- Cat. No.
- A22275
Sodium oxamate
Sodium oxamate (SO, Aminooxoacetic acid, Oxamic acid) is an inhibitor of lactate dehydrogenase (LDH) that specificly inhibits LDH?A.
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- Cat. No.
- A12274
GNE-140 racemate
Synonyms: GNE140
GNE-140 racemate is a racemate mixture of (R)-GNE-140 and (S)-GNE-140. (R)-GNE-140 is a potent lactate dehydrogenase A (LDHA) inhibitor.
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- Cat. No.
- A19496
LDH-IN-1
LDH-IN-1 is a novel pyrazole-based inhibitor of human lactate dehydrogenase (LDH) with IC50s of 32 and 27 nM for LDHA and LDHB, respectively.
In stock View Details -
- Cat. No.
- A20321
GSK2837808A
GSK2837808A is a potent and selective lactate dehydrogenase A (LDHA) inhibitor with IC50s of 1.9 and 14 nM for LDHA and LDHB, respectively.
In stock View Details -
- Cat. No.
- A20900
FX-11
Synonyms: LDHA Inhibitor FX11
FX-11 (LDHA Inhibitor FX11) is a potent lactate dehydrogenase A (LDHA) inhibitor with an IC50 of 23.3 μM for HeLa cell, a Ki value of 8 μM.
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- Cat. No.
- A21863
(R)-GNE-140
Synonyms: GNE140
(R)-GNE-140 is a potent lactate dehydrogenase A (LDHA) inhibitor, with IC50s of 3 nM and 5 nM for LDHA and LDHB, respectively; (R)-GNE-140 is 18-fold more potent than S enantiomer.
In stock View Details -
- Cat. No.
- A21867
(S)-GNE-140
Synonyms: GNE140
(S)-GNE-140 is the less active enantiomer of GNE-140 which can inhibit Lactate dehydrogenase A (LDHA).
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- Cat. No.
- A22146
GNE-140 racemic
GNE-140 racemic is a novel potent lactate dehydrogenase (LDHA) inhibitor.
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- Cat. No.
- A30064
Oxamic acid
Synonyms: Oxamidic acid
Oxamic acid is an inhibitor of lactate dehydrogenase-A (LDH-A), a key enzyme involved in cellular metabolism. This compound exhibits notable anti-tumor and anti-proliferative effects, specifically targeting cancer cells and promoting apoptosis. Oxamic acid is valuable for research applications focused on cancer metabolism and therapeutic strategies aimed at metastasis and tumor growth inhibition.
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- Cat. No.
- A30585
NHI-2
NHI-2 is a selective inhibitor of lactate dehydrogenase A (LDHA) with an IC50 of 14.7 µM, exhibiting significantly lower inhibition of LDHB (IC50 = 55.8 µM). This compound demonstrates potent anti-glycolytic properties, enhancing apoptosis and inducing cell cycle arrest in the S and G2 phases. NHI-2 exhibits broad-spectrum anti-proliferative effects on various cancer cell lines and influences key metabolic parameters such as extracellular acidification rate and ATP production. Additionally, NHI-2 has shown efficacy in suppressing tumor growth in murine models of B78 melanoma.
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- Cat. No.
- A31388
NCI-006
NCI-006 is an orally active lactate dehydrogenase (LDH) inhibitor, with IC50 values of 0.06 μM for LDHA and 0.03 μM for LDHB. It effectively suppresses intratumoral LDH activity, lactate production, and tumor growth in mouse models of pancreatic cancer. NCI-006 inhibits glycolysis and promotes apoptosis in vitro, enhancing the radiosensitivity of glycolytic tumor cell lines while preserving normal cells. Additionally, it demonstrates synergistic antitumor effects when combined with IACS-010759 against colorectal and gastric cancers, and it impairs tumor growth in Ewing sarcoma models.
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- Cat. No.
- A31866
ZG-2492
ZG-2492 is an orally active lactate dehydrogenase A (LDHA) inhibitor, exhibiting an IC50 of 156 nM. This compound effectively reduces lactate production, induces cell cycle arrest, and triggers apoptosis in pancreatic cancer cells. ZG-2492 demonstrates significant antitumor activity and serves as a valuable tool for research focused on pancreatic cancer and other related tumor types.
Out of stock
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- Cat. No.
- A32480
LDHA-IN-9
LDHA-IN-9 is a potent lactate dehydrogenase A (LDHA) inhibitor, exhibiting an IC50 of 25 nM. This compound effectively inhibits DLD-1 cell proliferation with a GI50 of 27 μM, primarily by inducing apoptosis. Additionally, LDHA-IN-9 demonstrates significant antitumor activity in murine models while maintaining a favorable toxicity profile at a dosage of 25 mg/kg. This compound is suitable for research applications targeting metabolic regulation and cancer therapeutics.
Out of stock
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- Cat. No.
