Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
2-[(2-Azidoethoxy-d4)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine is a deuterium-labeled compound that targets dihydropyridine receptors. This stable isotope variant is significant in researching the pharmacokinetics and metabolic pathways of dihydropyridine derivatives. It is particularly valuable in studies involving the pharmacological effects and interactions of calcium channel blockers, facilitating advanced analysis in medicinal chemistry and drug development. -
Pregabalin Impurity
Pregabalin lactam is an impurity of Pregabalin, a compound primarily targeting calcium channels. This metabolite is often utilized in quality control and analytical studies of Pregabalin formulations. Its presence in research can provide insights into compound stability and purity, contributing to a better understanding of Pregabalin's pharmacological profile. -
Na+/Ca2+ Channel Blocker
Flunarizine dihydrochloride is a potent dual blocker of Na+ and Ca2+ channels, specifically targeting T-type calcium channels. This compound exhibits significant anticonvulsant and antimigraine properties, making it valuable for neurological research. Additionally, Flunarizine dihydrochloride demonstrates peripheral vasodilatory effects, enhancing its potential applications in vascular studies. -
SERCA Inhibitor
2,5-Di-tert-butylhydroquinone is a potent inhibitor of Sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), demonstrating an IC50 of 400 nM. This compound disrupts the gating function of Glu309, thereby preventing calcium ions from accessing their binding site. Additionally, 2,5-Di-tert-butylhydroquinone influences the activity of key enzymes such as 5-lipoxygenase and COX-2, with IC50 values of 1.8 μM and 14.1 μM, respectively. It is utilized in research focused on cellular calcium regulation and inflammatory processes. -
Calcium Channel Antagonist
Ginsenoside Ro functions as a calcium channel antagonist, exhibiting an effective antiplatelet activity with an IC50 of 155 µM. This compound notably reduces the production of thromboxane A2 (TXA2) while minimally affecting the activities of cyclooxygenase-1 (COX-1) and thromboxane synthase (TXAS). Ginsenoside Ro is valuable in research related to cardiovascular diseases and platelet aggregation studies. -
Calcium Channels Antagonist
L-Phenylalanine, a competitive antagonist of the α2δ subunit of voltage-dependent calcium channels, exhibits a Ki of 980 nM. It also interacts with glycine- and glutamate-binding sites on N-methyl-D-aspartate receptors (NMDARs), with a KB value of 573 μM. This essential amino acid plays a significant role in various biological processes and is frequently utilized in research concerning neuropharmacology and receptor interactions, as well as in the synthesis of food flavors and pharmaceuticals. -
Calcium Channel Activator
Gomisin J is a lignan derived from Schisandra chinensis that primarily acts as a calcium channel activator. It enhances nitric oxide bioavailability through eNOS activation and regulates lipid metabolism via the AMPK pathway. Additionally, Gomisin J exhibits anti-inflammatory effects by inhibiting fetuin-A and NF-κB, while its activation of Nrf2/HO-1 boosts antioxidant capacity. This compound is relevant for studies focused on hypertension, non-alcoholic fatty liver disease, and cerebral ischemia-reperfusion injury. -
Calcium Channel Antagonist
Praeruptorin E serves as a calcium channel antagonist and is the primary bioactive constituent derived from Peucedanum praeruptorum, commonly known as Bai-Hua Qian Hu. This compound exhibits a pD2′ value of 5.2, indicating its efficacy in inhibiting calcium influx in target cells. Its biological activity makes it a valuable tool for research applications exploring calcium signaling pathways and related physiological processes. -
Calcium Channel Inhibitor
Ethosuximide is a calcium channel inhibitor primarily targeting T-type calcium channels, specifically blocking low voltage-activated currents. This compound is extensively used in research for its anti-epileptic properties as well as its potential therapeutic effects in various neurodegenerative disease models. Ethosuximide facilitates the study of calcium signaling pathways and their involvement in neuronal excitability and degeneration. -
Drug Derivative
(R)-Norverapamil is a pharmacologically active derivative of verapamil, primarily targeting L-type calcium channels. It exhibits significant cardiovascular effects, including the modulation of heart rate and contractility. This compound is commonly utilized in research focused on cardiac pharmacology, calcium channel modulation, and the investigation of cardiovascular diseases. -
