Catalog No.
Product Name
Application
Product Information
Citations
-
PROTAC Linkers
N-Desthiobiotin-N-bis(PEG4-NHS ester) is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It facilitates the effective conjugation of target proteins with E3 ligases, enhancing degradation pathways in cellular systems. This compound is valuable for research applications involving targeted protein degradation and the study of proteostasis. -
PROTAC Linker
Azido-PEG3-Ala-Boc functions as a PEG-based linker specifically designed for PROTAC synthesis. This compound features an azide group, enabling it to engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, Azido-PEG3-Ala-Boc can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, making it suitable for diverse applications in targeted protein degradation research. -
PROTAC Linker
m-PEG5-phosphonic acid is a polyethylene glycol (PEG)-derived linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound effectively facilitates the conjugation of ligand and target moieties, enabling the selective degradation of specific proteins within cells. m-PEG5-phosphonic acid is instrumental in the development of novel therapeutic strategies aimed at modulating protein levels for various research applications in cancer and other diseases. -
PROTAC linker
N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy5 is a PEG-based PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions, which are essential for conjugating azide-containing molecules. Its properties make it valuable for studies in targeted protein degradation and drug discovery applications. -
PROTAC Linker
Methyl-PEG3-Ald is a polyethylene glycol (PEG) based linker designed for the synthesis of PROTACs (proteolysis-targeting chimeras). It serves as a molecular scaffold to facilitate targeted protein degradation by linking an E3 ligase recruiter to a target protein ligand. This compound enhances the selectivity and efficacy of PROTACs, making it a valuable tool for studying protein regulation and degradation in various biological contexts. -
PROTAC Linker
THP-PEG5-OH is a polyethylene glycol (PEG)-based linker designed for the synthesis of PROTAC molecules. This linker facilitates the development of targeted protein degradation systems by connecting a ligand for a target protein to an E3 ligase ligand. Its versatility supports applications in drug discovery and the investigation of cellular processes involving protein degradation. -
PROTAC Linker
Mal-PEG2-PFP ester is a bifunctional linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This alkyl/ether-based compound facilitates the conjugation of target proteins to E3 ligases, enabling selective degradation of proteins of interest through the ubiquitin-proteasome pathway. Its tunable spacer length and functional groups enhance the efficiency and specificity of PROTAC development, making it a valuable tool in chemical biology and drug discovery research. -
PROTAC Linker
N-Me-N-bis(PEG2-propargyl) is a polyethylene glycol (PEG)-based linker specifically designed for PROTAC synthesis. This compound features an alkyne functional group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its application in the development of PROTACs facilitates targeted protein degradation, making it a valuable tool for researchers exploring therapeutic strategies in drug discovery and cellular biology. -
PROTAC Linkers
Bis-isopropyl-PEG1 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimeras) compounds. This linker facilitates the conjugation of target proteins to E3 ligases, enhancing the degradation of proteins of interest. Its application in PROTAC development supports a variety of research areas, including targeted protein degradation and drug discovery. -
PROTAC Linker
Fmoc-Val-Phe-Boc is a PROTAC linker utilized in targeted protein degradation applications. This compound acts as a maleimide-GGFG peptide linker, facilitating the efficient synthesis of bifunctional molecules. Key research applications include the development of PROTACs and other therapeutic agents, such as Deruxtecan, for precision oncology and related fields. -
PROTAC Linker
S-acetyl-PEG4-amine is a PEG-based PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the solubility and biological stability of PROTACs, making it suitable for drug development studies aimed at targeted protein degradation. Its structure allows for efficient conjugation to target proteins and E3 ligases, enabling researchers to investigate novel therapeutic strategies in various disease models. -
PROTAC Linker
S-Acetyl-PEG3-azide is a PEG-based linker designed for use in the synthesis of PROTACs, targeting protein degradation pathways via targeted ubiquitination. This compound contains an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-bearing partners. Additionally, S-Acetyl-PEG3-azide can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-reactive molecules such as DBCO or BCN. Its applications in chemical biology are crucial for the development of innovative therapeutic strategies. -
PROTAC Linkers
