AChE

Cat. No.

A78567

CAS No.

510-77-0

Galanthaminone

Synonyms: (-)-Narwedine; Narwedin

Galanthaminone is a competitive and reversible inhibitor of cholinesterase (ChE), primarily targeting acetylcholinesterase (AChE). This compound demonstrates significant biological activity in enhancing cholinergic transmission and is utilized in the study of mild to moderate Alzheimer's disease and related memory impairments. Its application in research aids in understanding the mechanisms underlying cognitive decline and potential therapeutic interventions.

Cat. No.

A78568

CAS No.

97230-46-1

Picfeltarraenin IB

Picfeltarraenin IB is a triterpenoid derived from Picria fel-terrae Lour that acts as a cholinesterase (ChE) inhibitor. This compound exhibits significant biological activity by inhibiting acetylcholinesterase (AChE), thereby modulating cholinergic signaling. It is primarily utilized in research settings focusing on therapeutic applications for herpes infections, cancer, and inflammation.

Cat. No.

A78570

CAS No.

103548-82-9

Huperzine B

Huperzine B is a Lycopodium alkaloid that acts primarily as a selective inhibitor of acetylcholinesterase (AChE). This compound demonstrates significant potential for enhancing cholinergic neurotransmission, which is crucial in the context of neurodegenerative disorders such as Alzheimer's disease. Research applications include studies focused on cognitive enhancement and memory preservation.

Cat. No.

A78571

CAS No.

209394-46-7

Ladostigil hemitartrate

Synonyms: TV-3326 hemitartrate

Ladostigil hemitartrate is a dual inhibitor of monoamine oxidase (MAO) and acetylcholinesterase (AChE), with established IC50 values of 37.1 μM for MAO-B and 31.8 μM for AChE. This compound is capable of crossing the blood-brain barrier and exhibits neuroprotective, antioxidant, and anti-inflammatory properties. Ladostigil hemitartrate is relevant for research into neurological disorders, including depression and Alzheimer's disease. Additionally, it functions as a click chemistry reagent, featuring an alkyne group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc).

Cat. No.

A78572

CAS No.

621-87-4

Phenoxyacetone

Synonyms: Phenoxy-2-propanone

Phenoxyacetone is a competitive inhibitor of acetylcholinesterase (AChE), targeting the enzyme responsible for the hydrolysis of the neurotransmitter acetylcholine. By inhibiting AChE, phenoxyacetone enhances cholinergic signaling, making it valuable for studying neurological conditions characterized by impaired neurotransmission. This compound is suitable for research applications focused on neuropharmacology and the exploration of treatments for Alzheimer's disease and other memory-related disorders.

Cat. No.

A78573

CAS No.

23141-27-7

Vincosamide

Vincosamide is a potent acetylcholinesterase (AChE) inhibitor derived from the extract of Psychotria leiocarpa. It exhibits anti-inflammatory properties, making it a valuable compound for studying neurodegenerative diseases related to cholinergic dysfunction. Research applications include exploring potential therapeutic strategies for conditions such as Alzheimer's disease and other disorders characterized by altered AChE activity.

Cat. No.

A78574

CAS No.

285138-81-0

Chlorpyrifos-d10

Chlorpyrifos-d10 is a deuterium-labeled variant of Chlorpyrifos, an organophosphate insecticide known for its action as a phosphorothionate. Its active metabolite, Chlorpyrifos oxon, functions as a potent inhibitor of acetylcholinesterase (AChE), thereby disrupting neurological function in a range of organisms, including insects and mammals. This stable isotope is valuable for studying metabolic pathways, neurotoxic effects, and enzyme interactions, particularly in the context of susceptibility to neurotoxicity modulated by plasma enzyme paraoxonase 1 (PON1).

Cat. No.

A78575

CAS No.

2631-40-5

Isoprocarb

Isoprocarb is a cholinesterase (ChE) inhibitor that functions as a carbamate insecticide. It effectively targets pests such as rice paddy lice and leafhoppers, making it valuable in agricultural research. Its role in inhibiting acetylcholinesterase (AChE) provides insights into neuromuscular function and the mechanisms of toxicity, contributing to studies on pest control and environmental impact assessments.

Cat. No.

A78576

CAS No.

