Poricoic acid A is a natural product derived from Poria cocos, exhibiting oral bioactivity as an anti-tumor agent. This compound plays a significant role in attenuating renal fibrosis by modulating the Gas6/Axl-NFκB/Nrf2 signaling pathway and activating AMPK while inhibiting Smad3, thus reducing fibroblast activation and abnormal extracellular matrix remodeling. Additionally, Poricoic acid A, in conjunction with Melatonin, has been shown to mitigate oxidative stress and inflammation, improving renal function and decreasing serum creatinine and urea levels in rodent models of ischemia-reperfusion injury. This highlights its potential in renal protection and cancer research applications.
Poricoic acid A is a natural product derived from Poria cocos, exhibiting oral bioactivity as an anti-tumor agent. This compound plays a significant role in attenuating renal fibrosis by modulating the Gas6/Axl-NFκB/Nrf2 signaling pathway and activating AMPK while inhibiting Smad3, thus reducing fibroblast activation and abnormal extracellular matrix remodeling. Additionally, Poricoic acid A, in conjunction with Melatonin, has been shown to mitigate oxidative stress and inflammation, improving renal function and decreasing serum creatinine and urea levels in rodent models of ischemia-reperfusion injury. This highlights its potential in renal protection and cancer research applications.
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