Catalog No.
Product Name
Application
Product Information
Citations
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Calcium Channel Modulator
Sadopine serves as an allosteric modulator of dihydropyridine-sensitive L-type calcium channels. The compound exhibits dual functionality, with (-)Sadopine acting as a positive allosteric modulator and (+)Sadopine functioning as a negative allosteric modulator. This modulation of calcium channel activity makes Sadopine relevant for research focused on cardiovascular physiology and the modulation of calcium signaling pathways. -
Calcium Channel Inhibitor
Ro 18-3981 is a dihydropyridine compound that selectively inhibits calcium channels in cardiac tissues. It demonstrates enhanced inhibitory potency at depolarized membrane potentials, with an IC50 value of 2.3 nM at -20 mV and 100 nM at -50 mV. This compound is useful for studying the role of calcium signaling in cardiac physiology and related pathologies. -
Calcium Absorption Inducer
PDDHV is a potent calcium absorption inducer that stimulates the vanillic acid receptor VR1, leading to increased influx of 45Ca2+. It effectively promotes 45Ca2+ uptake in rat dorsal root ganglion neurons with an EC50 of 70 nM and elicits calcium mobilization in VR1-transfected CHO cells with an EC50 of 125 nM. Additionally, PDDHV inhibits [3H]-resiniferatoxin binding to rat dorsal root ganglion membranes, showcasing its utility in calcium signaling research. -
Potassium/Calcium Channel Blocker
SB-237376 free base is a potent inhibitor of potassium and calcium channels, primarily targeting the rapidly activating delayed rectifier potassium current I(Kr) with an IC50 of 0.42 μM. Additionally, at elevated concentrations, it effectively blocks the L-type calcium current I(Ca,L). In studies utilizing rabbit ventricular models, SB-237376 free base has been shown to induce early afterdepolarizations (EADs) at a concentration of 3 µM. This compound presents a lower proarrhythmic risk compared to other known I(Kr) inhibitors, making it valuable for investigations into arrhythmia-related conditions. -
Ca2+- ATPase Activator
Rp-8-Br-cGMPS (Rp-8-bromo-Cyclic GMP sodium salt) is an effective activator of Ca2+-ATPase, promoting the reduction of cytosolic Ca2+ levels by enhancing the efflux of Ca2+ from cells. Additionally, it acts as an agonist of the rod cyclic nucleotide-gated (CNG) channel and functions as an inhibitor of protein kinase G (PKG). This compound is valuable for studies involving calcium signaling, cellular response mechanisms, and cardiovascular research. -
Stable Isotope
Teludipine-d6 is a deuterium-labeled analog of Teludipine hydrochloride, a potent lipophilic calcium channel blocker. This stable isotope is utilized in pharmacokinetic studies and metabolic research to trace the metabolic pathways of Teludipine without altering its pharmacological properties. It is well-suited for investigations requiring precise quantification of drug concentrations in biological systems. -
Calcium Channel Blocker
(S)-Azelnidipine is a selective calcium channel blocker that specifically targets L-type calcium channels. This compound exhibits significant biological activity by inhibiting calcium influx, which can lead to vasodilation and reduced cardiac workload. It is primarily utilized in research related to cardiovascular diseases, offering insights into hypertension and other related conditions. -
Calcium Channel Inhibitor
R 56865 is a calcium channel inhibitor that offers cardiomyocyte protection against digitoxin (ouabain)-induced myocardial calcium overload. This compound demonstrates a significant protective effect against digitoxin-induced intoxication, as evidenced in studies utilizing guinea pig papillary muscle. R 56865 is primarily utilized in research related to cardiac function and the mechanisms of arrhythmias. -
Calcium Channel Blocker
Tamolarizine hydrochloride is a calcium channel blocker that effectively crosses the blood-brain barrier to inhibit calcium influx in neurons. This compound is valuable for studying neuronal activity and modulating calcium-dependent processes in nervous system research. Its unique properties make it an important tool for investigating neurological disorders and calcium signaling pathways. -
Calcium Antagonist
BMS-188107 is a calcium antagonist that demonstrates anti-ischemic effects. This compound enhances post-ischemic contractile function and decreases lactate dehydrogenase release, making it a valuable tool in cardiovascular research. It is suitable for studies investigating calcium modulation and its impact on heart function and ischemic injury. -
L-type Calcium Channel Blocker
