Catalog No.
Product Name
Application
Product Information
Citations
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DNA Topoisomerase I/II Inhibitor
Corydamine is a 3-arylisoquinoline alkaloid that serves as a potent inhibitor of DNA topoisomerase I and II. This compound exhibits significant anti-cancer activity and is utilized in research applications aimed at understanding the mechanisms of tumorigenesis and the development of targeted cancer therapies. Its ability to interfere with DNA manipulation makes it an important tool in the study of cellular processes and treatment modalities in oncology. -
Topoisomerase I Inhibitor
Topoisomerase I Inhibitor 4 is a selective inhibitor of topoisomerase I, effectively targeting the enzyme to disrupt DNA replication. It demonstrates significant anti-proliferative effects on various cancer cell lines, including HepG2, A549, MCF-7, and HeLa, with IC50 values of 1.20 μM, 2.09 μM, 1.56 μM, and 1.92 μM, respectively. This compound is valuable for cancer research, particularly in studying mechanisms of tumor growth inhibition. -
Topoisomerase II Inhibitor
Pericosine A is a potent inhibitor of topoisomerase II, derived from the Periconia byssoides strain. This compound exhibits significant antitumor activity, demonstrating efficacy in both in vitro and in vivo settings, making it a valuable tool in cancer research. Additionally, Pericosine A inhibits the epidermal growth factor receptor (EGFR) kinase, further expanding its potential applications in therapeutic research targeting malignancies. -
Topoisomerase-1 Inhibitor
TP3011 (CH0793011) is a potent topoisomerase I inhibitor, demonstrating equipotent activity comparable to SN38. It effectively inhibits the growth of various cancer cell lines, exhibiting IC50 values in the sub-nanomolar range in vitro. This compound is valuable for research applications focused on cancer therapy and the study of topoisomerase-targeted mechanisms. -
Topoisomerase Inhibitor
Topoisomerase Inhibitor 2 (18C) is a potent bacterial topoisomerase inhibitor, demonstrating broad-spectrum activity against multidrug-resistant Gram-negative bacteria. This reagent is valuable for research targeting bacterial DNA replication and repair pathways, making it relevant for studies focused on antibiotic resistance mechanisms and the development of novel antimicrobial agents. -
Topoisomerase II Inhibitor
Topoisomerase II Inhibitor 8 is a potent inhibitor of topoisomerase II, demonstrating an IC50 of 0.52 μM. This compound exhibits significant anti-proliferative activity, effectively arresting the cell cycle at the G2/M phase. It is suitable for research applications involving cancer cell growth and the study of cell cycle regulation. -
Drug Derivative
(Rac)-7-Ethyl-10-hydroxycamptothecin is a derivative of (±)-10-hydroxycamptothecin, an indole alkaloid known for its ability to inhibit topoisomerase I. This compound demonstrates significant anticancer activity across various cancer cell lines, making it a valuable tool for biological research. Its application extends to studying the mechanisms of cancer cell proliferation and the development of novel chemotherapeutic agents. -
Resolvase Inhibitor
A20832 is a selective inhibitor of resolvase, targeting its recombination and topoisomerase activities. This compound effectively disrupts the site-specific recombination mediated by the Tn3-encoded resolvase protein, specifically at the strand cleavage step, while leaving the synapsis process unaffected. A20832 serves as a valuable tool for researchers investigating the mechanisms of genetic recombination and the role of resolvase in various biological contexts. -
Topoisomerase II Inhibitor
Suptopin-2 is a potent inhibitor of topoisomerase II, a key enzyme involved in DNA replication and cell division. By inhibiting this target, Suptopin-2 disrupts cell cycle progression and destabilizes microtubules, leading to cell cycle arrest. This compound plays a crucial role in research focused on cancer biology and the mechanistic study of cellular processes involving nucleocytoplasmic transport, specifically through the regulation of cyclin B1. -
TopoII Inhibitor