Biochemical Assay Reagents
Lifarizine is an organic compound that targets histamine H1 receptors and calcium channels, playing a role in modulating neurotransmitter release. Its primary applications in biochemical assays include studying cellular signaling pathways and exploring the pharmacological effects of antihistamines. Lifarizine is valuable in life science research for investigating potential therapeutic effects and mechanisms of action in various biological contexts. -
Calcium Channel Antagonist
Bepridil hydrochloride hydrate is a non-selective, long-acting calcium channel antagonist that also inhibits sodium and potassium channels. It exhibits antianginal properties and functions as a type I antiarrhythmic agent. Additionally, Bepridil hydrochloride hydrate inhibits the cardiac sodium-calcium exchanger (NCX1), making it valuable for research into cardiovascular disorders. -
Calcium Channel Blocker
Amlodipine maleate is a dihydropyridine calcium channel blocker that primarily targets voltage-dependent L-type calcium channels. By inhibiting calcium influx, it serves as an effective antianginal agent and contributes to the management of hypertension. Amlodipine maleate is utilized in research applications related to cardiovascular health, hypertension, and potential anticancer effects. -
Antiestrogen
Triphenylethylene is an antiestrogen agent that primarily functions by inhibiting L-type Ca2+ channels. This compound displays weak estrogenic activity and has been shown to relax duodenal intestinal muscle. Triphenylethylene is useful in research applications focusing on estrogen receptor modulation and the investigation of calcium channel dynamics in smooth muscle tissues. -
Anticonvulsant Agent
Methsuximide is an anticonvulsant agent that primarily targets T-type calcium channels. It is effective in managing petit mal seizures, as well as psychomotor and focal motor attacks. This compound is utilized in neurological research to investigate seizure mechanisms and the pharmacological modulation of epilepsy. Its selective action on calcium currents makes it a valuable tool for studying seizure activity and potential therapeutic interventions. -
T-channels Inhibitor
1-Octanol is a saturated fatty alcohol that selectively inhibits T-type calcium channels, demonstrating an IC50 of 4 μM for native T-currents. This compound serves as a valuable tool in pharmacological research aimed at understanding calcium signaling pathways. Additionally, its properties as a biofuel with diesel-like characteristics make it an interesting candidate for energy applications. -
Insecticide
Tetrachlorantraniliprole is an anthranilic diamide insecticide that targets insect ryanodine receptors, leading to disruption of calcium channels and subsequent muscle paralysis. This compound exhibits significant insecticidal activity against a range of agricultural pests, making it valuable for crop protection research. Its mechanism of action provides insight into the development of novel pest control strategies that minimize environmental impact. -
Stable Isotope
Barnidipine-d5 is a deuterium-labeled analog of Barnidipine, functioning as an L-type calcium antagonist with a strong affinity for [3H] initrendipine binding sites (Ki = 0.21 nmol/l). This compound exhibits selective action on calcium antagonist receptors and serves as an effective antihypertensive agent, primarily reducing peripheral vascular resistance through its vasodilatory effects. Barnidipine-d5 is suitable for research applications focused on cardiovascular pharmacology and calcium channel modulation. -
Calcium Channel
C18 LPA (PA(18:0e/0:0)) targets calcium channels and serves as a bioactive phospholipid involved in signal transduction via G protein-coupled receptors (GPCRs). This compound promotes smooth muscle contraction, chemotaxis, cytoskeletal rearrangement, and is implicated in neurotransmitter release and cell proliferation. Increased levels of C18 LPA in human plasma are correlated with ovarian cancer and atherosclerosis, indicating its potential utility as a biomarker in oncological and cardiovascular research. -
Sodium-Calcium Exchanger Inhibitor
KB-R7943 is a selective inhibitor of the sodium-calcium exchanger, exhibiting an IC50 value of 5.1 µM. This compound is utilized as a valuable tool in studies involving cardiac and renal failure models, facilitating research into calcium homeostasis and its implications in heart and kidney function. -
Calcium Channel Blocker
