Catalog No.
Product Name
Application
Product Information
Citations
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Drug Impurity
Donepezil impurity 6 hydrochloride is a known impurity of the acetylcholinesterase inhibitor Donepezil hydrochloride. This compound is critical in the analysis of drug purity and assists in the characterization of donepezil formulations during research and development. Its presence is essential for quality control and safety assessments in the pharmaceutical industry. -
Drug Impurity
Rivastigmine impurity 11 is a known impurity of Rivastigmine, a reversible inhibitor of acetylcholinesterase. This compound is of significant interest for quality control and toxicological studies in pharmaceutical research. Its analysis is crucial for ensuring the purity and safety of Rivastigmine formulations, supporting compliance with regulatory standards in drug development. -
Drug Impurity
Donepezil impurity 13 is a chemical impurity associated with Donepezil, a reversible inhibitor of acetylcholinesterase. It serves as an important reference standard in analytical chemistry for the assessment of pharmaceutical purity. This compound is utilized in the quality control and stability testing of Donepezil formulations, ensuring compliance with regulatory standards in drug development and manufacturing processes. -
Methyl 2-naphthoate Derivative
(+)-Mornaphthoate B is a methyl 2-naphthoate derivative isolated from the roots of Morinda officinalis var. officinalis. This compound has been shown to lack activity against acetylcholinesterase and butyrylcholinesterase. Its unique chemical structure and biological properties make (+)-Mornaphthoate B a potential candidate for research applications focused on non-small cell lung cancer and triple-negative breast cancer. -
Drug Derivative
Qinanone G is a derivative of 2-(2-phenylethyl)chromone, derived from the high-quality Chinese agarwood 'Qi-Nan' sourced from Aquilaria sinensis (Lour.) Glig. This compound exhibits no inhibitory activity against acetylcholinesterase (AChE) or cancer cell lines, making it a unique candidate for further exploration in pharmacological and botanical research applications. Its distinctive profile may contribute to studies focused on the bioactivity of natural products. -
Drug Impurity
Rivastigmine impurity 5 is a designated impurity associated with the cholinesterase inhibitor Rivastigmine. This compound serves as a critical reference standard for quality control and analytical chemistry in pharmaceutical research. Its analysis is essential for ensuring the purity of Rivastigmine formulations, thereby supporting regulatory compliance and safety assessments in drug development. -
Drug Impurity
Rivastigmine impurity 4 is a chemical impurity associated with Rivastigmine, a reversible inhibitor of acetylcholinesterase. This impurity is relevant in the quality control and analytical evaluation of Rivastigmine formulations. Research applications include pharmacokinetic studies and the assessment of drug stability. -
Drug Impurity
Donepezil impurity 22 is a known impurity associated with the cholinesterase inhibitor Donepezil. It serves as a valuable reference standard for the analysis and characterization of Donepezil formulations. This reagent is relevant for quality control and method validation in pharmaceutical research, ensuring the integrity and purity of therapeutic compounds. -
Drug Impurity
Rivastigmine impurity 2 is a known impurity associated with Rivastigmine, a reversible inhibitor of acetylcholinesterase. This compound can be utilized for analytical research and quality control studies in the pharmaceutical industry. Its characterization is essential for the assessment of drug purity and stability in formulations containing Rivastigmine. -
Drug Impurity
Rivastigmine impurity 8 is a chemical impurity associated with the cholinesterase inhibitor rivastigmine. This impurity serves as a reference standard for quality control and analytical applications in pharmaceutical research. It facilitates the identification and quantification of impurities in drug formulations, contributing to the assessment of drug purity and safety in clinical and preclinical studies. -
Drug Impurity
Donepezil impurity 21 is a known impurity of the cognitive-enhancing agent Donepezil, which primarily targets acetylcholinesterase to enhance cholinergic neurotransmission. This compound is essential for the analysis of Donepezil formulations, particularly in the context of pharmaceutical quality control and regulatory compliance. Its characterization aids in understanding the stability and purity of Donepezil, supporting ongoing research in neurodegenerative disease therapies. -
