MRT-81 is a potent antagonist of smoothened (Smo) receptors in both human and rodent models, exhibiting an IC50 value of 41 nM in Shh-light2 cells. This compound effectively inhibits hedgehog signaling pathways, making it a valuable tool in cancer research. Its ability to modulate Smo activity facilitates investigations into Hedgehog pathway-related tumors and their therapeutic interventions.
MRT-81 is a potent antagonist of smoothened (Smo) receptors in both human and rodent models, exhibiting an IC50 value of 41 nM in Shh-light2 cells. This compound effectively inhibits hedgehog signaling pathways, making it a valuable tool in cancer research. Its ability to modulate Smo activity facilitates investigations into Hedgehog pathway-related tumors and their therapeutic interventions.
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