Norverapamil, an N-demethylated metabolite of Verapamil, acts as an L-type calcium channel blocker and inhibits P-glycoprotein (P-gp) function. This compound is primarily utilized in research to study calcium ion dynamics and assess the role of P-gp in drug transport and resistance mechanisms. Its ability to modulate calcium influx makes it valuable for applications in cardiovascular and neuropharmacological investigations. -
Calcium Indicator
Rhod-FF tripotassium is a cell-impermeant calcium indicator targeting intracellular calcium levels, with a dissociation constant (Kd) of 320 μM. This derivative of Rhod-2 exhibits fluorescent properties, emitting light upon calcium ion binding, with excitation at 552 nm and emission at 580 nm. It is widely used in research applications to explore calcium dynamics and signaling within cellular environments. -
Calcium Channel Antagonist
Calcium Channel Antagonist 5 is a potent inhibitor of calcium channels, exhibiting a pIC50 of 5.50. This compound effectively modulates calcium influx in cells, making it valuable for studies in cardiovascular research and neuropharmacology. It is particularly useful in investigating the role of calcium channels in cellular excitability and signal transduction. -
Calcium Channel Modulator
Calcium channel-modulator-1 is an orally active agent that targets calcium channels, effectively inhibiting aortic contraction with an IC50 of 0.8 μM. This modulator is useful for investigating cardiovascular conditions and mechanisms associated with calcium signaling in vascular tissues. -
Calcium Channel
β-Amino Acid Imagabalin Hydrochloride is a selective ligand for the α2δ subunit of voltage-dependent calcium channels. This compound modulates calcium influx, thereby regulating neurotransmitter release and exhibiting anticonvulsant properties. It is primarily utilized in research focused on pain management, anxiety disorders, and seizure activity. -
Calcium Channel Modulator
Myomodulin is a neuropeptide that functions as a calcium channel modulator. It plays a critical role in neurotransmission and muscle contraction by regulating calcium ion flow in excitable tissues. Myomodulin is widely used in research to investigate neurophysiological processes and the modulation of synaptic activity in various model organisms, including molluscs and insects. -
Calcium Channel Antagonist
AE0047 Hydrochloride is a calcium channel antagonist that effectively inhibits calcium influx through the cell membrane. This compound demonstrates potential in the study of hypertensive diseases, making it a valuable tool for investigating cardiovascular physiology and related pathologies. Its role in modulating calcium signaling pathways can aid in understanding the mechanisms underlying hypertension and related disorders. -
Mineralocorticoid Receptor Modulator
Felodipine 3,5-Dimethyl Ester is a dihydropyridine derivative functioning primarily as a mineralocorticoid receptor modulator and a selective inhibitor of the voltage-dependent L-type calcium channel CaV1.2. This compound exhibits significant pharmacological activity by affecting calcium ion flux, which plays a crucial role in cardiovascular and renal physiology. Its applications extend to research in hypertension, heart failure, and other cardiovascular disorders related to calcium channel dysregulation. -
Maxi Calcium-activated Potassium Channel Blocker
1,12-Dodecanediamine (1,12-DD) is a reversible blocker of Maxi calcium-activated potassium channels. It effectively diminishes single-channel current amplitude, mean channel open time, and overall channel open probability. This compound is valuable for studies involving cellular electrical signal transduction mechanisms, allowing researchers to explore the role of these channels in various physiological and pathological processes. -
Dihydropyridine Calcium Antagonist
(S)-Nimodipine is a potent dihydropyridine calcium antagonist known for its selective effect on calcium channels. It exhibits significant biological activity, primarily in the management of cerebrovascular disorders by improving cerebral blood flow. This compound is especially valuable in research focusing on neurological conditions and the effects of calcium modulation in neuronal tissue. -
Calcium Channel Blocker
Verapamil hydrochloride is a calcium channel blocker primarily targeting L-type calcium channels. It exhibits potent inhibitory activity on P-glycoprotein and CYP3A4, contributing to its pharmacological profile. This compound is widely utilized in research related to hypertension, cardiac arrhythmias, and angina, facilitating studies on cardiovascular function and drug metabolism. -
L-type Calcium Chanel Inhibitor