Drug Impurity
Rivastigmine impurity 7 is a recognized impurity derived from Rivastigmine, a reversible inhibitor of the enzyme acetylcholinesterase. This compound is primarily utilized in pharmaceutical research to study the purity and stability of Rivastigmine formulations. Its presence is critical in ensuring the quality and efficacy of cholinesterase inhibitors for therapeutic applications, particularly in the treatment of Alzheimer's disease. -
Drug Impurity
Donepezil impurity 12 is a known impurity of the acetylcholinesterase inhibitor Donepezil. This compound is utilized primarily in pharmacological research for analytical purposes, such as assessing the quality and purity of Donepezil formulations. Its characterization aids in understanding the stability and safety profiles of Donepezil-based therapies. -
Drug Impurity
Donepezil impurity 15 is a chemical impurity associated with Donepezil, a reversible inhibitor of acetylcholinesterase. This impurity can serve as a reference standard in analytical and quality control laboratories for the characterization of Donepezil formulations. Research applications include stability testing, impurity profile assessments, and compliance with regulatory requirements in drug development. -
Methyl 2-naphthoate Derivative
(-)-Mornaphthoate D is a methyl 2-naphthoate derivative that targets various biological pathways. Isolated from the roots of Morinda officinalis var. officinalis, this compound demonstrates no inhibitory activity against acetylcholinesterase or butyrylcholinesterase. Its unique properties make it pertinent for research in non-small cell lung cancer and triple-negative breast cancer, contributing to the exploration of potential therapeutic strategies in oncology. -
Drug Derivative
(+)-Mornaphthoate C is a methyl 2-naphthoate derivative primarily investigated for its potential therapeutic applications. Derived from the roots of Morinda officinalis var. officinalis, this compound has demonstrated negligible activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) at a concentration of 50 μM. Additionally, (+)-Mornaphthoate C exhibits minimal cytotoxicity towards various cancer cell lines, making it a compound of interest in drug development research. -
Methyl 2-naphthoate Derivative
(-)-Mornaphthoate B is a methyl 2-naphthoate derivative isolated from the roots of Morinda officinalis var. officinalis. This compound does not exhibit inhibitory activity against acetylcholinesterase or butyrylcholinesterase. (-)-Mornaphthoate B serves as a valuable tool in cancer research, particularly in studies focused on non-small cell lung cancer and triple-negative breast cancer, contributing to understanding therapeutic strategies and mechanisms of action in these malignancies. -
Drug Derivative
Oximino oxamyl is a drug derivative known for its inhibitory action on acetylcholinesterase. This compound exhibits significant biological activity, making it useful in pharmacological studies focused on neurodegenerative diseases and pesticide resistance research. Its application extends to evaluating enzyme inhibition mechanisms and developing innovative therapeutic strategies. -
Stable Isotope
Donepezil-d4 is a deuterium-labeled analog of Donepezil, a potent and selective acetylcholinesterase (AChE) inhibitor that exhibits IC50 values of 8.12 nM for bovine AChE and 11.6 nM for human AChE. This stable isotope is primarily utilized in pharmacokinetic studies and metabolic research to trace the compound's bioavailability and metabolic pathways in biological systems. Donepezil-d4 serves as a valuable tool for elucidating the pharmacological effects of AChE inhibition in various neurological studies. -
Isotope-Labeled Compound
Dibucaine-d9 is a deuterium-labeled derivative of dibucaine, a potent sodium channel inhibitor. It serves as a selective inhibitor of pseudocholinesterase (SChE), making it valuable for studying cholinergic signaling. This isotope-labeled compound is particularly useful in pharmacokinetic studies and metabolic profiling, providing insights into drug metabolism and safety evaluation in chemical research. -
Stable Isotope
Rivastigmine metabolite-d6 is a stable isotope-labeled analog of Rivastigmine, designed for use in pharmacokinetic studies and metabolic research. This compound retains the pharmacological profile of Rivastigmine while enabling precise tracking and quantification in biological systems. It is particularly useful in studies assessing drug metabolism and pharmacodynamics, providing valuable insights into the metabolic pathways of cholinesterase inhibitors. -