Suloctidil is an orally active calcium channel blocker that primarily targets vasoconstriction pathways. It effectively antagonizes vasoconstriction induced by norepinephrine, angiotensin, and serotonin, while also inhibiting platelet function and exhibiting neuroprotective effects. Additionally, Suloctidil demonstrates antifungal activity against Candida albicans, influencing biofilm formation and virulence. This compound is applicable in research focused on vasospasm relief, antithrombosis, and treatment of superficial candidiasis. -
Calcium Channel Antagonist
CP-060 is a potent calcium channel antagonist that effectively inhibits calcium overload in cells. This compound also exhibits notable antioxidant properties and offers cardioprotective effects. CP-060 is valuable for research applications focused on cardiovascular diseases and cellular stress responses. -
Calcium Channel Inhibitor
McN5691 is a voltage-sensitive calcium channel inhibitor that selectively blocks calcium influx through L-type calcium channels. This action leads to reduced calcium-dependent cellular events, making it a valuable tool for investigating calcium signaling pathways. McN5691 is particularly useful in research focused on cardiovascular physiology and the modulation of muscle contraction mechanisms. -
Calcium Channel Chemical
α2δ ligand 1 selectively interacts with the α2δ-1 subunit of voltage-gated calcium channels. This compound is known to modulate calcium influx, which plays a crucial role in neuronal excitability and synaptic transmission. It is utilized in research applications focused on pain management, neurological disorders, and the exploration of synaptic plasticity. -
Calcium Channel Antagonist
Dopropidil is a calcium channel antagonist that modulates intracellular calcium levels. It exhibits anti-anginal properties and demonstrates significant anti-ischemic effects in various predictive animal models. This compound is valuable for research in cardiovascular pharmacology, particularly in the study of angina and ischemic heart disorders. -
Calcium Channel Antagonist
Darodipine is a potent calcium channel antagonist that selectively inhibits L-type calcium channels. This compound demonstrates significant biological activity by decreasing intracellular calcium levels, which can effectively reduce vascular smooth muscle contraction. Darodipine is primarily utilized in research applications focused on cardiovascular physiology, hypertension studies, and the exploration of calcium signaling pathways. -
Calcium Channel Inhibitor
ω-Hexatoxin-Hv1a is a selective inhibitor of L-type voltage-dependent calcium channels. This neurotoxin reduces intracellular calcium ion concentration, thereby mitigating apoptosis, necroptosis, and oxidative stress, while enhancing cellular recovery and energy levels. Its ability to induce paralysis and mortality in insects through the disruption of central nervous system neurotransmission underscores its potency, although it has limited oral toxicity. Consequently, ω-Hexatoxin-Hv1a is a valuable tool for research into ischemia-reperfusion injury, atopic dermatitis, and ischemic damage in cardiomyocytes and neurons. -
Calcium Channel Antagonist
UK 52831 is a long-acting dihydropyridine calcium channel antagonist that selectively inhibits calcium influx through L-type calcium channels. This compound exhibits significant cardiovascular activity, making it valuable for research into conditions such as hypertension and myocardial ischemia. Additionally, UK 52831 has potential applications in anti-inflammatory studies, providing insights into the role of calcium signaling in inflammatory processes. -
Calcium/Sodium Channel Blocker
LY393615 (NCC1048) is a selective blocker of neuronal calcium (Ca2+) and sodium (Na+) channels, demonstrating IC50 values of 1.9 μM and 5.2 μM for the α1A and α1B calcium channel subunits, respectively. This compound exhibits excellent brain penetration and displays neuroprotective effects in cerebral ischemia models, making it a valuable tool for research in neurological diseases. Its dual-channel blocking mechanism contributes to its potential applications in understanding neuronal excitability and neuroprotection. -
Calcium Channel Blocker
Leualacin is a calcium channel blocker derived from the fungus Hapsidospora irregularis. This compound demonstrates significant inhibition of calcium influx through voltage-gated calcium channels, leading to potential therapeutic effects in conditions characterized by excitability and muscle contraction disorders. It is applicable in research exploring cardiovascular function and neurophysiology, providing insights into calcium signaling pathways. -
Calcium Channel