THP-CH3-ethyl propionate is an alkyl ether-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the construction of bifunctional molecules that selectively degrade target proteins through the ubiquitin-proteasome pathway. It is suitable for applications in targeted protein degradation research and the development of novel therapeutic strategies. -
PROTAC Linkers
F-PEG2-COOH is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligases, promoting targeted degradation pathways. Its use is instrumental in drug discovery research, particularly in studies focused on the modulation of protein levels and elucidating protein function through targeted degradation strategies. -
PROTAC Linker
Thiol-PEG3-phosphonic acid serves as a PEG-based linker specifically designed for the formation of PROTAC (proteolysis-targeting chimeras). This compound facilitates the connection between target proteins and E3 ligases, promoting targeted protein degradation. It is instrumental in the development of therapeutic agents that harness targeted proteolytic mechanisms, thereby advancing research in drug discovery and protein regulation studies. -
PROTAC Linker
Bis-Mal-Lysine-PEG4-acid is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound allows for the conjugation of E3 ligase recruiters to target proteins, facilitating the targeted degradation of specific proteins via the ubiquitin-proteasome system. It is a valuable tool for researchers investigating protein function and cellular pathways, as well as developing novel therapeutic approaches. -
PROTAC Linkers
THP-PEG1-THP is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This linker facilitates the conjugation of target proteins to E3 ligases, enhancing the degradation of specific proteins via the ubiquitin-proteasome pathway. THP-PEG1-THP is essential for researchers developing novel therapeutic strategies that involve targeted protein degradation. -
PROTAC Linker
Biotin-PEG4-allyl is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of targeting moieties with E3 ligase recruiters, thereby promoting targeted protein degradation. Its biotin component enables efficient immobilization and enrichment of target proteins, making it a valuable tool in chemical biology and drug discovery research applications. -
PROTAC Linker
N-(Azido-PEG2)-N-Boc-PEG4-Boc is a PEG-based linker designed for use in the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an azide functional group that enables click chemistry reactions, specifically copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN functionalized compounds, making it a versatile tool for bioconjugation and drug development applications. -
PROTAC Linkers
Boc-NH-PEG8-propargyl is a PEG-based linker designed for the synthesis of PROTACs, primarily functioning as a key component in targeted protein degradation. This compound features an alkyne group that enables its application in click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc), facilitating the conjugation of azide-containing molecules. Its utility makes it a valuable tool in medicinal chemistry, particularly for enhancing the specificity and efficiency of PROTAC design and development. -
PROTAC Linker
Boc-Aminooxy-PEG3-acid is a PEG-based linker designed specifically for PROTAC (Proteolysis Targeting Chimeras) applications. This compound facilitates the synthesis of PROTACs, enabling the targeted degradation of specific proteins within cellular systems. Its unique structure enhances solubility and stability, making it a valuable tool in chemical biology and drug discovery research. -
PROTAC Linkers
(+) -Biotin-PEG6-hydrazide is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the recruitment of E3 ligases and targets specific proteins for degradation, thereby enabling the study of protein function and regulation in various biological contexts. Its hydrazide moiety allows for selective conjugation, enhancing the versatility of PROTAC development in chemical biology research. -
PROTAC Linkers
COOH-C-PEG2-NHCO-C2-COOH is a PROTAC linker designed for targeted protein degradation applications. This compound facilitates the synthesis of PCC16 chloride, enabling the selective modulation of protein targets in cellular systems. Its unique structure provides versatility in the development of bifunctional molecules for the research of protein-protein interactions and therapeutic agents. -
PROTAC Linker
Azido-PEG1-CH2CO2-NHS is an alkyl/ether-based PROTAC linker that facilitates the synthesis of PROTAC molecules. This click chemistry reagent features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing compounds. Additionally, it is compatible with strain-promoted alkyne-azide cycloaddition (SPAAC) reactions involving DBCO or BCN groups, making it valuable for advanced chemical biology applications. Its utility in constructing targeted protein degradation systems enhances its relevance in molecular biology research. -
PROTAC Linker
S-acetyl-PEG6-Boc is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the development of bifunctional molecules that can selectively degrade target proteins via the ubiquitin-proteasome system. Its application is critical in drug discovery and therapeutic research aimed at targeting hard-to-drug proteins. -