Diltiazem is an orally active L-type calcium channel blocker that exerts antihypertensive and antiarrhythmic effects. It is utilized in research related to cardiac arrhythmias, hypertension, and angina pectoris, making it valuable for studies focused on cardiovascular health. Its mechanism of action contributes to the modulation of calcium influx, which is critical in various cardiac and vascular functions. -
NMDA Receptor Inhibitor
Bupivacaine is an NMDA receptor inhibitor that modulates neuronal excitability by blocking sodium, L-calcium, and potassium channels. It exhibits potent inhibition of SCN5A channels, with an IC50 of 69.5 μM. This compound is primarily utilized in research focused on chronic pain mechanisms and therapeutic interventions. -
Calcium Channels Antagonist
Fluspirilene is a non-competitive antagonist of L-type calcium channels, demonstrating an IC50 of 0.03 μM. This compound exhibits significant antipsychotic activity, making it a valuable tool for research on schizophrenia and related neuropsychiatric disorders. Its long-acting injectable formulation facilitates studies on sustained pharmacological effects in therapeutic applications. -
T Calcium Channel Antagonist
Ulixacaltamide is a potent T-type calcium channel antagonist that demonstrates significant efficacy in modulating neurological disorders. It has been shown to slow the progression of epilepsy and effectively reduce tremors in an alkaline tremor animal model. Additionally, Ulixacaltamide reverses thermal hyperalgesia, providing a mechanism for pain relief in various preclinical settings. This compound is valuable for research applications focusing on neurological function and pain management. -
SERCA Blocker
JTV-519 hemifumarate is a selective blocker of the sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA), with additional activity as a partial agonist of ryanodine receptors in striated muscle. It exhibits antiarrhythmic and cardioprotective properties, making it a valuable tool for research on cardiac function and rhythm disorders. This compound is useful in studies exploring calcium handling in myocardial cells and its implications for heart disease therapies. -
T-type Calcium Channel Blocker
TTA-P2 is a selective T-type calcium channel blocker with a primary mechanism of inhibiting calcium influx through T-type channels, exhibiting an IC50 of 22 nM. This compound demonstrates significant biological activity by reducing mechanical hypersensitivity and alleviating both acute and chronic pain. Additionally, TTA-P2 lowers firing rates in neurons associated with temporal lobe epilepsy, effectively controlling synaptically evoked burst firing. Research applications include investigations into neurological disorders such as tremor and absence epilepsy. -
Calcium Channel Inhibitor
Tetracaine hydrochloride is a calcium channel inhibitor that effectively blocks the voltage-sensitive release of Ca2+ from the sarcoplasmic reticulum. This compound exhibits significant biological activity and is primarily utilized in topical applications within ophthalmology, as well as serving as an antipruritic agent. Its mechanism of action makes it valuable for research in pain relief and modulation of calcium signaling pathways. -
Neuroprotective Compound
REM127 is a neuroprotective small molecule that modulates calcium homeostasis in cells. It effectively restores calcium balance in cellular models affected by the pathological accumulation of tau protein, demonstrating potential to mitigate synaptic and cognitive deficits in Alzheimer's disease models. REM127 is capable of crossing the blood-brain barrier and may slow the progression of amyloid-beta and tau protein pathologies. This compound is suitable for research applications in neurodegenerative diseases. -
SERCA2a Activator
SERCA2a Activator 1 is an activator of the sarco/endoplasmic reticulum Ca2+-dependent ATPase 2a (SERCA2a). This compound alleviates the inhibitory effects of phospholamban, thereby improving both systolic and diastolic cardiac functions. SERCA2a Activator 1 is primarily utilized in research related to heart failure and cardiac physiology. -
Calcium Ions Activator
Calcium citrate tetrahydrate is a calcium ions activator that efficiently releases calcium ions, enhancing biological activity in various applications. Its rapid solubility and ability to maintain elevated calcium ion concentrations make it particularly useful for research focused on bone formation and mineralization. This reagent is essential for studies investigating calcium-related signaling pathways and the effects of calcium on cellular processes. -
Calcium Channel Blocker
