Catalog No.
Product Name
Application
Product Information
Citations
-
PROTAC Linker
m-PEG3-0-benzaldehyde is a polyethylene glycol (PEG)-derived linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound is essential for the construction of bifunctional molecules that facilitate targeted protein degradation, enabling researchers to study protein dynamics and cellular mechanisms. Its versatile properties make it suitable for applications in drug development and the exploration of novel therapeutic strategies in various diseases. -
PROTAC linker
endo-BCN-PEG8-acid serves as a PEG-based linker for PROTAC (Proteolysis Targeting Chimera) synthesis, enabling targeted protein degradation. This compound features a BCN moiety, allowing for strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its high efficiency and versatility make it an essential reagent for research in targeted therapeutic strategies and cellular signaling studies. -
PROTAC Linkers
Ald-CH2-PEG8-azide is a PEG-based linker designed for the synthesis of PROTACs (proteolysis-targeting chimeras). It features an azide functional group, enabling it to engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing compounds. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN moieties. This versatility makes Ald-CH2-PEG8-azide ideal for applications in targeted protein degradation and medicinal chemistry research. -
PROTAC Linkers
m-PEG12-Mal is a polyethylene glycol (PEG) based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the assembly of PROTACs by providing a flexible and solubilizing linker that can enhance cellular uptake and target specificity. It is particularly useful in the development of novel therapeutics that harness the ubiquitin-proteasome system for targeted protein degradation in various biological applications. -
PROTAC Linkers
Ms-PEG7-MS is a PEG-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the recruitment of E3 ubiquitin ligases to target proteins, promoting targeted protein degradation. Its flexibility and hydrophilicity enhance the efficacy and solubility of PROTAC constructs, making it valuable in drug discovery and development research. -
PROTAC Linkers
Azido-PEG16-acid is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). Featuring an azide functional group, this compound is capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted azide-alkyne cycloaddition (SPAAC) reactions with DBCO or BCN moieties. This reagent is essential for facilitating the precise assembly of PROTACs, contributing to advancements in targeted protein degradation research. -
PROTAC Linker
Amino-PEG4-benzyl ester is a PEG-based linker specifically designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the incorporation of a linker moiety that enhances the stability and cellular uptake of PROTACs. Its application is essential in target-specific protein degradation research, enabling the modulation of protein levels with high precision. -
PROTAC Linker
7-Oxoheptanoic acid serves as a versatile linker for PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the selective degradation of target proteins by connecting E3 ligases to target proteins, thereby modulating cellular activities. Its application is critical in innovative drug design and protein modulation research, enabling the development of therapeutics that can selectively eliminate disease-associated proteins. -
PROTAC Linker
Benzyl-PEG7-amine is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (PROteolysis TArgeting Chimeras). This compound facilitates the efficient conjugation of target proteins to E3 ligases, enhancing protein degradation pathways. Its applications extend to chemical biology and drug development, making it a valuable tool for researchers investigating targeted protein degradation mechanisms. -
PROTAC Linker
SPDP-PEG6-NHS ester is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligases, enabling selective degradation of specific proteins in cellular contexts. It is applicable in various research areas, including targeted protein degradation and therapeutic development. -
PROTAC Linker
Carboxyrhodamine 110-PEG3-Azide is a PEG-based linker designed for the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an azide functional group that permits efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-modified partners. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN derivatives, making it versatile for various click chemistry applications in chemical biology research. -
PROTAC Linker
DBCO-PEG1 is a PEG-based PROTAC linker designed for the synthesis of PROTACs. It features a DBCO group that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This reagent is crucial for the development of targeted protein degradation strategies in chemical biology research, facilitating the efficient assembly of bifunctional small molecules for therapeutic applications. -
PROTAC Linker
