Catalog No.
Product Name
Application
Product Information
Citations
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Metabolomic Signature Of Hyperlipidemia
Sphingomyelin (d18:1/12:0) is a metabolomic biomarker associated with hyperlipidemia. This compound displays significant potential for diagnosing dyslipidemia and may aid in the early detection and prevention of adverse cardiovascular events. Its role in lipid metabolism research makes it a valuable tool for studies focusing on cardiovascular health and related metabolic disorders. -
Glycerol Glycoside
2-O-(α-D-Glucopyranosyl)glycerol is a glycerol glycoside with notable applications in biochemical research. This compound exhibits significant properties related to membrane stabilization and cell protection, particularly under stress conditions. It is primarily extracted from the marine blue-green alga Oscillatoria sp., and serves as a valuable tool in studies of osmoregulation and cellular responses to environmental changes. Researchers can utilize this reagent in various biological assays to investigate its functional roles and potential therapeutic applications. -
Quinone Derivative
7PPD-Q is a quinone derivative with antioxidant properties derived from substituted p-phenylenediamine. This compound exhibits toxicity against the marine bacterium Vibrio fischeri, with an EC50 value of 14.9 mg/L. 7PPD-Q may be utilized in research focused on assessing the environmental impact of pollutants and the effects of oxidative stress in various biological systems. -
Natural Product
3-Methyl-2-butenal, a natural product derived from hops, is characterized by its conjugated aldehyde structure. This compound exhibits key biological activity, including potential applications in flavoring and fragrance development due to its unique aroma. Additionally, 3-Methyl-2-butenal serves as a valuable reagent in organic synthesis and can be employed in various research applications focused on natural product chemistry. -
Phenylpropanoid Glycoside
Tadehaginoside is a phenylpropanoid glycoside that plays a crucial role in regulating lipogenesis and glucose metabolism. This compound exhibits antioxidant properties and offers hepatoprotective effects by modulating Nrf2 and NF-κB signaling pathways, thereby mitigating oxidative stress and inflammation in liver cells. Tadehaginoside is applicable in research focusing on obesity and diabetes, providing insights into metabolic regulation and associated pathologies. -
Diterpenoid
Pterisolic acid B is an ent-Kaurane diterpenoid with notable biological activity. Isolated from the fern Pteris semipinnata of the Pteridaceae family, it exhibits potential in various research applications, including pharmacological studies and natural product chemistry. Its unique structure and properties make it a valuable reagent for investigating diterpenoid mechanisms and interactions. -
Antioxidant Natural Compound
4-Methoxychalcone-1 is a naturally occurring chalcone with notable antioxidant properties. This compound exhibits significant anti-inflammatory, antitumor, and antibacterial activities, making it a valuable tool in biological research. Its applications include studying inflammation and tumor models, providing insights into therapeutic strategies against oxidative stress-related diseases. -
Flavonoid
Pratensein is a flavonoid that demonstrates neuroprotective properties by mitigating β-amyloid-induced cognitive impairment. It acts by reducing oxidative damage and restoring synaptic integrity as well as brain-derived neurotrophic factor (BDNF) levels. This compound is useful in research focused on neurodegenerative diseases and cognitive dysfunction. -
Diterpene alkaloid
Karacoline is a diterpene alkaloid derived from the plant Aconitum kusnezoffii that modulates the NF-κB signaling pathway. This compound plays a significant role in reducing the degradation of the extracellular matrix (ECM), making it valuable for research into intervertebral disc degeneration (IDD) and related conditions. Its ability to influence ECM stability positions Karacoline as a candidate for studying therapeutic interventions in degenerative disc diseases. -
Naphthohydroquinone Dimer