2425632-57-9

BChE-IN-17

BChE-IN-17 is a potent and selective inhibitor of butyrylcholinesterase (BChE) with IC50 values of 10.5 nM for equivalent BChE and 32.5 nM for human BChE. This compound demonstrates a remarkable over 1000-fold selectivity for BChE compared to acetylcholinesterase (AChE). Additionally, BChE-IN-17 exhibits low neurotoxicity and offers moderate neuroprotective effects, making it a valuable reagent for research in neurodegenerative diseases and cholinergic signaling pathways.

Cat. No.

A78577

CAS No.

13241-32-2

Neoeriocitrin

Neoeriocitrin, a potent acetylcholinesterase (AChE) inhibitor isolated from Drynaria Rhizome, demonstrates significant biological activity in promoting proliferation and osteogenic differentiation in MC3T3-E1 cells. This compound is valuable for research in neurodegenerative diseases, where AChE inhibition is critical, as well as in studies focused on bone biology and regenerative medicine.

Cat. No.

A78578

CAS No.

17472-50-3

Cyclanoline chloride

Cyclanoline chloride is a potent cholinesterase inhibitor that disrupts the breakdown of acetylcholine, thereby enhancing cholinergic neurotransmission. This compound is primarily utilized in research applications focusing on neurodegenerative diseases and paralysis, as it contributes to understanding the role of neurotransmitter regulation in synaptic function. Its inhibitory effects on cholinesterase make it a valuable tool for studying cholinergic signaling pathways.

Cat. No.

A78580

CAS No.

5336-90-3

9-Acridinecarboxylic acid

9-Acridinecarboxylic acid is a potent cholinesterase (ChE) inhibitor, acting on both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). It serves as a precursor for various derivatives that exhibit nanomolar inhibitory activity. This compound is crucial for research in neurodegenerative diseases and provides insights into the modulation of cholinergic signaling pathways.

Cat. No.

A78581

CAS No.

209394-18-3

Ladostigil hydrochloride

Synonyms: TV-3326 hydrochloride

Ladostigil hydrochloride is a potent dual inhibitor of acetylcholinesterase (AChE) and monoamine oxidase-B (MAO-B), exhibiting IC50 values of 37.1 µM and 31.8 µM, respectively. This compound demonstrates neuroprotective, antioxidant, and anti-inflammatory properties, making it valuable for research related to depression and Alzheimer's disease. Additionally, Ladostigil hydrochloride functions as a click chemistry reagent, featuring an alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), facilitating diverse chemical applications.

Cat. No.

A78582

CAS No.

25650-68-4

Ebeiedinone

Ebeiedinone is a steroidal alkaloid obtained from Fritillaria species that functions as a cholinesterase (ChE) inhibitor. At a concentration of 0.1 mM, it demonstrates a substantial inhibitory effect of 69.0% on human whole blood cholinesterase activity. This compound is valuable for research involving neuropharmacology and the study of cholinergic signaling pathways.

Cat. No.

A78583

CAS No.

1883548-90-0

Donepezil-d5 hydrochloride

Synonyms: E2020-d5

Donepezil-d5 hydrochloride is a stable deuterium-labeled analogue of Donepezil, which acts as a reversible and selective inhibitor of acetylcholinesterase (AChE) with an IC50 value of 6.7 nM. Its high selectivity for AChE over butyrylcholinesterase (BuChE) makes it a valuable tool in studying cholinergic signaling. Donepezil-d5 also demonstrates neuroprotective effects against Aβ42-induced neurotoxicity, making it relevant in Alzheimer's disease research and other neurodegenerative studies.

Cat. No.

A78585

CAS No.

98704-22-4

AChE-IN-65

AChE-IN-65 is a mixed inhibitor of acetylcholinesterase (AChE) with a Ki of 556.4 μM, demonstrating potency against the AChE from Electrophorus electricus. This compound is valuable for research applications focused on the modulation of cholinergic signaling and the study of neurodegenerative diseases. AChE-IN-65 can aid in understanding the role of AChE in synaptic transmission and its potential as a therapeutic target.

Cat. No.

A78586

CAS No.

142698-19-9

(R)-Donepezil

Synonyms: (R)-E2020 free base

(R)-Donepezil is a specific and potent inhibitor of acetylcholinesterase (AChE). As the R-enantiomer of Donepezil, it demonstrates notable efficacy in enhancing cholinergic neurotransmission. This compound is primarily utilized in neuropharmacological research, particularly in studies related to Alzheimer's disease and other cognitive disorders, where modulation of AChE activity is critical for therapeutic development.