Amino-PEG11-acid is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). Its primary function is to facilitate the conjugation between a target protein ligand and an E3 ligase ligand, promoting targeted protein degradation. This compound is valuable in drug discovery and development, enabling the investigation of protein function and the modulation of cellular pathways through proteolysis. -
PROTAC Linker
NH-bis(m-PEG4) is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to ubiquitin ligases, enhancing the targeted degradation of specific proteins within cellular systems. Its versatility in various biochemical applications makes it an essential tool for researchers developing novel therapeutics that leverage the ubiquitin-proteasome pathway. -
PROTAC Linker
Azido-PEG8-azide is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs. It features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, this compound can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-functionalized partners, making it a versatile tool for applications in targeted protein degradation research. -
PROTAC Linkers
Diketone-PEG4-PFP ester is a PEG-based linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the assembly of bifunctional molecules that enhance substrate degradation via the ubiquitin-proteasome system. Its robust chemical properties enable efficient conjugation to various targeting and E3 ligase components, making it a vital tool for researchers investigating targeted protein degradation. -
PROTAC Linker
Propargyl-PEG3-sulfone-PEG3-propargyl is a PEG-based linker designed for the synthesis of PROTACs through its unique functionality in click chemistry. This compound features an alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc), enabling efficient conjugation with azide-containing molecules. Its application in the development of targeted protein degradation systems provides researchers with a versatile tool for studying protein interactions and cellular pathways. -
PROTAC linker
N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy3 is a PEG-based PROTAC linker designed to facilitate the synthesis of PROTACs. This compound features an alkyne functional group that enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its applications in chemical biology include the development of targeted protein degradation strategies, allowing for innovative therapeutic approaches in drug discovery and research. -
PROTAC Linker
Tos-PEG3-C2-methyl ester is a PEG-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the targeted degradation of proteins by linking an E3 ligase ligand to a warhead, enabling precise modulation of protein levels in biological systems. It serves as a valuable tool in drug discovery, particularly in the development of novel therapeutic agents aimed at degrading disease-related proteins. -
PROTAC Linker
Bis-aminooxy-PEG7 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the successful conjugation of target proteins to ligands, enabling selective degradation of proteins of interest via the ubiquitin-proteasome system. Its application in PROTAC development is crucial for advancing studies in targeted protein degradation and therapeutic interventions in various diseases. -
PROTAC Linkers
TCO-PEG6-acid is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It features a TCO (Trans-Cyclooctene) moiety that enables efficient ligation with a specific cyclopropene partner, facilitating the selective degradation of target proteins. This compound is essential for researchers developing targeted protein degradation strategies and studying cellular processes involving controlled protein levels. -
PROTAC Linker
Propargyl-PEG8-SH is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Featuring an alkyne group, this compound facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, enabling efficient conjugation in chemical biology applications. Its utility in developing targeted protein degradation strategies makes it a valuable reagent for researchers focusing on novel therapeutic approaches and drug discovery. -
PROTAC Linker
Bis-propargyl-PEG8 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an alkyne functional group, allowing it to facilitate copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its unique properties make Bis-propargyl-PEG8 a valuable tool in chemical biology and drug development, particularly in the creation of targeted protein degradation systems. -
PROTAC Linker
Boc-NH-Piperidine-C5-OH is a specialized PROTAC linker utilized in targeted protein degradation strategies. This compound plays a crucial role in the synthesis of PROTAC molecules, specifically facilitating the formation of PIN1 degrader-1. Its application enables precise modulation of protein levels within cellular environments, making it valuable for research in proteomics and targeted therapy development. -
PROTAC Linker
Biotin-C1-PEG3-C3-amine TFA is a PEG-based linker utilized in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates targeted protein degradation by conjugating an E3 ligase ligand with a protein of interest, enhancing the efficacy of PROTAC-based strategies in biochemical research. Its unique structure allows for improved solubility and potency within various cellular contexts, making it a valuable tool for studies in chemical biology and therapeutic development. -