Stable Isotope
Desethyl(methyl)carbamic acid rivastigmine-d6 is a deuterium-labeled analogue of Desethyl(methyl)carbamic acid rivastigmine, targeting acetylcholinesterase. This stable isotope is utilized in pharmacokinetic studies and metabolic tracing, providing insights into the mechanism of action and distribution of rivastigmine in biological systems. Its incorporation in experimental designs enhances the understanding of cholinergic therapies in neurodegenerative diseases. -
Drug Impurity
Donepezil impurity 18 is a chemical impurity associated with Donepezil, a reversible inhibitor of acetylcholinesterase. It serves as a crucial reference standard for assessing the purity and quality of Donepezil formulations in pharmaceutical research. This impurity may also aid in investigations into the stability and degradation pathways of Donepezil, facilitating improved drug development processes. -
Drug Impurity
Donepezil impurity 11 is a chemical impurity associated with Donepezil, a cholinesterase inhibitor used in the treatment of Alzheimer's disease. This impurity is relevant for quality control and analysis in pharmaceutical research, as it may affect the efficacy and safety profile of the primary compound. The identification and quantification of such impurities are essential for ensuring compliance with regulatory standards and enhancing the reliability of drug formulations. -
Drug Impurity
Rivastigmine impurity 13, also known as Rivastigmine impurity D, is a characterized impurity associated with Rivastigmine, a cholinesterase inhibitor primarily used in the treatment of Alzheimer's disease and other dementias. This impurity may be utilized in quality control and analytical studies to assess the purity and composition of Rivastigmine formulations. Its presence highlights the importance of monitoring drug impurities to ensure safety and efficacy in pharmaceutical products. -
Cholinesterase (ChE) Inhibitor
Pyridostigmine bromide is an orally active cholinesterase (ChE) inhibitor that enhances acetylcholine levels by inhibiting the enzyme responsible for its breakdown. This compound demonstrates significant biological activity in modulating cholinergic signaling, making it useful in studying neurodegenerative disorders and neuromuscular junction diseases. Its applications extend to cardiovascular disease research, where it can elucidate cholinergic mechanisms underlying cardiac function and dysfunction. -
Cholinesterase (ChE) Inhibitor
Corydaline is an isoquinoline alkaloid that functions as a cholinesterase (ChE) inhibitor with an IC50 of 226 μM. In addition to its cholinergic activity, Corydaline acts as a μ-opioid receptor agonist (Ki of 1.23 μM) and demonstrates significant antiviral effects by inhibiting enterovirus 71 (EV71) replication, with an IC50 of 25.23 μM. This compound also exhibits anti-angiogenic, anti-allergic, gastric-emptying, and antinociceptive properties, making it a valuable reagent for various biological research applications. -
Cholinesterase (ChE) Inhibitor
Sinapine thiocyanate is a cholinesterase (ChE) inhibitor known for its multifaceted biological activities. This alkaloid, derived from cruciferous plant seeds, exhibits anti-inflammatory, antioxidant, antitumor, anti-angiogenic, and radioprotective properties. Its ability to inhibit acetylcholinesterase (AChE) highlights its potential in research related to neurodegenerative disorders such as Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease. -
AChE/D2DR Inhibitor
Itopride hydrochloride is a potent acetylcholinesterase (AChE) inhibitor and dopamine D2 receptor antagonist. By enhancing gastric motility through its antidopaminergic and anti-AChE effects, Itopride hydrochloride serves as an effective gastrointestinal prokinetic agent. This compound is particularly useful for investigating conditions such as gastroesophageal reflux disease (GERD) and related gastrointestinal disorders. -
AChE Reactivator
Pralidoxime chloride is a potent reactivator of acetylcholinesterase (AChE), targeting AChE inhibited by organophosphate agents. It operates through a direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent, facilitating the restoration of AChE activity. Pralidoxime chloride is primarily utilized as an antidote for organophosphate poisoning, making it a critical reagent in toxicological research and therapeutic applications. -
Anticholinergic Drug
Benactyzine hydrochloride is a competitive inhibitor of butyrylcholinesterase (BChE) with a Ki of 0.01 mM, functioning primarily as an anticholinergic agent. It demonstrates significant promise in the study of organophosphate poisoning, aiding research into the mechanisms of cholinergic dysfunction. Its ability to modulate cholinergic activity makes it a valuable tool in neuropharmacological research and therapeutic explorations. -
