Z-DEVD-FMK

Catalog No.: A13503

Caspase-3 Inhibitor

Z-DEVD-FMK

Z-DEVD-FMK Chemical Structure

CAS NO. 210344-95-9

Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor.

Availability: In stock

Package Price Qty
2 mg
$80.00
5 mg
$145.00
25 mg
$400.00
10mM * 1mL in DMSO
$210.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Yosefzon Y, .et al. Caspase-3 Regulates YAP-Dependent Cell Proliferation and Organ Size, Mol Cell, 2018, May 17;70(4):573-587.e4 PMID: 29775577
  • Akashi E, .et al. Effects of galectin-9 on apoptosis, cell cycle and autophagy in human esophageal adenocarcinoma cells, Oncol Rep, 2017, Jul;38(1):506-514 PMID: 28586026
  • Wenquan Liang, .et al. Shikonin induces mitochondria-mediated apoptosis and enhances chemotherapeutic sensitivity of gastric cancer through reactive oxygen species, Sci Rep, 2016, 6: 38267 PMID: 27905569

Biological Activity

Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor.
Targets
Caspase-3
In vitro DMSO 100 mg/mL (149.55 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 14.96 mL 74.78 mL 149.55 mL
0.5 mM 2.99 mL 14.96 mL 29.91 mL
1 mM 1.5 mL 7.48 mL 14.96 mL
5 mM 0.3 mL 1.5 mL 2.99 mL

*The above data is based on the productmolecular weight 668.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13503
Actions Inhibitor
M. Wt 668.66
Formula C30H41FN4O12
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 210344-95-9
Synonyms Caspase-3 Inhibitor
SMILES O=C(N[[email protected]@H](C(C)C)C(N[[email protected]](C(CF)=O)CC(OC)=O)=O)[[email protected]](CCC(OC)=O)NC([[email protected]](CC(OC)=O)NC(OCC1=CC=CC=C1)=O)=O

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