Catalog No.
Product Name
Application
Product Information
Citations
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Drug Impurity
Donepezil impurity 12 is a known impurity of the acetylcholinesterase inhibitor Donepezil. This compound is utilized primarily in pharmacological research for analytical purposes, such as assessing the quality and purity of Donepezil formulations. Its characterization aids in understanding the stability and safety profiles of Donepezil-based therapies. -
Drug Impurity
Donepezil impurity 15 is a chemical impurity associated with Donepezil, a reversible inhibitor of acetylcholinesterase. This impurity can serve as a reference standard in analytical and quality control laboratories for the characterization of Donepezil formulations. Research applications include stability testing, impurity profile assessments, and compliance with regulatory requirements in drug development. -
Drug Intermediate
5,6-Dimethoxyindan-1-one is a versatile drug intermediate employed in the synthesis of diverse active pharmaceutical ingredients. It has applications in the development of antiviral compounds and acetylcholinesterase butyrylcholinesterase inhibitors. This reagent serves as a critical building block in medicinal chemistry, facilitating the exploration of new therapeutic agents. -
Drug Intermediate
4-Hydroxy-3,3-dimethylcyclohexanone serves as a crucial intermediate in the synthesis of human acetylcholinesterase (hAChE) inhibitors. Its role in the development of hAChE inhibitors makes it significant for research in neuropharmacology and disease models related to cholinergic dysfunction. This compound's unique structural properties facilitate the exploration of therapeutic agents targeting cognitive disorders. -
Drug Impurity
Donepezil impurity 6 is a known impurity associated with the cholinesterase inhibitor Donepezil. Its presence is significant for quality control and regulatory compliance in pharmaceutical formulations. This compound can be utilized in research to study the by-products and degradants of Donepezil, aiding in the development of more refined synthetic pathways and enhancing the understanding of drug stability and efficacy. -
Drug Impurity
Rivastigmine impurity 12 (m-Methoxyacetophenone) is a known impurity associated with Rivastigmine, an acetylcholinesterase inhibitor used in the treatment of Alzheimer's disease. This compound serves as a valuable reference material for analytical chemistry applications, particularly in the development and validation of analytical methods for drug quality control. Its characterization contributes to ensuring the safety and efficacy of pharmaceutical formulations containing Rivastigmine. -
Metabolite
Pirimicarb-desmethyl is a key metabolite of the carbamate insecticide pirimicarb, functioning primarily through the inhibition of acetylcholinesterase activity. This compound offers valuable insights into the metabolic pathways of pirimicarb and can be used to study its environmental persistence and toxicological effects. Its application is important in both agricultural research and the assessment of pesticide safety. -
Methyl 2-naphthoate Derivative
(-)-Mornaphthoate D is a methyl 2-naphthoate derivative that targets various biological pathways. Isolated from the roots of Morinda officinalis var. officinalis, this compound demonstrates no inhibitory activity against acetylcholinesterase or butyrylcholinesterase. Its unique properties make it pertinent for research in non-small cell lung cancer and triple-negative breast cancer, contributing to the exploration of potential therapeutic strategies in oncology. -
Drug Derivative
(+)-Mornaphthoate C is a methyl 2-naphthoate derivative primarily investigated for its potential therapeutic applications. Derived from the roots of Morinda officinalis var. officinalis, this compound has demonstrated negligible activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) at a concentration of 50 μM. Additionally, (+)-Mornaphthoate C exhibits minimal cytotoxicity towards various cancer cell lines, making it a compound of interest in drug development research. -
Methyl 2-naphthoate Derivative
(-)-Mornaphthoate B is a methyl 2-naphthoate derivative isolated from the roots of Morinda officinalis var. officinalis. This compound does not exhibit inhibitory activity against acetylcholinesterase or butyrylcholinesterase. (-)-Mornaphthoate B serves as a valuable tool in cancer research, particularly in studies focused on non-small cell lung cancer and triple-negative breast cancer, contributing to understanding therapeutic strategies and mechanisms of action in these malignancies. -
Drug Derivative