Prenylamine is a calcium channel blocker belonging to the amphetamine chemical class. It acts by inhibiting calcium influx through voltage-gated calcium channels, leading to vasodilation. This compound has potential applications in the research of cardiovascular conditions, particularly angina pectoris, by modulating vascular tone and reducing myocardial oxygen demand. -
Stable Isotope
Verapamil-d3 hydrochloride is a deuterium-labeled derivative of the calcium channel blocker, verapamil hydrochloride. It serves as a potent inhibitor of P-glycoprotein (P-gp) and CYP3A4, facilitating detailed pharmacological studies. This stable isotope is primarily utilized in research related to hypertension, cardiac arrhythmias, and angina, providing insight into drug metabolism and transport mechanisms in various biological systems. -
Calcium Receptor Activator
γ-Glutamylserine (γ-Glu-Ser) is a calcium receptor activator that plays a critical role in various cellular signaling pathways. This compound exhibits potential neuroprotective effects, making it relevant for research in Parkinson's disease. Additionally, γ-Glutamylserine may be utilized in studies focused on metabolic disorders, including diabetes and obesity. -
Phenylalkylamine Calcium Antagonist
Gallopamil hydrochloride is a phenylalkylamine calcium antagonist that exhibits potent antiarrhythmic and vasodilatory properties. It effectively inhibits acid secretion in a concentration-dependent manner, with an IC50 value of 10.9 μM. This compound is utilized in various research applications focused on cardiovascular function and gastrointestinal acid regulation. -
Calcium Channel
D-myo-Inositol-1,3,4,5-tetraphosphate sodium functions as a signaling molecule by regulating calcium channels. It is produced through the phosphorylation of inositol 1,4,5-trisphosphate by inositol 1,4,5-triphosphate 3-kinase. This compound is utilized in research focused on cellular signaling pathways, particularly those involving calcium mobilization and inositol phosphate metabolism. Its key biological activity makes it valuable for studies exploring neurotransmission, smooth muscle contraction, and other calcium-dependent processes. -
Calcium Channel Inhibitor
Lidoflazine is a potent inhibitor of calcium channels, specifically known for its high affinity blockade of the HERG potassium channel. This compound exhibits antianginal properties, making it relevant in studies related to cardiac function and arrhythmias. Notably, Lidoflazine is associated with a risk of QT interval prolongation and ventricular arrhythmia, which underscores its importance in pharmacological research aiming to understand cardiovascular safety profiles. -
Calcium Channel
PPZ2 is a diacylglycerol (DAG)-activated agonist of the TRPC3, TRPC6, and TRPC7 calcium channels. It promotes neuronal development and survival through its ability to elicit cation currents and calcium ion (Ca(2+)) influx in cultured central neurons in a dose-dependent manner. PPZ2 induces BDNF-like neurite outgrowth and provides neuroprotection, effects that are negated following TRPC channel knockdown or inhibition. Additionally, PPZ2 enhances the activation of the calcium-dependent transcription factor cAMP response element binding protein, highlighting the role of calcium signaling in its neurotrophic actions. -
Calcium Channel Inhibitor
Pranidipine is a potent, long-acting 1,4-dihydropyridine calcium channel inhibitor, specifically designed to modulate calcium influx in vascular smooth muscle cells. Its primary biological activity involves the reduction of blood pressure, making it an effective antihypertensive agent. This compound is widely used in cardiovascular research to investigate mechanisms underlying hypertension and to evaluate therapeutic strategies for managing elevated blood pressure. -
Calcium Influx Inhibitor
Carboxyamidotriazole Orotate is an orotate salt of Carboxyamidotriazole, a potent inhibitor of calcium influx. It acts primarily as a cytostatic agent targeting nonvoltage-operated calcium channels and disrupting calcium-mediated signaling pathways. This compound demonstrates notable anti-tumor, anti-inflammatory, and antiangiogenic properties, making it valuable in cancer research and the study of inflammatory diseases. -
L-type calcium channel Blocker
(R)-Nimodipine is an L-type calcium channel blocker that effectively penetrates the blood-brain barrier, with an IC50 value of 5 nM. By inhibiting calcium channels on the hypothalamic-pituitary-adrenal axis, (R)-Nimodipine reduces corticosterone release, thereby mitigating memory impairment and behavioral abnormalities associated with immobilization stress. This compound is frequently utilized in research focused on aneurysmal subarachnoid hemorrhage, cerebral ischemia, epilepsy, age-related neurodegenerative diseases, and the effects of alcohol intoxication. -
