Oleocanthal is a phenolic seciridoid compound primarily known for its inhibition of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). This agent exhibits significant anti-inflammatory and neuroprotective properties, along with reducing reactive oxygen species (ROS) and nitric oxide (NO) while upregulating Nrf-2 and HO-1. Oleocanthal also has demonstrated efficacy in reducing amyloid-beta (Aβ) deposition and shows anticancer activity across various cancer types, including colon, breast, liver, and melanoma. Additionally, it displays anti-Leishmania activity against L. major, making it a valuable reagent for Alzheimer’s disease and cancer research.
Oleocanthal is a phenolic seciridoid compound primarily known for its inhibition of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). This agent exhibits significant anti-inflammatory and neuroprotective properties, along with reducing reactive oxygen species (ROS) and nitric oxide (NO) while upregulating Nrf-2 and HO-1. Oleocanthal also has demonstrated efficacy in reducing amyloid-beta (Aβ) deposition and shows anticancer activity across various cancer types, including colon, breast, liver, and melanoma. Additionally, it displays anti-Leishmania activity against L. major, making it a valuable reagent for Alzheimer’s disease and cancer research.
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