AChE

Cat. No.

A74063

CAS No.

79606-45-4

4-Chloro-N,N-diisopropylbenzamide

4-Chloro-N,N-diisopropylbenzamide is an amide with significant relevance as a substrate for cytochrome P450 enzymes in vivo and for acetylcholinesterase in vitro. This compound plays a crucial role in metabolic studies, enabling the investigation of enzyme kinetics and substrate specificity. Its application extends to research focused on drug metabolism and neuropharmacology.

Cat. No.

A74615

CAS No.

2490589-11-0

sEH/AChE-IN-3

sEH/AChE-IN-3 is a potent dual inhibitor of soluble epoxide hydrolase (sEH) and acetylcholinesterase (AChE), demonstrating IC50 values of 0.4 nM for human sEH and 1.94 nM for human AChE. This compound also exhibits inhibitory activity against human butyrylcholinesterase with an IC50 of 615 nM, and shows strong inhibition in both mouse sEH and AChE with IC50 values of 4.3 nM and 2.61 nM, respectively. Due to its ability to penetrate the blood-brain barrier, sEH/AChE-IN-3 is suitable for research applications in neuropharmacology and the study of neurological disorders.

Cat. No.

A74618

CAS No.

2490589-12-1

sEH/AChE-IN-4

sEH/AChE-IN-4 is a potent dual inhibitor targeting soluble epoxide hydrolase (sEH) and acetylcholinesterase (AChE). It demonstrates impressive inhibitory activity with IC50 values of 3.1 nM against human sEH, 1660 nM against human AChE, 179 nM against human butyrylcholinesterase (hBChE), 14.5 nM against murine sEH, and 102 nM against murine AChE. This compound has potential applications in research areas related to neurodegenerative diseases and pain modulation, effectively crossing the blood-brain barrier.

Cat. No.

A75077

CAS No.

25615-14-9

Kaempferol-3,7-di-O-β-glucoside

Synonyms: Kaempferol 3,7-diglucoside

Kaempferol-3,7-di-O-β-glucoside is a flavonol that acts as an inhibitor of α-amylase, α-glucosidase, and acetylcholinesterase. This compound has demonstrated protective effects on differentiating neuronal cells, specifically SH-SY5Y, against injury induced by Amyloid β peptide. Its enzyme inhibitory properties and neuroprotective effects indicate potential applications in Alzheimer's disease research and therapeutics.

Cat. No.

A75110

CAS No.

62346-14-9

Luteolin 5,3'-dimethyl ether

Luteolin 5,3'-dimethyl ether is a flavonoid compound that serves as a potent inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). This compound demonstrates significant biological activities, including free radical scavenging and enzyme inhibitory effects. It is particularly useful in research focused on neurodegenerative diseases, diabetes, and disorders related to skin pigmentation. Additionally, it can be isolated from the dried roots of Alhagi maurorum, further emphasizing its natural origin and therapeutic potential.

Cat. No.

A75113

CAS No.

20143-97-9

7β-Hydroxybufalin

7β-Hydroxybufalin is a bufadienolide that acts as a potent inhibitor of α-glucosidase and acetylcholinesterase. Isolated from the venom of Bufo bufo gargarizans, this compound demonstrates significant biological activity relevant to the modulation of carbohydrate and neurotransmitter metabolism. 7β-Hydroxybufalin is utilized in research applications focused on metabolic disorders and neurodegenerative diseases.

Cat. No.

A75391

CAS No.

1129-41-5

Metolcarb

Metolcarb is an N-methylcarbamate insecticide that functions by inhibiting acetylcholinesterase, leading to the accumulation of acetylcholine and consequent disruption of neural transmission in pest organisms. This compound is utilized in agricultural practices to effectively manage various insect populations, enhancing crop protection. Its efficacy in targeting insects makes it a valuable tool in integrated pest management strategies.

Cat. No.

A75771

CAS No.

119963-50-7

1,2-Didehydrotanshinone IIA

1,2-Didehydrotanshinone IIA is an inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), demonstrating an IC50 value of 5.98 μM for BChE. Additionally, this compound acts as an indoleamine 2,3-dioxygenase (IDO) inhibitor, with an IC50 value of 4.68 µM. Its dual inhibitory activity positions 1,2-Didehydrotanshinone IIA as a valuable reagent for research into neurodegenerative diseases and immune modulation.

Cat. No.

A78240

CAS No.

2439107-75-0

Aβ1–42 aggregation inhibitor 1

Aβ1–42 aggregation inhibitor 1 is a potent inhibitor of Aβ1-42 aggregation, targeting its self-mediated aggregation pathway. This compound effectively inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) with IC50 values of 2.64 μM and 1.29 μM, respectively. At a concentration of 25 μM, it reduces Aβ1-42 aggregation by 51.29%. Aβ1–42 aggregation inhibitor 1 is suitable for research applications focused on the mechanisms of Alzheimer's disease and potential therapeutic interventions.