Rubipodanone A is a naphthohydroquinone dimer known for its cytotoxic effects on various cancer cell lines, including A549, BEL-7402, HeLa, HepG2, SGC-7901, and U251. Additionally, Rubipodanone A exhibits significant activation of NF-κB at concentrations of 20 and 40 μM. This compound is valuable for research focused on cancer biology and cellular signaling pathways. -
Amide Alkaloid
Coumaperine is an amide alkaloid known for its ability to inhibit NF-κB signaling pathways. This compound has demonstrated anticancer activity against non-small cell lung cancer and Hodgkin's lymphoma, making it valuable for cancer research. Additionally, Coumaperine derivatives exhibit antibacterial properties, further expanding their potential applications in biomedical studies. -
Natural Product
14-Deoxy-11,12-didehydroandrographiside is a natural product derived from Andrographis paniculate. This compound exhibits significant biological activity, including anti-inflammatory and antioxidant properties. It is commonly utilized in research related to pharmacology, traditional medicine, and the investigation of natural remedies for various health conditions. -
Chlorinated Alkaloid
Dauricumine is a chlorinated alkaloid that functions as an inhibitor of NF-κB ligand-induced differentiation of mouse bone marrow-derived macrophages into multinucleated osteoclasts. This compound is significant in research applications focused on bone metabolism and osteoclastogenesis, providing insights into the regulation of inflammatory responses and potential therapeutic approaches for bone-related disorders. -
Alkaloid
Mahanimbine is an orally active alkaloid derived from Murraya koenigii, primarily targeting metabolic pathways. This compound demonstrates significant inhibition of metabolic complications associated with a high-fat diet in murine models. Its biological activity positions Mahanimbine as a valuable tool for research in metabolic disease and obesity-related studies. -
Natural Product
Heliangin is a sesquiterpenoid derived from the herb Helianthus tuberosus L. It exhibits anti-inflammatory and antioxidant properties, making it a valuable compound for studying natural product pharmacology. Heliangin is primarily used in research focusing on its potential therapeutic applications in various health conditions, including oxidative stress-related disorders. -
Triterpenoid Saponin
Elatoside F is a triterpenoid saponin that exhibits significant anti-inflammatory activity. It effectively inhibits lipopolysaccharide-induced production of nitric oxide and the activation of the nuclear factor NF-κB. Elatoside F can be isolated in a single step from the plant Aralia elata, making it a valuable compound for research into inflammation and related pathways. -
β-amyloid Plaques Imaging Ligand
MeS-IMPY is a selective imaging ligand for β-amyloid plaques, demonstrating high binding affinity to β-amyloid extracted from human brains affected by Alzheimer's disease (AD) with Ki values of 7.93 nM and 8.95 nM for isolated plaques and brain homogenates, respectively. This compound shows promise as a radioligand for positron emission tomography (PET) imaging of β-amyloid plaques, facilitating the evaluation of AD pathology in research applications. -
Phenolic Compound
Maesopsin is a phenolic compound derived from Hoveniae Lignum known for its antioxidant properties. This compound exhibits potential biological activity by scavenging free radicals and may play a role in cellular protection against oxidative stress. Maesopsin is of interest in research applications focused on investigating the therapeutic effects of phenolic compounds in various biological systems. -
Fungal Meroterpenoid/AChE inhibitor
Territrem B is a fungal meroterpenoid that serves as an irreversible inhibitor of acetylcholinesterase (AChE). It is isolated from Aspergillus terreus and exhibits significant neurotoxic activity. This compound is valuable for studying AChE-related pathways and can aid in the development of therapeutic agents for neurological disorders. -
4-quinolinone Alkaloid
Leiokinine A is a 4-quinolinone alkaloid with demonstrated potential in modulating various biological pathways. Isolated from Esenbeckia leiocarpa, it exhibits significant biological activities, making it a valuable compound for research in pharmacological and biochemical studies. Its diverse applications include investigations into its effects on cellular processes and potential therapeutic properties. -
Indole Alkaloid
