AChE

Cat. No.

A78595

CAS No.

36940-87-1

2'-O-Succinyl-cAMP

2'-O-Succinyl-cAMP is a cAMP analog that serves as a valuable tool for covalent coupling with acetylcholinesterase. This compound facilitates the development of tracers in classical heterogeneous competitive enzyme immunoassays, enabling precise determination of cAMP levels in various biological samples. Its utility in research applications makes it an important reagent for investigations into cellular signaling pathways and cAMP-mediated processes.

Cat. No.

A78596

CAS No.

1217704-11-4

Physostigmine-d3

Synonyms: Eserine-d3

Physostigmine-d3 is the deuterated form of Physostigmine, a reversible inhibitor of acetylcholinesterase (AChE). This compound effectively crosses the blood-brain barrier, enhancing central cholinergic neurotransmission, and is utilized in research for its ability to reverse memory deficits in transgenic mouse models of Alzheimer's disease. Additionally, Physostigmine serves as an antidote for anticholinergic poisoning, making it significant for studies in neuropharmacology and toxicology.

Cat. No.

A78597

CAS No.

1261394-20-0

Donepezil-d7 hydrochloride

Synonyms: E2020-d7

Donepezil-d7 hydrochloride is a deuterium-labeled variant of Donepezil, a potent inhibitor of acetylcholinesterase (AChE). This compound exhibits specific inhibition with IC50 values of 8.12 nM for bovine AChE and 11.6 nM for human AChE. Donepezil-d7 hydrochloride is primarily used in chemical research to trace the metabolism and pharmacokinetics of Donepezil in various biological systems.

Cat. No.

A78598

CAS No.

263248-42-6

Zanapezil fumarate

Synonyms: TAK-147 fumarate

Zanapezil fumarate is a potent, reversible, and selective inhibitor of acetylcholine esterase (AChE). It exhibits significant inhibition of AChE activity in rat cerebral cortex homogenates, with an IC50 value of 51.2 nM, while also displaying moderate inhibition of muscarinic M1 and M2 receptor binding, with Ki values of 234 and 340 nM respectively. This compound is utilized in research focusing on the early stages of Alzheimer's disease, aiding in the exploration of therapeutic strategies for cognitive decline.

Cat. No.

A78599

CAS No.

4569-86-2

Methylene Violet 3RAX

Methylene Violet 3RAX is a phenazine dye primarily targeting mitochondria for cellular staining. This reagent can alter DNA molecular structure and induce the production of reactive singlet oxygen. It also exhibits inhibitory activity against human erythrocyte acetylcholinesterase (AChE) and human plasma butyrylcholinesterase (BChE) with inhibition constants (Ki) of 1.58 and 0.51 µM, respectively. Methylene Violet 3RAX is valuable for researching potential photosensitizers aimed at mitochondrial targeting in photodynamic therapy (PDT).

Cat. No.

A78600

CAS No.

123702-95-4

Kuwanon U

Kuwanon U is a potent cholinesterase inhibitor that demonstrates effective inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with IC50 values of 19.69 µM and 10.11 µM, and inhibition constants (Ki) of 6.48 µM and 9.59 µM, respectively. This compound shows promise for research applications concerning Alzheimer’s disease (AD), providing a valuable tool for studying cholinergic function and neurodegeneration.

Cat. No.

A78601

CAS No.

164724-79-2

P11149

P11149 is a competitive inhibitor of acetylcholinesterase (AChE) that exhibits weak oral bioavailability and the ability to penetrate the blood-brain barrier. With an IC50 of 1.3 μM against rat butyrylcholinesterase (BChE) and AChE, P11149 displays significant cholinergic activity and behavioral efficacy. This Galanthamine derivative is primarily used in research related to Alzheimer's disease, aiding in the exploration of therapeutic strategies for cognitive impairment associated with this neurodegenerative disorder.

Cat. No.

A78602

CAS No.

134332-50-6

Galanthamine N-Oxide

Galanthamine N-Oxide is an acetylcholinesterase (AChE) inhibitor derived from the bulbs of Zephyranthes concolor. It exhibits a potent inhibitory effect on electric eel AChE with an EC50 value of 26.2 μM. Additionally, Galanthamine N-Oxide effectively hampers substrate accommodation in the active sites of Torpedo californica AChE, human AChE, and human butyrylcholinesterase (hBChE), making it a valuable tool for research in neuropharmacology and cholinergic signaling pathways.

