Sorafenib (Nexavar)

Catalog No.: A10001

Raf inhibitor

Sorafenib (Nexavar) Chemical Structure

CAS NO. 475207-59-1

Sorafenib (Nexavar) is a novel, small molecular inhibitor of several tyrosine protein kinases (VEGFR and PDGFR) and RAF/MEK/ERK cascade inhibitor with an IC50 of 6, 22, 38 nM for Raf-1, wt BRAF and V599E mutant BRAF.

Availability: In stock

Package Price Qty
100 mg
$50.00
10mM * 1mL in DMSO
$60.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Sorafenib (Nexavar) is a novel, small molecular inhibitor of several tyrosine protein kinases (VEGFR and PDGFR) and RAF/MEK/ERK cascade inhibitor with an IC50 of 6, 22, 38 nM for Raf-1, wt BRAF and V599E mutant BRAF.
Targets
Target Value
Raf-1IC50: 6nM
VEGFR2/Flk1IC50: 15nM
B-RafIC50: 22nM
B-Raf(V599E)IC50: 38nM
PDGFRβIC50: 57nM
mPDGFRβIC50: 57nM
FLT3IC50: 58nM
c-KitIC50: 68nM
VEGFR2IC50: 90nM
FGFR1IC50: 580nM
ERK1IC50: >10μM
MEK1IC50: >10μM
EGFRIC50: >10μM
HER2IC50: >10μM
IGF-1RIC50: >10μM
c-MetIC50: >10μM
PKBIC50: >10μM
PKAIC50: >10μM
CDK1/CyclinBIC50: >10μM
PKCαIC50: >10μM
PKCγIC50: >10μM
Pim1IC50: >10μM
In vitro DMSO 63 mg/mL heating (135.53 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.7 mL 78.49 mL 156.99 mL
0.5 mM 3.14 mL 15.7 mL 31.4 mL
1 mM 1.57 mL 7.85 mL 15.7 mL
5 mM 0.31 mL 1.57 mL 3.14 mL

*The above data is based on the productmolecular weight 637. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10001
Actions Inhibitor
M. Wt 637
Formula C21H16ClF3N4O3.C7H8O3S
Solubility DMSO>127mg/mL Water <1mg/mL Ethanol <1mg/mL
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 475207-59-1
Synonyms Bay 43-9006
SMILES CC1=CC=C(C=C1)S(=O)(=O)O.CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F

Product Tags

Product Tags

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
Keywords:buy Sorafenib (Nexavar) | Sorafenib (Nexavar) Supplier | purchase Sorafenib (Nexavar) | Sorafenib (Nexavar) cost | Sorafenib (Nexavar) manufacturer | order Sorafenib (Nexavar) | Sorafenib (Nexavar) distributor | buy 475207-59-1| 475207-59-1 Supplier | purchase 475207-59-1 | 475207-59-1 cost | 475207-59-1 manufacturer | order 475207-59-1 | 475207-59-1 distributor
Rewards