Dichlorogelignate is a selective inhibitor of topoisomerase II (Topo II), demonstrating complete inhibition at a concentration of 50 μM. This compound is instrumental in studying the role of Topo II in DNA manipulation processes, making it valuable for cancer research and drug discovery applications targeting cellular proliferation and genomic stability. -
Topoisomerase I Inhibitor
Lurtotecan dihydrochloride is a semisynthetic analog of Camptothecin that acts as a topoisomerase I inhibitor. This compound exhibits significant anticancer activity, making it a valuable tool in cancer research. Its ability to interfere with DNA replication and transcription provides insights into tumor biology and therapeutic strategies. Researchers may utilize Lurtotecan dihydrochloride in studies of cancer cell survival, resistance mechanisms, and drug efficacy. -
Topoisomerase II Inhibitor
Bakuchicin, a topoisomerase II inhibitor derived from Psoralea corylifolia, demonstrates significant biological activity by inhibiting the enzyme's function. In cellular models infected with Simian virus 40 (SV40), Bakuchicin exhibits an IC50 value of 404 μM against topoisomerase II. This compound is primarily utilized in research focused on virology and anti-infection studies. -
Topoisomerase II Inhibitor
Topoisomerase IIα-IN-9 (NSC85582) is a bisphenol compound that serves as a moderate inhibitor of DNA topoisomerase II, with an IC50 value of 571 μM. This compound demonstrates notable cell growth inhibition, exhibiting IC50 values of 117 μM in K562 cells and 218 μM in CHO cells. Topoisomerase IIα-IN-9 is valuable for research applications focused on cancer biology and the mechanisms of drug resistance. -
topoisomerases I/II inhibitor
Becatecarin is an analog of rebeccamycin that primarily targets topoisomerases I and II. This compound exerts antitumor effects by intercalating into DNA, consequently inhibiting the catalytic activity of these enzymes. Due to its mechanism of action, Becatecarin is valuable in cancer research, particularly in studies exploring DNA damage and repair pathways. -
Topoisomerase II Inhibitor
8-Chloro-ATP tetrasodium is an analog of ATP that functions as an inhibitor of topoisomerase II (Topo II). It effectively inhibits DNA synthesis and promotes the formation of DNA double-stranded breaks (DSBs). 8-Chloro-ATP tetrasodium also obstructs the ATP hydrolysis activity catalyzed by Topo II. This compound is valuable for research applications focused on cell division, DNA repair mechanisms, and topoisomerase function. -
Weak Inhibitor of Cell Proliferation
(S)-Gyramide A is a weak inhibitor of cell proliferation that targets DNA gyrase. Its primary biological activity involves interference with DNA supercoiling, which can disrupt bacterial cell division. Research applications of (S)-Gyramide A include studies on bacterial growth inhibition and the elucidation of the role of DNA gyrase in cell cycle regulation. This reagent is valuable for investigating potential antibacterial strategies and understanding the molecular mechanisms of cell proliferation. -
Makaluvamines
Makaluvamine A is a naturally occurring compound that targets topoisomerase II, exerting significant inhibitory effects on this enzyme. Derived from Fijian sponges of the genus Zyzzya, Makaluvamine A demonstrates notable cytotoxic activity against HCT-116 human colon cancer cells. This compound may serve as a valuable tool for cancer research and drug development investigations focused on topoisomerase-targeting therapies. -
Anticancer Agent
Ethonafide is an anthracene-derived compound that functions as an anticancer agent by inhibiting topoisomerase II activity. It stabilizes the enzyme-DNA complex, thereby impacting both topoisomerase IIα and β. This mechanism of action makes Ethonafide a valuable tool for research in cancer therapy and the exploration of potential treatments for malignancies. -
Topoisomerase II Inhibitor
HU 331 is a selective inhibitor of Topoisomerase II, demonstrating significant anticancer properties. This compound has exhibited potent inhibitory effects on various human cancer cell lines in vitro, as well as efficacy in reducing the growth of human tumor xenografts in vivo using nude mice models. HU 331 is valuable for research applications focused on cancer biology and therapeutics targeting DNA topology. -
Topoisomerase II Inhibitor