Oximino oxamyl is a drug derivative known for its inhibitory action on acetylcholinesterase. This compound exhibits significant biological activity, making it useful in pharmacological studies focused on neurodegenerative diseases and pesticide resistance research. Its application extends to evaluating enzyme inhibition mechanisms and developing innovative therapeutic strategies. -
Methyl 2-naphthoate Derivative
(+)-Mornaphthoate B is a methyl 2-naphthoate derivative isolated from the roots of Morinda officinalis var. officinalis. This compound has been shown to lack activity against acetylcholinesterase and butyrylcholinesterase. Its unique chemical structure and biological properties make (+)-Mornaphthoate B a potential candidate for research applications focused on non-small cell lung cancer and triple-negative breast cancer. -
Drug Derivative
Qinanone G is a derivative of 2-(2-phenylethyl)chromone, derived from the high-quality Chinese agarwood 'Qi-Nan' sourced from Aquilaria sinensis (Lour.) Glig. This compound exhibits no inhibitory activity against acetylcholinesterase (AChE) or cancer cell lines, making it a unique candidate for further exploration in pharmacological and botanical research applications. Its distinctive profile may contribute to studies focused on the bioactivity of natural products. -
Stable Isotope
Donepezil-d4 is a deuterium-labeled analog of Donepezil, a potent and selective acetylcholinesterase (AChE) inhibitor that exhibits IC50 values of 8.12 nM for bovine AChE and 11.6 nM for human AChE. This stable isotope is primarily utilized in pharmacokinetic studies and metabolic research to trace the compound's bioavailability and metabolic pathways in biological systems. Donepezil-d4 serves as a valuable tool for elucidating the pharmacological effects of AChE inhibition in various neurological studies. -
Isotope-Labeled Compound
Dibucaine-d9 is a deuterium-labeled derivative of dibucaine, a potent sodium channel inhibitor. It serves as a selective inhibitor of pseudocholinesterase (SChE), making it valuable for studying cholinergic signaling. This isotope-labeled compound is particularly useful in pharmacokinetic studies and metabolic profiling, providing insights into drug metabolism and safety evaluation in chemical research. -
Stable Isotope
Rivastigmine metabolite-d6 is a stable isotope-labeled analog of Rivastigmine, designed for use in pharmacokinetic studies and metabolic research. This compound retains the pharmacological profile of Rivastigmine while enabling precise tracking and quantification in biological systems. It is particularly useful in studies assessing drug metabolism and pharmacodynamics, providing valuable insights into the metabolic pathways of cholinesterase inhibitors. -
Stable Isotope
Nor neostigmine-d6 is a stable isotope-labeled analog of Nor neostigmine, specifically incorporating deuterium atoms. This compound is primarily used as a tracer in pharmacokinetic studies and metabolic pathway analysis involving cholinesterase inhibitors. It facilitates the investigation of drug interactions and the mechanistic understanding of its biological effects in both in vitro and in vivo settings. -
Stable Isotope
Phosmet-d6 is a deuterated stable isotope of Phosmet, a widely used organophosphate insecticide. Its primary mechanism is the inhibition of acetylcholinesterase, leading to accumulation of acetylcholine and disruption of neurological function in pests. Phosmet-d6 is utilized in environmental and toxicological studies, providing valuable insights into residue analysis and metabolic pathways of pesticides in various biological systems. -
Aldicarb Metabolite
Aldicarb sulfoxide-d3 is a deuterium-labeled metabolite of Aldicarb that serves as a valuable tool in chemical research. This compound primarily targets glutathione-linked enzymes, demonstrating significant inhibitory effects on cholinesterase (ChE) and carboxylesterase (CaE) pathways, with IC50 values of 10 μM in zebrafish models. Its utility extends to studies on metabolic pathways and enzyme interactions, contributing to a deeper understanding of neuroactive compounds and their biological implications. -
Stable Isotope
Methiocarb sulfone-d3 is a stable isotope-labeled variant of Methiocarb sulfone, which serves as an effective inhibitor of acetylcholinesterase. This compound is utilized in biological research for pharmacokinetic studies, providing insights into the metabolism and behavior of mothiocarb sulfone in various biological systems. Its deuterated form enhances the precision of quantitative analysis in mass spectrometry. -
Stable Isotope