AChE Inhibitor
Acotiamide is a selective and reversible inhibitor of acetylcholinesterase (AChE), exhibiting an IC50 value of 1.79 μM. It has demonstrated the ability to enhance gastric contractility and promote accelerated gastric emptying. This compound is valuable for investigating functional dyspepsia related to gastric motility dysfunction and intestinal inflammation. -
AChEI Inhibitor, XO Inhibitor, Thromboxane Inhibitor
Imidazole acts as an inhibitor of acetylcholinesterase (AChEI), xanthine oxidase (XO), and thromboxane. This heterocyclic aromatic compound exhibits significant biological activities, including antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic properties. By inhibiting the conversion of endoperoxides (PGG2 and PGH2) to thromboxane A2, Imidazole plays a role in cardiovascular research. Additionally, its derivatives have shown potential in inhibiting the SARS-CoV-2 3CLPro enzyme, making it a valuable candidate for studies related to Alzheimer's disease, gout, COVID-19, and thrombo-embolic conditions. -
Cholinesterase (ChE) Inhibitor
Demecarium Bromide is a potent cholinesterase (ChE) inhibitor, exhibiting an apparent affinity (Kiapp) of 0.15 μM. It primarily functions by inhibiting the enzyme cholinesterase, thereby increasing acetylcholine levels. This compound is widely utilized in research related to glaucoma treatment and the study of acetylcholine metabolism, providing valuable insights into neurodegenerative diseases and neurotransmission pathways. -
Antidepressant Agent
Protriptyline hydrochloride is a potent tricyclic antidepressant with a primary mechanism of action involving the inhibition of acetylcholinesterase (AChE), with an IC50 of 0.06 mM, as well as the reduction of amyloid beta (Aβ) self-assembly. This compound exhibits significant antidepressant activity and is valuable for research related to depression and Alzheimer's disease. It serves as a useful reagent for studying neurochemical pathways implicated in mood disorders and neurodegenerative conditions. -
Acetylcholinesterase Inhibitor
Neostigmine methyl sulfate is a reversible inhibitor of acetylcholinesterase, primarily targeting the peripheral nervous system. This compound enhances cholinergic transmission by preventing the breakdown of acetylcholine, resulting in increased neurotransmitter levels at the neuromuscular junction. It is widely used in research applications related to neuromuscular disorders and pharmacological studies of cholinergic function. -
Monoamine Oxidase Inhibitor
Minaprine dihydrochloride is a selective monoamine oxidase inhibitor that penetrates the blood-brain barrier. It exhibits biological activity by reducing intraneuronal dopamine metabolism, lowering levels of striatal homovanillic acid and dihydroxyphenylacetic acid, while increasing levels of 3-methoxytyramine and 5-hydroxytryptamine in the striatum. Additionally, Minaprine dihydrochloride weakly inhibits acetylcholinesterase activity and displays both convulsant and antidepressant properties, making it a valuable reagent for research in neuropharmacology and mood disorder studies. -
AChE Inhibitor
Ambenonium chloride is a potent, reversible inhibitor of acetylcholinesterase (AChE), demonstrating a high affinity for the enzyme. With an IC50 value of 0.7 nM for human AChE, this compound effectively enhances cholinergic transmission. It is primarily utilized in research applications focused on neurological disorders, particularly those involving impaired cholinergic function. -
Organophosphorus (OP) Pesticide
Dichlofenthion is an organophosphorus (OP) pesticide that functions by inhibiting acetylcholinesterase, leading to the accumulation of acetylcholine at nerve synapses. This mechanism results in heightened nerve signal transmission, making it effective in pest control. Dichlofenthion is primarily utilized for managing sheep maggot fly populations, contributing to agricultural pest management strategies. -
Pesticide
Pyrolan is a carbamate ester pesticide that acts by inhibiting acetylcholinesterase, leading to an accumulation of acetylcholine in synapses. This mechanism results in heightened neurotransmission, which ultimately disrupts normal physiological processes in target pests. Pyrolan is primarily utilized in agricultural settings for pest control in various crops, contributing to effective management of pest populations. Its use supports research into pesticide efficacy and resistance mechanisms within target species. -
