Peptides

Laminin B1 (1363-1383) is a cell-adhesion peptide derived from residues 1363-1383 of the Laminin B1 chain, specifically targeting laminin receptors. This peptide promotes cell adhesion and plays a crucial role in cell migration and tissue regeneration. It is widely used in studies related to cellular interactions, extracellular matrix composition, and tissue engineering applications.

WSHPQFEK is a short peptide tag known for its high affinity for streptavidin, making it an effective tool for the separation, purification, and detection of recombinant proteins. Its reliable binding properties facilitate various applications in molecular biology and biochemistry research, enhancing the study of protein interactions and functions. This peptide tag is an essential component for researchers looking to streamline their protein purification processes.

Inotocin is a neuropeptide that belongs to the oxytocin/vasopressin family, specifically found in insects. Unlike its counterparts, Inotocin does not play a role in water balance regulation but is believed to influence reproductive behaviors, particularly parental care. This compound is valuable for research into neuropeptide signaling and its effects on behavior in model organisms.

CKGGRAKDC is an adipose tissue homing peptide that functions as a ligand for prohibitin, which is abundantly present in the vasculature of adipose tissue. This peptide facilitates the targeted delivery of therapeutic agents or biomolecules to adipose tissues, making it a valuable tool for studies related to obesity, metabolic disorders, and fat-targeted drug delivery. Its ability to specifically home in on adipose tissue enhances the efficiency of various research applications.

Livagen is an activity peptide that functions as an inducer, increasing the number of nucleolar organizer regions and nucleoli per cell. This compound is valuable for research into nucleolus-related cellular processes, as it may facilitate the study of nucleolar dynamics and their implications in cellular function and pathology.

PFVYLI is a hydrophobic penetrating peptide designed to enhance the delivery of therapeutics, particularly when used to modify doxorubicin-loaded stealth persistent liposomes (PFV-ssls-dox). This compound facilitates cellular uptake and improves the therapeutic efficacy of doxorubicin in breast cancer research applications. Its capacity to penetrate cellular membranes makes it a valuable tool for studying drug delivery mechanisms and optimizing cancer treatment strategies.

Antho-Rwamide II is a neuropeptide derived from the sea anemone Anthopleura elegantissima, known for its ability to induce contraction in the musculature of the organism. This peptide plays a significant role in neurotransmission, making it a valuable tool for studying the functions of the nervous system in invertebrate models. Researchers can utilize Antho-Rwamide II to gain insights into neuropeptide signaling and its impact on muscle responses and neuronal communication.

KQSSKALQR is a BCR-ABL peptide that plays a crucial role in inducing CD8+ T cell responses. This peptide is particularly relevant for research applications focused on chronic myeloid leukemia (CML), offering potential insights into vaccine development and immunotherapeutic strategies. Its ability to elicit specific immune responses makes KQSSKALQR a valuable tool for studying T cell-mediated immunity in the context of CML.

Astin J is an acyclic peptide derived from the roots of Aster tataricus. This compound is primarily studied for its unique structural properties and potential interactions in biochemical pathways, although it does not display antitumor activity. Its applications in research include investigations into peptide interactions and the exploration of natural product chemistry.

HLA-B*0801-binding EBV peptide, derived from the Epstein-Barr virus (EBV) epitope FLRGRAYGL, specifically binds to the HLA-B*0801 molecule. This peptide allows for the presentation to CD8+ T cells via HLA-B*0801, facilitating the activation of a tailored immune response. The peptide is instrumental in research related to immune recognition of EBV and the development of T cell-based immunotherapies.

SHLP-5 is a mitochondrial-derived peptide encoded by the 16s ribosomal RNA (MT-RNR2) gene, with a unique mechanism of action involving the modulation of various cellular processes. This biologically active microprotein exhibits potential neuroprotective, cardioprotective, and anti-inflammatory effects, making it valuable for research applications in diabetes, Alzheimer's disease, cardiovascular disorders, and prostate cancer. SHLP-5 serves as a critical tool for elucidating the role of mitochondrial peptides in health and disease.

MGCVQCKDKEA is an 11-residue peptide derived from the Src kinase Fyn, functioning as a membrane-anchoring motif. This peptide enhances the cell surface expression of TMC1 and TMC2 proteins, which are critical for mechanosensory transduction in the inner ear. MGCVQCKDKEA is valuable for research into diseases related to inner ear mechanical conduction channels.

AtPep1 is a plant elicitor peptide that plays a critical role in the innate immune response of plants. It activates the transcription of the defensin gene PDF1.2 and stimulates the production of hydrogen peroxide (H2O2), essential for defense against pathogens. This peptide is commonly isolated from Arabidopsis leaf extracts and is valuable for research into plant immunity and stress response mechanisms.

Rhizonin A is a cyclic heptapeptide derived from Rhizopus microsporus van Tieghem, known for its ability to promote plant growth. This compound has been implicated in various biological activities, including enhancing seed germination and improving root development in plants. Its potential applications in agricultural research make it a valuable reagent for studies aimed at understanding plant physiology and growth regulation.

H-Met-Met-OH, also known as L-Methionyl-L-methionine, is a dipeptide comprised of two methionine residues. This compound exhibits potential health benefits, particularly in nutritional studies and dietary applications. It is orally bioactive, making it suitable for research involving amino acid metabolism, protein synthesis, and supplementation effects in various animal models.