Semotiadil recemate fumarate is a vasoselective Ca2+ channel antagonist that inhibits calcium influx in vascular smooth muscle cells. It primarily targets L-type calcium channels, leading to vasodilation and reduced vascular resistance. This compound is significant in research related to cardiovascular diseases and may offer therapeutic insights into hypertension and related conditions. -
T-Type Calcium Channel Inhibitor
T-Type Calcium Channel Inhibitor 2 is a selective inhibitor of T-type calcium channels, specifically targeting Cav3.1 (α1G), Cav3.2 (α1H), and Cav3.3 (α1I), with IC50 values of 31.0, 83.1, and 69.3 µM, respectively. This compound exhibits significant cytotoxic activity against A549 and HCT-116 cancer cell lines, with IC50 values of 5.0 and 6.4 µM. It serves as a useful tool in the investigation of calcium channel involvement in various physiological processes and potential therapeutic targets in cancer research. -
Calcium Channel Antagonist
Flosatidil is an orally active calcium channel antagonist that effectively inhibits calcium influx through L-type calcium channels. Its primary biological activities include antianginal and antihypertensive effects, making it a valuable compound for cardiovascular research. Flosatidil is utilized in studies investigating the modulation of vascular tone and cardiac output, contributing to the understanding of hypertension and angina management. -
Calcium Channel Antagonist
Lomerizine is an antagonist of L- and T-type voltage-gated calcium channels, primarily inhibiting calcium influx into cells. This activity is associated with its potential to modulate vascular smooth muscle contraction and neurotransmitter release. Lomerizine is utilized in research to investigate cardiovascular diseases and neurological disorders related to calcium channel dysregulation. -
Anti-inflammatory Agent
LQFM020 is an orally active pyrazole derivative that functions as an anti-inflammatory agent. It effectively inhibits calcium channels while activating potassium and nitric oxide/cGMP pathways, leading to reduced vasoconstriction. LQFM020 exhibits significant anti-inflammatory and analgesic properties, making it a valuable reagent for research focused on inflammation and pain mechanisms. -
Calcium Channel
Levamlodipine (gentisate) is a potent calcium channel blocker primarily employed for its antihypertensive and antianginal effects. This pharmacologically active amino ester exhibits significant biological activity by inhibiting calcium influx into cardiovascular cells, thereby reducing blood pressure and alleviating angina. Additionally, high enantiomeric purity can be assessed through fast capillary electrophoresis, yielding a resolution of 9.8, which underscores its utility in compound analysis and development within chemical research. -
Isotope-Labeled Compounds
Verapamil-d7 is a deuterium-labeled derivative of Verapamil, a calcium channel blocker and a potent inhibitor of the P-glycoprotein (P-gp) transporter. This isotope-labeled compound is utilized in pharmacokinetic studies and metabolic research, providing insights into drug interactions and transport mechanisms. Its applications extend to investigating conditions such as hypertension, cardiac arrhythmias, and angina, making it a valuable tool in cardiovascular research. -
Calcium Channel Antagonist
Araguspongin B is a potent calcium channel antagonist that specifically targets inositol 1,4,5-trisphosphate (IP3) receptors. It effectively inhibits the calcium-releasing activity induced by IP3, demonstrating an IC50 value of 0.6 μM in cerebral microsomes. This compound is recognized for its vasodilatory properties and is valuable for research exploring calcium signaling pathways and their implications in various physiological and pathological processes. -
Calcium-sensitizing Agent
BA 41899 is a selective calcium-sensitizing agent that enhances cardiac contractility without phosphodiesterase (PDE) III inhibition or other inotropic mechanisms. This compound is valuable for investigating mechanisms underlying cardiovascular diseases, particularly congestive heart failure (CHF). Its unique activity profile makes it a useful tool for researchers studying cardiac physiology and therapeutic interventions in heart disease. -
Calcium Channel Agonist
LND 796 is a calcium channel agonist with positive inotropic effects reminiscent of digitalis. It demonstrates a concentration-dependent increase in contractility in guinea pig papillary muscles, enhancing both contraction components and slow action potential amplitude, particularly in partially potassium-depolarized conditions. The mechanism of action involves increased calcium influx through calcium channels and inhibition of sodium-potassium ATPase. Due to its unique profile, LND 796 may have potential applications in the treatment of congestive heart failure. -
