Catalog No.
Product Name
Application
Product Information
Citations
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Lipid
C20:4 Anandamide (AEA) is a bioactive lipid that acts as an endocannabinoid, primarily targeting cannabinoid receptors in the central nervous system. This compound is known for its involvement in pain modulation, appetite regulation, and neuroprotection. C20:4 AEA is commonly utilized in research to investigate the physiological effects of endocannabinoids and their potential therapeutic applications in various neurological and inflammatory conditions. -
Biochemical Assay Reagent
CGS 21680 sodium is an adenosine A2A receptor agonist that selectively activates the A2A receptor, influencing various signaling pathways. This compound exhibits biological activities such as modulation of neurotransmission and anti-inflammatory effects, making it useful in research involving neurological and cardiovascular studies. It is commonly employed in biochemical assays to explore the roles of adenosine receptors in cellular processes and their potential therapeutic applications. -
Biochemical Assay Reagent
Oleoylsulfamide is a selective inhibitor of cannabinoid receptor 1 (CB1). This compound can be utilized as a biochemical assay reagent to investigate the role of CB1 in various physiological processes. It is particularly valuable in studies related to metabolic disorders, pain modulation, and neuroprotection. -
Lipid
C17:1 Anandamide is a synthetic derivative of anandamide, a significant endocannabinoid that interacts primarily with cannabinoid receptors. This compound demonstrates key biological activities, including modulation of pain perception, appetite, and mood regulation. C17:1 Anandamide is useful for studying the endocannabinoid system and its implications in various therapeutic areas, such as neurobiology and pain management. Its unique lipid structure enables investigations into lipid signaling pathways and their role in cellular processes. -
Lipid
NBD AA is a fluorescent analog of anandamide that selectively targets cannabinoid receptors. This compound plays a critical role in lipid signaling pathways and is utilized in studies examining endocannabinoid system functions. Its fluorescent properties make NBD AA an effective tool for visualizing lipid distribution and activity in live cell imaging and various biochemical assays. -
Lipid
N-Arachidonoyl-L-Serine sodium is a lipid compound that acts as an analog of anandamide, a well-known endocannabinoid. This reagent exhibits important biological activities, including the modulation of pain sensation, inflammation, and neuroprotection. It is utilized in research exploring cannabinoid receptor pathways and their therapeutic potential in various neurological and inflammatory disorders. -
Lipid
C18:2 Anandamide phosphate sodium is a phospholipid derivative of anandamide, acting primarily on cannabinoid receptors. This compound exhibits bioactive properties that influence lipid signaling pathways and modulate neuronal communication. It is applicable in research exploring endocannabinoid system dynamics, neuroprotection, and potential therapeutic avenues for neurological disorders. -
Lipid
N-Oleoyl-L-serine sodium is an analog of anandamide that primarily targets lipid signaling pathways. This compound exhibits notable biological activity as a cannabinoid receptor modulator, influencing physiological processes such as pain perception and inflammation. It is frequently used in research applications focused on neurobiology and lipid metabolism. -
Platelet Aggregation Inhibitor
Cloricromen is a potent platelet aggregation inhibitor that functions by targeting the mechanisms involved in thrombus formation. Demonstrating efficacy in inhibiting platelet aggregation in both human subjects and experimental models, Cloricromen is a valuable reagent for research in cardiovascular disease and thrombotic disorders. Its application in studying platelet function and related pathologies makes it an essential tool for investigations in vascular biology. -
Neuroleptic Agent
Fenaperone hydrochloride is a neuroleptic agent that primarily targets dopamine receptors in the central nervous system. It exhibits antipsychotic properties, making it relevant for research in neurological disorders and psychiatric conditions. Its mechanism includes modulation of neurotransmitter activity, contributing to its potential therapeutic effects in various mental health applications. -