Retelliptine is a Topoisomerase II inhibitor with notable anticancer properties. This derivative of ellipticine demonstrates the ability to bind to DNA, thereby impeding the function of Topoisomerase II during DNA replication. Its mechanism of action makes it valuable in the study of cancer therapeutics and cell cycle regulation. -
SN-38 Derivative
10-Boc-SN-38 is a tert-butyloxycarbonyl (Boc)-protected derivative of SN-38, the active metabolite of the chemotherapeutic agent Irinotecan. This compound serves as a valuable tool in the study of anti-cancer mechanisms and drug metabolism. Its modification allows for enhanced stability and selectivity in various biological assays, making it useful for drug development and pharmacological research applications. -
Topoisomerase I inhibitor
Topoisomerase I inhibitor 9 is a selective inhibitor of leishmanial topoisomerase IB, demonstrating significant antileishmanial activity against Leishmania donovani promastigotes. The compound exhibits an IC50 value of 34.81 μM, indicating its potential utility in research aimed at developing therapeutic strategies for leishmaniasis. This reagent is valuable for studies focusing on the role of topoisomerases in parasite biology and drug discovery efforts targeting leishmaniasis. -
Topo II Catalytic Inhibitor
NU/ICRF 500 is a potent inhibitor of topoisomerase II catalytic activity, critical for DNA replication and repair. This compound has been shown to increase the formation of CREST-negative micronuclei in human lymphocytes, highlighting its role in genotoxicity studies and cancer research. It serves as a valuable tool for investigating the mechanisms of DNA damage and the effects of topoisomerase inhibition in various biological contexts. -
Top1 Catalytic Inhibitor
Guajadial C is a potent Topoisomerase I (Top1) catalytic inhibitor that effectively delays the DNA damage typically induced by Top1 poisons. This compound exhibits significant cytotoxicity towards various cancer cell lines, making it a valuable tool for research in cancer biology and therapeutic strategies targeting Top1-mediated pathways. Its potential applications include investigations into mechanisms of resistance and the development of novel anticancer therapies. -
Topo II Inhibitor
9-Hydroxyellipticin is a potent inhibitor of topoisomerase II (Topo II) and ryanodine receptors (RyR), demonstrating high affinity for DNA with a pKa value of 9.8 at pH 7.4. This compound exhibits significant antitumor and antioxidant activities, with IC50 values of 1.6 μM in HeLa S-3 cells and 1.2 μM in 293T cells. Additionally, 9-hydroxyellipticin has shown promising anticancer effects in murine models of L1210 leukemia, making it a valuable reagent for cancer research and therapeutic studies. -
DNA topoisomerase Inhibitor
Tafluposide is a potent DNA topoisomerase inhibitor that exhibits significant antitumor activity. This compound interferes with DNA replication and transcription processes, making it a valuable tool for cancer research. Its ability to disrupt the normal workings of topoisomerases positions tafluposide as a promising candidate for further studies in cancer therapy. -
Topoisomerases II Inhibitor
8-Chloro-ATP is an analog of ATP that serves as a potent inhibitor of topoisomerase II (Topo II). This compound effectively inhibits DNA synthesis and induces the formation of DNA double-stranded breaks (DSBs) through its action on Topo II-catalyzed ATP hydrolysis. It is a valuable tool for research applications focused on understanding the mechanisms of DNA replication and the role of topoisomerases in cellular processes. -
Intermediate Reactant
(S)-Benzyl 2-cyclopropyl-2-hydroxyacetate serves as an intermediate reactant in the synthesis of Camptothecin, a potent inhibitor of DNA topoisomerase I. With an IC50 value of 679 nM, Camptothecin exhibits significant biological activity in cancer research, particularly in targeting cell division and apoptosis. This compound is essential for studies focused on the development of antitumor agents and the exploration of related therapeutic applications. -
Purine Nucleoside Analog
3-O-(4-Methoxybenzyl)-4-C-hydroxymethyl-1,2-O-isopropylidine-alpha-D-ribofuranose is a purine nucleoside analog that exhibits significant anticancer activity. It primarily targets indolent lymphoid malignancies through mechanisms such as the inhibition of DNA synthesis and the induction of apoptosis. This compound is valuable for research focusing on cancer therapeutics and the underlying molecular pathways involved in tumor progression. -
