Other inhibitors

Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs, is originally discovered as the anti-hemorrhagic factors.

CNT2 inhibitor-1 is a potent concentrative nucleoside transporter 2 Inhibitor (CNT2), with an IC50 of 640 nM for hCNT2.

(E)-Alprenoxime is the isomer of the Alprenoxime. Alprenoxime is a site-activated ocular β-blocker.

Ombrabulin is a synthetic water-soluble analogue of combretastatin A4, derived from the South African willow bush (Combretum caffrum), with potential vascular-disrupting and antineoplastic activities.

Carebastine is the active carboxylic acid metabolite of Ebastine.

Teglarinad chloride, also known as GMX1777, is a water-soluble prodrug of a cyanoguanidine compound with potential antineoplastic activity. In vivo, teglarinad chloride is rapidly converted into active drug through hydrolytic cleavage of a carbonate ester bond.

Pyronaridine Tetraphosphate is a common antimalarial agent that has been found to enhance the antitumor activity of doxorubicin against multidrug-resistant cancers K562/A02 and MCF-7/ADR.

FR194738 free base is a squalene epoxidase inhibitor. FR194738 inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC50 of 9.8 nM.

S107 is a RyR-selective 1,4-benzothiazepine derivative that stabilizes RyR2 channels by enhancing the binding affinity of calstabin2 to mutant and/or PKA-phosphorylated channels.

TD-198946, a thienoindazole derivative, is a potent chondrogenic agent.

Prohydrojasmon racemate is a synthesized plant gowth regulator.

Cyclamic acid is one of the most widely used artificial sweeteners.

Freselestat is a potent neutrophil elastase inhibitor. Freselestat reduces inflammatory mediators during simulated extracorporeal circulation. ONO-6818 significantly reduced interleukin 8 and C5b-9 production. ONO-6818 did not modulate changes of CD11b and L-selectin during recirculation.

Embramine is an antihistamine and anticholinergic

Histone H2A is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells.

Prochloraz manganese is a sterol C-14 demethylation inhibitor which impairs biosynthesis of ergosterol, an essential compound for the stability and functioning of lipoprotein membranes

Ibutamoren, also known as MK-677 (L-163,191), is a drug which acts as a potent, orally active growth hormone secretagogue, mimicking the GH stimulating action of the endogenous hormone ghrelin.

Cardiolipin is an important component of the inner mitochondrial membrane, where it constitutes about 20% of the total lipid composition.

Ravuconazole is an ergosterol biosynthesis inhibitor and antifungal agen

Ceftobiprole medocaril is a fifth-generation[2] cephalosporin antibiotic with activity against methicillin-resistant Staphylococcus aureus, penicillin-resistant Streptococcus pneumoniae, Pseudomonas aeruginosa, and enterococci.

Doripenem is a compound used as an antibacterial agent.

An Oxytetracycline metabolite

D2PM (hydrochloride) is a psychoactive designer drug that has recently been demonstrated to have toxic effects in humans.

Lomifylline is a methylxanthine analogue which induces Ca2+-release from intracellular stores via the ryanodine receptor.

Tafenoquine is an 8-aminoquinoline drug manufactured by GlaxoSmithKline that is being investigated as a potential treatment for malaria, as well as for malaria prevention.

SNT207858 is a 22 nM MC4 antagonist with a 170-fold selectivity vs. MC3 and a 40-fold selectivity versus MC5.

4-Epi Minocycline is an impurity of Minocyclin, a second generation tetracycline antibiotic.

stearoyl-CoA desaturase 1 (SCD1) inhibitor. Used to selectively eliminate undifferentiated human pluripotent stem cells (hPSCs) from culture; induces ER stress, attenuates protein synthesis and induces apoptosis in hPSCs. Prevents teratoma formation in immunocompromised mice.

Disodium (R)-2-Hydroxyglutarate is a competitive inhibitor of ??-ketoglutarate-dependent dioxygenases with Ki of 0.628 mM.

Bioymifi is a potent and selective small molecule agonist of DR5 that directly targets DR5, specifically binds the ECD of DR5 (Kd ~1.2 μM), and induces the formation of DR5 aggregates and DR5 activation.

Lupulone, a hop bitter acid, activates different death pathways involving apoptotic TRAIL-receptors, in human colon tumor cells and in their derived metastatic cells.

Ciliobrevin D is the first specific small molecule antagonist of cytoplasmic dynein

Fluzinamide is an effective antiepileptic.

NMDI14 is a nonsense mediated RNA decay (NMD) inhibitor.

A nucleoside analog used in the treatment of viral infections (including those caused by human immunodeficiency virus, cytomegalovirus, and herpes virus).

S-Gboxin, a functional analogue of Gboxin, inhibits growth of mouse and human glioblastoma (GBM) with an IC50 of 470 nM. Antitumour activity.

Glycolic acid oxidase inhibitor 1 is a glycolate oxidase inhibitor, extracted from patent EP0021228A1, in Table IV.

AKR1C3-IN-1 is a potent, highly selective inhibitor of AKR1C3, with an IC50 of 13 nM.

BT-11 is an orally available LANCL2 binding compound for treating inflammatory bowel disease.

GATA4-NKX2-5-IN-1 (Compound 3) dose-dependently inhibits the GATA4?CNKX2-5 transcriptional synergy with an IC50 of 3 μM.

N6022 is a potent, specific, and fully reversible inhibitor of S-nitrosoglutathione reductase (GSNOR) with an IC50 of 8 nM and a Ki of 2.5 nM.

Benzophenonetetracarboxylic acid (3,3',4,4'-Benzophenonetetracarboxylic acid) is particularly useful in the preparation of high performance polyimides and also useful as curing agents for epoxy resins.

Exo1 is a chemical inhibitor of the exocytic pathway.

Arbidol is a Russian-made potent broad-spectrum antiviral with demonstrated activity against a number of enveloped and non-enveloped viruses.

Lodenosine is a failed experimental agent for the treatment of HIV

Trimipramine (Surmontil, Rhotrimine, Stangyl) is a tricyclic antidepressant (TCA). It has antidepressant, anxiolytic, antipsychotic, sedative, and analgesic effects

Panipenem is a carbapenem antibiotic used in combination with betamipron

Triphendiol (NV-196) is a synthetic isoflavene. Triphendiol (NV-196) is another investigational drug in the Marshall Edwards, Inc., oncology drug pipeline. Triphendiol is broadly cytostatic and cytotoxic against most forms of human cancer cells in vitro, and has been shown to cause cell cycle arrest (or stop cells increasing in number) and to induce apoptosis (or initiate programmed cell death) in various cancer cell lines.

ME-143 is a derivative of triphendiol and is a highly potent, pan acting anti-cancer.

Amsilarotene (TAC-101) is a retinobenzoic acid with potential antineoplastic activity.