Plasiaticine B is an indole alkaloid isolated from Plantago asiatica. It demonstrates low cytotoxicity in HL-60, A-549, and MCF-7 cell lines, with an IC50 greater than 40 μM. Additionally, Plasiaticine B exhibits minimal inhibitory activity on acetylcholinesterase (AChE), with an inhibition rate below 60%. This compound may be utilized in research exploring the biological roles of indole alkaloids and their potential therapeutic applications. -
Alkaloid Compound
Lycodoline is an alkaloid compound known for its inhibition of butyrylcholinesterase (BChE), with an IC50 value of 667 μM. This specific activity makes Lycodoline a valuable tool in studies focused on neurodegenerative diseases where cholinergic signaling is disrupted. Its properties may contribute to research on cognitive enhancement and therapeutic strategies targeting cholinergic pathways. -
Cholinesterase Inhibitors; Lupane Derivative; Molecular Modeling; Triterpenoid
3β-Hydroxy-lup-20(29)-en-16-one is a potent dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), exhibiting a notable selectivity for BChE with an IC50 value of 28.9 μM. This lupane derivative serves as a valuable tool in the study of cholinergic signaling pathways and triterpenoid research. Its inhibitory properties position it as a potential candidate for neurodegenerative disease research applications, particularly in disorders characterized by cholinergic dysregulation. -
Alkaloid
3-Acetylnerbowdine is an alkaloid that can be isolated from the bulbs of N. bowdenii. This compound is primarily utilized in the study of acetylcholinesterase activity, providing insights into neurotransmission and potential therapeutic targets for neurological disorders. Its role in biological research may contribute to the understanding of cholinergic system modulation. -
Triglucosylnaphthalene Derivative
Aloveroside A is a triglucosylnaphthalene derivative extracted from the ethanolic extract of Aloe vera. It exhibits weak beta-secretase (bACE) inhibitory activity, with an inhibition rate of approximately 18.68% at a concentration of 100 μg/mL. This compound may be of interest in research related to neurodegenerative conditions and enzyme inhibition studies. -
Natural Product
Dihydrokaempferol-3-O-β-D-glucoside is a natural product that acts as an inhibitor of acetylcholinesterase (AChE). Isolated from the bark of Cudrania tricuspidata, this compound demonstrates potential biological activity in modulating cholinergic signaling. Its research applications include studies on neurodegenerative diseases and exploration of cognitive enhancement mechanisms. -
Natural Products
Mephentermine hydrochloride is a sympathomimetic amine that primarily acts as a vasoconstrictor, significantly increasing peripheral resistance. This compound has been shown to exhibit biological activity as an inhibitor of monoamine oxidase A and B (MAO-A/B), making it valuable for cardiovascular research and the study of metabolic pathways in natural products. Its derivatives may further enhance understanding of neurotransmitter regulation and cardiovascular function. -
Cyclic Ketone
Dihydrofuran-3(2H)-one is a cyclic ketone that serves as a building block for the synthesis of cyclic ketone inhibitors targeting serine proteases, particularly plasmin. Its unique structural properties make it valuable for exploring protease inhibition and related biological pathways. This compound is useful in biochemical research designed to elucidate the mechanisms of serine protease activity and potential therapeutic interventions. -
Ketone Inhibitor
(Z-LL)2 ketone is a potent ketone inhibitor with an IC50 value of 50 nM. This compound effectively inhibits the processing of the pro-signal peptide, making it a valuable tool in studies of peptide maturation and processing pathways. The biological activity of (Z-LL)2 ketone supports research applications in biochemistry and molecular biology, particularly concerning peptide signaling mechanisms. -
Natural Product
1,2-Di-(9Z-hexadecenoyl)-sn-glycerol is a diacylglycerol derivative sourced from the fungus Stereum hirsutum. This compound exhibits potential thrombin-inhibiting activity, making it a valuable tool in the study of antithrombotic drug development. Its unique properties allow for exploration in various biochemical and pharmacological research applications. -
Polyphenol Oxidase Inhibitor