Purine Nucleoside Analog
2′-Azido-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer effects are primarily due to the inhibition of DNA synthesis and the induction of apoptosis. Additionally, this compound serves as a versatile click chemistry reagent, incorporating an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing molecules, including those with DBCO or BCN moieties. -
Nucleoside Metabolite
(S)-5-Amino-3-oxohexanoic acid acts as a nucleoside metabolite with significant implications in biochemical research. This compound plays a role in metabolic pathways involving amino acid synthesis and nucleoside metabolism. It is utilized in studies of enzyme activity and may contribute to the understanding of metabolic disorders and nucleoside-related functions in cellular processes. -
Purine Nucleoside Analog
2’-O-Acetyl-5’-O-(p-toluoyl)-3’-deoxy-3’-fluoro-5-methyluridine is a purine nucleoside analog. This compound exhibits significant antitumor activity against indolent lymphoid malignancies by targeting DNA synthesis and inducing apoptotic pathways. Its unique mechanism of action makes it a valuable tool for cancer research and a promising candidate for therapeutic development. -
Purine Nucleoside Analog
Thymine 1-β-D-arabinofuranoside is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This compound is suitable for studies focused on the development and exploration of novel therapeutic strategies in oncology. -
Purine Nucleoside Analog
3’-O-MOE-5Me-C(Bz)-2’-phosphoramidite is a purine nucleoside analog that acts by targeting critical pathways involved in cancer biology. This compound exhibits broad antitumor activity, particularly against indolent lymphoid malignancies, by inhibiting DNA synthesis and inducing apoptosis in cancerous cells. It is a valuable reagent for researchers investigating therapeutic strategies in oncology and nucleic acid-based applications. -
Purine Nucleoside Analog
5-O-Benzoyl-1,2,3-tri-O-acetyl-4-C-methyl-D-ribofuranose is a purine nucleoside analog that demonstrates significant antitumor activity. This compound functions primarily by inhibiting DNA synthesis and inducing apoptosis, making it a valuable tool for research in cancer biology. It is particularly relevant for investigating treatments for indolent lymphoid malignancies and other related malignancies. -
Purine Nucleoside Analog
N1-(1,1,1-Trifluoroethyl)pseudouridine is a purine nucleoside analog that exerts its antitumor effects by inhibiting DNA synthesis and promoting apoptosis. This compound is primarily utilized in the research of indolent lymphoid malignancies, where it demonstrates significant potential for therapeutic applications. Its unique structure and biological activity make it a valuable tool for studying cancer cell proliferation and survival mechanisms. -
Nucleoside Metabolite
11,14,15-THETA (11,14,15-Trihydroxyeicosatrienoic acid) is a nucleoside metabolite known for its role in various biological processes. This compound exhibits significant bioactivity, influencing lipid signaling pathways and inflammatory responses. It is commonly utilized in research exploring metabolic pathways, inflammation, and cell signaling mechanisms. -
Adenosine Analog
8-Methylthio-adenosine is an adenosine analog that primarily acts as a smooth muscle vasodilator. It has demonstrated the potential to inhibit cancer progression, making it a valuable tool in cancer research and therapeutic investigations. This compound is relevant for studies exploring the biochemical pathways influenced by adenosine and its analogs. -
Guanosine Analog
1,2'-O-Dimethylguanosine is a guanosine analogue that primarily targets Toll-like receptor 7 (TLR7). It exhibits immunostimulatory activities and has been shown to induce type I interferons in certain animal models, leading to antiviral effects. This compound serves as a valuable tool in research focused on innate immunity and therapeutic applications in viral infections. -
Purine Nucleoside Analog
5’(R)-C-Methyl-3-deazauridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable reagent for cancer research. This compound is suitable for studies focused on the mechanisms of action of nucleoside analogs and their therapeutic potential in oncology. -
