Z-VAD-FMK

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Pan Caspase Inhibitor

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Catalog No. A12373

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Z-VAD-FMK 1mg A12373-1

Regular Price: $40.00

Special Price: $32.00

Z-VAD-FMK 5mg A12373-5

Regular Price: $120.00

Special Price: $96.00

Z-VAD-FMK 10mg A12373-10

Regular Price: $200.00

Special Price: $160.00

Z-VAD-FMK 25mg A12373-25

Regular Price: $350.00

Special Price: $280.00

Z-VAD-FMK 10mM * 1mL in DMSO A12373-10mM-D

Regular Price: $246.00

Special Price: $196.80

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo.

Z-VAD-FMK

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Chemical Information

Catalog Num A12373
Actions Inhibitor
M. Wt 467.49
Formula C22H30FN3O7
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 187389-52-2
Synonyms N/A
SMILES code C[[email protected]@H](C(=O)N[[email protected]@H](CC(=O)OC)C(=O)CF)NC(=O)[[email protected]](C(C)C)NC(=O)OCC1=CC=CC=C1
Chemical Name Benzyloxycarbonyl-Val-Ala-Asp(OMe)-?fluoromethylketone

Biological Activity

Description
Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo.
Targets
Pan-caspase (THP.1, Jurkat T-cells)

Solubility

Solubility (25°C) * In vitro DMSO 93 mg/mL (198 mM)
Water <1 mg/mL (<1 mM)
Ethanol 24 mg/mL heating (51 mM)
In vivo DMF 84 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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