Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
DBCO-NHCO-PEG5-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, enabling efficient conjugation. Its unique properties make it suitable for applications in targeted protein degradation research and the development of novel therapeutic strategies. -
PROTAC Linker
Bromoacetamido-C2-PEG2-NH-Boc is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the effective delivery of E3 ligases to target proteins, enhancing the targeted protein degradation pathway. Its structural properties support the development of novel therapeutic agents aimed at modulating protein levels within cellular systems, thereby serving as a valuable tool in chemical biology and drug discovery research. -
PROTAC Linker
Boc-azetidine-2C-oxotetrahydropyrimidin-bromophenyl serves as an effective PROTAC linker, facilitating the formation of targeted protein degraders. This compound plays a crucial role in the synthesis of the PROTAC GSPT1 degrader-1, enabling the selective degradation of specific proteins of interest. Its application in chemical research enhances the development of therapies aimed at modulating protein levels in various biological contexts. -
PROTAC Linkers
m-PEG8-O-alkyne is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an alkyne functional group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc), enabling the effective conjugation of azide-containing molecules. m-PEG8-O-alkyne is instrumental in the development of targeted protein degradation strategies, making it valuable for probing cellular mechanisms and therapeutic interventions in various biological contexts. -
PROTAC Linkers
m-PEG8-ethoxycarbonyl-propanoic acid serves as a PEG-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features a unique ethoxycarbonyl group that enhances solubility and stability, facilitating efficient conjugation to target proteins. It plays a crucial role in targeted protein degradation research and can be utilized in various applications, including drug development and the study of protein homeostasis. -
PROTAC Linkers
Tetra(cyanoethoxymethyl) methane is a versatile PROTAC linker characterized by its alkyl chain structure. This compound facilitates the synthesis of proteolysis-targeting chimeras (PROTACs), enabling selective degradation of targeted proteins through the ubiquitin-proteasome pathway. Its application is crucial in advancing research in targeted protein degradation and drug discovery. -
PROTAC Linker
OMs-PEG2-NHAlloc-PEG2-Boc is a versatile PROTAC linker designed for targeted protein degradation applications. This compound facilitates the synthesis of PROTACs, including the specific SMARCA2/4-degrader-28, enabling the selective modulation of protein levels in cellular models. Its unique structure allows for efficient conjugation, contributing to the advancement of targeted therapies in chemical biology research. -
PROTAC Linker
Triethylene glycol monododecyl ether is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enabling the selective degradation of specific proteins within cells. Its application in research is crucial for the advancement of targeted protein degradation strategies in drug discovery and development. -
PROTAC Linker
Chloroacetamido-C4-NHBoc is an alkyl/ether-based linker specifically designed for use in proteolysis-targeting chimeras (PROTACs). This compound facilitates the formation of PROTACs by serving as a versatile connector between the target protein and an E3 ligase, enabling targeted protein degradation. Its unique structural properties enhance the efficacy of PROTACs in various biochemical applications, providing researchers with a valuable tool for studying protein function and cellular processes. -
PROTAC Linker
Ald-C2-PEG4-azide serves as a PEG-based PROTAC linker, facilitating the synthesis of PROTAC compounds. This compound features an azide functional group enabling its participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups, making it a versatile tool for bioconjugation and targeted protein degradation studies. -
PROTAC Linkers
Azido-PEG11-CH2COOH is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features an azide group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-functionalized molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-containing compounds, making it a versatile tool for targeted protein degradation studies and related biological research applications. -
PROTAC Linker
Bis-propargyl-PEG12 is a PEG-based linker designed for the synthesis of PROTACs, facilitating the development of targeted protein degradation strategies. This compound features an alkyne group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its unique chemistry supports the assembly of bifunctional drug conjugates, making it a valuable tool in chemical biology and therapeutic research applications. -
PROTAC Linker
Trityl-PEG8-azide is a PEG-based linker specifically designed for PROTAC synthesis, facilitating targeted protein degradation. This compound features an azide group, enabling its use in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-functionalized molecules. Additionally, it supports strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds, making it a versatile tool in chemical biology and drug development research. -