Biochemical Assay Reagent
1,3-Dipropyl-7-methylxanthine is a selective antagonist of adenosine receptors, primarily targeting the A1 subtype. It exhibits potent inhibitory effects on adenosine-mediated signaling pathways, making it valuable in biochemical assays for studying adenosine receptor functions. This compound is commonly utilized in research examining cellular processes influenced by adenosine, such as neurotransmission, inflammation, and metabolic regulation. -
Biochemical Assay Reagent
5'-Ethylcarboxamido-2',3'-isopropylidene adenosine is a selective agonist targeting A2B adenosine receptors. This compound enhances A2B receptor activity, making it valuable for investigating the physiological roles of adenosine signaling in various biological processes. It serves as a pertinent tool in biochemical assays and research applications aimed at understanding adenosine's effects and its potential as a therapeutic target in drug development. -
Biochemical Reagent
Nestifylline is a biochemical reagent that functions primarily as an antagonist of adenosine receptors. It exhibits significant activity in modulating airway constriction, making it a valuable tool for studying respiratory diseases, particularly bronchospasm. Researchers can utilize Nestifylline to explore mechanisms underlying airway responsiveness and potential therapies for respiratory disorders. -
PGF2α Analog
Fenprostalene is a potent analog of prostaglandin F2α (PGF2α) that primarily targets the prostaglandin pathway. This compound is effective in veterinary medicine for inducing corpus luteum regression and lowering blood progesterone levels in dogs. Its primary applications include the treatment of pyometra and the induction of abortion, making it a critical reagent in reproductive health studies and veterinary practices. -
Amino Acid Derivatives
H-Lys(Fmoc)-OH hydrochloride is an amino acid derivative featuring an Fmoc protecting group. This compound serves as a key intermediate for the synthesis of diacylated GLP-1 derivatives, which possess antidiabetic properties. Its utility in peptide synthesis makes it an important reagent in chemical biology and drug development. -
Amino Acid Derivatives
Boc-Leu-OH hydrate (N-Boc-L-leucine monohydrate) is a protected form of the amino acid leucine, featuring a Boc protecting group. It serves as a useful intermediate in peptide synthesis, particularly for the generation of L-prolyl-L-leucyl-glycinamide, a peptide mimetic known for its modulatory effects on dopamine receptors. This compound is valuable in research focused on neuropharmacology and peptide therapeutics. -
H3 Agonist
Immepip dihydrobromide acts as a selective agonist for the H3 histamine receptor. It is known to attenuate cortical histamine release, thereby influencing neurotransmitter dynamics. This compound is applicable in the study of neurological disorders, providing insights into histaminergic system modulation and its potential therapeutic effects. -
Smoothened Agonist
SAG dihydrochloride is a potent Smoothened (Smo) receptor agonist, with an EC50 of 3 nM and a Kd of 59 nM. This compound effectively activates the Hedgehog signaling pathway, providing a robust mechanism to counteract the inhibitory effects of Cyclopamine. SAG dihydrochloride is valuable for research in developmental biology, cancer biology, and therapeutic strategies targeting Hedgehog-related pathways. -
Smoothened Antagonist
KAAD-Cyclopamine is an antagonist of the Smoothened receptor, a critical component of the Hedgehog signaling pathway. This compound effectively inhibits hedgehog signaling, thereby influencing cell proliferation and differentiation processes. It is widely used in research related to developmental biology, cancer, and regenerative medicine, facilitating the study of signaling cascades and their implications in various diseases. -
hSMOX Inhibitor
JNJ-1289 is a potent and selective inhibitor of human spermine oxidase (hSMOX), exhibiting a competitive and allosteric mechanism of action with an IC50 value of 50 nM. This compound is primarily utilized in research studies focused on polyamine catabolism, inflammation, and various cancer models, providing valuable insights into the role of hSMOX in these biological processes. -
Smo Probe
