Verubecestat (MK-8931)

Catalog No.: A16113

β-secretase/BACE1 inhibitor

Verubecestat (MK-8931)

Verubecestat (MK-8931) Chemical Structure

CAS NO. 1286770-55-5

Verubecesta is a potent and selective beta-secretase inhibitor, and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor.

Availability: In stock

Package Price Qty
5 mg
$70.00
10 mg
$110.00
50 mg
$400.00
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Biological Activity

Verubecesta is a potent and selective beta-secretase inhibitor, and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor.
In vitro DMSO 77 mg/mL (188.07 mM)
Water Insoluble
Ethanol 39 mg/mL (95.26 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.43 mL 122.13 mL 244.25 mL
0.5 mM 4.89 mL 24.43 mL 48.85 mL
1 mM 2.44 mL 12.21 mL 24.43 mL
5 mM 0.49 mL 2.44 mL 4.89 mL

*The above data is based on the productmolecular weight 409.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16113
Actions Inhibitor
CAS No. 1286770-55-5
Formula C17H17F2N5O3S
M. Wt 409.41
Solubility DMSO
Purity >98%
Synonyms MK-8931, MK 8931, MK8931
SMILES O=C(C1=NC=C(F)C=C1)NC2=CC=C(F)C([[email protected]@](C3)(C)N=C(N)N(C)S3(=O)=O)=C2
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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