Trimethylammonium chloride-13C3 is a stable isotope-labeled compound that serves as a valuable tool in metabolic studies. As an endogenous metabolite, it inhibits deacetylation processes and acts as a non-competitive inhibitor of acetylcholinesterase. This reagent is essential for research applications involving metabolic pathway analysis and enzyme inhibition assays. -
Stable Isotope
Desethyl(methyl)carbamic acid rivastigmine-d6 is a deuterium-labeled analogue of Desethyl(methyl)carbamic acid rivastigmine, targeting acetylcholinesterase. This stable isotope is utilized in pharmacokinetic studies and metabolic tracing, providing insights into the mechanism of action and distribution of rivastigmine in biological systems. Its incorporation in experimental designs enhances the understanding of cholinergic therapies in neurodegenerative diseases. -
Organic Phosphorus Pesticide
Phoxim is an organic phosphorus pesticide that primarily targets acetylcholinesterase, leading to the inhibition of cholinergic transmission. It exhibits potent insecticidal and acaricidal activity, making it effective against a variety of agricultural pests. Phoxim is commonly employed in agricultural research to explore pest control mechanisms and the effects of chemical exposure on agricultural ecosystems. -
Insecticide
Fenthion-d6 is a deuterated form of the organophosphorus insecticide Fenthion. This compound primarily targets the enzyme acetylcholinesterase, leading to the inhibition of cholinergic neurotransmission. Fenthion-d6 is valuable in chemical research for studying insecticide metabolism and environmental analysis. It is especially useful for tracing metabolic pathways and understanding pesticide behavior in various biological systems. -
Insecticide
Propetamphos is an organophosphorus insecticide that primarily targets acetylcholinesterase, disrupting normal neurotransmission in insects. This compound exhibits significant cytotoxic effects and induces oxidative stress, contributing to its insecticidal activity. Propetamphos is commonly used in research studies focused on insect physiology, toxicology, and the development of pest control strategies. -
Organic Phosphorus Pesticide
Isochlorothion is an organic phosphorus pesticide that acts primarily through the inhibition of acetylcholinesterase, leading to increased levels of acetylcholine in synaptic clefts. This mechanism results in heightened neurotoxicity, making it effective in agricultural applications for pest control. Isochlorothion is commonly utilized in research to study the effects of organophosphates on environmental systems and human health. -
Organophosphorus Insecticide
Aspon is an organophosphorus insecticide that primarily targets the nervous systems of insects by inhibiting acetylcholinesterase activity. It demonstrates significant biological activity in pest control applications and can also serve as a phosphorus source for various bacteria, promoting microbial growth and metabolism. This dual functionality makes Aspon valuable for both entomological studies and microbiological research. -
Insecticide
Formothion is an organophosphate insecticide that primarily targets the nervous system of insects, inhibiting acetylcholinesterase activity. This compound exhibits strong insecticidal properties, making it an effective agent in agricultural pest control. Additionally, Formothion's persistence in the environment following biomass burning provides a valuable opportunity to study pesticide dynamics and their ecological impact. -
Pesticide
Chlorethoxyfos is an organophosphate pesticide that acts primarily by inhibiting acetylcholinesterase, leading to an accumulation of acetylcholine at synaptic junctions. Its biological activity makes it effective in agricultural applications for pest control. Chlorethoxyfos undergoes oxidative transformation to form its more active oxon derivative in chlorinated laboratory water, which enhances its efficacy in targeted pest management strategies. -
Insecticide
Tebupirimfos is a potent insecticide that acts as an acetylcholinesterase inhibitor, disrupting neurotransmission in insects. Its primary mechanism involves the irreversible inhibition of the enzyme, leading to paralysis and death in targeted pest species. Tebupirimfos is commonly utilized in agricultural applications to manage various insect populations effectively, ensuring crop protection and yield stability. -
Pesticide
Fensulfothion oxon is a pesticide characterized by its sulfoxide group, which acts as a potent inhibitor of acetylcholinesterase. This inhibition disrupts the normal breakdown of acetylcholine, leading to increased neurotransmitter levels and subsequent toxic effects on target pests. Its primary applications include agricultural pest control and research into the mechanisms of pesticide action and environmental impact. -
