Z-DEVD-FMK

Name: Z-DEVD-FMK
Brand: Adooq Bioscience
SKU: A13503
Rating: 100 (4 reviews)

Catalog No.: A13503

Caspase-3 Inhibitor

Product Citations (4)

Z-DEVD-FMK Chemical Structure

CAS NO. 210344-95-9

Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor.

Availability: In stock

Package	Price	Qty
2 mg	$80.00
5 mg	$145.00
25 mg	$400.00
10mM * 1mL in DMSO	$210.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq Z-DEVD-FMK

Roi Ankawa, .et al. Apoptotic cells represent a dynamic stem cell niche governing proliferation and tissue regeneration, Dev Cell, 2021, Jul 12;56(13):1900-1916 PMID: 34197726
Yosefzon Y, .et al. Caspase-3 Regulates YAP-Dependent Cell Proliferation and Organ Size, Mol Cell, 2018, May 17;70(4):573-587.e4 PMID: 29775577
Akashi E, .et al. Effects of galectin-9 on apoptosis, cell cycle and autophagy in human esophageal adenocarcinoma cells, Oncol Rep, 2017, Jul;38(1):506-514 PMID: 28586026
Wenquan Liang, .et al. Shikonin induces mitochondria-mediated apoptosis and enhances chemotherapeutic sensitivity of gastric cancer through reactive oxygen species, Sci Rep, 2016, 6: 38267 PMID: 27905569

Biological Activity

Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor.

Targets

Caspase-3

Solubility *

In vitro (25°C)	DMSO	98 mg/mL (146.56 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+30% PEG 400+5% Tween 80+ddH2O	1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	14.96 mL	74.78 mL	149.55 mL
0.5 mM	2.99 mL	14.96 mL	29.91 mL
1 mM	1.5 mL	7.48 mL	14.96 mL
5 mM	0.3 mL	1.5 mL	2.99 mL

*The above data is based on the productmolecular weight 668.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A13503
Actions	Inhibitor
CAS No.	210344-95-9
Formula	C30H41FN4O12
M. Wt	668.66
Purity	>98%
Synonyms	Caspase-3 Inhibitor
SMILES	O=C(N[[email protected]@H](C(C)C)C(N[[email protected]](C(CF)=O)CC(OC)=O)=O)[[email protected]](CCC(OC)=O)NC([[email protected]](CC(OC)=O)NC(OCC1=CC=CC=C1)=O)=O
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.