Cat. No.

A78241

CAS No.

101246-66-6

Phenserine ((-)-Eseroline phenylcarbamate)

Synonyms: (-)-Eseroline phenylcarbamate; (-)-Phenserine

Phenserine is a potent, noncompetitive inhibitor of acetylcholinesterase (AChE), derived from Physostigmine. It selectively targets AChE and has been shown to reduce the formation of β-amyloid precursor protein (APP) and β-amyloid peptide (Aβ). This compound is primarily utilized in research related to cognitive function and the progression of Alzheimer's disease, demonstrating potential therapeutic benefits in enhancing cognitive performance.

Cat. No.

A78264

CAS No.

865795-23-9

Buntanetap L-Tartrate

Synonyms: (+)-Phenserine L-Tartrate; ANVS401 L-Tartrate

Buntanetap L-Tartrate is a selective acetylcholinesterase (AChE) inhibitor with an IC50 of 22.2 nM. This compound functions as a neurotoxic protein translation inhibitor, targeting proteins such as amyloid precursor protein (APP), α-synuclein (αSYN), and huntingtin protein (HTT). By obstructing the mRNA translation of β-amyloid precursor protein, Buntanetap reduces its production and exhibits anti-inflammatory properties. Its applications include research related to Alzheimer's disease and Parkinson's disease.

Cat. No.

A78285

CAS No.

1731-88-0

Methyl tridecanoate

Methyl tridecanoate is a β-amyloid aggregation inhibitor that demonstrates a moderate capacity to impede the formation of β-amyloid fibrils, which are implicated in neurodegenerative diseases such as Alzheimer's. Additionally, this compound displays weak inhibition of acetylcholinesterase (AChE), an enzyme involved in cholinergic neurotransmission. Its dual activity suggests potential applications in research focused on Alzheimer's pathology and related cognitive disorders.

Cat. No.

A78312

CAS No.

136765-50-9

Protriptyline-d3

Protriptyline-d3 is a deuterated analog of the tricyclic antidepressant Protriptyline, serving as a stable isotope for research applications. It exerts potent inhibition of acetylcholinesterase (AChE) with an IC50 value of 0.06 mM and effectively inhibits amyloid beta (Aβ) self-assembly. This compound is valuable for studying the mechanisms underlying depression and Alzheimer's disease.

Cat. No.

A78316

CAS No.

2417977-65-0

Aβ-IN-5

Aβ-IN-5 is a potent Aβ aggregation inhibitor, demonstrating oral bioavailability. It effectively inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) with IC50 values of 21.29 μM and 1.32 μM, respectively. This compound exhibits significant neuroprotective effects while maintaining low neurotoxicity, making it a valuable tool for research on neurodegenerative diseases, particularly Alzheimer’s disease.

Cat. No.

A78325

CAS No.

2761149-17-9

hAChE/Aβ1-42-IN-1

hAChE/Aβ1-42-IN-1 is a potent cholinesterase (ChE) inhibitor that effectively inhibits human acetylcholinesterase (hAChE) and prevents the aggregation of Aβ1-42 peptides. This compound demonstrates favorable relative safety in HepG2 cell lines and exhibits excellent blood-brain barrier (BBB) penetration, exhibiting a wide safety margin. hAChE/Aβ1-42-IN-1 is a valuable tool for research focusing on Alzheimer's disease (AD) and related neurodegenerative conditions.

Cat. No.

A78326

CAS No.

438-60-8

Protriptyline

Protriptyline is a potent tricyclic antidepressant (TCA) primarily targeting neurotransmitter reuptake mechanisms. It exhibits significant inhibition of acetylcholinesterase (AChE) activity, with an IC50 value of 0.06 mM, and effectively disrupts Aβ self-assembly. This compound is utilized in research focused on depression and Alzheimer’s disease, providing insights into therapeutic strategies for these conditions.

Cat. No.

A78346

CAS No.

2003213-07-6

BuChE-IN-6

BuChE-IN-6 is a potent and selective inhibitor of butyrylcholinesterase (BuChE), exhibiting IC50 values of 0.46 μM and 0.51 μM for equine and human BuChE, respectively. This compound also demonstrates the ability to inhibit self-aggregation of amyloid-beta 42 (Aβ42), making it a valuable tool for research related to neurodegenerative diseases. Its unique properties support investigations into cholinergic dysfunction and the pathogenesis of Alzheimer's disease.

Cat. No.

A78352

CAS No.

