Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
Br-PEG6-CH2COOtBu is a PEG-based linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound facilitates the connection between a target protein ligand and an E3 ligase ligand, enhancing targeted protein degradation. Its primary application lies in drug discovery and development, particularly in the design of novel therapeutics that harness the ubiquitin-proteasome system. -
PROTAC Linker
Bromo-PEG5-phosphonic acid is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins by linking inhibitors to E3 ligases, enhancing their therapeutic potential. It serves as a valuable tool in the development of targeted protein degradation strategies for various research applications, including cancer therapeutics and cellular signaling studies. -
PROTAC Linkers
1,3-Bis-aminooxy propane is an alkyl chain-based PROTAC linker that facilitates the construction of Proteolysis Targeting Chimeras (PROTACs). This compound is designed to enhance the selective degradation of target proteins through the ubiquitin-proteasome system. Its application in chemical biology research aids in exploring cellular pathways and the development of novel therapeutic agents. -
PROTAC Linker
THP-PEG9-THP is a polyethylene glycol (PEG)-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the efficient and selective degradation of target proteins through CRBN-mediated ubiquitination. It is essential for researchers exploring targeted protein degradation strategies in various cellular and in vivo models. -
PROTAC Linker
Propargyl-PEG3-phosphonic acid is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. Its utility in connecting target proteins with E3 ligases makes it valuable for researchers exploring targeted protein degradation pathways. -
PROTAC Linkers
Tos-PEG13-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the creation of bifunctional molecules that selectively target and degrade specific proteins within cells. Its application is crucial for therapeutic development in cancer research and the study of protein regulation mechanisms. -
PROTAC Linker
N-(Boc-PEG5)-N-bis(PEG4-acid) is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the development of PROTAC molecules by providing solubility and stability, enhancing their effectiveness in targeted protein degradation studies. Its application spans the design of innovative therapeutic agents aimed at modulating specific protein interactions within cellular systems. -
PROTAC Linkers
CHO-C-PEG2-C-CHO is a PEG-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the effective recruitment of E3 ligases and enhances the targeted degradation of specific proteins, making it a valuable tool in drug development and protein modulation studies. Its unique structure allows for flexibility and stability in the formation of bifunctional agents, supporting various research applications in targeted protein degradation and cellular signaling pathways. -
PROTAC Linker
Acid-PEG2-ethyl propionate is a polyethylene glycol (PEG)-based linker specifically designed for PROTAC (Proteolysis Targeting Chimera) applications. This compound facilitates the synthesis of PROTACs by enhancing the solubility and stability of the resultant conjugates. It is ideal for research focused on targeted protein degradation and the development of innovative therapeutic strategies. -
PROTAC Linker
t-Boc-aminooxy-PEG6-propargyl is a PEG-based linker designed for use in the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an alkyne group that enables its participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions, making it a versatile tool in chemical biology. Its ability to efficiently link various functional groups broadens its applications in drug discovery and development. -
PROTAC Linker
Ald-Ph-amido-PEG2-C2-Boc is a PEG-based PROTAC linker designed for the synthesis of targeted protein degraders. This compound facilitates the conjugation of small molecules to E3 ligases, enabling efficient ubiquitination and subsequent proteasomal degradation of specific proteins. Its application in PROTAC development supports research in targeted therapy and drug discovery by enhancing the specificity and efficacy of protein modulation. -
PROTAC Linker
Bis-PEG4-t-butyl ester is a PEG-based linker specifically designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the conjugation of targeting ligands to E3 ligases, enabling the selective degradation of target proteins. Its unique structure enhances the pharmacokinetic properties of resulting PROTACs, making it a valuable tool for research in targeted protein degradation and drug discovery. -
PROTAC Linker
Methyltetrazine-propylamine is a versatile PROTAC linker that facilitates the construction of proteolysis-targeting chimeras (PROTACs). This linker features an alkyl chain structure, enhancing the stability and functionality of the resulting conjugates. It is ideal for researchers focusing on targeted protein degradation and the development of innovative therapeutic modalities for various diseases. -
PROTAC Linkers