PROTAC Linker
Acid-PEG6-mono-methyl ester is a polyethylene glycol (PEG)-based linker specifically designed for use in PROTAC synthesis. This compound facilitates targeted protein degradation by enabling the formation of bifunctional degraders that engage with E3 ligases and their protein targets. Its versatile structure supports a range of research applications in drug discovery and the development of novel therapeutic agents. -
PROTAC Linker
endo-BCN-PEG4-Boc is a PEG-based PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the solubility and stability of PROTACs, thereby improving their pharmacokinetic properties. It is essential for research applications involving targeted protein degradation, allowing for the selective modulation of protein levels within cells. -
PROTAC linker
N-(m-PEG4)-N'-(Biotin-PEG2-amido-PEG4)-Cy5 is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the targeted degradation of specific proteins by linking E3 ligases with the substrate of interest. Its biotin moiety allows for easy detection and purification, making it valuable for research applications in protein studies and drug development. -
PROTAC Linker
m-PEG4-phosphonic acid ethyl ester is a polyethylene glycol (PEG)-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). It facilitates the selective degradation of target proteins by recruiting E3 ligases, thus offering a powerful tool for investigating protein function and disease mechanisms. This compound is essential for researchers developing PROTACs aimed at targeted protein degradation in various biological studies. -
PROTAC Linker
Chloro-PEG5-chloride is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins and E3 ligases, enhancing the development of targeted protein degradation strategies. Chloro-PEG5-chloride is an essential tool for researchers investigating the modulation of protein levels for therapeutic applications. -
PROTAC Linker
Benzyl-PEG6-azide is a polyethylene glycol (PEG)-based reagent designed as a PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide functional group which enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with dibenzocyclooctyne (DBCO) or bicyclo[6.1.0]non-4-yne (BCN) derivatives, making it a versatile tool in chemical biology for targeted protein degradation studies. -
PROTAC Linkers
N-Boc-N-bis(PEG3-acid) is a polyethylene glycol (PEG)-based PROTAC linker that facilitates the targeted degradation of proteins through the recruitment of E3 ligases. This compound is essential for the development of PROTACs, enabling efficient target modulation and enabling studies in cellular pathways. Its unique structural properties enhance solubility and improve pharmacokinetic profiles, making it a valuable tool for researchers in chemical biology and drug discovery. -
PROTAC Linkers
SPDP-PEG12-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of targeting ligands to E3 ligase recruiters, enhancing targeted protein degradation. It is primarily utilized in research applications focused on protein regulation and degradation pathways, providing a tool for innovative therapeutic strategies in cancer and other diseases. -
PROTAC Linker
Hydroxy-PEG3-acrylate is a polyethylene glycol (PEG)-based linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligase, enhancing selective degradation pathways. Its versatility makes it a valuable tool in chemical biology research, particularly in studies focused on targeted protein degradation and drug discovery. -
PROTAC linker
N-(m-PEG4)-N'-(m-PEG4)-O-(m-PEG4)-O'-(azide-PEG4)-Cy5 functions as a PEG-based PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound is equipped with an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. Additionally, it supports strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, making it a versatile tool for chemical biology applications in targeted protein degradation research. -
PROTAC Linker
Aminooxy-PEG8-acid is a PEG-based linker designed for Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the construction of PROTACs by providing a versatile connection to E3 ligases and target proteins. Its enabling role in the development of targeted protein degradation strategies makes it a valuable tool in chemical biology research, especially for studying protein dynamics and therapeutic interventions. -
PROTAC Linker
PEG7-O-MS is a polyethylene glycol (PEG) based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the effective recruitment of E3 ligases to target proteins, thereby enhancing the degradation of unwanted cellular proteins. PEG7-O-MS is crucial for researchers focused on targeted protein degradation and drug discovery applications. Its utilization aids in the development of innovative therapeutic strategies by enabling selective ubiquitination and proteosomal degradation of target proteins. -
PROTAC Linker
