MRT-10 is a smoothened (Smo) antagonist that effectively inhibits Smo activity with an IC50 of 0.65 μM in various Hedgehog (Hh) signaling assays. By binding to the Bodipycyclopamine-binding site on the Smo receptor, MRT-10 serves as a valuable tool for investigating the roles of Hedgehog signaling in cancer biology. Its application may extend to studies focused on tumor growth and progression influenced by aberrant Hedgehog pathway activation.
MRT-10 is a smoothened (Smo) antagonist that effectively inhibits Smo activity with an IC50 of 0.65 μM in various Hedgehog (Hh) signaling assays. By binding to the Bodipycyclopamine-binding site on the Smo receptor, MRT-10 serves as a valuable tool for investigating the roles of Hedgehog signaling in cancer biology. Its application may extend to studies focused on tumor growth and progression influenced by aberrant Hedgehog pathway activation.
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