Catalog No.
Product Name
Application
Product Information
Citations
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Calcium Channel inhibitor
Tetrandrine is a calcium channel blocker. It inhibits the degranulation of mast cells.Tetrandrine has anti-inflammatory and anti-fibrogenic actions, which make tetrandrine and related compounds potentially useful in the treatment of lung silicosis, liver cirrhosis, and rheumatoid arthritis. - Troxerutin(Trihydroxyethylrutin) is a flavonol, a type of flavonoid. It is more accurately a hydroxyethylrutoside. It can be isolated from Sophora japonica, the japanese pagoda tree.It is used as a vasoprotective.
- Vanillylacetone is similar in chemical structure to other flavor chemicals such as vanillin and eugenol. It is used as a flavor additive in spice oils and in perfumery to introduce spicy aromas.
- Xanthone is an organic compound. It can be prepared by the heating of phenyl salicylate. In 1939, xanthone was introduced as an insecticide and it currently finds uses as ovicide for codling moth eggs and as a larvicide. Xanthone is also used in the preparation of xanthydrol, which is used in the determination of urea levels in the blood
- Yohimbine hydrochloride (Antagonil) is a α2-adrenoceptor antagonist (pKi values are 8.52, 8.00 and 9.17 for human α2A, α2B and α2C receptors respectively)
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5-alpha reductase inhibitor
β-sitosterol reduces blood levels of cholesterol, and is sometimes used in treating hypercholesterolemia. β-Sitosterol inhibits cholesterol absorption in the intestine. When the sterol is absorbed in the intestine, it is transported by lipoproteins and incorporated into the cellular membrane. -
anti-psoriatic agent
Periplogenin is a naturally occurring furanocoumarin found in Angelica dahurica roots, with potent anti-psoriatic effects. Periplogenin induces adipocyte differentiation. -
anti-inflammatory agent
Acetosyringone is a phenolic natural product with analgesic, antipyretic and anti-inflammatory actions. -
natural product
L-Quebrachitol is a natural product isolated from many plants, promotes osteoblastogenesis by uppregulation of BMP-2, runt-related transcription factor-2 (Runx2), MAPK (ERK, JNK, p38α), and Wnt/β-catenin signaling pathway. -
flavonoid
Loureirin A is a flavonoid extracted from Dragon's Blood, can inhibit Akt phosphorylation, and has antiplatelet activity. -
flavonoid
Kaempferol 3-neohesperidoside (Kaempferol 3-O-neohesperidoside) is a flavonoid. Kaempferol 3-neohesperidoside exhibits insulinomimetic effect on the rat soleus muscle. -
natural pterostilbene analogue
3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells (IC50s of 9.0, 40.2, and 70.9 ?M for COLO 205, HCT-116, and HT-29 cells, respectively) by inducing apoptosis and autophagy. -
neuroprotective agent
Nootkatone, a neuroprotective agent from Alpiniae Oxyphyllae Fructus, has antioxidant and anti-inflammatory effects. -
neuroprotection agent
Beta-Asarone, found in certain plants such as Acorus and Asarum, could pass the blood-brain barrier and exerts neuroprotection effects. -
anti-diabetes agent
(2S,3R,4S)-4-Hydroxyisoleucine is an orally active compound isolated from Trigonella foenum-graecum, with anti-diabetes and anti-diabetic nephropathy activity. -
anti-inflammatory agent
Anthraquinone-2-carboxylic acid is a major anthraquinone isolated from Brazilian taheebo, with anti-inflammatory activity and antinociceptive. -
antioxidant anti-inflammatory agent
Nodakenetin, isolated from Angelica decursiva, possesses antioxidant anti-inflammatory activities. Nodakenetin has the potential to be an antiarthritic and nerve tonic. -
antioxidant agent
Ligustrazine hydrochloride (Tetramethylpyrazine, Tetrapyrazine) is a chemical compound found in natto and in fermented cocoa beans with anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities. - Plitidepsin is a cyclic depsipeptide isolated from the marine tunicate Aplidium albicans. Plitidepsin displays a broad spectrum of antitumor activities, inducing apoptosis by triggering mitochondrial cytochrome c release, initiating the Fas/DC95, JNK pathway and activating caspase 3 activation. This agent also inhibits elongation factor 1-a, thereby interfering with protein synthesis, and induces G1 arrest and G2 blockade, thereby inhibiting tumor cell growth.
- (E)-[6]-Dehydroparadol, extracted from patent US 9272994, compound M15, shows growth inhibition and induction of apoptosis against human cancer cells with IC50 values of 43.02 μM in HCT-116 cell and 41.59 μM in H-1299 cell, respectively.