Antidepressant
Depramine, a tricyclic antidepressant, primarily targets neurotransmitter reuptake mechanisms, elevating levels of norepinephrine and serotonin in the synaptic cleft. It exhibits significant biological activity through the inhibition of acetylcholinesterase, Mg2+-ATPase, and Na+/K+ ATPase. Depramine is utilized in research focused on depression and related mood disorders, facilitating studies on neurotransmitter dynamics and cellular signaling pathways involved in antidepressant efficacy. -
AChE Inhibitor
1,1'-Bi-2-naphthol is a potent acetylcholinesterase (AChE) inhibitor, demonstrating an IC50 value of 21.9 μM against human AChE. This compound also exhibits cytotoxic effects on Artemia nauplii, making it valuable for studies in neuropharmacology and toxicology. Its dual functionality positions it as a useful reagent in researching cholinergic signaling and the potential effects of AChE inhibition. -
Cholinesterase (ChE) Inhibitor
Physostigmine, a reversible acetylcholinesterase (AChE) inhibitor, effectively increases acetylcholine levels in the central nervous system by crossing the blood-brain barrier. This compound enhances cholinergic neurotransmission and has been shown to reverse memory deficits in transgenic mice models of Alzheimer's disease. Additionally, Physostigmine serves as a critical antidote for anticholinergic poisoning, providing valuable insights for neuropharmacological research and therapeutic applications. -
Fenthion Metabolite
Fenthoxon is a metabolite of fenthion, an organophosphate insecticide that primarily acts by inhibiting acetylcholinesterase activity. This inhibition leads to the accumulation of acetylcholine at synapses, resulting in neurotoxic effects on insect populations. Fenthoxon is utilized in research to study the environmental impact and metabolic pathways of organophosphate compounds, as well as their neurotoxic mechanisms in various biological systems. -
Insecticide
Phorate sulfone, a metabolite of phorate, primarily targets acetylcholinesterase, exhibiting inhibitory activity with an IC50 of 40 μM. This results in the accumulation of acetylcholine at both cellular and subcellular levels. Phorate sulfone is valuable for researching the mechanisms and effects associated with severe phorate poisoning. -
Fenthion Insecticide
Fenthion sulfoxide is a metabolite of the organophosphate insecticide Fenthion, primarily involved in the inhibition of acetylcholinesterase activity. This compound is relevant in studies investigating pesticide metabolism and environmental impacts, particularly concerning its formation on agricultural products such as grapes. Research applications include toxicology assessments and investigations into the persistence and degradation of organophosphate residues in the environment. -
Disulfoton Metabolite
Disulfoton sulfone is a metabolic byproduct of the organophosphorus pesticide Disulfoton, primarily targeting acetylcholinesterase. This compound exhibits significant biological activity as an inhibitor of cholinesterase, which can lead to increased levels of acetylcholine at synapses. Researchers utilize Disulfoton sulfone in studies focused on neurotoxicity, pesticide metabolism, and mechanisms of organophosphate toxicity, contributing to our understanding of their effects on human health and the environment. -
Organic Phosphorus Pesticide
Phoxim is an organic phosphorus pesticide that primarily targets acetylcholinesterase, leading to the inhibition of cholinergic transmission. It exhibits potent insecticidal and acaricidal activity, making it effective against a variety of agricultural pests. Phoxim is commonly employed in agricultural research to explore pest control mechanisms and the effects of chemical exposure on agricultural ecosystems. -
Insecticide
Fenthion-d6 is a deuterated form of the organophosphorus insecticide Fenthion. This compound primarily targets the enzyme acetylcholinesterase, leading to the inhibition of cholinergic neurotransmission. Fenthion-d6 is valuable in chemical research for studying insecticide metabolism and environmental analysis. It is especially useful for tracing metabolic pathways and understanding pesticide behavior in various biological systems. -
Insecticide
Propetamphos is an organophosphorus insecticide that primarily targets acetylcholinesterase, disrupting normal neurotransmission in insects. This compound exhibits significant cytotoxic effects and induces oxidative stress, contributing to its insecticidal activity. Propetamphos is commonly used in research studies focused on insect physiology, toxicology, and the development of pest control strategies.
