesity, making it a valuable tool for studying these conditions. -
Anthraquinone
Questin is an anthraquinone compound known for its antibacterial and anticancer properties. It effectively inhibits Cdc25B phosphatase and demonstrates significant antibacterial activity against various bacterial strains, including Vibrio harveyi, Vibrio anguillarum, Vibrio cholerae, and Vibrio parahemolyticus, with minimum inhibitory concentrations (MIC) ranging from 31.25 µg/mL to 125 µg/mL. Additionally, Questin exhibits antiprotozoal effects against the protozoan pathogen Tritrichomonas foetus with an MIC of 12.5 µg/mL and shows potential anticancer activity against lung and colon cancer. -
Natural Compound
3-O-cis-p-Coumaroyl maslinic acid is a natural compound derived from the ethyl acetate extract of Miconia albicans leaves. This compound exhibits a potent inhibition of protein tyrosine phosphatase 1B (PTP1B) with an IC50 value of 0.46 μM, highlighting its significance in metabolic and signaling pathways. Additionally, it demonstrates antimicrobial activity against Gram-positive bacteria and yeasts, making it a valuable candidate for research in pharmacology and microbiology. -
Flavonoid
Rivularin, also known as Skullcapflavone, is a flavonoid derived from Radix scutellariae. It exhibits significant antioxidant properties and has been shown to modulate various signaling pathways, making it a valuable reagent in studies of cellular stress responses and neuroprotection. Its biological activities are of interest in pharmacological research, particularly in the fields of inflammation, cancer, and neurodegenerative diseases. -
Natural Product
2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside is a natural product derived from the roots of Polygonaceae species, primarily targeting inflammatory pathways. This compound exhibits significant inhibition of 5-HETE, HHT, and thromboxane B2 formation and is known for its hypotensive, anti-aging, anti-inflammatory, hypolipidemic, cardioprotective, and neuroprotective properties. Its diverse biological activities make it a valuable reagent for research in cardiovascular health, neurodegenerative diseases, and age-related conditions. -
Natural product
Ginkgo biloba extract primarily targets oxidative stress in neuronal cells, promoting mitochondrial stability and regulating Bcl-2 family proteins to inhibit apoptotic cascades. This natural product demonstrates protective effects against various forms of neuronal damage, including alleviation of testicular injury through SKP2 activation and suppression of Beclin1-independent autophagy. Additionally, Ginkgo biloba extract mitigates neurotoxicity induced by Aβ by disrupting multiple pathways involved in glucose uptake, ROS accumulation, and mitochondrial dysfunction. Its diverse biological activities make it a valuable tool for research into conditions such as Alzheimer's disease, Parkinson's disease, cerebral hypoperfusion, stroke, and traumatic brain injury. -
Alkaloid Compound
N-Methylnuciferine iodide is an alkaloid compound extracted from Lotus Plumule, known for its potential neuroprotective effects. It has been shown to ameliorate depression-like behavior induced by lipopolysaccharides, making it a valuable tool for studying the mechanisms of inflammation-related mood disorders. This compound may facilitate research into therapeutic strategies for managing depression and related pathologies. -
Active Alkaloid
6-(1-Hydroxyethyl)-5,6-dihydrochelerythrine is an active alkaloid known for its ability to disrupt the structural integrity of cellular organelles, including early endosomes, mitochondria, and autophagosomes. This compound is particularly relevant in the study of neurodegenerative diseases, such as Parkinson's disease, as it has been investigated in patient-derived olfactory cells. Its unique properties make it a valuable tool for researchers exploring cellular function and organelle dynamics in pathological conditions. -
Natural Product
7,8-Didehydrocimigenol is a triterpenoid natural product primarily known for its inhibitory effects on TNF-α-induced VCAM-1 expression. It modulates key signaling pathways by inhibiting NF-kB activity and phosphorylation of ERK1/2 and Akt, while simultaneously increasing PPAR-γ expression. This compound is relevant for research on cardiovascular disorders, including atherosclerosis, offering valuable insights into potential therapeutic approaches. -
Natural Toxin
Biliatresone is a natural toxin derived from Dysphania glomulifera and D. littoralis, functioning primarily as an isoflavonoid within the 1,2-diaryl-2-propenone class. This compound is known to induce extrahepatic biliary atresia in zebrafish models, making it a valuable tool for research into developmental biology and hepatic disorders. Its unique biological activity facilitates studies on gene expression and signaling pathways related to biliary function and development. -
Flavonoid Glycoside
Isorhoifolin is a flavonoid glycoside derived from Hemistepta lyrata, functioning primarily as a bioactive compound with potential protective properties. It has demonstrated an anti-leakage effect, suggesting a role in maintaining cellular integrity. This compound is of interest in studies related to cell protection, oxidative stress, and related therapeutic applications in various biomedical research fields. -
Phenolic Acid