Ms-PEG6-MS is a PEG-based PROTAC linker designed for facilitating the synthesis of PROTAC molecules. This compound enables the efficient conjugation of target-binding moieties to E3 ligase recognition elements, thereby promoting targeted protein degradation. It is commonly utilized in chemical biology research to study protein interactions and develop novel therapeutic agents that harness the ubiquitin-proteasome system. -
PROTAC Linkers
NH-bis-PEG5 is a polyethylene glycol (PEG) linker designed for use in the synthesis of PROTACs (PROteolysis TArgeting Chimeras). Its unique structure facilitates the construction of bifunctional molecules that selectively target proteins for ubiquitination and subsequent degradation. This compound is instrumental in advancing research in targeted protein degradation therapies and investigating cellular processes involving protein modulation. -
PROTAC Linkers
Bis-PEG7-t-butyl ester is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (proteolysis targeting chimera) synthesis. This compound facilitates the development of novel PROTACs by providing a flexible and soluble linker that enhances target protein degradation. It is valuable in drug discovery and development research, particularly in studies focused on targeted protein modulation and therapeutic strategies. -
PROTAC Linkers
Bis-PEG25-acid is a polyethylene glycol (PEG) based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the development of innovative therapeutics by enhancing the solubility and stability of the resulting PROTACs. Its ability to connect ligands and promote targeted protein degradation makes it a valuable tool in drug discovery and chemical biology research. -
PROTAC Linker
m-PEG16-alcohol is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the formation of PROTACs that enable targeted protein degradation, thereby providing a valuable tool for dissecting protein function and understanding disease mechanisms. Its application is particularly relevant in the development of novel therapeutic strategies for various biomedical research fields, including cancer and neurodegenerative disorders. -
PROTAC Linkers
Mal-amide-PEG2-oxyamine-Boc is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. It facilitates the conjugation of target proteins for degradation, enabling specific modulation of protein levels in cellular contexts. This compound is essential for developing targeted protein degradation strategies in drug discovery and therapeutic applications. -
PROTAC Linkers
Hydroxy-PEG24-Boc is a poly(ethylene glycol)-based linker specifically designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound enhances the solubility and cellular uptake of PROTAC molecules, facilitating targeted protein degradation. Its application is crucial in the development of innovative therapies aimed at modulating protein levels within various biological pathways. -
PROTAC Linker
Biotinyl-NH-PEG3-C3-amido-C3-COOH (DIPEA) is a PEG-based linker specifically designed for proteolysis-targeting chimeras (PROTACs). This compound enables the conjugation of a biotin moiety for enhanced target engagement and recruitment of E3 ligases. It is a valuable tool for researchers working on targeted protein degradation and therapeutic applications in cellular biology. -
PROTAC Linker
Boc-NH-C3-O-Ph(NO2)-methylester-O-pyrrolidine-2,5-dione is a versatile linker designed for the synthesis of PROTACs, specifically utilized in the development of BRD4 Degrader-26. This compound enables the assembly of targeted protein degraders, facilitating the selective ubiquitination and subsequent degradation of BRD4 protein. Its application in chemical biology research supports the exploration of targeted therapies and novel approaches to modulate protein levels in various disease contexts. -
PROTAC Linker
N-Boc-N-bis(PEG3-NHS ester) functions as a PEG-based PROTAC linker, facilitating the design and synthesis of PROTAC molecules. This compound enhances the solubility and stability of PROTACs, thereby improving their efficacy in targeted protein degradation studies. Its unique structure allows for the formation of stable conjugates, making it a valuable tool in chemical biology and drug discovery applications. -
PROTAC Linker
Propargyl-PEG3-phosphonic acid diethyl ester is a versatile PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This reagent features an alkyne group that enables its participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc), facilitating the efficient conjugation of azide-containing molecules. The incorporation of this linker enhances the stability and bioactivity of resulting PROTACs, making it valuable in targeted protein degradation studies and related research applications. -
PROTAC Linkers
THP-PEG8-OH is a polyethylene glycol (PEG)-derived linker designed for use in the synthesis of PROTAC (proteolysis-targeting chimeras). This compound facilitates the formation of PROTACs by providing a flexible and hydrophilic spacer, enhancing the efficacy and solubility of the resultant bioconjugates. THP-PEG8-OH is primarily employed in chemical biology research to study targeted protein degradation and to develop novel therapeutics. -
PROTAC Linkers