PROTAC Linker
Propargyl-PEG4-Sulfone-PEG4-Boc is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis targeting chimeras). This compound features an alkyne group, facilitating click chemistry applications through copper-catalyzed azide-alkyne cycloaddition (CuAAC) with azide-containing partners. Its unique structure enables selective protein degradation, making it a valuable tool in the advancement of targeted protein modulation and drug discovery research. -
PROTAC Linkers
Acid-PEG9-NHS ester is a polyethylene glycol (PEG) linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enhancing selective protein degradation pathways. It is an essential tool for researchers focusing on targeted protein modulation and therapeutic applications in cancer and other diseases. -
PROTAC Linkers
Benzyl-PEG5-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). It enhances the solubility and stability of PROTAC constructs, enabling the selective degradation of target proteins through the ubiquitin-proteasome system. This versatile linker is instrumental in the development of therapeutic agents for targeted protein degradation research. -
PROTAC Linker
Benzyl-PEG3-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the effective conjugation of target proteins with E3 ligases, enhancing the degradation of specific proteins in cellular systems. Its application is critical in chemical biology research, particularly in studies focused on targeted protein degradation and therapeutic development. -
PROTAC Linkers
Azido-PEG4-THP is a PEG-based linker designed for use in the synthesis of PROTACs. It features an azide group that facilitates click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. This versatility makes Azido-PEG4-THP an essential tool in chemical biology for the development of targeted protein degradation strategies. -
PROTAC Linkers
Propargyl-PEG-amine is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the conjugation of various warheads to the E3 ligase, promoting targeted degradation of specific proteins within cells. It is particularly valuable in the development of novel therapeutic agents aimed at modulating protein levels and investigating cellular pathways implicated in various diseases. -
PROTAC Linkers
DBCO-PEG9-DBCO is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound features a DBCO ( dibenzocyclooctyne) moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its ability to create covalent bonds enhances the stability and efficacy of PROTACs, making it a valuable tool for targeted protein degradation studies and drug discovery applications. -
PROTAC linker
N-PEG3-N'-(propargyl-PEG4)-Cy5 is a PEG-based linker designed for use in the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an alkyne group that enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its applications extend to chemical biology and drug discovery, particularly in the development of innovative therapeutic strategies targeting specific protein interactions. -
PROTAC Linker
Dde Biotin-PEG4-Picolyl azide is a PEG-based PROTAC linker designed for the synthesis of targeted protein degradation agents. This compound functions through click chemistry, featuring an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. Its unique structure and reactivity make it a valuable tool for advancing research in targeted protein degradation and other applications in chemical biology. -
PROTAC Linker
Br-PEG3-ethyl acetate is a polyethylene glycol (PEG)-derived linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of targeting moieties to E3 ligase, enabling the selective degradation of target proteins through the ubiquitin-proteasome system. It is utilized in research applications aiming to develop novel therapeutic strategies for diseases involving aberrant protein accumulation. -
PROTAC Linkers
Azido-PEG12-propargyl is a versatile PEG-based linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as enabling ring strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN functionalized compounds. Its effective application in the development of PROTACs supports targeted protein degradation research, offering significant potential for therapeutic interventions in various diseases. -
PROTAC Linkers
t-Boc-Aminooxy-PEG7-amine is a polyethylene glycol (PEG)-based linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). It features an aminooxy functional group that facilitates the conjugation of ligands to E3 ligase, enabling targeted degradation of specific proteins. This compound is essential for researchers developing novel PROTAC therapeutics and studying targeted protein degradation mechanisms. -
PROTAC Linkers