Cyanidin 3-sophoroside chloride is a potent non-competitive reversible inhibitor of polyphenol oxidase (PPO) and tyrosinase. This compound demonstrates significant anti-browning activity, making it valuable for enhancing the antioxidant capacity of fruits and extending their storage longevity. Additionally, it is of interest in research applications focused on food preservation and antioxidant mechanisms. -
Natural Product
Pseudostellarin G is a natural cyclic octapeptide that targets tyrosinase, an enzyme crucial for melanin synthesis. It demonstrates effective inhibition of melanin production, making it valuable for research into skin pigmentation disorders and potential therapeutic applications in hyperpigmentation. Pseudostellarin G is a useful tool for studying melanogenesis and developing skin-related treatments. -
Collagenase Inhibitor
Cyclo(l-Pro-d-Leu) is a potent collagenase inhibitor, extracted from R. atalantica. It is primarily used in research focusing on connective tissue disorders and wound healing, where collagenase activity is a critical factor. Additionally, this compound demonstrates a mild inhibitory effect on tyrosinase, making it valuable for studies related to melanogenesis and skin pigmentation. -
Mushroom Tyrosinase Diphenolase Inhibitor
Tyrosinase-IN-33 is a pyridine-based compound that acts as a potent inhibitor of mushroom tyrosinase diphenolase activity. It effectively reduces enzyme activity, with an IC50 value of 9.0 μM, making it a valuable tool for research into melanogenesis and related disorders. This compound is suitable for studies investigating enzymatic inhibition and the regulation of pigmentation processes. -
Natural Product
Schisanhenol B is a natural product derived from Schisandra chinensis known for its inhibitory activity against tyrosinase. This compound exhibits significant binding affinity for PIK3CG, making it a valuable tool in cardiovascular research, particularly in the study of heart failure mechanisms. Its biological activity positions Schisanhenol B as a promising candidate for further investigation in therapeutic applications related to cardiac health. -
Natural Product
Taxiphyllin is a plant-derived cyanogenic glycoside that primarily inhibits tyrosinase activity. This compound demonstrates notable cytotoxic effects in BRL-3A cells, with an IC50 value of 18.75 μM, and exhibits antimicrobial properties against Staphylococcus aureus, showing an EC50 of 0.96 μM. Taxiphyllin is useful in studies involving enzyme inhibition, cell viability, and antimicrobial resistance research. -
Indole Alkaloid
Apovincamine is an indole alkaloid isolated from Alstonia pneumatophora, a plant in the Apocynaceae family. This compound exhibits anti-melanogenesis activity, making it a valuable tool for research in skin pigmentation and related disorders. Its potential applications include studying the mechanisms of melanin production and exploring therapeutic approaches for hyperpigmentation conditions. -
Xanthine Oxidase Inhibitor
Purpurogallin is a naturally occurring phenolic compound extracted from Quercus species, exhibiting potent inhibition of xanthine oxidase (XO) with an IC50 value of 0.2 μM. This compound demonstrates significant antioxidant and anti-inflammatory properties, making it valuable for research in oxidative stress and inflammation-related studies. Its ability to modulate XO activity can be leveraged in the investigation of conditions such as gout and hyperuricemia. -
Natural Product
4-Nitrocinnamic acid is a phenylpropanoid compound that can be extracted from the heartwood of Cassia garrettiana. It exhibits notable biological activity with applications in the study of natural products and their effects on various biological pathways. This compound can serve as a useful tool in pharmacological research and the exploration of therapeutic agents derived from plant sources. -
Natural Products
2,5-Dihydroxy-4-methoxyacetophenone is a natural product isolated from the roots of Cynanchum paniculatum Kitagawa, demonstrating significant bioactivity. This compound effectively inhibits glutamate-induced cytotoxicity in the hippocampal HT22 cell line and markedly reduces MMP-13 expression in SW1353 cells. Its potential for mitigating cartilage degradation makes it valuable for research applications focused on neuroprotection and cartilage health. -
