AChE

Cat. No.

A78535

CAS No.

9000-81-1

Acetylcholinesterase, Fly head

Synonyms: ACHE; EC 3.1.1.7

Acetylcholinesterase, Fly head (ACHE; EC 3.1.1.7) is a crucial cholinergic enzyme that functions at neuromuscular junctions and cholinergic synapses. This enzyme catalyzes the hydrolysis of acetylcholine and other choline esters, leading to the production of acetate and choline. Its primary biological activity involves the termination of neuronal transmission, ensuring precise signaling by preventing excessive acetylcholine activation at synaptic sites. Acetylcholinesterase, Fly head is essential for studies exploring synaptic function, cholinergic signaling, and neuromuscular disorders.

Cat. No.

A78536

CAS No.

5598-15-2

Chlorpyrifos-oxon

Chlorpyrifos-oxon is a potent phosphorylating agent primarily known for its ability to inhibit acetylcholinesterase (AChE). This active metabolite of Chlorpyrifos can induce cross-linking of tubulin subunits, leading to significant disruption of microtubule function. Its biological activity provides valuable insights into neurotoxic mechanisms and potential pathways for studying neurodegenerative diseases.

Cat. No.

A78537

CAS No.

6485-40-1

(-)-Carvone (l-Carvone)

(-)-Carvone is a neurotoxin that functions as an irreversible inhibitor of acetylcholinesterase (AChE). This compound is utilized primarily for its biological activity as a bird repellent, as well as its ability to inhibit larval growth, reduce pupation rates, and increase larval mortality. Research applications include studies on insect neurobiology and pest control strategies.

Cat. No.

A78540

CAS No.

57-64-7

Physostigmine salicylate

Synonyms: Eserine salicylate

Physostigmine salicylate is a reversible acetylcholinesterase (AChE) inhibitor that effectively crosses the blood-brain barrier, enhancing central cholinergic neurotransmission. It has demonstrated the ability to reverse memory deficits in transgenic mice models of Alzheimer's disease, making it a valuable tool in neurodegeneration research. Additionally, Physostigmine salicylate serves as an antidote for anticholinergic poisoning, highlighting its significance in pharmacological studies and therapeutic applications.

Cat. No.

A78541

CAS No.

321-64-2

Tacrine

Tacrine is a potent acetylcholinesterase (AChE) inhibitor, with an IC50 value of 109 nM. This compound is recognized for its ability to ameliorate cognitive deficits, particularly in aged rodent models. Additionally, Tacrine is associated with potential hepatotoxicity and is frequently utilized in research focusing on Alzheimer's disease and related neurodegenerative disorders.

Cat. No.

A78542

CAS No.

27661-36-5

Cyanidin-3-O-galactoside chloride

Synonyms: Ideain chloride

Cyanidin-3-O-galactoside chloride is an antioxidant agent that demonstrates significant potential in mitigating oxidative stress. Extracted from hawthorn fruit peel, this compound is known for its ability to inhibit acetylcholinesterase (AChE) activity. Its biological activities make it valuable for research in neuroprotective studies and the exploration of therapeutic applications in neurodegenerative diseases.

Cat. No.

A78543

CAS No.

501-92-8

Chavicol

Synonyms: p-Hydroxyallylbenzene

Chavicol, a cholinesterase (ChE) inhibitor, demonstrates potent inhibition of acetylcholinesterase, with an IC50 of 7.42 μM. This compound exhibits anti-cancer properties, effectively suppressing the growth, survival, migration, and invasion of various cancer cell lines. Notably, Chavicol shows significant cytotoxic effects, evidenced by a notable concentration of approximately 31 μg/mL in A-549 cells. Its dual activities underscore its potential utility in cancer research and therapeutic development.

Cat. No.

A78544

CAS No.

64-47-1

Physostigmine hemisulfate

Synonyms: Eserine hemisulfate

Physostigmine hemisulfate is a reversible inhibitor of acetylcholinesterase (AChE), effectively enhancing cholinergic neurotransmission by crossing the blood-brain barrier. This compound has demonstrated the ability to reverse cognitive deficits in transgenic mouse models of Alzheimer's disease, making it a valuable tool for neurological research. Additionally, Physostigmine hemisulfate serves as an antidote for anticholinergic poisoning, underscoring its significance in pharmacological studies and clinical applications.