Bis-PEG25-TFP ester is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound features a TFP (trifluoroethyl phthalimide) moiety that facilitates the conjugation of target proteins to ubiquitin ligases, promoting their degradation via the cellular ubiquitin-proteasome system. Bis-PEG25-TFP ester is essential for the development of targeted protein degradation therapies and supports various applications in chemical biology and drug discovery research. -
PROTAC Linkers
Mal-amido-PEG9-amine is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the targeted degradation of proteins by connecting ligands to E3 ubiquitin ligases, thereby enhancing the selectivity and efficacy of PROTAC molecules. Its effective application in chemical biology allows researchers to investigate protein function and develop new therapeutic strategies. -
PROTAC Linker
N-Boc-N-bis(PEG4-NHS ester) is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of proteins or small molecules, enhancing their solubility and stability. Its primary applications include drug development and targeted degradation research, making it a valuable tool for investigations into protein regulation and cellular mechanisms. -
PROTAC Linker
PEG2-Cl is a polyethylene glycol-based PROTAC linker designed to facilitate the synthesis of targeted proteolysis-targeting chimeras (PROTACs). This compound enhances the stability and solubility of PROTACs, allowing for improved cellular uptake and efficacy. PEG2-Cl is pivotal in the development of novel therapeutic agents aimed at modulating protein degradation for various research applications in drug discovery and development. -
PROTAC Linker
Thiol-C9-PEG7 is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates target protein degradation by enabling the conjugation of ligands to E3 ligases, thereby promoting the selective ubiquitination of specific proteins. Its application is essential in research focused on targeted protein degradation and the development of innovative therapeutic strategies. -
PROTAC Linker
Tos-PEG3-CH2COOH is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enhancing targeted protein degradation. Its flexible structure and solubility make it suitable for various research applications in drug discovery and development, particularly in investigating protein interactions and cellular pathways. -
PROTAC Linker
1-Isothiocyanato-PEG4-alcohol is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the conjugation of target proteins with E3 ligases, thereby enhancing proteolytic degradation pathways. It is suitable for applications involving targeted protein degradation research and the development of novel therapeutic agents. -
PROTAC Linker
DBCO-NH-Boc is a PROTAC linker featuring a dibenzocyclooctyne (DBCO) moiety that enables efficient synthesis of PROTACs through click chemistry. This compound facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, providing a versatile approach for targeted protein degradation research. Its unique structure enhances connectivity and stability, making it suitable for various applications in chemical biology and drug discovery. -
PROTAC Linkers
Methyl-PEG4-acyl chloride is a PEG-derived compound that serves as an effective linker for PROTAC (proteolysis-targeting chimera) synthesis. Its primary mechanism involves facilitating the assembly of bifunctional molecules designed to induce targeted protein degradation. This reagent is essential for researchers developing PROTACs to explore the modulation of protein function and cellular pathways in various biological contexts. -
PROTAC Linkers
Br-PEG7-NHBoc is a PEG-based PROTAC linker designed for the synthesis of proteolysis targeting chimeras (PROTACs). This compound enhances the solubility and stability of PROTACs, facilitating their application in targeted protein degradation studies. It can be utilized in various research contexts, including drug discovery and novel therapeutic development, targeting specific proteins for degradation. -
PROTAC Linker
Hydroxy-PEG2-C2-sulfonic acid is a PEG-based linker designed specifically for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the targeted degradation of specific proteins within cells, enabling researchers to explore the role of these proteins in various biological processes. Hydroxy-PEG2-C2-sulfonic acid is essential for developing novel therapeutic strategies that harness the power of targeted protein degradation in disease models. -
PROTAC Linkers
Mal-PEG5-Boc is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis-targeting chimeras). This compound facilitates the conjugation of E3 ligases to target proteins, enhancing the degradation of specific proteins through the ubiquitin-proteasome pathway. Its structural attributes make it suitable for a variety of research applications focused on targeted protein degradation and therapeutic development. -
PROTAC Linker
Propargyl-PEG10-Boc is a PEG-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an alkyne group that facilitates the copper-catalyzed azide-alkyne cycloaddition (CuAAc), allowing for efficient conjugation with azide-containing molecules. Its application is essential for advancing research in targeted protein degradation and drug discovery. -