Cat. No.

A78587

CAS No.

5589-41-3

Dihydrowithaferin A

Synonyms: 2,3-Dihydrowithaferin A

Dihydrowithaferin A is a withanolide derived from Withania somnifera, acting primarily as an acetylcholinesterase (AChE) inhibitor. This compound demonstrates significant biological activity by modulating cholinergic transmission, making it useful in research related to neurodegenerative disorders such as Alzheimer’s disease. Its ability to inhibit AChE positions Dihydrowithaferin A as a valuable tool in the exploration of therapeutic approaches targeting cholinergic dysfunction.

Cat. No.

A78588

CAS No.

142057-80-5

(S)-Donepezil

Synonyms: (S)-E2020 free base

(S)-Donepezil is an S-enantiomer of Donepezil, serving as a specific and potent inhibitor of acetylcholinesterase (AChE). This compound enhances cholinergic neurotransmission by preventing the degradation of acetylcholine, making it a valuable tool in neuropharmacological research. It is primarily utilized in studies related to neurodegenerative diseases, particularly Alzheimer's disease, where modulation of AChE activity is of significant interest.

Cat. No.

A78589

CAS No.

6297-14-9

AChE-IN-23

AChE-IN-23 is a potent acetylcholinesterase (AChE) inhibitor, demonstrating an IC50 value of 48.3 μM. This compound effectively inhibits the breakdown of acetylcholine, thereby enhancing cholinergic signaling. AChE-IN-23 has potential applications in research focused on neurological disorders, including Alzheimer's disease and other conditions associated with cholinergic dysfunction.

Cat. No.

A78590

CAS No.

1088-17-1

Isomerazin

Isomerazin is a coumarin compound known for its inhibitory effects on cholinesterase (ChE). This compound has demonstrated significant biological activity in the modulation of cholinergic neurotransmission, making it valuable for research into neurodegenerative diseases and cognitive disorders. Its application in studies related to Alzheimer's disease further highlights its potential as a therapeutic agent in cholinergic system-related research.

Cat. No.

A78591

CAS No.

366448-34-2

Serine Hydrolase inhibitor-21

Serine Hydrolase Inhibitor-21 is a potent inhibitor of serine hydrolases, exhibiting a Ki value of 429 nM for butyrylcholinesterase (BuChE). This compound is particularly relevant for research into Alzheimer’s disease, as it may help to elucidate the role of serine hydrolase activity in neurodegeneration. Its mechanism of action may provide insights into potential therapeutic strategies for the treatment of Alzheimer's and related disorders.

Cat. No.

A78592

CAS No.

7412-78-4

Glycyl-L-glutamic acid

Synonyms: H-Gly-Glu-OH; Gly-Glu

Glycyl-L-glutamic acid is a neurotrophic factor that plays a crucial role in the maintenance of acetylcholinesterase (AChE) content and activity. This compound does not directly influence AChE synthesis but may help prevent degeneration of preganglionic neurons. Its biological activity makes it valuable for research focused on neuroprotection and neuronal health.

Cat. No.

A78593

CAS No.

1128086-25-8

Donepezil-d5

Synonyms: E2020-d5 free base

Donepezil-d5 is a deuterium-labeled form of Donepezil, a potent and selective inhibitor of acetylcholinesterase (AChE). It demonstrates inhibitory activities with IC50 values of 8.12 nM for bovine AChE and 11.6 nM for human AChE. This stable isotope is valuable for pharmacokinetic studies and metabolic profiling in research related to neurodegenerative diseases, particularly Alzheimer's disease.

Cat. No.

A78594

CAS No.

2284-20-0

4-Methoxyphenyl isothiocyanate

Synonyms: 4-Methylphenyl ITC

4-Methoxyphenyl isothiocyanate primarily acts as an antioxidant, demonstrating a notable IC50 value of 1.25 mM for the scavenging of DPPH radicals. It displays significant antioxidant capacity, equivalent to 11.7 mM TE based on ORAC testing, and prolongs oxidation in the Briggs–Rauscher reaction by approximately 9180 seconds. In addition to its antioxidant properties, 4-Methoxyphenyl isothiocyanate exhibits moderate inhibitory activity against cholinesterases, with 30.4% inhibition of acetylcholinesterase and 17.9% inhibition of butyrylcholinesterase. This compound is valuable for research in antioxidative mechanisms and potential applications in addressing neurological disorders.