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SHLP-4

Catalog No.: B19757
Mitochondrial-Derived Peptide
SHLP-4 is a mitochondrial-derived peptide that plays a role in cellular signaling and metabolism. This biologically active microprotein, encoded by the 16S ribosomal RNA (MT-RNR2) gene, has been shown to enhance the proliferation of mouse NIT-1 insulinoma cells. SHLP-4 is suitable for research applications focused on diabetes and cardiovascular diseases, providing insights into mitochondrial function and its influence on metabolic health.
SHLP-4 1191923-94-0 Mitochondrial-Derived Peptide
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Research use only. We do not sell to patients.
Data Sheet SDS Compound Handling Instructions

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionSHLP-4 is a mitochondrial-derived peptide that plays a role in cellular signaling and metabolism. This biologically active microprotein, encoded by the 16S ribosomal RNA (MT-RNR2) gene, has been shown to enhance the proliferation of mouse NIT-1 insulinoma cells. SHLP-4 is suitable for research applications focused on diabetes and cardiovascular diseases, providing insights into mitochondrial function and its influence on metabolic health.
Product Information
Catalog NumB19757
FormulaC145H232N38O33S3
Molecular Weight3131.82
CAS Number1191923-94-0
SequenceMet-Leu-Glu-Val-Met-Phe-Leu-Val-Asn-Arg-Arg-Gly-Lys-Ile-Cys-Arg-Val-Pro-Phe-Thr-Phe-Phe-Asn-Leu-Ser-Leu
Sequence shorteningMLEVMFLVNRRGKICRVPFTFFNLSL
SMILESC(N[C@@H](CC1=CC=CC=C1)C(N[C@H](C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC3=CC=CC=C3)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(O)=O)=O)CO)=O)CC(C)C)=O)CC(N)=O)=O)=O)=O)[C@@H](C)O)=O)(=O)[C@H]4N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC5=CC=CC=C5)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCSC)N)=O)CC(C)C)=O)CCC(O)=O)=O)C(C)C)=O)CCSC)=O)=O)CC(C)C)=O)C(C)C)=O)CC(N)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)=O)CCCCN)=O)[C@H](CC)C)=O)CS)=O)CCCNC(=N)N)=O)C(C)C)=O)CCC4
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