BODIPY-Cyclopamine is a fluorescent ligand targeting the Smoothened (SMO) receptor, crucial for Hedgehog signaling pathway regulation. Dysregulation of this pathway is linked to tumorigenesis, making BODIPY-Cyclopamine valuable for research related to cancer biology. Utilizing the NanoBRET (Nanofluorescein bioluminescence resonance energy transfer) technique, this compound facilitates the sensitive detection of energy transfer between SMO and the fluorescent probe, enabling high-throughput screening and kinetic studies. Additionally, investigating the binding dynamics of BODIPY-Cyclopamine can assist in the development of SMO-targeted therapeutics. -
Smo Receptors Antagonist
MRT-81 is a potent antagonist of smoothened (Smo) receptors in both human and rodent models, exhibiting an IC50 value of 41 nM in Shh-light2 cells. This compound effectively inhibits hedgehog signaling pathways, making it a valuable tool in cancer research. Its ability to modulate Smo activity facilitates investigations into Hedgehog pathway-related tumors and their therapeutic interventions. -
Smo Antagonist
IHR-1 is a cell membrane impermeable antagonist of Smoothened (Smo), a key component of the Hedgehog signaling pathway. This compound effectively inhibits Smo activity, making it a valuable tool for studying Hedgehog-related biological processes and disease states, such as cancer and developmental disorders. IHR-1's specificity for Smo allows for targeted research into the mechanistic roles of this pathway in various cellular contexts. -
Smo Inhibitor
MRT-83 hydrochloride is a potent Smoothened (Smo) receptor antagonist. By inhibiting the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo, MRT-83 hydrochloride demonstrates significant biological activity. This compound is particularly relevant for research applications focused on cancer and associated signaling pathways. -
Smo Antagonist
MRT-10 is a smoothened (Smo) antagonist that effectively inhibits Smo activity with an IC50 of 0.65 μM in various Hedgehog (Hh) signaling assays. By binding to the Bodipycyclopamine-binding site on the Smo receptor, MRT-10 serves as a valuable tool for investigating the roles of Hedgehog signaling in cancer biology. Its application may extend to studies focused on tumor growth and progression influenced by aberrant Hedgehog pathway activation. -
Smoothened Inhibitor
Glasdegib maleate is a potent smoothened inhibitor that selectively targets the human Smoothened (SMO) protein. With an IC50 value of 4 nM, this orally bioavailable compound effectively modulates the Hedgehog signaling pathway, making it valuable for research in cancer biology and developmental processes. Glasdegib maleate is primarily used in studies investigating tumor growth and metastasis driven by aberrant Hedgehog signaling. -
Smo Inhibitor
Glasdegib hydrochloride is a potent smoothened (SMO) inhibitor, primarily targeting the Hedgehog signaling pathway. It exhibits high affinity for human SMO, with an IC50 of 4 nM, making it an effective tool for research in cancer biology and developmental processes. This compound is valuable for studies investigating the role of SMO in tumorigenesis and therapeutic resistance in various malignancies. -
SMO Inhibitor
AZD7254 is an orally active Smoothened (SMO) inhibitor with a reported EC50 of 1.0 nM against Sonic Hedgehog (Shh) protein. This compound effectively modulates hedgehog signaling pathways, making it a valuable tool for investigating the role of SMO in various cancers and developmental disorders. Its potent inhibition of SMO activity supports research applications in targeted therapies and pathway analysis. -
Smo Antagonist
MRT-14 is a potent Smoothened (Smo) antagonist, specifically targeting the Hedgehog (Hh) signaling pathway. By inhibiting Smo, MRT-14 disrupts the signal transduction linked to Hh morphogens. This compound demonstrates potential for research applications in various cancers associated with dysregulated Hh signaling. -
Smo Agonist
(Rac)-SAG is a potent agonist of the Smoothened (Smo) receptor, exhibiting an EC50 of 3 nM and a Kd of 59 nM. This compound activates the Hedgehog signaling pathway, making it an invaluable tool in studies focused on Smo-mediated processes. Additionally, (Rac)-SAG can counteract the inhibition of Smo by Cyclopamine, facilitating research into signaling and developmental biology. -
SMO Inhibitor