PROTAC Linker
Lipoamido-PEG4-acid is a polyethylene glycol (PEG)-based linker used in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the recruitment of E3 ubiquitin ligases, thereby promoting targeted degradation of specific proteins within cells. Its design enhances solubility and stability, making it a valuable tool in chemical biology and drug discovery applications focused on targeted protein degradation. -
PROTAC linker
N-(Azido-PEG2)-N-bis(PEG4-Boc) is a PEG-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide group that enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. It provides a versatile approach for researchers developing PROTACs, facilitating targeted protein degradation in various biological applications. -
PROTAC Linkers
Azido-PEG4-nitrile functions as a PEG-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). It features an azide group that enables engagement in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing compounds. Additionally, Azido-PEG4-nitrile can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) using dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) moieties. This versatility makes it valuable for researchers aiming to develop targeted degradation strategies in chemical biology. -
PROTAC Linkers
Mal-amido-PEG8-TFP ester is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the formation of covalent bonds between proteins, thereby enabling targeted protein degradation. It is essential for researchers developing PROTACs aimed at modulating protein levels in various biological systems. -
PROTAC Linker
Ethyl-trans-4-benzylcyclohexane-1-carboxylate is a versatile PROTAC linker that plays a critical role in targeted protein degradation applications. This compound facilitates the conjugation of ligands to E3 ligase, promoting the ubiquitination and subsequent degradation of specific target proteins. Its structural features enable the development of efficient PROTAC molecules for various biological research studies, including drug discovery and mechanistic investigations of protein homeostasis. -
PROTAC Linker
Ald-Ph-amido-C2-PEG3-azide is a PEG-based PROTAC linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkynyl compounds, as well as strain-promoted azide-alkyne cycloaddition (SPAAC) reactions with DBCO or BCN-modified molecules. Its versatile reactivity makes it a valuable tool for researchers in the development of targeted protein degradation strategies. -
PROTAC Linker
Bis-PEG3-t-butyl ester serves as a PEG-based linker specifically designed for PROTAC (PROteolysis TArgeting Chimeras) synthesis. This compound facilitates targeted protein degradation by connecting the E3 ligase to the protein of interest, thereby enabling efficient manipulation of cellular protein levels. Its structural features enhance solubility and biocompatibility, making it an essential tool for research into targeted therapies and protein regulation in various biological contexts. -
PROTAC Linker
N-(Azido-PEG3)-N-bis(PEG3-acid) is a PEG-based linker specifically designed for PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound features an azide group that allows it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-bearing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions utilizing DBCO or BCN groups. Its versatility in click chemistry enables efficient labeling and tissue targeting, making it a valuable tool for drug discovery and protein degradation studies. -
PROTAC Linkers
N-(Mal-PEG6)-N-bis(PEG3-amine) is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the conjugation of target proteins to E3 ligases, promoting ubiquitination and subsequent degradation. It plays a crucial role in the development of targeted protein degradation strategies, making it valuable for research in cellular signaling and disease therapeutics. -
PROTAC Linkers
m-PEG3-S-PEG1-C2-Boc is a PEG-based PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the solubility and stability of PROTAC constructs, thereby improving their biological activity in target protein degradation studies. Its functionality supports research applications in targeted protein degradation, enabling researchers to explore novel therapeutic strategies in various diseases. -
PROTAC Linkers
Trityl-PEG10-azide is a PEG-based linker specifically designed for the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an azide functional group that allows for efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, Trityl-PEG10-azide can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-modified compounds, making it a versatile tool for chemical biology applications in PROTAC development. -
PROTAC Linker
Propargyl-PEG3-methyl ester is a PEG-based linker designed for use in the synthesis of PROTACs, utilizing its alkyne functionality. This compound can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), facilitating the conjugation of azide-containing molecules. Its structural properties make it suitable for advancing studies in targeted protein degradation and related therapeutic applications, enhancing the versatility and efficacy of PROTAC design.