Calcium Channel Blocker
Nemadipine-A is a selective inhibitor of the EGL-19 L-type calcium channel. This compound demonstrates the ability to sensitize TRAIL-resistant cancer cells to TRAIL-mediated apoptosis. It is primarily utilized in research focused on cancer therapy and calcium signaling pathways. -
Calcium Channel Blocker
Methyl homoveratrate functions as a voltage-sensitive calcium channel blocker. This compound serves as a metabolite of RWJ-26240 and can be detected in plasma, urine, and fecal extracts. Its role in calcium channel inhibition makes it a valuable tool for investigating calcium signaling pathways and related physiological processes in various research applications. -
Calcium Channel Antagonist
Praeruptorin C serves as a calcium channel antagonist, exhibiting a pD2′ value of 5.7. Derived from Peucedanum praeruptorum, this bioactive compound plays a significant role in modulating calcium influx across cellular membranes. Research applications include studies on cardiovascular function and smooth muscle contraction, making it a valuable tool for investigating calcium-related physiological processes. -
Ligand for the α2δ Subunit of Voltage-gated Calcium Channels
Crisugabalin is a selective ligand targeting the α2δ subunit of voltage-gated calcium channels, exhibiting an IC50 of 3.96 nM in rat models. This compound effectively inhibits the binding of [3H]gabapentin to the α2δ subunit, leading to reduced calcium influx and decreased neuronal excitability, ultimately impairing nociceptive transmission. Crisugabalin has demonstrated efficacy in alleviating mechanical allodynia and various pain models, including neuropathic and inflammatory pain. Its applications are relevant in research contexts involving chronic pain syndromes such as diabetic neuropathy, fibromyalgia, and postherpetic neuralgia. -
Calcium Channel Antagonist
(+)-Niguldipine hydrochloride is a calcium channel antagonist that effectively induces vasodilation by inhibiting calcium influx through cell membranes. This compound demonstrates significant biological activity by antagonizing U-46619-induced coronary vasoconstriction in guinea pig Langendorff heart preparations, with a pID50 value of 11.37. Additionally, it binds to calcium channels in guinea pig skeletal muscle membranes with a Ki of 9.75 and exhibits blood pressure-lowering effects in spontaneously hypertensive rats, with a pED30 of 7.1. (+)-Niguldipine hydrochloride is utilized in research related to cardiovascular diseases, including hypertension, angina pectoris, and arrhythmias. -
Calcium Channel Antagonist
Clopimozide is a calcium channel antagonist that inhibits [3H]nitrendipine binding with an IC50 value of 17 nM. This orally active antipsychotic agent is utilized in research to investigate both negative and positive symptoms of schizophrenia, contributing to a deeper understanding of the neurobiological mechanisms underlying this disorder. Its selective action on calcium channels allows for targeted studies in pharmacology and therapeutics related to schizophrenia. -
Calcium Channel Antagonist
BTT-266 is a calcium channel antagonist that functions by inhibiting the interaction between CaVα1-AID and CaVβ3, exhibiting a Ki value of 1.4 μM. It effectively modulates the activation of voltage-dependent CaV2.2 channels. BTT-266 demonstrates analgesic properties in models of neuropathic pain, making it a valuable tool for research into pain modulation and potential therapeutic applications. -
Calcium Channel
2-Chloro-ATP sodium is an analog of ATP that acts as an antagonist of the purinergic P2Y1 receptor, inhibiting intracellular calcium mobilization induced by ADP in Jurkat cells with a Ki of 2.3 μM. Additionally, it serves as an agonist for the purinergic P2X receptor, generating inward currents in HEK293 cells with varying affinities (EC50 of 0.5 and 2.5 μM). This compound also induces concentration-dependent relaxation of precontracted guinea pig cecal strips. Furthermore, 2-Chloro-ATP sodium is utilized to investigate substrate specificity among cyclic nucleotide-dependent protein kinases, including protein kinase A (PKA) and PKG. -
Calcium Channel Inhibitor
Nothofagin is a dihydrochalcone that acts as a calcium channel inhibitor. By blocking calcium influx, it downregulates NF-κB translocation, providing a mechanism to modulate inflammatory responses. This compound exhibits antioxidant properties and has potential applications in research related to septic responses and vascular inflammation.