m-PEG4-amino-Mal is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It features a terminal maleimide group for efficient ligation to thiol-containing proteins or peptides, facilitating targeted protein degradation. This versatile linker is suitable for various applications in drug discovery and development, particularly in the study of protein functions and the investigation of novel therapeutic strategies. -
PROTAC Linker
N-(Biotin-PEG4)-N-bis(PEG4-Boc) is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound enables the covalent attachment of biotin and facilitates the effective degradation of target proteins through the ubiquitin-proteasome system. Its application spans across studies in targeted protein degradation and therapeutic development, making it a valuable tool in chemical biology research. -
PROTAC Linker
Boc-PEG2-sulfonic acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the effective coupling of target proteins to E3 ligases, enhancing the development of novel therapeutic agents through targeted protein degradation. Its application plays a significant role in advancing pharmacological research and drug discovery. -
PROTAC Linker
3-(Dimethoxymethyl)-1-oxa-8-azaspiro[4.5]decane serves as a versatile PROTAC linker, enabling the development of targeted protein degradation strategies. This compound plays a crucial role in facilitating the selective degradation of specific proteins within cellular systems. Its application is significant in research focusing on therapeutic interventions that utilize the ubiquitin-proteasome system for protein modulation. -
PROTAC Linker
m-PEG8-Mal is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This reagent facilitates the conjugation of a target protein ligand to an E3 ligase ligand, enabling the targeted degradation of specific proteins within cells. It is instrumental in research applications focusing on targeted protein modulation and therapeutic development through the PROTAC technology. -
PROTAC Linker
Azido-PEG1-C1-Boc is a versatile PROTAC linker that facilitates the synthesis of targeted protein degraders. Featuring an azide group, this compound is compatible with copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, and can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. Its unique reactivity and functionalization capabilities make it an essential tool in chemical biology and drug development research. -
PROTAC Linker
1,4-Dimethylpiperidine functions as a versatile PROTAC linker, facilitating the formation of targeted protein degradation complexes. Its unique structural attributes enhance the efficiency of targeting various proteins for degradation in cellular systems. This compound is significant in studies focused on degradative therapeutics and the discovery of novel treatments through targeted protein modulation. -
PROTAC Linker
Carboxy-PEG4-phosphonic acid ethyl ester is a PEG-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the targeted degradation of specific proteins through the ubiquitin-proteasome system, enabling innovative strategies in drug discovery and cellular research. Its unique chemical properties make it an essential component for developing advanced therapeutic modalities in various biological applications. -
PROTAC Linker
Methyl acetate-PEG1 is a PEG-based PROTAC linker designed to facilitate the development of Proteolysis Targeting Chimeras (PROTACs). This compound enables the effective conjugation of targets to E3 ligases, enhancing the degradation of specific proteins within cells. It is suitable for research applications involving targeted protein degradation, offering a versatile tool for pharmaceutical and biochemical studies. -
PROTAC Linker
Propargyl-PEG2-Tos is a PEG-based PROTAC linker specifically designed for the synthesis of PROTACs. This compound features an alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. It serves as an essential tool for researchers exploring targeted protein degradation and expanding the capabilities of PROTAC technology in therapeutic applications. -
PROTAC Linker
Aminooxy-PEG3-C2-Boc is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound features an aminooxy functionality that facilitates the conjugation of target proteins, enhancing the selective degradation of specific proteins by cellular proteasomes. It is primarily utilized in chemical biology research to develop novel PROTACs for targeted protein degradation studies. -
PROTAC Linker
Bromo-PEG2-phosphonic acid serves as a PEG-based linker for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the covalent attachment of the ubiquitin-proteasome system to target proteins, enabling selective degradation through targeted protein elimination. Its utility in PROTAC development makes it an essential reagent for researchers focusing on protein modulation and therapeutic applications in cancer and other diseases. -
PROTAC Linker
Pyrene-amido-PEG4-CH2CH2COOH is a PEGylated linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound facilitates the assembly of PROTACs by connecting a targeting moiety to an E3 ligase, promoting ubiquitin-mediated degradation of specific proteins. Its unique structural properties enhance solubility and cellular uptake, making it suitable for exploring targeted protein degradation in various biological research contexts. -
