Catalog No.: A13503

Caspase-3 Inhibitor


Z-DEVD-FMK Chemical Structure

CAS NO. 210344-95-9

Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor.

Availability: In stock

Package Price Qty
2 mg
5 mg
25 mg
10mM * 1mL in DMSO
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Roi Ankawa, .et al. Apoptotic cells represent a dynamic stem cell niche governing proliferation and tissue regeneration, Dev Cell, 2021, Jul 12;56(13):1900-1916 PMID: 34197726
  • Yosefzon Y, .et al. Caspase-3 Regulates YAP-Dependent Cell Proliferation and Organ Size, Mol Cell, 2018, May 17;70(4):573-587.e4 PMID: 29775577
  • Akashi E, .et al. Effects of galectin-9 on apoptosis, cell cycle and autophagy in human esophageal adenocarcinoma cells, Oncol Rep, 2017, Jul;38(1):506-514 PMID: 28586026
  • Wenquan Liang, .et al. Shikonin induces mitochondria-mediated apoptosis and enhances chemotherapeutic sensitivity of gastric cancer through reactive oxygen species, Sci Rep, 2016, 6: 38267 PMID: 27905569

Biological Activity

Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor.
In vitro (25°C) DMSO 98 mg/mL (146.56 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+30% PEG 400+5% Tween 80+ddH2O 1 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 14.96 mL 74.78 mL 149.55 mL
0.5 mM 2.99 mL 14.96 mL 29.91 mL
1 mM 1.5 mL 7.48 mL 14.96 mL
5 mM 0.3 mL 1.5 mL 2.99 mL

*The above data is based on the productmolecular weight 668.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13503
Actions Inhibitor
CAS No. 210344-95-9
Formula C30H41FN4O12
M. Wt 668.66
Purity >98%
Synonyms Caspase-3 Inhibitor
SMILES O=C(N[[email protected]@H](C(C)C)C(N[[email protected]](C(CF)=O)CC(OC)=O)=O)[[email protected]](CCC(OC)=O)NC([[email protected]](CC(OC)=O)NC(OCC1=CC=CC=C1)=O)=O

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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