SMO-IN-1 is an orally active Smoothened (SMO) inhibitor that demonstrates an EC50 of 89 nM for sonic hedgehog (Shh) protein. This compound is effective in disrupting the hedgehog signaling pathway, making it a valuable tool in cancer research and developmental biology studies. It may be particularly relevant for investigating tumors associated with aberrant hedgehog signaling. -
Smoothened Antagonist
SMO-IN-4 is a potent oral antagonist of the Smoothened (SMO) protein, displaying an IC50 of 24 nM. This compound demonstrates significant antitumor activity and is utilized in research focused on hedgehog signaling pathways and cancer therapy. SMO-IN-4 serves as a valuable tool for investigating SMO-related mechanisms in various malignancies. -
Smo Antagonist
PF-5274857 hydrochloride is a potent, selective antagonist of Smoothened (Smo) with an IC50 of 5.8 nM and a Ki of 4.6 nM. Its oral bioavailability and ability to penetrate the blood-brain barrier enhance its utility in research on tumors, particularly brain tumors and brain metastases associated with an activated Hedgehog (Hh) signaling pathway. This compound is valuable for studies aimed at understanding Smo-mediated tumorigenesis and developing targeted therapeutics. -
Smo Activator
7-keto-25-Hydroxycholesterol is an oxysterol that acts as an activator of Smoothened (Smo). This compound interacts specifically with the extracellular cysteine-rich domain (CRD) of Smo, facilitating its activation. Research applications include studies on hedgehog signaling pathways and the exploration of Smo’s role in developmental biology and cancer. -
Smo Inhibitor
Saridegib hydrochloride is a selective inhibitor of Smoothened (Smo), a critical component of the Hedgehog (Hh) signaling pathway. By targeting Smo, this compound effectively disrupts Hh-mediated signaling, which is implicated in various developmental processes and diseases, including cancer. It is utilized in research to explore the role of the Hh pathway in tumorigenesis and as a potential therapeutic approach in Smo-dependent malignancies. -
ARα2c Inhibitor
BAY-2925976 is an α2C adrenergic receptor (ARα2C) inhibitor that selectively blocks receptor activity. This compound is primarily utilized in research related to obstructive sleep apnea (OSA), providing insights into its underlying mechanisms and potential therapeutic approaches. BAY-2925976 aids in elucidating the role of ARα2C in respiratory regulation and sleep disorders. -
β-AR Antagonist
Lubabegron fumarate is a selectiveβ-adrenergic receptor (β-AR) modulator, exhibiting antagonistic properties at both β1 and β2 receptor subtypes while acting as an agonist at the β3 subtype in bovine species. This compound effectively reduces ammonia (NH3) gas emissions from livestock and their waste, making it a valuable tool for improving environmental sustainability in agricultural practices. Lubabegron fumarate is primarily used in research applications focused on animal health and emissions management. -
Histamine Methylated Product
3-Methylhistamine dihydrochloride is a methylated derivative of histamine that serves as a significant biomarker in the study of immune responses. This compound has been shown to be upregulated in vaccinated murine models, making it useful for research applications focused on immunological studies and histamine-related pathways. Its role in the modulation of immune activity positions it as a valuable reagent in exploring allergic reactions and other histamine-mediated processes. -
Endogenous Metabolite
8-(3-Chlorostyryl)caffeine is a selective antagonist of the A2a adenosine receptor, demonstrating a significant 520-fold selectivity in radioligand binding assays conducted in rat brain. It effectively inhibits adenylylase with a 22-fold selectivity in rat chromaffin cells. Co-administration with the A1-selective antagonist CPX has been shown to enhance exercise activity. Additionally, 8-(3-Chlorostyryl)caffeine exhibits potent inhibitory activity against MAO-B in primate mitochondrial systems. This compound serves as a valuable tool for studying adenosine receptor signaling and its effects on physiological processes. -
Endogenous Metabolite
Palmitoleoyl ethanolamide (POEA) is an endogenous fatty amide that functions primarily as a signaling molecule through the activation of cannabinoid receptors. It has been shown to exhibit anti-inflammatory and analgesic properties, making it relevant for research in pain management and inflammatory disorders. POEA's involvement in metabolic processes also positions it as a valuable target for studies in obesity and metabolic syndrome. -