PROTAC Linker
Dimethylamino-PEG2-C2-NH2 is a polyethylene glycol (PEG)-derived linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the connection between target proteins and E3 ubiquitin ligases, promoting ubiquitination and subsequent degradation of specific proteins. Its application is crucial in drug discovery and development, particularly in targeted protein degradation research. -
PROTAC Linker
Bis-PEG11-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins and E3 ligases, thereby enabling targeted protein degradation. Its application in research aids in the exploration of therapeutic strategies involving protein modulation and degradation pathways. Bis-PEG11-acid contributes significantly to the development of innovative PROTAC-based therapeutics. -
PROTAC Linker
Boc-NH-PEG6-propargyl is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its versatility in linker design makes it suitable for applications in drug discovery and development, particularly in the field of targeted protein degradation. -
PROTAC Linker
Boc-aminooxy-PEG4-propargyl is a PEG-based linker designed for use in the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an alkyne group that enables its application in click chemistry, specifically permitting copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its functional properties make it an essential tool for researchers in drug development and biotechnology applications, particularly in the engineering of bifunctional small molecules. -
PROTAC Linker
Aniline-piperazine-C3-NH-Boc is a PROTAC linker designed for the synthesis of targeted protein degradation molecules. It facilitates the construction of conjugates such as Pomalidomide-C3-adavosertib and AZD1775, a Wee1 inhibitor. This compound is valuable for researchers investigating the mechanisms of protein regulation and degradation in various biological contexts. Its application in PROTAC technology enables innovative approaches to therapeutic development by enhancing targeted protein destruction. -
PROTAC Linkers
m-PEG9-t-Butyl ester is a polyethylene glycol (PEG) based linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound facilitates the development of bifunctional molecules that induce proteasome-mediated degradation of target proteins. Its structure provides favorable solubility and biocompatibility, making it suitable for applications in targeted protein degradation research and drug discovery. -
PROTAC linker
N-(Azide-PEG3)-N'-(PEG4-acid)-Cy5 is a PEG-based linker designed for the synthesis of PROTACs, functioning primarily through click chemistry mechanisms. It features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, this compound is capable of participating in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN moieties, making it useful for selective protein degradation studies and related applications in chemical biology. -
PROTAC Linkers
PEG2-bis(phosphonic acid diethyl ester) serves as a PEG-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It facilitates the effective engagement of target proteins for ubiquitination and subsequent degradation. This compound is essential in the development of targeted protein degradation strategies, contributing to advancements in cancer therapy and other areas of biomedical research. -
PROTAC Linkers
t-Boc-Aminooxy-PEG8-alcohol is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It features a t-Boc-protected aminooxy group, facilitating the conjugation of E3 ligase ligands to target proteins. This compound plays a crucial role in enhancing the degradation of specific proteins, making it valuable for drug discovery and the study of protein modulation in cellular processes. -
PROTAC Linkers
SPDP-PEG4-acid is a PEG-based linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates targeted protein degradation by linking a target protein to an E3 ligase, enhancing the efficacy of PROTAC-based therapeutic strategies. It is a valuable tool in chemical biology for developing novel approaches in targeted therapy and studying protein interactions. -
PROTAC Linker
m-PEG7-CH2-OH is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of ligand-receptor pairs, enhancing the degradation of specific target proteins via the ubiquitin-proteasome system. It is valuable in biochemical research aimed at developing targeted therapeutics and investigating protein functionality. -
PROTAC Linker
Hydroxy-PEG4-CH2COOH sodium salt is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTAC (proteolysis targeting chimera) molecules. Its hydroxyl group enhances solubility and protein interaction, facilitating the targeted degradation of specific proteins in cellular systems. This reagent is essential for researchers developing innovative PROTAC therapies in applications including cancer treatment and protein regulation studies. -
PROTAC Linkers
Acryloyl-PEG4-OH is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound facilitates the conjugation of target proteins to E3 ubiquitin ligases, enabling targeted protein degradation. Its versatile application in PROTAC development makes it a valuable tool for research in protein regulation and therapeutic interventions. -