Cat. No.

A78603

CAS No.

60755-80-8

O-Desmethyl Galanthamine

Synonyms: Sanguinine

O-Desmethyl Galanthamine is an acetylcholinesterase (AChE) inhibitor with an IC50 of 1.83 μM. As a galanthamine-type alkaloid, it effectively modulates cholinergic signaling by preventing the breakdown of acetylcholine. This compound is primarily utilized in research focused on neurodegenerative diseases, including Alzheimer's disease, where AChE inhibition is of therapeutic interest.

Cat. No.

A78604

CAS No.

6735-59-7

Pralidoxime

Pralidoxime is a potent reactivator of acetylcholinesterase (AChE), targeting the recovery of enzyme activity inhibited by nerve agents. It functions through a direct nucleophilic attack by its oxime moiety on the phosphorus atom of the bound inhibitor, effectively reversing the effects of organophosphate poisoning. Pralidoxime is utilized in various research applications focused on neurotoxicology and antidote development.

Cat. No.

A78605

CAS No.

209394-27-4

Ladostigil

Synonyms: TV-3326

Ladostigil is a dual inhibitor of monoamine oxidase (MAO) and acetylcholinesterase (AChE), demonstrating IC50 values of 37.1 μM for MAO-B and 31.8 μM for AChE. This compound exhibits neuroprotective, antioxidant, and anti-inflammatory properties, making it valuable for research in conditions such as depression and Alzheimer's disease. Additionally, Ladostigil features an alkyne functional group, enabling it to serve as a click chemistry reagent through copper-catalyzed azide-alkyne cycloaddition (CuAAc).

Cat. No.

A78606

CAS No.

16088-19-0

Norneostigmine

Norneostigmine is a potent inhibitor of acetylcholinesterase (AChE) with the ability to penetrate the blood-brain barrier. It demonstrates a 50% inhibition of mouse brain AChE within 10 minutes of treatment, exhibiting efficacy comparable to other known AChE inhibitors. This reagent is valuable for investigating memory disorders, including Alzheimer's disease and related cognitive impairments, facilitating research into potential therapeutic strategies.

Cat. No.

A78607

CAS No.

142852-51-5

Zanapezil

Synonyms: TAK-147

Zanapezil is a potent, reversible, and selective inhibitor of acetylcholine esterase (AChE). With an IC50 of 51.2 nM in rat cerebral cortex homogenates, Zanapezil effectively inhibits AChE activity, while also demonstrating moderate inhibition of muscarinic M1 and M2 receptor binding, with Ki values of 234 nM and 340 nM, respectively. This compound serves as a valuable tool for research focused on the early stages of Alzheimer's disease (AD).

Cat. No.

A78608

CAS No.

73731-87-0

Broussonin A

Broussonin A is a potent butyrylcholinesterase (BChE) inhibitor, exhibiting an IC50 of 4.16 µM. This diarylpropane natural product is derived from the bark of Broussonetia papyrifera through solid fermentation processes. Broussonin A is primarily utilized in research investigating neurodegenerative diseases and the modulation of cholinergic signaling pathways. Its inhibitory activity makes it a valuable tool for studying the role of BChE in various biological contexts.

Cat. No.

A78609

CAS No.

94492-23-6

Osmanthuside B

Osmanthuside B is an acetylcholinesterase inhibitor derived from Pseuderanthemum carruthersii (Seem.) Guill. var. atropurpureum (Bull.) Fosb. This compound exhibits weak inhibitory activity against acetylcholinesterase, making it a valuable tool for research into neurotransmission processes and potential therapeutic applications in neurodegenerative diseases. Its effects on cholinergic signaling pathways can provide insights into mechanisms of action for various biochemical studies.

Cat. No.

A78610

CAS No.

142852-50-4

Zanapezil free base

Synonyms: TAK-147 free base

Zanapezil free base is a potent, reversible, and selective inhibitor of acetylcholine esterase (AChE). It demonstrates significant AChE activity inhibition in homogenates of the rat cerebral cortex, with an IC50 value of 51.2 nM. Additionally, Zanapezil exhibits moderate inhibition of muscarinic M1 and M2 receptor binding, with Ki values of 234 nM and 340 nM, respectively. This compound is suitable for research focused on the early stages of Alzheimer's disease, contributing to the understanding of cholinergic dysfunction in neurodegenerative disorders.

