Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
Azido-PEG4-propargyl is a PEG-based linker designed for the synthesis of PROTACs through precise chemical conjugation. Its structure features an azide group conducive to copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-bearing molecules, enhancing modularity in compound design. Additionally, it can participate in ring strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. This reagent is essential for researchers developing targeted protein degradation technologies. -
PROTAC Linkers
Propargyl-PEG1-acrylate is a PEG-based PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). Featuring an alkyne functional group, it enables efficient click chemistry reactions through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. This reagent is crucial for advancing research in targeted protein degradation and other bioconjugation applications. -
PROTAC Linker
Azido-PEG3-MS is a PEG-based linker designed for use in the synthesis of PROTACs, utilizing its azide functionality for click chemistry applications. This compound facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. The versatility of Azido-PEG3-MS makes it a valuable tool in the development of targeted protein degradation strategies in chemical biology research. -
PROTAC Linkers
Benzyl-PEG3-MS is a polyethylene glycol (PEG)-based linker designed specifically for the synthesis of PROTACs (proteolysis targeting chimeras). This compound facilitates the selective degradation of target proteins by linking a target ligand to an E3 ligase ligand, enhancing the efficacy of the PROTAC. Its biocompatibility and flexibility make Benzyl-PEG3-MS an essential reagent for researchers aiming to explore targeted protein degradation strategies in various biological systems. -
PROTAC Linker
Propargyl-PEG4-Sulfone-PEG4-acid is a PEG-based linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features an alkyne moiety that facilitates the copper-catalyzed azide-alkyne cycloaddition (CuAAc) reaction with azide-functionalized molecules. Its key biological activity supports the development of PROTACs for targeted protein degradation, making it a valuable tool in therapeutic research and drug discovery applications. -
PROTAC Linker
Azido-PEG12-alcohol is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs through click chemistry. It features an azide group, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it supports strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with compounds incorporating DBCO or BCN groups. This versatility makes Azido-PEG12-alcohol a valuable tool for advancing targeted protein degradation research and related applications in chemical biology. -
PROTAC Linkers
(2-Pyridyldithio)-PEG2-Boc is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound features a pyridyldithio moiety that facilitates the covalent attachment of an E3 ligase recruiter to a target protein, thus enabling targeted protein degradation. Its application in PROTAC development makes it valuable for studies focused on selective protein modulation and therapeutic interventions in various disease models. -
PROTAC linker
N-(PEG2-Boc)-N-bis(PEG2-propargyl) is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc), enabling efficient conjugation with azide-containing molecules. Its application in PROTAC development supports targeted protein degradation research, providing researchers with a valuable tool for protein modulation studies. -
PROTAC Linker
Thiol-C10-amide-PEG8 is a PEG-based linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimeras). This compound facilitates targeted protein degradation by connecting an E3 ligase with a specific target protein, advancing research in molecular biology and drug discovery. Its unique structure enhances solubility and stability, making it an essential component for developing effective PROTAC therapeutics. -
PROTAC linker
m-PEG5-azide is a PEG-based PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). Featuring an azide group, it participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-containing molecules. This versatile reagent is essential for advancing research in targeted protein degradation and related fields. -
PROTAC Linker
Propargyl-PEG7-Boc is a PEG-based linker designed for the synthesis of PROTACs, specifically functioning as a tool in targeted protein degradation. This compound features an alkyne group that enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. Its unique properties facilitate the development of bifunctional proteins, making it valuable in chemical biology and therapeutic research applications. -
PROTAC Linker
Cbz-Pip-2C-Pip-C-Pip is a PROTAC linker designed for use in targeted protein degradation applications. This compound facilitates the synthesis of PROTACs, such as Cbl-b-IN-1, enabling the selective modulation of protein levels within cells. It serves as a valuable tool for researchers investigating the dynamics of protein function and the development of innovative therapeutic strategies. -
PROTAC Linker
Thiol-C9-PEG5 is a polyethylene glycol (PEG) linker designed for PROTAC (proteolysis-targeting chimera) synthesis. This compound facilitates the development of bifunctional molecules that can recruit E3 ligases for targeted protein degradation. Its compatibility with diverse drug-like compounds makes it a valuable tool in medicinal chemistry and drug discovery applications. -