Insecticide
Demeton-O-methyl is an organophosphate insecticide that functions by inhibiting acetylcholinesterase, leading to the accumulation of acetylcholine at synaptic junctions, ultimately causing paralysis and death in targeted insect pests. This compound is widely utilized in agricultural research to study pest control strategies and the effects of organophosphate exposure on non-target organisms. Its effectiveness and mode of action make it a valuable reagent for entomological studies and pesticide development. -
Drug Impurity
Donepezil impurity 10 is a known impurity associated with the compound Donepezil, a reversible inhibitor of the enzyme acetylcholinesterase. This reagent is significant for analytical studies aimed at monitoring the purity of Donepezil in pharmaceutical formulations. It serves as a reference standard in quality control processes and method development, ensuring compliance with regulatory guidelines in drug manufacturing and research applications. -
Drug Impurity
Donepezil impurity 18 is a chemical impurity associated with Donepezil, a reversible inhibitor of acetylcholinesterase. It serves as a crucial reference standard for assessing the purity and quality of Donepezil formulations in pharmaceutical research. This impurity may also aid in investigations into the stability and degradation pathways of Donepezil, facilitating improved drug development processes. -
Drug Impurity
Donepezil impurity 11 is a chemical impurity associated with Donepezil, a cholinesterase inhibitor used in the treatment of Alzheimer's disease. This impurity is relevant for quality control and analysis in pharmaceutical research, as it may affect the efficacy and safety profile of the primary compound. The identification and quantification of such impurities are essential for ensuring compliance with regulatory standards and enhancing the reliability of drug formulations. -
Drug Impurity
Rivastigmine impurity 13, also known as Rivastigmine impurity D, is a characterized impurity associated with Rivastigmine, a cholinesterase inhibitor primarily used in the treatment of Alzheimer's disease and other dementias. This impurity may be utilized in quality control and analytical studies to assess the purity and composition of Rivastigmine formulations. Its presence highlights the importance of monitoring drug impurities to ensure safety and efficacy in pharmaceutical products. -
Cholinesterase (ChE) Inhibitor
Pyridostigmine bromide is an orally active cholinesterase (ChE) inhibitor that enhances acetylcholine levels by inhibiting the enzyme responsible for its breakdown. This compound demonstrates significant biological activity in modulating cholinergic signaling, making it useful in studying neurodegenerative disorders and neuromuscular junction diseases. Its applications extend to cardiovascular disease research, where it can elucidate cholinergic mechanisms underlying cardiac function and dysfunction. -
Cholinesterase (ChE) Inhibitor
Corydaline is an isoquinoline alkaloid that functions as a cholinesterase (ChE) inhibitor with an IC50 of 226 μM. In addition to its cholinergic activity, Corydaline acts as a μ-opioid receptor agonist (Ki of 1.23 μM) and demonstrates significant antiviral effects by inhibiting enterovirus 71 (EV71) replication, with an IC50 of 25.23 μM. This compound also exhibits anti-angiogenic, anti-allergic, gastric-emptying, and antinociceptive properties, making it a valuable reagent for various biological research applications. -
Cholinesterase (ChE) Inhibitor
Sinapine thiocyanate is a cholinesterase (ChE) inhibitor known for its multifaceted biological activities. This alkaloid, derived from cruciferous plant seeds, exhibits anti-inflammatory, antioxidant, antitumor, anti-angiogenic, and radioprotective properties. Its ability to inhibit acetylcholinesterase (AChE) highlights its potential in research related to neurodegenerative disorders such as Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease. -
AChE/D2DR Inhibitor
Itopride hydrochloride is a potent acetylcholinesterase (AChE) inhibitor and dopamine D2 receptor antagonist. By enhancing gastric motility through its antidopaminergic and anti-AChE effects, Itopride hydrochloride serves as an effective gastrointestinal prokinetic agent. This compound is particularly useful for investigating conditions such as gastroesophageal reflux disease (GERD) and related gastrointestinal disorders. -
AChE Reactivator