PSMα2 is a potent phenol-soluble modulin peptide that targets mouse neutrophils. It is known to induce a significant influx of leukocytes, making it valuable for studies on immune response mechanisms and inflammation. PSMα2 serves as a useful tool in research applications focused on elucidating neutrophil behaviors and their roles in various disease states.

Prolylvaline (Pro-Val) is a dipeptide composed of proline and valine. This compound exhibits specific binding properties with fluorescein isothiocyanate (FITC) and demonstrates unique imprinting effects in Tetrahymena, leading to negative imprinting outcomes. Prolylvaline can be utilized in research to differentiate proline dipeptides with varying partner amino acids, thus providing insights into the structural and functional relationships of dipeptides based on amino acid positioning.

Cyclo(Gly-Tyr) is a cyclic dipeptide that serves as a biochemical modulator due to its unique conformational stability. It exhibits key biological activities, potentially influencing neurotransmitter systems and cellular signaling pathways. This compound is valuable for research applications in peptide chemistry, neurobiology, and drug development, aiding in the exploration of peptide-based therapeutics and their physiological roles.

SmBiT Tag is an 11 amino acid complementary peptide (VTGYRLFEEIL) that exhibits low affinity for LgBiT. This peptide is designed to facilitate bioluminescence assays and is instrumental in various protein-protein interaction studies. Its unique properties enable the precise measurement of molecular interactions in live cells, making it a valuable tool for researchers in the field of cellular signaling and protein technology.

Palmitoyl tripeptide-5 diTFA is a bioactive peptide known for its anti-aging properties, primarily acting on skin regeneration and cellular repair. This compound promotes collagen synthesis and enhances skin elasticity, making it a valuable ingredient in cosmetic formulations aimed at reducing the appearance of fine lines and wrinkles. Its application extends to various skincare products designed to improve overall skin texture and resilience.

L-Tryptophanylglycine (Trp-Gly) is a dipeptide that functions as an inhibitor of Ceronapril uptake in Caco-2 cells, exhibiting a Ki value of 7.19 mM. This compound can be utilized in studies of intestinal absorption and transport mechanisms, contributing valuable insights into drug bioavailability and the effects of dipeptides on cellular uptake processes.

SDSSD is an osteoblast-targeting peptide that specifically binds to osteoblasts via periostin interactions. This peptide can be utilized to modify nanomaterials for in-depth studies of osteoblast-induced bone diseases, facilitating research into mechanisms of bone regeneration and pathology. Its selective targeting capabilities make it an essential tool for exploring osteoblast biology and developing potential therapeutic strategies.

Ac-RFAAKAA-COOH is a cysteine-containing polypeptide characterized by its reactive lysine residue, making it a valuable substrate for covalent modification and chemical reactivity assays. This compound forms stable covalent adducts with isothiocyanates, which facilitates peptide depletion studies over time. Ac-RFAAKAA-COOH serves as a model peptide in direct peptide reactivity assays and is assessed using fluorescamine-based free amine assays. Its applications extend to research related to allergic contact dermatitis and skin sensitization mechanisms.

Sialylglyco peptide is a sialylated glycopeptide that specifically targets N-Glycans. It exhibits key biological activity by participating in cell recognition processes and modulating cellular interactions. This compound is valuable in research applications focused on glycan recognition, cell signaling, and the study of glycoprotein-related diseases.

REF1 peptide is a potent PORK1 agonist with an EC50 of 0.028 nM in tomato. By binding to the extracellular domain of PORK1, REF1 peptide triggers receptor autophosphorylation, leading to the activation of downstream MPK3/MPK6 signaling pathways involved in defense and regeneration. This compound promotes callus formation and, with prolonged exposure, inhibits shoot regeneration, while enhancing regeneration and transformation efficiency in both recalcitrant dicotyledonous and monocotyledonous crops.

Arginylaspartic acid acetate is a dipeptide that contains arginine and aspartic acid. It is recognized for its role in various biological processes, including modulation of cell signaling and enhancement of peptide transport. This reagent serves as a valuable tool in research applications focused on peptide biology, drug design, and cellular interactions.

A7RC is a tumor-targeted peptide that incorporates Cysteine at the C-terminal of the A7R sequence (ATWLPPR). It serves as a ligand for the NRP-1 receptor, playing a crucial role in the regulation of intracellular signaling pathways associated with tumor vascularization and growth. A7RC is primarily utilized in research focusing on targeted cancer therapies and the modulation of tumor microenvironments.

H-His-Arg-OH is a dipeptide featuring guanidine groups that serves as a potent dissociating agent. It effectively reduces the critical micelle concentration, facilitating the formation of stable nano emulsions. This reagent is valuable in research applications involving nanoparticle stabilization and formulation development.

Phos-FLAG is a phosphorylated FLAG peptide that facilitates Staudinger-like linkage reactions with azide-modified cell surface glycans and glycoproteins. This reactive probe allows for the quantitative detection of azide-labeled glycans in various biological samples, including isolated cell and organ lysates. Phos-FLAG is particularly valuable for studying glycan modifications and their roles in cellular processes and disease states. Its application in click chemistry further enhances its utility in the field of glycobiology.