PROTAC Linker
PEG2-ethyl acetate is a PEG-based linker designed for PROTAC (PROteolysis TArgeting Chimeras) synthesis. This compound facilitates the formation of PROTACs by providing a flexible and hydrophilic spacer, which enhances target protein degradation. Its application includes the development of targeted proteolysis strategies for therapeutic interventions in various diseases. -
PROTAC Linkers
Biotin-PEG6-amine is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). It facilitates the conjugation of biotin moieties to protein targets, thereby enhancing the accessibility of the target for ubiquitination. This compound is crucial for developing novel therapeutic strategies involving targeted protein degradation, enabling researchers to investigate protein function and pathway modulation in various cellular contexts. -
PROTAC Linker
Ald-Ph-PEG5-Boc is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the effective conjugation of ligands to target proteins, thereby promoting targeted degradation. Ald-Ph-PEG5-Boc is instrumental in advancing research on targeted protein degradation and optimizing PROTAC development for therapeutic applications. -
PROTAC Linkers
m-PEG3-amido-C3-triethoxysilane is a polyethylene glycol (PEG)-based linker designed for PROTAC (Proteolysis Targeting Chimeras) applications. This compound facilitates the synthesis of PROTACs by providing a flexible and biocompatible moiety that can enhance the efficacy of targeted protein degradation. Its unique structure allows for optimized binding and stability, making it a valuable tool in chemical biology and drug discovery. -
PROTAC Linker
DNP-PEG3-DNP is a polyethylene glycol (PEG) based linker designed for use in PROTAC (proteolysis-targeting chimeras) synthesis. This compound facilitates the effective conjugation of targeting and E3 ligase recruiting moieties essential for targeted protein degradation. DNP-PEG3-DNP is pivotal in the development of novel therapeutic approaches aimed at modulating protein levels in various biological contexts. -
PROTAC Linker
Thiol-PEG6-acid is a PEG-based linker specifically designed for use in PROTAC (PROteolysis TArgeting Chimeras) synthesis. This compound facilitates the conjugation of target proteins to E3 ligases, promoting targeted degradation via the ubiquitin-proteasome pathway. Its applications extend to advancing research in protein degradation, targeted therapy development, and chemical biology. -
PROTAC Linkers
HS-PEG7-CH2CH2COOH is a polyethylene glycol (PEG)-based linker ideal for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of targeting moieties to ubiquitin ligase components, enhancing the efficacy of targeted protein degradation. It serves as a versatile tool for researchers investigating the modulation of protein levels in various biological systems. -
PROTAC Linkers
m-PEG12-2-methylacrylate is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins with E3 ligases, enhancing the degradation of specific proteins through the ubiquitin-proteasome system. Its application in PROTAC development underscores its importance in studying protein function, cellular signaling pathways, and potential therapeutic interventions. -
PROTAC Linkers
Mal-amido-PEG9-NHS ester is a PEG-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the formation of conjugates by providing a stable chemical connection between target proteins and E3 ligases, thus enhancing targeted protein degradation. Its unique structure supports various biological applications in drug discovery and therapeutic development, making it an essential reagent for researchers exploring novel PROTAC modalities. -
PROTAC Linker
S-acetyl-PEG5-alcohol is a polyethylene glycol (PEG)-based linker specifically designed for PROTAC (proteolysis-targeting chimeras) synthesis. This compound enhances the solubility and pharmacokinetic properties of PROTAC molecules, enabling targeted degradation of proteins. It serves as a valuable tool in chemical biology and drug discovery research, facilitating the development of innovative therapeutic agents. -
PROTAC Linker
N-(Amino-PEG4)-N-bis(PEG4-Boc) is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the development of targeted protein degradation strategies by providing optimal solubility and flexibility in the linker design. N-(Amino-PEG4)-N-bis(PEG4-Boc) is suitable for applications in cellular and molecular research aimed at modulating protein levels and studying associated biological processes. -
PROTAC Linkers
Cl-PEG6-acid is a PEG-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the selective degradation of target proteins by linking E3 ligases to the protein of interest, thus enhancing the therapeutic potential in targeted protein degradation studies. Cl-PEG6-acid is suitable for a range of research applications, including drug discovery and the development of novel therapeutic strategies. -
PROTAC Linkers
1,1,1-Trifluoroethyl-PEG4-aminooxy is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTAC (proteolysis-targeting chimeras). This compound facilitates the conjugation of ligands for targeted protein degradation, enabling selective modulation of protein levels in biological systems. Its unique structure supports efficient and stable interactions, making it suitable for research applications in drug development and cellular biology studies focused on degrading specific proteins. -