Natural Product
Stephavanine is a natural product derived from the roots of Stephania abyssinica. This compound exhibits notable biological activities, including anti-inflammatory and analgesic effects. It is utilized in research applications focused on pharmacological studies of traditional herbal remedies and the elucidation of mechanisms underlying its therapeutic potential. -
Phenolic Diterpene
7-Methoxyrosmanol is a phenolic diterpene derived from rosemary. It is known to inhibit the cAMP-mediated activation of the PEPCK and G6Pase promoters, implicating its role in metabolic pathways. This compound is relevant for research in metabolic regulation and may provide insights into the modulation of gluconeogenesis and other related processes. -
Monosaccharide
L-Mannose is a naturally occurring monosaccharide that serves as a substrate for mannose-6-phosphate isomerase. It plays a crucial role in glycoprotein synthesis and nucleotide sugar metabolism. L-Mannose is frequently utilized in research applications related to carbohydrate metabolism, cellular signaling, and the study of glycosylation processes in various biological systems. -
Benzoquinone Derivative
2,6-Dimethylbenzoquinone (2,6-DMBQ) is a benzoquinone derivative that functions as an electron acceptor in Photosystem II-mediated photoelectrochemical water oxidation. It facilitates electron transfer between spinach chloroplast Photosystem II membranes and carbon paste electrodes, making it valuable for studying photosynthetic electron transport and oxygen evolution. Additionally, 2,6-DMBQ undergoes direct photolysis in aqueous solution under 365 nm, yielding 2,6-dimethylhydroquinone and 3-hydroxy-2,6-dimethylbenzoquinone, which may have implications in photodynamic studies. -
Quinone Reductase Activator
Cryptolepinone is a potent quinone reductase activator, demonstrating a CD value of 0.02 μg/mL. Isolated from Sida acuta, it effectively inhibits the formation of preneoplastic lesions in a mouse mammary organ culture assay, reducing lesions by 83.3% at a concentration of 10 μg/mL following DMBA induction. This compound is of interest in anti-cancer research, particularly in studies focusing on chemoprevention and tumor progression. -
Diterpenoid
Dehydroabietinol is an abietane diterpenoid that primarily targets spleen tyrosine kinase (SYK), exhibiting kinase inhibition with an IC50 value of 46.4 μM. This compound is particularly relevant for research into immune-mediated diseases, providing valuable insights into the modulation of immune responses through its inhibitory effects on SYK activity. -
Phenolic Trisaccharide
Toralactone 9-O-triglucoside is a phenolic trisaccharide that can be isolated from Cassia seed. This compound exhibits significant biological activity relevant to research on estrogen-related diseases, including breast cancer, prostate cancer, osteoporosis, and cardiovascular disease. Its unique structure and properties make it a valuable tool for studying the effects of phenolic compounds on hormone-related pathways and associated disorders. -
Ester of Terpenoid Acids
Tschimganin is an ester of terpenoid acids that exhibits estrogenic activity, derived from the plant F. tschimganica. This compound has been shown to promote uterine growth in immature rats, making it a valuable tool for research on estrogen function and reproductive biology. Its potential application spans areas such as endocrinology and developmental biology. -
Fmoc-protected Unnatural Amino Acid
Fmoc-(S)-2-(4-pentenyl)Ala-OH is an Fmoc-protected unnatural amino acid designed for use in polypeptide synthesis. This compound enables the incorporation of bioorthogonal functionalities, facilitating further modification and assembly of complex peptide structures. Its applications extend to the investigation of peptide interactions and the development of novel therapeutics. -
Unnatural Amino Acid
L-m-Tyrosine is an unnatural amino acid that serves as a precursor in the synthesis of neurotransmitters. It has been shown to decrease levels of dopamine, norepinephrine, and serotonin in animal models, indicating its potential role in neurological research. This compound may contribute to studies focusing on neurodegenerative disorders such as Parkinson's disease and Alzheimer's disease, as well as inflammatory conditions like arthritis.