2-Amino-1,3-bis(carboxylethoxy)propane is a PEG-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). It serves as a versatile connector that facilitates the conjugation of targeting ligands to E3 ligases, enabling targeted protein degradation. This compound is valuable in the development of novel therapeutic agents aimed at selectively modulating protein levels within cells. -
PROTAC Linker
Biotin-PEG2-C4-alkyne is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an alkyne functionality, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its application in PROTAC development facilitates targeted protein degradation, making it essential for research in therapeutic protein modulation and drug discovery. -
PROTAC Linker
N-Boc-N-bis(PEG4-azide) is a PEG-based linker designed for the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an azide group enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it is compatible with strain-promoted alkyne-azide cycloaddition (SPAAC) reactions involving DBCO or BCN groups, making it a versatile tool for chemical biology applications, including drug discovery and development. -
PROTAC Linkers
m-PEG3-Sulfone-PEG3-acid is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the conjugation of targeting and E3 ligase recruiters, enhancing the development of targeted protein degradation applications. Its properties support the design of PROTACs for research in cellular mechanisms and therapeutic interventions in various diseases, including cancer. -
PROTAC Linker
Bis-propargyl-PEG6 is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the assembly of polymer-linked multimers, particularly of guanosine-3', 5'-cyclic monophosphates. As a click chemistry reagent, Bis-propargyl-PEG6 contains an alkyne functionality that enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, making it valuable for various bioconjugation applications in chemical biology. -
PROTAC Linkers
Hydroxy-PEG2-CH2COONa is a polyethylene glycol (PEG) based PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances solubility and biocompatibility, thereby improving the pharmacological properties of novel PROTACs. It is essential for studies targeting selective protein degradation and for advancing research in targeted therapies. -
PROTAC Linkers
m-PEG3-Propanoyl chloride is a polyethylene glycol (PEG) based linker designed for the synthesis of PROTAC (Proteolysis Targeting Chimeras). It enables the formation of potent PROTACs that selectively target and degrade specific proteins within cells. This compound is essential for researchers focusing on targeted protein degradation and drug development in various biological studies. -
PROTAC Linker
Benzyl-PEG3-amine is a polyethylene glycol (PEG)-based linker designed for PROTAC (proteolysis-targeting chimera) applications. This compound serves as a crucial component in the synthesis of PROTACs, enabling targeted protein degradation. Its flexible structure facilitates the conjugation of different ligands, enhancing the efficacy of drug discovery and biomedical research focused on protein modulation and disease intervention. -
PROTAC Linker
Thiol-PEG3-phosphonic acid ethyl ester is a PEG-based PROTAC linker that facilitates the construction of proteolysis-targeting chimeras (PROTACs). This compound is crucial for the development of targeted protein degradation strategies, enabling researchers to selectively modulate protein levels. Its application extends to synthetic biology and drug discovery, providing a versatile tool for exploring complex cellular mechanisms. -
PROTAC Linkers
Propargyl-PEG5-PFP ester is a PEG-based linker designed for use in the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an alkyne functional group, enabling its application in click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its ability to create stable linkages makes it valuable for advancing research in targeted therapeutic strategies and bioconjugation. -
PROTAC Linker
Butoxycarbonyl-PEG5-sulfonic acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimera) molecules. This compound facilitates the coupling of target proteins to E3 ligases, enabling targeted protein degradation. Its applications include drug discovery and development within the realm of targeted therapeutics and protein modulation studies. -
PROTAC Linkers
6-Hydroxy-1-(4-(2-hydroxyethyl)piperazin-1-yl)hexan-1-one serves as a key linker in the development of PROTAC molecules targeting METTL3. This compound is integral for facilitating the degradation of specific proteins, thereby enabling cellular pathway modulation and functional studies. Researchers can employ this linker to explore targeted protein degradation applications in various biological contexts. -
PROTAC Linkers
Hexane-1,6-diyldiphosphonic acid serves as an alkyl chain-based linker for PROTAC (Proteolysis Targeting Chimeras) applications. This reagent facilitates the synthesis of PROTACs by providing a functionalized scaffold that connects target proteins to E3 ligases, enabling targeted protein degradation. It is crucial for researchers developing PROTACs to study cellular processes and therapeutic interventions in various diseases.