Salvianolic acid Y is a phenolic acid that shares a planar structure with Salvianolic acid B, exhibiting notable protective properties. This compound has demonstrated the ability to mitigate cell injury induced by hydrogen peroxide (H2O2), making it a valuable reagent for studies focused on oxidative stress and cellular protection. Its application in research related to antioxidant activity and cellular responses to oxidative damage enhances its utility in various biochemical investigations. -
Aldehyde Oxidase Substrate
Phthalazine is a substrate for human aldehyde oxidase 1, facilitating the generation of reactive oxygen species (ROS) that contribute to enzyme inactivation. As a nitrogen-containing organic heterocyclic compound, Phthalazine demonstrates significant antitumor activity across various cancer types, including blood cancer, breast cancer, colon cancer, lung cancer, and renal cancer. This reagent is valuable for research focused on cancer biology and the mechanisms underlying oxidative stress in tumorigenesis. -
Quinone
D-α-Tocopherylquinone is a quinone derivative that serves as an oxidation product of α-Tocopherol (vitamin E). It exhibits significant antioxidant and anticoagulant properties, effectively reducing oxidative damage from lipid peroxidation. D-α-Tocopherylquinone interacts with liver cytosolic proteins, notably binding to glutathione-S-transferase (GST), facilitating its transport for metabolism or bile excretion. This compound is valuable for research applications focused on oxidative stress, metabolic pathways, and potential therapeutic interventions in related disorders. -
Phenolic Compound
Brevifolincarboxylic acid is a phenolic compound that targets α-glucosidase, inhibiting its activity with an IC50 value of 323.46 μM. This compound exhibits an inhibitory effect on the aryl hydrocarbon receptor (AhR) and possesses antioxidant properties by scavenging reactive oxygen species (ROS). Additionally, it enhances glucose uptake in myotubes and demonstrates antitumor activity against lung and gastric cancers. Brevifolincarboxylic acid is valuable for research in diabetes and inflammatory diseases. -
Natural Pigment
Pelargonidin 3,5-diglucoside chloride is a natural pigment derived from red fruits and vegetables, primarily known for its role as a reactive oxygen species (ROS) and reactive nitrogen species (RNS) scavenger. This compound demonstrates significant biological activity by inhibiting enzymes that contribute to the generation of ROS, RNS, and pro-inflammatory cytokines. Its antioxidant properties make Pelargonidin 3,5-diglucoside chloride valuable for research in oxidative stress, inflammation, and potential therapeutic applications in various health conditions. -
Phenolic Seciridoid
Oleocanthal is a phenolic seciridoid compound primarily known for its inhibition of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). This agent exhibits significant anti-inflammatory and neuroprotective properties, along with reducing reactive oxygen species (ROS) and nitric oxide (NO) while upregulating Nrf-2 and HO-1. Oleocanthal also has demonstrated efficacy in reducing amyloid-beta (Aβ) deposition and shows anticancer activity across various cancer types, including colon, breast, liver, and melanoma. Additionally, it displays anti-Leishmania activity against L. major, making it a valuable reagent for Alzheimer’s disease and cancer research. -
Natural Products
Cannflavin C is a natural product isolated from Cannabis sativa, primarily known for its potent antioxidant properties. This compound exhibits significant biological activity that may contribute to cellular protection against oxidative stress. Cannflavin C is of interest in research applications focused on the therapeutic potential of cannabis-derived substances and their role in oxidative damage mitigation. -
Natural Product
Magnoloside F is a natural product derived from Magnolia officinalis, primarily known for its potent antioxidant activity. This compound is of interest in research focused on oxidative stress and its implications in various diseases. Magnoloside F may offer valuable insights into the development of therapeutic strategies targeting oxidative damage. -
Natural Product
Maritimetin is a natural product classified as an aurone, isolated from Coreopsis tinctoria. It exhibits potent antioxidant activity, demonstrated by its strong DPPH radical-scavenging ability with an IC50 value of 4.12 μM. This compound is applicable in research focusing on cardiovascular disease mechanisms and potential therapeutic strategies. -
Triterpenoid
Eburicoic acid is a triterpenoid that exhibits protective effects on the liver by mitigating CCl4-induced hepatic damage through its antioxidant and anti-inflammatory properties. Additionally, it demonstrates antidiabetic and antihyperlipidemic activities, making it a valuable compound for research focused on metabolic disorders and liver health. Its diverse biological activities support its use in studies aimed at understanding complex pathophysiological conditions. -
Flavonoid Glycoside
3'-Methoxy tamarixin is a flavonoid glycoside known for its antioxidant properties. Isolated from the leaves of Cadaba farinosa Forssk, this compound demonstrates significant free radical scavenging activity, with an antioxidant efficacy of 49.1%. It serves as a valuable reagent for research focused on oxidative stress and the protective effects of flavonoids in various biological systems. -
Flavonoid Glycoside