PROTAC Linker
m-PEG3-Sulfone-PEG3-azide is a PEG-based linker specifically designed for PROTAC synthesis. Featuring an azide functional group, this compound enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing substrates. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN moieties, facilitating the development of innovative targeted protein degradation strategies in chemical biology research. -
PROTAC Linker
m-PEG20-alcohol is a polyethylene glycol (PEG) based linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). It facilitates the conjugation of protein targets to E3 ligases, enhancing the development of targeted protein degradation strategies. This reagent is essential for researchers studying protein modulation and degradation pathways as well as designing novel therapeutic agents in drug discovery. -
PROTAC Linker
TCO-amine is an alkyl chain-based linker designed for the synthesis of PROTACs (proteolysis-targeting chimeras). As a click chemistry reagent, TCO-amine features a TCO group that participates in inverse electron demand Diels-Alder (iEDDA) reactions with Tetrazine-containing molecules. This allows for precise conjugation in the development of targeted protein degradation strategies, facilitating studies in cellular biology and therapeutic applications. -
PROTAC Linker
m-PEG4-Hydrazide is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). Its unique hydrazide functionality facilitates the conjugation of target proteins with E3 ubiquitin ligases, thereby promoting targeted protein degradation. This compound is an essential tool for researchers exploring targeted therapy and studying protein regulation mechanisms. -
PROTAC Linkers
DBCO-NH-(CH2)4COOH is a Proximity-Activated Linker (PROTAC) that facilitates targeted protein degradation by linking target proteins to E3 ligases. This compound features a DBCO functional group, which enables efficient reaction through strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its use in PROTAC synthesis supports research in protein modulation and therapeutic development, providing a versatile tool for advancing insights in cellular biology and drug discovery. -
PROTAC Linker
Cbz-NH-PEG8-C2-acid is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (proteolysis-targeting chimeras) synthesis. This compound facilitates the development of targeted protein degradation strategies by connecting a ligand for the protein of interest with an E3 ligase. Its hydrophilic properties enhance solubility and improve pharmacokinetic profiles, making it a valuable tool for researchers in the field of targeted therapeutics. -
PROTAC Linker
Bis-propargyl-PEG2 is a PEG-based PROTAC linker designed for the synthesis of PROTACs. It facilitates the creation of demethylvancomycin dimers through its reactive alkyne groups. This reagent is a versatile click chemistry tool, participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc), allowing for the incorporation of azide-containing molecules into complex biological systems. -
PROTAC linker
N-(m-PEG4)-N'-(azide-PEG4)-Cy3 is a PEG-based linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimeras). This molecule features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing substrates, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN functionalities. Its efficient coupling capabilities make it valuable for advancing research in targeted protein degradation and the development of therapeutic modalities. -
PROTAC Linker
S-acetyl-PEG2-Boc is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (Proteolysis Targeting Chimeras) applications. This compound facilitates the synthesis of PROTACs, enabling targeted ubiquitination and degradation of specific proteins within cellular systems. Its structure enhances solubility and provides flexibility, making it suitable for optimizing the efficacy of targeted protein degradation studies in drug discovery and development. -
PROTAC Linker
Biotin-PEG12-acid is a biotin-conjugated polyethylene glycol (PEG) linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This linker facilitates enhanced target degradation by connecting E3 ligases to specific proteins, enabling targeted protein degradation. Its versatile structure allows for streamlined development of PROTACs aimed at studying protein function and therapeutic interventions in various diseases. -
PROTAC Linker
m-PEG9-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It facilitates the conjugation of biomolecules, enhancing the efficiency of target protein degradation. This compound is valuable in the development of novel therapeutic strategies in targeted protein modulation research. -
PROTAC Linkers
m-PEG4-C6-phosphonic acid ethyl ester functions as a PEG-based linker for PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound enables efficient conjugation of proteins, facilitating targeted protein degradation in cellular systems. It is primarily utilized in the development of novel PROTACs for therapeutic applications in various disease models.