SERCA Inhibitor
4,4'-Methylenebis(2,6-di-tert-butylphenol) is a selective inhibitor of sarco/endoplasmic reticulum calcium ATPase (SERCA), with an IC50 value of 17 μM. This compound plays a critical role in modulating calcium homeostasis and is valuable for research into cellular processes and disorders linked to calcium dysregulation. Its application extends to studying various diseases where altered calcium signaling is implicated. -
Calcium Channel Inhibitor
A-39355 is a calcium channel inhibitor that effectively reverses multidrug resistance in tumor cells. It enhances the cytotoxicity of antitumor compounds by increasing their accumulation within resistant cells and inhibiting their efflux. Unlike traditional calcium antagonists, A-39355 exhibits minimal hypotensive effects. This compound is particularly useful for research focused on overcoming treatment resistance in cancer therapy. -
L-type Calcium Channel Inhibitor
Diltiazem malate is a potent inhibitor of L-type calcium channels, effectively modulating calcium influx in cardiac and vascular smooth muscle. It exhibits significant antihypertensive and antiarrhythmic properties, making it valuable for the investigation of cardiovascular conditions. Diltiazem malate is commonly used in research related to cardiac arrhythmia, hypertension, and angina pectoris. -
Ca2+ Antagonist
SR33805 oxalate is a potent calcium (Ca2+) channel antagonist, specifically blocking L-type calcium channels. It demonstrates effective inhibition with EC50 values of 4.1 nM in depolarized conditions and 33 nM under polarized conditions. This reagent is valuable for research into acute and chronic heart failure, aiding in the understanding of Ca2+ signaling in cardiac pathophysiology. -
Potassium/Calcium/Sodium Channel Blocker
NIP-142 is a benzopyran derivative that functions as a potassium, calcium, and sodium channel blocker. It selectively inhibits potassium channels abundant in atrial muscle, leading to an increase in the effective refractory period (ERP) and action potential duration (APD) in the atrium, while sparing ventricular repolarization. Additionally, NIP-142 dampens L-type and T-type calcium channels and sodium channels, enhancing its anti-arrhythmic properties. This compound is particularly useful in the study of atrial fibrillation and related arrhythmias. -
Calcium Cage
DMNPE-4 AM-caged-calcium functions as a highly selective calcium cage, exhibiting a dissociation constant (Kd) for Ca2+ of 48 nM and 19 nM at pH 7.2 and pH 7.4, respectively. Upon photolysis, the compound releases Ca2+ with significantly enhanced availability, achieving a Kd of approximately 2 nM. This photolabile calcium chelator is instrumental for studies involving calcium signaling and dynamics in cellular research applications. -
Calcium Antagonist
Emopamil is a calcium channel antagonist that is effective in mitigating ischemia-induced neuronal cell damage. By inhibiting calcium influx, it helps in protecting neuronal cells from necrosis and apoptosis under ischemic conditions. This compound holds potential for research applications focused on neuroprotection and the study of calcium-mediated pathways in various neurological disorders. -
P-glycoprotein Inhibitor
Niguldipine monohydrochloride is a selective P-glycoprotein inhibitor known for its action as a calcium channel blocker. It demonstrates significant anticancer properties by inhibiting Cav 3.2, with an IC50 of 0.9 μM. This compound is primarily utilized in tumor research to explore its effects on drug resistance and the transport of therapeutic agents across cellular membranes. -
Calcium Channel Blocker
Sornidipine is a potent calcium channel blocker that primarily targets L-type calcium channels to inhibit calcium ion influx into cells. This mechanism results in decreased vascular smooth muscle contraction, promoting vasodilation and effectively lowering blood pressure. Sornidipine is valuable for research applications focusing on the cardiovascular system, particularly in studies related to hypertension and associated cardiovascular disorders. Additionally, it has been noted for its ability to reduce neurogenic inflammation, further expanding its relevance in cardiovascular research. -
Stable Isotope
Ethosuximide-d5 is a stable isotopically labeled form of Ethosuximide, an established anti-epileptic agent. This compound acts primarily as a blocker of low voltage activated T-type calcium channels, contributing to its therapeutic effects. Ethosuximide-d5 is valuable for research applications involving neurodegenerative disease models and mechanisms of epilepsy, enabling precise metabolic studies and tracking within biological systems.