229476-71-5

hAChE/hBACE-1-IN-4

hAChE/hBACE-1-IN-4 is a quinazoline derivative that functions as a dual inhibitor of human acetylcholinesterase (hAChE) and human β-site amyloid precursor protein cleaving enzyme 1 (hBACE-1). It exhibits potent inhibitory activity with IC50 values of 0.283 μM for hAChE and 0.231 μM for hBACE-1. This compound demonstrates the ability to inhibit amyloid-beta (Aβ) aggregation and shows favorable properties such as non-neurotoxicity, blood-brain barrier permeability, and oral bioavailability. hAChE/hBACE-1-IN-4 is suitable for research applications related to Alzheimer's disease.

Cat. No.

A78355

CAS No.

2742707-36-2

AChE-IN-19

AChE-IN-19 is a potent inhibitor of acetylcholinesterase (AChE), exhibiting an IC50 value of 0.56 μM. This compound also demonstrates the ability to inhibit amyloid beta (Aβ) aggregation, contributing to its neuroprotective properties. AChE-IN-19 has been shown to exert minimal toxicity on SH-SY5Y neuronal cells, making it a valuable tool for research applications related to Alzheimer's disease.

Cat. No.

A78359

CAS No.

181114-32-9

AChE/Aβ-IN-5

AChE/Aβ-IN-5 is a bifunctional inhibitor that targets acetylcholinesterase (AChE) and reduces the auto-induced aggregation of amyloid-β (Aβ) peptides. This compound has demonstrated the ability to significantly ameliorate cognitive deficits induced by scopolamine and Aβ in murine models. It serves as a valuable tool for research into neurodegenerative diseases, particularly Alzheimer's disease, by providing insights into the mechanisms underlying cognitive impairment.

Cat. No.

A78364

CAS No.

616885-87-1

Memoquin

Memoquin is an AChE inhibitor with significant anti-amyloid and antioxidant properties. It exhibits oral bioavailability and selectively inhibits BACE-1 and AChE, with IC50 values of 108 nM and 1.55 nM, respectively. Memoquin is noted for its ability to enhance cognitive function while preventing Aβ-induced neurotoxicity associated with oxidative stress. This compound is valuable for research into Alzheimer's disease and related neurodegenerative disorders.

Cat. No.

A78367

CAS No.

156910-61-1

Phenserine tartrate

Synonyms: (-)-Eseroline phenylcarbamate tartrate; (-)-Phenserine (+)-tartrate

Phenserine tartrate is a selective, noncompetitive inhibitor of acetylcholinesterase (AChE) derived from Physostigmine. This compound has been shown to reduce the formation of β-amyloid precursor protein (APP) and β-amyloid peptide (Aβ), key factors involved in Alzheimer's disease pathology. Phenserine tartrate has demonstrated potential in improving cognitive performance and may help slow the progression of Alzheimer's disease, making it a valuable tool for research in neurodegenerative disorders.

Cat. No.

A78369

CAS No.

2761149-22-6

ChE/Aβ1-42-IN-1

ChE/Aβ1-42-IN-1 is a potent inhibitor of acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), and amyloid-beta peptide (Aβ1-42) aggregation, exhibiting IC50 values of 0.062 µM, 0.767 µM, and 1.227 µM, respectively. This compound demonstrates significant blood-brain barrier (BBB) penetration, making it a promising candidate for research into Alzheimer's disease. ChE/Aβ1-42-IN-1's multi-targeted mechanism positions it as a valuable tool for studying therapeutic strategies in neurodegenerative disorders.

Cat. No.

A78375

CAS No.

3058182-98-9

hAChE-IN-10

hAChE-IN-10 is a potent inhibitor of human acetylcholinesterase (AChE), demonstrating an IC50 of 6.34 nM. This compound exhibits significant antioxidant properties and effectively scavenges free radicals. Additionally, hAChE-IN-10 has been shown to inhibit Cu2+-induced aggregation of Aβ1-42, reduce amyloid plaque formation, and provide neuroprotective effects. It has also been linked to the improvement of cognitive deficits in mouse models induced by scopolamine, making it a valuable tool for studying neurodegenerative diseases and cognitive impairment.

Cat. No.

A78384

CAS No.

3105860-84-9

MAO-B-IN-50

MAO-B-IN-50 is a selective inhibitor of monoamine oxidase B (MAO-B), demonstrating an IC50 value of 0.06 μM. This compound is effective in inhibiting the aggregation of amyloid-beta (Aβ40/42) and Tau proteins, with overall IC50 values near 1 μM. Additionally, MAO-B-IN-50 shows potent selective inhibition of acetylcholinesterase (AChE) with an IC50 of 1.78 μM. It is suitable for use in research related to Alzheimer's disease.