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food antioxidant
Propyl gallate is a common food antioxidant. Propyl gallate can inhibit the production of acrolein, glyoxal and methylglyoxal. -
fragrance ingredient
Methyl dihydrojasmonate is a fragrance ingredient with a jasmine-like odor, used in many fragrance mixtures. -
anti-cancer agent
8-Oxocoptisine is a natural protoberberine alkaloid with anti-cancer activity. -
Natural Product
Thymoquinone is a natural product derived from Nigella sativa that primarily targets the VEGFR2-PI3K-Akt signaling pathway. It exhibits a range of biological activities, including antioxidant, anti-inflammatory, anticancer, antiviral, anticonvulsant, antifungal, and antiangiogenic effects, alongside hepatoprotective properties. Thymoquinone is valuable for research applications in areas such as Alzheimer's disease, cancer, cardiovascular disorders, infectious diseases, and inflammation. -
Biotin-Phenol Analog
Biotin-4-aminophenol is a biotin-phenol analog that facilitates the generation of free radicals. This compound exhibits enhanced and selective conjugation to tyrosine residues in proteins, outperforming previously reported analogs such as BP1. Its remarkable reactivity makes it a valuable tool for studying protein modifications and interactions in various biological research applications. -
Alkaloid
Conophylline is a vinca alkaloid derived from the leaves of the tropical plant Ervatamia microphylla. This compound functions as a differentiation inducer for pancreatic cells and demonstrates potent biological activity by suppressing hepatic stellate cells (HSC) while inducing apoptosis. It is of particular interest in research focused on pancreatic differentiation and the modulation of liver fibrosis. -
Alkaloid
Berberine (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine (Natural Yellow 18) induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Berberine (Natural Yellow 18) has antineoplastic properties.
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Fumonisin
Fumonisin B4 is a derivative of fumonisin. Fumonisin B4 has low albumin binding capacity. -
Natural Product
Epimedin A, one of the main flavonoid active components in Herba Epimedii, is orally active. Epimedin A can inhibit osteoclastogenesis, differentiation, and bone resorption. Epimedin A also possesses anti-inflammatory activity. Epimedin A can be used in the research of osteoporosis and inflammatory diseases. -
Flavonoid Glycoside
Vitexin-2"-O-rhamnoside is an orally active flavonoid glycoside. Vitexin-2"-O-rhamnoside inhibits Apoptosis, increases the phosphorylation levels of PI3K/Akt, inhibits caspase-3, SOD activity, and promotes cytokine (IL-2, IL-6, and IL-12) secretion. Vitexin-2"-O-rhamnoside strongly inhibits DNA synthesis in MCF-7 cells with an IC50 of 17.5 μM. Vitexin-2"-O-rhamnoside enhances immune function and improves the absorption of active compounds. Vitexin-2"-O-rhamnoside has antioxidant activity. Vitexin-2"-O-rhamnoside is used in the study of cardiovascular disease and immune-related diseases. -
Iiridoid Glycoside
Loganin is an iridoid glycoside known for its potent anti-inflammatory, antioxidant, and antitumor properties. It demonstrates protective effects against acute lung injury and pulmonary fibrosis by upregulating the Nrf2/HO-1 signaling pathway in response to LPS-mediated inflammation and oxidative stress. Additionally, Loganin mitigates neuroinflammation associated with spinal cord injury, highlighting its potential relevance in research on inflammatory and neuroprotective therapies. -
Natural Product
(S)-(+)-Carvone is a natural product that exerts its effects primarily through the modulation of oxidative stress and inflammation pathways. It enhances the activity of antioxidant enzymes such as superoxide dismutase (SOD) and catalase (CAT), while reducing levels of proinflammatory cytokines and oxidative stress markers. Additionally, (S)-(+)-Carvone promotes apoptotic cell death via activation of caspases and demonstrates potential therapeutic effects in conditions such as skin cancer, liver protection, arthritis, and cognitive enhancement. Its multifaceted biological activities make it valuable for research in oxidative stress-related diseases and inflammation. -
Aristolactam-Type Alkaloid
Stigmalactam is an aristolactam-type alkaloid derived from Orophea enterocarpa, known for its anticancer properties. It induces apoptosis through the mitochondrial pathway, involving the activation of caspases 3 and 9, along with a reduction in mitochondrial membrane potential. Additionally, Stigmalactam demonstrates antioxidant activity by lowering reactive oxygen species (ROS) production. This reagent is suitable for research in the contexts of liver and breast cancer. -
Atisane Diterpenoid
Acrofolione A is an atisane diterpenoid that exhibits significant anticancer properties. It effectively induces G0/G1 phase cell cycle arrest and apoptosis in human NALM-6 pre-B cell leukemia cells, making it a valuable tool for leukemia research. This compound provides insights into mechanisms of cell cycle regulation and potential therapeutic strategies for treating leukemia. -