Cat. No.

A78611

CAS No.

13710-70-8

(±)-Marmesin

(±)-Marmesin is a precursor for linear furanocoumarins, which are important in various biological processes. This compound exhibits strong inhibitory activity against acetylcholinesterase, making it relevant for research in neuropharmacology and potential therapeutic applications. It serves as a valuable tool in studies investigating the modulation of cholinergic pathways and the development of related drug candidates.

Cat. No.

A78613

CAS No.

118909-22-1

Velnacrine maleate

Synonyms: HP 029; Hydroxytacrine maleate

Velnacrine maleate is an orally active cholinesterase inhibitor that targets the enzyme acetylcholinesterase, thus increasing acetylcholine levels in the brain. This compound is primarily utilized in research studying Alzheimer's disease and its associated cognitive decline. Through modulation of cholinergic neurotransmission, Velnacrine maleate provides insights into potential therapeutic strategies for neurological disorders.

Cat. No.

A78614

CAS No.

866245-79-6

Octahydroaminoacridine succinate

Octahydroaminoacridine succinate is a potent inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). This compound is primarily utilized in Alzheimer's disease research, where modulation of cholinergic activity plays a crucial role in therapeutic strategies. Its ability to effectively inhibit these enzymes makes it a valuable tool for understanding the underlying mechanisms of neurodegeneration and developing potential treatments.

Cat. No.

A78615

CAS No.

1334106-34-1

ASS234

ASS234 is a potent monoamine oxidase (MAO) inhibitor, targeting MAO-A and MAO-B with IC50 values of 5.2 nM and 43 nM, respectively. In addition to its primary activity, ASS234 also exhibits inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), with IC50 values of 350 nM and 460 nM, respectively. This compound can be utilized in research related to neurodegenerative diseases, mood disorders, and cholinergic signaling pathways.

Cat. No.

A78616

CAS No.

744206-31-3

SD-6

SD-6 is a potent and orally active inhibitor of human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBChE), displaying IC50 values of 0.907 µM and 1.579 µM, respectively. This compound exhibits favorable blood-brain barrier permeability and is characterized by a lack of neurotoxicity. SD-6 is primarily utilized in research related to Alzheimer's disease, making it a valuable tool for investigating cholinergic signaling pathways and therapeutic strategies.

Cat. No.

A78617

CAS No.

133740-30-4

BChE-IN-11

BChE-IN-11 is a potent and selective non-competitive inhibitor of butyrylcholinesterase (BChE), exhibiting an IC50 of 2.1 μM. This compound is primarily utilized in research related to Alzheimer's disease, where it aids in the examination of cholinergic dysfunction. Its capacity to effectively inhibit BChE makes it a valuable tool for studying disease mechanisms and potential therapeutic strategies in neurodegenerative disorders.

Cat. No.

A78618

CAS No.

1346242-31-6

Rivastigmine carbamate impurity

Synonyms: 3-Nitrophenyl ethyl(methyl)carbamate

Rivastigmine carbamate impurity (3-Nitrophenyl ethyl(methyl)carbamate) is a byproduct of Rivastigmine, a potent cholinesterase (ChE) inhibitor. This compound selectively inhibits both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), demonstrating IC50 values of 0.037 μM and 4.15 μM, respectively. Rivastigmine carbamate impurity is primarily utilized in the investigation of cholinergic system modulation and the pharmacological profiling of cholinesterase inhibitors in neurodegenerative disease research.

Cat. No.

A78619

CAS No.

93780-80-4

Isorosmanol

Isorosmanol is an abietane-type diterpene that functions as an acetylcholinesterase (AChE) inhibitor. It exhibits antioxidant, neuroprotective, and neurotrophic properties, making it of interest in neurological research. Additionally, Isorosmanol has been shown to inhibit melanin synthesis, highlighting its potential applications in studies related to pigmentation and neurodegenerative diseases.

Cat. No.

A78621

CAS No.

22048-97-1

Leptomerine

Leptomerine is an alkaloid derived from the stems of Esenbeckia leiocarpa Engl. that functions as an acetylcholinesterase (AChE) inhibitor. With an IC50 of 2.5 μM, it exhibits significant anticholinesterase activity, potentially contributing to therapeutic strategies for Alzheimer’s disease. This compound is valuable for research aimed at understanding cholinergic dysfunction and developing cognitive-enhancing therapies.