KAAD-Cyclopamine

Catalog No.: A84825
Smoothened Antagonist
KAAD-Cyclopamine is an antagonist of the Smoothened receptor, a critical component of the Hedgehog signaling pathway. This compound effectively inhibits hedgehog signaling, thereby influencing cell proliferation and differentiation processes. It is widely used in research related to developmental biology, cancer, and regenerative medicine, facilitating the study of signaling cascades and their implications in various diseases.
Grouped product items
Size Price Stock Qty
25µg
$135.00
In stock
50µg
$215.00
In stock
1mg
$1,735.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionKAAD-Cyclopamine is an antagonist of the Smoothened receptor, a critical component of the Hedgehog signaling pathway. This compound effectively inhibits hedgehog signaling, thereby influencing cell proliferation and differentiation processes. It is widely used in research related to developmental biology, cancer, and regenerative medicine, facilitating the study of signaling cascades and their implications in various diseases.
Product Information
Catalog NumA84825
FormulaC44H63N3O4
Molecular Weight697.99
CAS Number306387-90-6
SMILESC[C@H]([C@@](N1CCNC(CCCCCNC(CCC2=CC=CC=C2)=O)=O)([H])[C@](C[C@H](C)C1)([H])O3)[C@@]43C(C)=C(C[C@@]5([H])[C@@]6([H])CC=C(C7)[C@@]5(CCC7=O)C)[C@@]6([H])CC4
SynonymsCyclopamine-KAAD
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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