PROTAC Linker
Boc-PEG4-sulfonic acid is a PEG-based linker designed for use in PROTAC synthesis. It enhances the solubility and stability of PROTACs, facilitating their application in targeted protein degradation research. This compound is instrumental in the development of innovative therapeutic strategies by enabling the selective modulation of protein levels within cellular systems. -
PROTAC Linker
Benzyl-PEG8-Ots is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the precise conjugation of a target protein to an E3 ligase, promoting targeted protein degradation. It plays a crucial role in advancing research in protein modulation and therapeutic development, particularly in studies focusing on cancer and other diseases where protein homeostasis is disrupted. -
PROTAC Linker
Azido-PEG3-Sulfone-PEG4-Boc is a PEG-derived linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide functional group that enables click chemistry reactions, specifically copper-catalyzed azide-alkyne cycloaddition (CuAAC) with alkyne-containing partners. Additionally, it can participate in strain-promoted azide-alkyne cycloaddition (SPAAC) with dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) compounds. This versatility makes Azido-PEG3-Sulfone-PEG4-Boc a valuable tool for studies in targeted protein degradation and other applications in chemical biology. -
PROTAC Linkers
Propargyl-PEG12-amine is a PEG-based linker designed for use in the synthesis of PROTACs. It features an alkyne functional group, allowing it to engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing partners. This compound is instrumental in facilitating the development of targeted protein degradation strategies, enhancing research in therapeutic interventions and cellular regulation. -
PROTAC Linkers
BnO-PEG1-CH2COOH is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features a carboxylic acid moiety, facilitating conjugation to target proteins and small molecules. It plays a crucial role in the development of bifunctional degrader molecules, enabling selective degradation of target proteins in various cellular contexts. This linker can significantly advance research in targeted protein degradation and drug development. -
PROTAC Linker
4-Hydroxy-1-piperidinepropanamide is a versatile PROTAC linker utilized in the development of PROTAC-based degraders, specifically for DDR1 degradation. This compound facilitates the targeted protein degradation pathway by connecting E3 ubiquitin ligases to specific protein targets. It is essential for researchers focusing on the modulation of protein levels through targeted degradation strategies in various biological studies. -
PROTAC linker
N-(t-Boc-Aminooxy-PEG2)-N-bis(PEG3-propargyl) is a PEG-based linker designed for use in the synthesis of PROTACs through a targeted compound degradation mechanism. This compound features an alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAC), enabling efficient conjugation with azide-containing molecules. N-(t-Boc-Aminooxy-PEG2)-N-bis(PEG3-propargyl) is instrumental in the creation of innovative therapeutic agents and is applicable in drug discovery research. -
PROTAC linker
N-(m-PEG4)-N'-(azide-PEG4)-Cy7 is a PEG-based linker designed for use in PROTAC (proteolysis targeting chimeras) synthesis. This compound features an azide functional group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing partners, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. Its biological activity in forming stable linkages facilitates targeted proteolysis research applications, making it a valuable tool for molecular biology and drug development studies. -
PROTAC Linkers
Boc-N-Amido-PEG3-azide is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with dibenzocyclooctyne (DBCO) or bicyclo[6.1.0]nonyne (BCN) groups, making it a versatile tool for chemical research and development in targeted protein degradation studies. -
PROTAC Linker
NH-bis(PEG3-acid) is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound enhances the solubility and stability of PROTACs, facilitating targeted protein degradation. Its unique structure allows for effective conjugation to ligands and proteins, contributing to advancements in drug discovery and therapeutic development. -
PROTAC Linkers
Pyrene azide 3 is a PEG-based PROTAC linker designed for the synthesis of PROTACs. It features an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-bearing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-containing compounds, making it versatile for targeted protein degradation applications in chemical biology research. -
PROTAC Linker
N-(Boc-PEG4)-NH-PEG4-NH-Boc is a polyethylene glycol (PEG)-based linker optimized for the development of PROTACs (Proteolysis Targeting Chimeras). This compound serves as a valuable tool in the synthesis of bi-functional molecules intended for targeted protein degradation. It enables the efficient conjugation of various functional moieties, facilitating research in targeted therapies and the modulation of protein levels in cellular systems.