PROTAC Linkers
m-PEG3-S-Acetyl is a PEG-derived linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of the targeting ligand to the E3 ubiquitin ligase, enhancing the degradation of specific proteins within cells. Its application is crucial for researchers developing targeted protein degradation technologies to explore cellular mechanisms and therapeutic interventions. -
PROTAC Linkers
TCO-PEG4-TCO is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound plays a crucial role in facilitating the targeted degradation of specific proteins, enabling the development of novel therapeutic strategies. Its application in research underscores its importance in the fields of protein modulation and targeted therapy. -
PROTAC Linkers
m-PEG5-Boc is a PEG-based PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound effectively enhances the solubility and stability of the PROTAC molecule, promoting efficient protein degradation. It is particularly valuable in chemical biology research for the development of targeted protein degradation strategies. -
PROTAC Linkers
Boc-NH-PEG20-CH2CH2COOH is a PEG-derived linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the recruitment of E3 ligases to specific target proteins, enabling targeted degradation pathways. Its unique chemical structure enhances solubility and stability, making it an essential tool for researchers investigating ubiquitin-proteasome system modulation and targeted protein degradation applications. -
PROTAC Linkers
Iodoacetyl-PEG4-NHS ester is a PEG-based linker designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound contains an iodoacetyl group that facilitates efficient conjugation to target proteins, enabling targeted degradation through the ubiquitin-proteasome system. Its versatility in forming stable linkages makes it valuable for researchers investigating targeted protein degradation and related therapeutic applications. -
PROTAC Linker
Boc-aminooxy-PEG2-propargyl is a PEG-based linker designed for the synthesis of PROTACs (proteolysis-targeting chimeras). It features an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. This compound is essential for developing targeted protein degradation strategies and facilitates the construction of complex molecular architectures in chemical biology research. -
PROTAC Linker
N-(Aminooxy-PEG3)-N-bis(PEG4-Boc) is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of a target protein to an E3 ligase, enabling targeted protein degradation. Its construction of aminooxy and Boc-protected entities allows for functionalization and versatility in drug design, making it a valuable tool for researchers exploring targeted therapies and protein modulation. -
PROTAC Linker
Ethyl-PEG4-alcohol is a polyethylene glycol (PEG)-based linker utilized in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound enhances solubility and facilitates the efficient conjugation of a target protein ligand with an E3 ligase ligand, enabling selective degradation of target proteins. It is primarily applied in chemical biology and drug discovery to investigate protein function and modulation. -
SMARCA2 PROTAC degrader
PROTAC SMARCA2 degrader-17 (compound I-290) is a potent PROTAC degrader designed to selectively target and degrade the SMARCA2 protein. It demonstrates effective degradation in A549 cells with a DC50 value of less than 100 nM and achieves a maximum degradation rate exceeding 90% after 24 hours of treatment. This reagent is valuable for research in cancer biology and the investigation of SMARCA2-related pathways. -
SMARCA2 PROTAC degrader
PROTAC SMARCA2 degrader-16 (compound I-278) is a PROTAC designed to selectively degrade the SMARCA2 protein. It demonstrates significant biological activity by efficiently reducing SMARCA2 levels in A549 cells, achieving a DC50 value of less than 100 nM and a maximum degradation rate exceeding 90% after 24 hours of treatment. This compound is invaluable for research applications involving the modulation of SMARCA2 in cancer biology and therapeutic development. -
SMARCA2 Degrader
PROTAC SMARCA2 degrader-25 is a potent heterobifunctional molecule that targets SMARCA2 for degradation via the proteasome pathway. With a DC50 value of less than 0.01 μM, this compound efficiently engages the target protein using a specific ligand, a link to facilitate the interaction, and an E3 ligase ligand to promote ubiquitination. Its high efficiency makes it a valuable tool in investigating the role of SMARCA2 in various biological processes and diseases. -
SMARCA2/4 PROTAC degrader
PROTAC SMARCA2/4-degrader-32 is a PROTAC degrader that targets SMARCA2 and SMARCA4 proteins. It demonstrates effective degradation of these proteins in A549 cells, achieving DC50 values below 100 nM and a maximum degradation rate exceeding 90% after 24 hours of treatment. This compound is suitable for research applications focusing on the regulation of chromatin remodeling and its implications in various cancers. -
SMARCA2/4 PROTAC degrader