Purine Nucleoside Analog
3’-Azido-3’-deoxy-5-iodouridine is a purine nucleoside analog that targets DNA synthesis pathways to exhibit antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer effects are primarily mediated through inhibition of DNA replication and the induction of apoptosis. Additionally, this compound serves as a versatile click chemistry reagent, featuring an azide group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne, DBCO, or BCN-functionalized molecules. This makes it a valuable tool for bioconjugation applications in chemical biology research. -
Adenosine Analog
3,5-Bis-O-(2,4-dichlorobenzyl)adenosine is an adenosine analog that primarily serves as a vasodilator through its action on smooth muscle. This compound has also demonstrated potential in inhibiting cancer progression, making it relevant for various therapeutic research applications. Its structural modifications allow for enhanced biological activity, contributing to studies in drug design and development focused on cardiovascular and oncology therapies. -
Purine Nucleoside Analog
3’-Deoxy-3’-α-C-methyl-5-methyluridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis, leading to the induction of apoptosis in malignant cells. This compound is valuable for research applications centered on cancer biology and the development of novel therapeutic strategies against lymphoid cancers. -
Guanosine Analog
3'-O-MOE-G(iBu)-2'-phosphoramidite is a guanosine analog that targets Toll-like receptor 7 (TLR7). This compound exhibits immunostimulatory activity, which can lead to the induction of type I interferons in various animal models, thereby generating antiviral effects. Its unique properties make it valuable for research applications focused on immune response and antiviral therapies. -
Purine Nucleoside Analog
3'-Amino-3'-deoxy-5-fluorouridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanisms of action involve the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound is valuable for researchers studying cancer biology and the therapeutic potential of nucleoside analogs in oncology. -
Thymidine Analog
1-(β-D-Xylofuranosyl)-5-methyluracil is a thymidine analog that functions by incorporating into replicated DNA. This compound exhibits insertional activity, making it useful for labeling cells and investigating DNA synthesis dynamics. It serves as a valuable tool in studies of cell proliferation and nucleic acid metabolism. -
Pyrimidine Nucleoside Analog
4-Amino-6-bromo-5-cyano-1-(beta-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine is a pyrimidine nucleoside analog that targets nucleic acid metabolism. This compound demonstrates significant biological activity, including the inhibition of DNA and RNA synthesis, as well as antiviral and immunomodulatory effects. Its versatile properties make it a valuable tool for research applications in cancer biology, virology, and immune response studies. -
Nucleoside Metabolite
(24E)-3α,7α-Dihydroxy-5β-cholest-24-enoyl-CoA is a nucleoside metabolite that plays a critical role in cholesterol metabolism. It serves as a substrate for various enzymatic reactions involved in lipid biosynthesis and has potential applications in studying cellular pathways related to lipid synthesis and degradation. This compound is valuable for researchers investigating metabolic disorders and cholesterol-related diseases. -
Purine Nucleoside Analog
2-Chloro-N6-cyclopentyl-2'-deoxy-2'-fluoro-beta-D-arabinoadenosine is a purine nucleoside analog that targets mechanisms involved in DNA synthesis. This compound exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its pharmacological effects are linked to the induction of apoptosis and inhibition of cellular proliferation, making it a valuable tool for cancer research and therapeutic development. -
Purine Nucleoside Analog
2-Aminomethyl adenosine is a purine nucleoside analog known for its antitumor activity against indolent lymphoid malignancies. This compound exerts its effects primarily through the inhibition of DNA synthesis and the induction of apoptosis. Its applications in cancer research make it a valuable tool for studying the mechanisms of tumor cell proliferation and survival.