Pralidoxime chloride is a potent reactivator of acetylcholinesterase (AChE), targeting AChE inhibited by organophosphate agents. It operates through a direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent, facilitating the restoration of AChE activity. Pralidoxime chloride is primarily utilized as an antidote for organophosphate poisoning, making it a critical reagent in toxicological research and therapeutic applications. -
Anticholinergic Drug
Benactyzine hydrochloride is a competitive inhibitor of butyrylcholinesterase (BChE) with a Ki of 0.01 mM, functioning primarily as an anticholinergic agent. It demonstrates significant promise in the study of organophosphate poisoning, aiding research into the mechanisms of cholinergic dysfunction. Its ability to modulate cholinergic activity makes it a valuable tool in neuropharmacological research and therapeutic explorations. -
AChE Inhibitor
Acotiamide is a selective and reversible inhibitor of acetylcholinesterase (AChE), exhibiting an IC50 value of 1.79 μM. It has demonstrated the ability to enhance gastric contractility and promote accelerated gastric emptying. This compound is valuable for investigating functional dyspepsia related to gastric motility dysfunction and intestinal inflammation. -
AChEI Inhibitor, XO Inhibitor, Thromboxane Inhibitor
Imidazole acts as an inhibitor of acetylcholinesterase (AChEI), xanthine oxidase (XO), and thromboxane. This heterocyclic aromatic compound exhibits significant biological activities, including antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic properties. By inhibiting the conversion of endoperoxides (PGG2 and PGH2) to thromboxane A2, Imidazole plays a role in cardiovascular research. Additionally, its derivatives have shown potential in inhibiting the SARS-CoV-2 3CLPro enzyme, making it a valuable candidate for studies related to Alzheimer's disease, gout, COVID-19, and thrombo-embolic conditions. -
Cholinesterase (ChE) Inhibitor
Demecarium Bromide is a potent cholinesterase (ChE) inhibitor, exhibiting an apparent affinity (Kiapp) of 0.15 μM. It primarily functions by inhibiting the enzyme cholinesterase, thereby increasing acetylcholine levels. This compound is widely utilized in research related to glaucoma treatment and the study of acetylcholine metabolism, providing valuable insights into neurodegenerative diseases and neurotransmission pathways. -
Antidepressant Agent
Protriptyline hydrochloride is a potent tricyclic antidepressant with a primary mechanism of action involving the inhibition of acetylcholinesterase (AChE), with an IC50 of 0.06 mM, as well as the reduction of amyloid beta (Aβ) self-assembly. This compound exhibits significant antidepressant activity and is valuable for research related to depression and Alzheimer's disease. It serves as a useful reagent for studying neurochemical pathways implicated in mood disorders and neurodegenerative conditions. -
Acetylcholinesterase Inhibitor
Neostigmine methyl sulfate is a reversible inhibitor of acetylcholinesterase, primarily targeting the peripheral nervous system. This compound enhances cholinergic transmission by preventing the breakdown of acetylcholine, resulting in increased neurotransmitter levels at the neuromuscular junction. It is widely used in research applications related to neuromuscular disorders and pharmacological studies of cholinergic function. -
Monoamine Oxidase Inhibitor
Minaprine dihydrochloride is a selective monoamine oxidase inhibitor that penetrates the blood-brain barrier. It exhibits biological activity by reducing intraneuronal dopamine metabolism, lowering levels of striatal homovanillic acid and dihydroxyphenylacetic acid, while increasing levels of 3-methoxytyramine and 5-hydroxytryptamine in the striatum. Additionally, Minaprine dihydrochloride weakly inhibits acetylcholinesterase activity and displays both convulsant and antidepressant properties, making it a valuable reagent for research in neuropharmacology and mood disorder studies. -
AChE Inhibitor
Ambenonium chloride is a potent, reversible inhibitor of acetylcholinesterase (AChE), demonstrating a high affinity for the enzyme. With an IC50 value of 0.7 nM for human AChE, this compound effectively enhances cholinergic transmission. It is primarily utilized in research applications focused on neurological disorders, particularly those involving impaired cholinergic function. -
Organophosphorus (OP) Pesticide
Dichlofenthion is an organophosphorus (OP) pesticide that functions by inhibiting acetylcholinesterase, leading to the accumulation of acetylcholine at nerve synapses. This mechanism results in heightened nerve signal transmission, making it effective in pest control. Dichlofenthion is primarily utilized for managing sheep maggot fly populations, contributing to agricultural pest management strategies.