PROTAC SMARCA2/4-degrader-16 (compound I-337) is a potent PROTAC degrader designed to selectively target and degrade SMARCA2 and SMARCA4 proteins. It demonstrates significant biological activity in A549 cells, achieving DC50 values of less than 100 nM and over 90% maximum degradation rate (Dmax%) after 24 hours of treatment. This compound is valuable for research applications focused on understanding the role of SMARCA2 and SMARCA4 in tumor biology and for exploring targeted protein degradation strategies. -
SMARCA2 PROTAC degrader
PROTAC SMARCA2 degrader-12 is a molecule specifically designed to induce degradation of the SMARCA2 protein. This PROTAC exhibits potent biological activity, effectively degrading SMARCA2 proteins in A549 cells with a DC50 value of less than 100 nM and achieving over 90% maximum degradation after 24 hours of treatment. This reagent is suitable for research applications focusing on targeted protein degradation and the functional analysis of SMARCA2 in cancer biology. -
Molecular Glue Degrader
(S)-dHTC1 is a molecular glue degrader that targets the transcriptional co-activator ENL. This compound exhibits high-affinity binding to the E3 ligase upon forming the ENL:dHTC1 complex, with an IC50 value of 93 nM. In MV4;11 cells, (S)-dHTC1 effectively degrades ENL, demonstrating a DC50 value of 26 nM. This reagent is valuable for studying mechanisms in acute myeloid leukemia. -
AR PROTAC Degrader
TD-802 is an androgen receptor (AR) PROTAC degrader that demonstrates substantial microsomal stability. It exhibits notable antitumor efficacy in vivo, making it a valuable tool for investigating metastatic castration-resistant prostate cancer. This compound is essential for research aimed at understanding AR modulation and its impacts on cancer progression. -
SMARCA2/4 Degrader
PROTAC SMARCA2/4-degrader-35 is an efficient degrader targeting the SMARCA2 and SMARCA4 proteins, demonstrating a DC50 of less than 2.5 nM. This compound promotes the ubiquitination and subsequent degradation of the target proteins via the recruitment of E3 ligases. Its potent biological activity makes it valuable for research applications focused on epigenetics and cancer biology, particularly in studies targeting the modulation of chromatin remodeling complexes. -
SMARCA2 PROTAC degrader
PROTAC SMARCA2 degrader-14 is a targeted protein degradation compound designed to selectively degrade the SMARCA2 protein. Demonstrating a DC50 value of less than 100 nM, it achieves maximum degradation rates exceeding 90% in A549 cells following a 24-hour treatment. This reagent serves as a valuable tool for research applications focused on elucidating the role of SMARCA2 in various biological processes and therapeutic contexts. -
HaloTag PROTAC Degrader
Chlorohexane-PEG-clozapine is a HaloTag PROTAC degrader that employs clozapine to selectively target and promote the degradation of HaloTag fusion proteins. It effectively reduces luminescence intensity and decreases the protein levels of Halo-Eluc, facilitating the study of target protein dynamics and function. This reagent is valuable for research applications focusing on targeted protein degradation and modulation of protein levels in cellular systems. -
MAGE-A3 PROTAC Degrader
KL-465 is a PROTAC degrader designed to target and degrade MAGE-A3, exhibiting a DC50 of 2 μM in HeLa cells. This compound effectively inhibits the viability of MAGE-A3 positive cancer cell lines, including HCT116, A375, and HeLa, making it a valuable tool for cancer research. Its unique mechanism facilitates targeted protein degradation, offering potential insights into therapeutic interventions for tumors expressing MAGE-A3. -
SMARCA2/4 PROTAC Degrader
PROTAC SMARCA2/4 degrader-41 is a potent degrader targeting the SMARCA2 and SMARCA4 proteins, exhibiting DC50 and IC50 values both below 0.1 μM. This compound facilitates the selective degradation of these ATP-dependent chromatin remodelers, making it a valuable tool for studying SMARCA2/4-related or SMARCA2/4-deficient cancers. Its application in cancer research can aid in elucidating the role of these proteins in tumorigenesis and therapeutic resistance. -
DYRK2 PROTAC Degrader
PROTAC DYRK2 degrader 1 is a selective degrader targeting DYRK2, functioning through the ubiquitin-proteasome system. It exhibits DC50 values of 1.607 μM in MDA-MB-231 cells and 3.265 μM in HeLa cells, effectively inducing DYRK2 degradation. This compound is valuable for research focused on triple-negative breast cancer and cervical cancer, facilitating the exploration of targeted protein degradation mechanisms in these malignancies. -
PROTAC ERα Degrader
PROTAC ERα Degrader-7 is a highly effective degradative compound specifically targeting estrogen receptor alpha (ERα). It operates through a PROTAC mechanism and exhibits a DC50 value of 0.000006 µM, demonstrating its potent biological activity. This compound features a cereblon-binding moiety and an ERα-binding ligand, characterized by a benzofused partially saturated six-membered carbocyclic or heterocyclic ring structure. PROTAC ERα Degrader-7 is valuable for research applications focused on hormone signaling and therapeutic strategies in hormone-responsive cancers. -
PROTAC ERα Degrader
NEP168 is a potent ERα PROTAC degrader that utilizes the GID4 E3 ligase for targeted protein degradation. This compound effectively reduces ERα levels, offering valuable insights into estrogen receptor-related signaling pathways. NEP168 serves as a crucial tool for investigating breast cancer biology and may aid in the development of novel therapeutic strategies.