Cat. No.

A78546

CAS No.

123855-51-6

N-Boc-4-piperidinemethanol

N-Boc-4-piperidinemethanol is an acetylcholinesterase (AChE) inhibitor that serves as a valuable tool for neurological research. It is particularly relevant in studies focused on Alzheimer's Disease, aiding in the investigation of cholinergic dysfunction. This compound may contribute to the development of therapeutic strategies targeting AChE activity.

Cat. No.

A78547

CAS No.

41198-08-7

Profenofos

Profenofos is an insecticide that functions as an acetylcholinesterase (AChE) inhibitor, leading to neurotoxicity in target pest species. Its primary mechanism involves the inhibition of AChE, resulting in the accumulation of acetylcholine at synapses, which disrupts normal neural function. Profenofos is effective for the control of a wide range of insect pests on field crops, vegetables, and fruit crops, making it valuable for agricultural research and pest management studies.

Cat. No.

A78548

CAS No.

9001-08-5

Cholinesterase, Horse serum

Synonyms: EC 3.1.1.8; BCHE; Horse serum

Cholinesterase, Horse serum is a catalytic enzyme comprising acetylcholinesterase (AChE) and butyryl cholinesterase (BChE). These enzymes facilitate the hydrolysis of various substrates, including the hydrolysis of 6-monoacetylmorphine (6-MAM) to morphine. This reagent is valuable in biochemical research, particularly in studies involving neurotransmitter metabolism and the pharmacokinetics of opioid compounds.

Cat. No.

A78549

CAS No.

86831-54-1

Rhodiosin

Rhodiosin is a dual inhibitor of CYP2D6 and acetylcholinesterase (AChE), extracted from the root of Rhodiola rosea. It exhibits an IC50 value of 0.761 μM for CYP2D6 and a Ki of 0.769 μM. This compound demonstrates notable antioxidant and neuroprotective properties, contributing to the regulation of the HIF-1α signaling pathway, which is vital for central nervous system protection. Rhodiosin serves as a valuable tool for research in neuropharmacology and metabolic studies.

Cat. No.

A78550

CAS No.

114-90-9

Obidoxime dichloride

Obidoxime dichloride is a potent antidote that acts primarily as a reactivator of acetylcholinesterase (AChE) inhibited by organophosphate compounds, such as sarin. By effectively restoring AChE activity, it mitigates the toxic effects associated with nerve agent exposure. Obidoxime dichloride is widely utilized in research focused on the effects of organophosphate poisoning and the development of therapeutic countermeasures.

Cat. No.

A78551

CAS No.

30560-19-1

Acephate

Acephate is a broad-spectrum anticholinesterase insecticide that functions by inhibiting acetylcholinesterase (AChE) activity in insects. This inhibition disrupts neurotransmission, leading to the effective control of various insect species. Acephate is widely utilized in agricultural and horticultural applications to manage pest populations, thereby enhancing crop yield and quality.

Cat. No.

A78552

CAS No.

40581-17-7

Violanthin

Violanthin is a cholinesterase (ChE) inhibitor derived from the stems of Dendrobium officinale. It exhibits significant antioxidant and antibacterial properties, making it a valuable compound for biological research. Violanthin effectively inhibits acetylcholinesterase (AChE) with an IC50 value of 79.80 μM, indicating its potential application in studies related to neurodegenerative diseases and cholinergic signaling.

Cat. No.

A78554

CAS No.

2375858-08-3

Pyridostigmine-d6 bromide

Pyridostigmine-d6 bromide is a deuterated form of Pyridostigmine, functioning as a reversible cholinesterase inhibitor and parasympathomimetic agent. This stable isotope is useful for metabolic studies and tracking the pharmacokinetics of drugs in biological systems. Its labeling with deuterium allows for enhanced precision in mass spectrometry applications and other analytical techniques in chemical research.