- A32716
LDH-IN-5
LDH-IN-5 is a potent inhibitor of Lactate Dehydrogenase (LDH), exhibiting neuroprotective properties. This compound effectively inhibits cell apoptosis, reduces reactive oxygen species (ROS) and malondialdehyde (MDA) production, and enhances superoxide dismutase (SOD) activity. LDH-IN-5 is instrumental in researching neurological disorders, particularly in the context of ischemic stroke.
Out of stock
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- Cat. No.
- A33081
Galloflavin potassium
Galloflavin potassium is a selective inhibitor of lactate dehydrogenase, primarily targeting the conversion of pyruvate to lactate. This compound effectively disrupts aerobic glycolysis in PLC/PRF/5 cells, promoting apoptotic cell death. Galloflavin potassium is valuable for research applications related to cancer biology, particularly in studies focused on metabolic reprogramming and the Warburg effect.
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- Cat. No.
- A75827
Galloflavin
Galloflavin is a potent lactate dehydrogenase (LDH) inhibitor, specifically targeting both LDH-A and LDH-B with calculated inhibition constants of 5.46 μM and 15.06 μM, respectively. By inhibiting LDH, Galloflavin disrupts glycolysis and ATP production, thereby hindering the proliferation of cancer cells. This compound is valuable for research applications focused on metabolic regulation and cancer therapeutics.
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- Cat. No.
- A75829
LDHA-IN-3
LDHA-IN-3 is a potent noncompetitive inhibitor of lactate dehydrogenase (LDHA), exhibiting an IC50 of 145.2 nM. This selenobenzene compound effectively disrupts LDHA activity, which plays a critical role in cancer metabolism. LDHA-IN-3 is suitable for research applications focused on elucidating metabolic pathways in cancer and exploring potential therapeutic interventions.
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- Cat. No.
- A75832
3-Acetylpyridine adenine dinucleotide, 90%
Synonyms: 3-APAD; 90%; 3-Acetylpyridine NAD
3-Acetylpyridine adenine dinucleotide is a potent inhibitor of lactate dehydrogenase (LDH), an enzyme critical for the conversion of pyruvate to lactate in cellular metabolism. As an analog of nicotinamide adenine dinucleotide (NAD), it offers valuable insight into NAD-dependent enzymatic processes. This compound is useful in both biochemical studies and metabolic research, providing a means to explore LDH's role in various pathophysiological conditions.
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- Cat. No.
- A75833
CHK-336
CHK-336 is a potent LDHA inhibitor, exhibiting an IC50 of less than 1 nM. It effectively reduces lactate production in mouse hepatocytes, making it a valuable tool for studying metabolic disorders such as hyperoxaluria. This compound facilitates exploration of LDHA's role in various biological processes and therapeutic interventions.
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- Cat. No.
- A75834
Glomeratose A
Glomeratose A is a potent lactate dehydrogenase inhibitor derived from the plant Polygala tenuifolia. This compound demonstrates significant biological activity by modulating lactate production, thereby impacting metabolic processes associated with various diseases. Research applications include investigations into metabolic pathways, cancer biology, and the role of lactate in cellular signaling.
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- Cat. No.
- A75836
RS6212
RS6212 is a specific inhibitor of lactate dehydrogenase (LDH) with an IC50 value of 12.03 μM. This compound demonstrates potent anticancer activity and effectively inhibits tumor growth in various cancer cell lines. RS6212 is valuable for research applications focused on cancer metabolism and therapeutic strategies targeting LDH in oncology.
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- Cat. No.
- A75837
NCATS-SM1441
NCATS-SM1441 is a potent lactate dehydrogenase (LDH) inhibitor with an IC50 value of 40 nM. By effectively inhibiting LDH activity, NCATS-SM1441 reduces lactic acid production in cancer cells, which may hinder their proliferation. This compound is valuable for investigations into cancer metabolism and therapeutic strategies targeting metabolic pathways in oncological research.
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- Cat. No.
- A75839
LDHA-IN-5
LDHA-IN-5 is a potent inhibitor of lactate dehydrogenase (LDHA), targeting its enzymatic activity to modulate metabolic pathways. This compound exhibits significant potential in research applications related to metabolic disorders, including primary hyperoxaluria. By inhibiting LDHA, LDHA-IN-5 may help to reduce lactate levels and influence cellular metabolism, making it a valuable tool for understanding disease mechanisms and developing therapeutic strategies.
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- Cat. No.
- A75842
LDHA-IN-6
LDHA-IN-6 is a potent inhibitor of lactate dehydrogenase-A (LDHA), exhibiting an IC50 of 46 nM. This compound demonstrates significant antitumor activity, making it a valuable tool for research in cancer metabolism and therapeutic development. Its ability to modulate LDHA activity facilitates investigations into the metabolic pathways associated with tumor growth and proliferation.
Out of stock
All 3 sizes