Endogenous Metabolite
5-OAHSA is an endogenous metabolite that functions as a lipid mediator. It is known to lower blood glucose levels, enhance glucose tolerance, and stimulate the secretion of glucagon-like peptide-1 (GLP-1) and insulin. 5-OAHSA is valuable for research applications focused on metabolic regulation and inflammation modulation. -
Endogenous Metabolite
Hydroxy bosentan is an endogenous metabolite derived from Bosentan, primarily processed by the cytochrome P450 system in the liver. This compound retains 10%-20% of Bosentan's pharmacological activity, serving as a significant contributor to the overall therapeutic effects of the parent compound. Hydroxy bosentan is useful in research focused on metabolic pathways and the pharmacokinetics of endothelin receptor antagonists. -
Endogenous Metabolite
1-Methylhistamine dihydrochloride is a metabolite of histamine that primarily targets histamine receptors. This compound exhibits significant biological activity in the modulation of allergic responses and neurotransmission processes. It is widely utilized in research applications focusing on histamine signaling pathways and its role in various physiological and pathological conditions. -
Drug Metabolite
Desmethyl Bosentan is an active metabolite of the endothelin receptor antagonist bosentan. It functions primarily by activating the pregnane X receptor (PXR), as demonstrated in CV-1 monkey kidney cells expressing the human receptor in a reporter assay at a concentration of 25 μM. This compound is valuable for studying drug metabolism and the regulatory pathways involved in pharmacokinetics and toxicology research. -
DAGL-α/DAGL-β Inhibitor
LEI105 is a selective and reversible dual inhibitor of diacylglycerol lipase (DAGL)-α and DAGL-β. This compound effectively decreases levels of 2-arachidonoylglycerol in Neuro2A cells, demonstrating its potential to modulate endocannabinoid signaling. Research applications include investigations into the mechanisms underlying obesity, metabolic disorders, and neuroinflammation, as well as studies of cannabinoid receptor-mediated synaptic plasticity in mouse hippocampal slices. -
Drug Metabolite
Quetiapine sulfoxide dihydrochloride is a primary metabolite of the second-generation antipsychotic quetiapine. This compound functions as a 5-HT receptor agonist and a dopamine receptor antagonist, contributing to its pharmacological effects. It is commonly utilized in research related to neuropharmacology and metabolic profiling of antipsychotic drugs, offering insights into the drug's therapeutic activity and safety profile. -
Metabolite of Acebutolol
Diacetolol is an active metabolite of the beta-adrenoceptor antagonist Acebutolol. It exhibits pharmacological activity by selectively inhibiting β1-adrenergic receptors, which plays a significant role in cardiovascular research. Diacetolol is utilized to study beta-blocker pharmacodynamics and to explore its effects on heart rate and blood pressure regulation. -
Drug Metabolite
3-Hydroxy Medetomidine is a primary metabolite of the α2-adrenergic receptor agonist medetomidine. This compound exhibits important biological activity as it participates in modulating adrenergic signaling pathways. Research applications include studies on drug metabolism and the pharmacokinetics of sedatives in both veterinary and medical contexts. -
Lurasidone Metabolite
Lurasidone Metabolite 14283 hydrochloride is a significant active metabolite of the antipsychotic agent Lurasidone, which targets serotonin and dopamine receptors. This compound plays a crucial role in the pharmacological activity of Lurasidone, contributing to its efficacy in the treatment of schizophrenia. Research applications include studying the metabolic profile of Lurasidone and its pharmacodynamics in neural systems. -
5-HT2A Inverse Agonist
N-Desmethyl Pimavanserin is a potent inverse agonist of the 5-HT2A receptor, serving as an active metabolite of Pimavanserin. With high affinity demonstrated by a pIC50 of 8.73 and pKd of 9.3, this compound has significant implications in research focused on psychiatric disorders, such as schizophrenia and Parkinson's disease psychosis. Its role in modulating serotonergic signaling makes it an important reagent for studies investigating the therapeutic potential of 5-HT2A antagonism.