Cat. No.

A78555

CAS No.

14208-10-7

p-Xylene bis(pyridinium bromide)

p-Xylene bis(pyridinium bromide) serves as a cationic charged quencher. This compound exhibits inhibitory activity on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50 values of 1540 μM and 529 μM, respectively. It is suitable for research applications focusing on cholinergic signaling and enzyme inhibition studies.

Cat. No.

A78556

CAS No.

3779-42-8

AChE-IN-84

AChE-IN-84 is a potent inhibitor of acetylcholinesterase (AChE), a key enzyme responsible for the hydrolysis of the neurotransmitter acetylcholine. This compound demonstrates significant biological activity in modulating cholinergic signaling pathways, making it an essential tool for studying neurodegenerative diseases such as Alzheimer's. AChE-IN-84 is useful in research applications focusing on cognitive enhancement and synaptic function restoration.

Cat. No.

A78557

CAS No.

2597-03-7

Phenthoate

Phenthoate is a cholinesterase (ChE) inhibitor that functions primarily as an organophosphorus pesticide. This compound demonstrates low toxicity in animals while effectively inhibiting acetylcholinesterase (AChE), which can provide insights into neurotoxicity and enzyme regulation. Phenthoate is widely used in research applications examining the biochemical pathways of neurotransmission and potential environmental impacts of pesticide exposure.

Cat. No.

A78558

CAS No.

795316-16-4

ACG548B

ACG548B is a potent inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with IC50 values of 1.78 µM and 0.496 µM, respectively. It exhibits strong affinity and selectivity for AChE over BChE and choline kinase (ChoK). ACG548B is suitable for research applications focused on myasthenia gravis and the mechanisms of neuromuscular blockade.

Cat. No.

A78560

CAS No.

30044-78-1

Pseudocoptisine chloride

Synonyms: Isocoptisine chloride

Pseudocoptisine chloride is a quaternary alkaloid derived from the benzylisoquinoline structure, isolated from Corydalis tuber. This compound functions as an acetylcholinesterase (AChE) inhibitor, demonstrating an IC50 of 12.8 μM. Pseudocoptisine chloride exhibits notable anti-inflammatory and anti-amnestic properties, making it a valuable reagent for research related to neurodegenerative diseases and cognitive function studies.

Cat. No.

A78561

CAS No.

55696-57-6

Manghaslin

Manghaslin is a flavonoid glycoside that serves as an anti-inflammatory agent. It exhibits inhibitory activity against acetylcholinesterase (AChE), with an IC50 value of 94.92 μM. This compound is relevant for research into the modulation of inflammation and potential neuroprotective effects.

Cat. No.

A78562

CAS No.

98886-44-3

Fosthiazate

Fosthiazate is a broad-spectrum nematicide that primarily targets plant parasitic nematodes, including Meloidogyne spp., Globodera spp., and Pratylenchus spp. Its mechanism of action involves the inhibition of acetylcholinesterase synthesis, disrupting neurotransmitter regulation in nematodes. This compound is utilized in agricultural research to manage nematode populations effectively and enhance crop health.

Cat. No.

A78564

CAS No.

830-81-9

1-Naphthyl acetate

1-Naphthyl acetate serves as a chromogenic substrate specifically for the detection of acetylcholinesterase (AChE) activity in erythrocytes. This compound is particularly valuable in research related to organophosphorus pesticide poisoning, enabling the assessment of enzymatic activity and its inhibition. Its colorimetric properties facilitate quantitative analysis in various biochemical studies.

Cat. No.

A78565

CAS No.

7630-74-2

Dehydronuciferine

Dehydronuciferine acts as an inhibitor of cholinesterase, specifically targeting acetylcholinesterase (AChE) with an IC50 value of 25 μg/mL. This compound is derived from the leaves of Nelumbo nucifera (lotus) and demonstrates potential in research applications related to neurodegenerative diseases and cognitive disorders. Its ability to modulate cholinergic signaling makes it a valuable tool for studying cholinergic system functions and developing therapeutic strategies.