Farobin B is a flavonoid glycoside with potent antioxidant properties, primarily targeting reactive oxygen species. It has demonstrated significant activity in the ORAC assay, indicating its capacity to neutralize oxidative stress. This compound is extracted from the leaves of Fargesia robusta 'Pingwu', making it valuable for research related to oxidative stress, cellular protection, and the biological effects of flavonoids. -
Phenolic Amide Glycoside Compound
N-trans-Feruloyltyramine 4′-O-β-D-glucopyranoside is a phenolic amide glycoside compound sourced from Suaeda japonica. It demonstrates significant antioxidant activity by effectively scavenging DPPH free radicals and reducing reactive oxygen species (ROS) generation induced by hydrogen peroxide in cellular environments. This compound shows potential for research into cardiovascular and neurodegenerative diseases, highlighting its relevance in studies focused on oxidative stress and cellular protection. -
Flavonoid
Ladanetin-6-O-β-D-glucopyranoside is a flavonoid known for its antioxidative properties. This compound exhibits significant potential in cardioprotection, making it valuable for research into cardiovascular health. Its ability to scavenge free radicals positions it as a promising candidate for studies aimed at developing therapies for heart-related conditions. -
Flavonoid
Axillarin is a natural flavonoid known for its anti-glycating and antioxidant properties. This compound demonstrates the ability to inhibit the formation of advanced glycation end-products (AGEs), which are implicated in various age-related diseases. Axillarin is commonly used in research focused on oxidative stress, diabetes, and other metabolic disorders, contributing valuable insights into potential therapeutic applications. -
Natural Products
α-Terthienylmethanol is a terthiophene compound that targets natural products with significant biological activity. It exhibits potent cytotoxicity against human endometrial cancer cell lines, specifically Hec1A and Ishikawa, with an IC50 value of less than 1 μM. This compound is known to enhance intracellular levels of reactive oxygen species (ROS) while reducing glutathione (GSH) levels, making it a valuable reagent for cancer research and oxidative stress studies. -
Oligostilbene Compound
(+)-Isoampelopsin F is an oligostilbene compound derived from the roots of Caragana sinica. This compound has been characterized for its limited biological activity, demonstrating negligible effects on DPPH radical scavenging and lipid peroxidation inhibition, with IC50 values exceeding 200 μM. Its research applications may involve exploring structure-activity relationships or studying secondary metabolite profiles in plant extracts. -
Alkaloid
N-Demethylsinomenine is a morphinane alkaloid derived from Sinomenium acutum. This compound exhibits protective effects against hydrogen peroxide-induced cellular injury, making it a valuable tool in evaluating cellular stress responses. Its potential applications in research extend to neurodegenerative diseases, including Alzheimer's disease, where it may aid in understanding disease mechanisms and therapeutic approaches. -
Natural Flavonoid
Cedrin is a natural flavonoid derived from Cedrus deodara, targeting neuroprotective mechanisms. It exhibits significant protective effects on PC12 cells against neurotoxicity induced by Aβ1-42. Cedrin's biological activity includes the reduction of reactive oxygen species overproduction, elevation of superoxide dismutase activity, and a decrease in malondialdehyde levels, making it a valuable reagent for research on neurodegenerative diseases and oxidative stress. -
Phenylpropanoids
1-O-Caffeoyl-β-D-glucopyranose is a phenylpropanoid compound that demonstrates notable antioxidant activity by effectively scavenging DPPH radicals in vitro, with an IC50 value of 37.7 μM. This reagent is useful in research applications focused on oxidative stress, as well as studies investigating the role of phenylpropanoids in plant metabolism and potential therapeutic effects in various biological systems. -
Natural Product
Farnesyl acetate is a natural product derived from the leaves of Amomum gagnepainii, classified as a sesquiterpene. It exhibits notable toxicity against red palm weevil larvae, with an LD50 of 7867 ppm, making it a potential candidate for pest control applications in agricultural research. Its biological activity suggests further investigation into its mechanisms of action and potential uses in integrated pest management strategies. -
Pentachlorophenol Derivative
3,4,5-Trichlorocatechol is a catechol derivative of pentachlorophenol that acts as a potent inducer of oxidative DNA lesions. This compound is primarily used in research related to genotoxicity and DNA damage mechanisms. Its ability to generate reactive oxygen species makes it valuable in studies investigating environmental toxins and their impact on genetic material. -
Flavonoid Compound
5-n-Tricosylresorcinol is a flavonoid compound known for its unique self-association properties due to the presence of a meta-hydroxyl group, which allows it to form a staggered-chain conformation with hexagonal symmetry in the polar head groups. This compound exhibits protective effects against hydrogen peroxide-induced DNA damage, making it a valuable tool in research focused on oxidative stress and cellular protection mechanisms. Its distinct structural characteristics and biological activities make it suitable for studies in lipid chemistry and cellular resilience.
