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  1. CRBN modulator

    TD-106 is a cereblon (CRBN) modulator, which can be used for targeted protein degradation. BRD4 PROTACs with TD-106 induce BRD4 degradation.
  2. cereblon (CRBN) modulator

    CC-885 is a cereblon (CRBN) modulator with potent anti-tumour activity.
  3. CRBN modulator

    Iberdomide (CC-220) is a cereblon (CRBN) modulator with an IC50 of 60 nM.
  4. CRBN modulator

    CRBN modulator-1, a Thalidomide analog and a CRBN modulator extracted from WO2020006262A1, compound 10, has an IC50 of 3.5 μM and a Ki of 0.98 μM.

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