Natural Product
Alisol B acetate is a triterpenoid compound derived from the tubers of Alisma plantago-aquatica Linn. It exhibits various biological activities, including anti-inflammatory and hepatoprotective effects. This compound serves as a valuable tool in research applications focused on natural product studies, pharmacology, and drug discovery. -
Flavonoid Derivative
Curcumin monoglucoside is a flavonoid derivative that exhibits potent antioxidant, anti-apoptotic, and neuroprotective properties, alongside notable antibacterial activity. This compound is primarily utilized in research related to neurodegenerative disorders, including Parkinson's disease, due to its potential to mitigate neuronal damage and improve cellular resilience. Its diverse biological activities make it a valuable tool for investigating therapeutic strategies in various pathological conditions. -
Pentacyclic Triterpenoid
α-Amyrin acetate is a pentacyclic triterpenoid that exhibits significant anti-proliferative effects on cancer cells and promotes apoptosis. Additionally, it has been shown to lower blood glucose levels, making it relevant for studies in metabolic diseases such as diabetes. This compound is valuable for research applications focused on cancer, particularly breast cancer, and metabolic disorders. -
Natural Product
Isosilybin B is a flavonolignan with significant anticancer activity primarily targeting prostate cancer. Isolated from Silybum marianum, it regulates cell cycle-related proteins by downregulating cyclins D3, D1, A, and E, as well as Cdk4, Cdk2, and Cdc25A. Additionally, Isosilybin B activates Caspases 9 and 3, promoting apoptosis and reducing levels of the androgen receptor (AR) and prostate-specific antigen (PSA). This compound is valuable for research focused on cancer biology and therapeutic interventions. -
Anti-tumor Natural Compound
Tigilanol tiglate is a natural compound that activates protein kinase C (PKC) and C1 domains, leading to mitochondrial and endoplasmic reticulum dysfunction. This dysregulation triggers the unfolded protein response (UPR), resulting in ATP depletion, organelle expansion, and the activation of apoptotic pathways including Caspase activation and gasdermin E cleavage, ultimately driving terminal necrosis. Due to its anti-tumor and immunomodulatory properties, tigilanol tiglate is valuable for research on head and neck squamous cell carcinoma and soft tissue sarcoma. -
Iridoid Glucoside
Patrinoside aglucone is an iridoid glucoside isolated from Valeriana tuberosa, exhibiting significant anticancer properties through G2/M phase tumor cell cycle arrest and apoptosis induction. This compound effectively inhibits the proliferation of cancer stem cells, such as MDA-MB-231 and U-251MG. Additionally, Patrinoside aglucone demonstrates potent anti-inflammatory activity, as evidenced by its ability to inhibit nitric oxide release (IC50: 43.44 μM) and reduce levels of pro-inflammatory cytokines including TNF-α, IL-1β, IL-6, PGE2, and COX-2. -
Iridoidal Glucoside
Loganic acid 6′-O-β-D-glucoside, an iridoidal glucoside, is derived from the Gentiana rhodantha plant of the Gentianaceae family. This compound demonstrates an inhibitory effect on lipopolysaccharide (LPS)-induced nitric oxide (NO) and tumor necrosis factor-alpha (TNF-α) production in RAW264.7 macrophage cells. Its biological activity makes it a valuable reagent for research related to inflammation and immune response mechanisms. -
Natural Products
Dihydrodehydrodiconiferyl alcohol is a neolignan primarily derived from Anogeissus acuminata. This compound exhibits significant cytotoxic activity against melanoma cancer cell lines, making it a valuable tool for cancer research. Its unique properties and biological activity position it for investigations into natural product-derived therapeutic strategies and potential anti-cancer applications. -
Natural Product
Cardenolide B-1 is a natural product derived from the plant species Nerium oleander. This steroid compound exhibits notable biological activity, primarily serving as a potent inhibitor of Na+/K+ ATPase. It is widely utilized in research applications focused on cell signaling, cardiovascular function, and the development of cardiotoxic agents. -
Triterpenoid Compound
Pachymic acid is a lanostrane-type triterpenoid from P. cocos. Pachymic acid inhibits Akt and ERK signaling pathways. -
Furoquinoline Alkaloid
Skimmianine is an orally active furoquiniline alkaloid present mainly in the Rutaceae family. Skimmianine has analgesic, antispastic, sedative, and anti-inflammatory properties. Skimmianine inhibits acetylcholinesterase (AChE) (IC50 = 8.6 μg/mL). Skimmianine exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity. Skimmianine has antioxidant and anti-inflammatory effects on ischemia-reperfusion (IR) injury. Skimmianine exerts anti-inflammatory effects through activation of the phosphatidylinositol-3-kinase (PI3K)-protein kinase B (AKT) pathway. Skimmianine is neuroprotective by targeting the NF-κB activation pathway to prevent neuroinflammation. Skimmianine inhibits the release of histamine, intracellular Ca2+ signaling and protein kinase C signaling.
