Catalog No.
Product Name
Application
Product Information
Citations
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Purine Nucleoside Analog
N1-Methyl-2'-deoxyadenosine is a purine nucleoside analog that serves as a DNA adduct. This compound demonstrates significant antitumor activity, particularly against indolent lymphoid malignancies. Its biological effects are attributed to mechanisms such as inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research and therapeutic applications. -
Adenosine Analog
8-Bromoadenosine is an adenosine analog known for its vasodilatory effects on smooth muscle and its potential to inhibit cancer progression. This compound can effectively quench the intrinsic fluorescence of human serum albumin through a static quenching mechanism. 8-Bromoadenosine serves as a precursor for synthesizing various adenosine phosphates, such as Acadesine, Clofarabine, Fludarabine phosphate, and Vidarabine, making it valuable for biochemical research and therapeutic applications. -
Nucleoside Analogue
2'-O,4'-C-Methylenecytidine is a bicyclic nucleoside analogue known for its fixed N-type conformation. This compound serves as a key building block for the synthesis of oligonucleotides, allowing for the formation of stable duplexes with complementary DNA and RNA strands. Its unique structural properties make it valuable for various applications in nucleic acid research and therapeutic development. -
Cytidine Analog
DMT-2'-OMe-Bz-C is a cytidine analog that primarily inhibits DNA methyltransferases. This compound exhibits significant anti-metabolic and anti-tumor activities, making it valuable in cancer research. It is utilized in studies exploring epigenetic modulation and the role of DNA methylation in gene regulation and tumorigenesis. -
Purine Nucleoside Analog
1,N6-Ethenoadenosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis. This compound is valuable for research applications focused on cancer biology and therapeutic development. -
Nucleoside Antimetabolite/Analog
Isocytosine is a synthetic nucleoside analog and structural isomer of cytosine. This compound serves as a nucleobase in the study of unnatural nucleic acid analogs, particularly when used in combination with Isoguanine. Isocytosine facilitates research into hachimoji RNA systems, contributing to advancements in genetic coding and nucleic acid chemistry. -
Purine Nucleoside Analog
4-Thio-2’-deoxyuridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis, which subsequently induces apoptotic pathways in malignant cells. This compound is valuable in cancer research and may serve as a tool for studying DNA synthesis inhibition and apoptosis in oncological studies. -
Purine Nucleoside
8-Bromoguanosine is a brominated derivative of guanosine that targets purine nucleosides. It has been shown to significantly reduce the conformational heterogeneity of RNA, thereby enhancing its functional capabilities. This compound is useful in various molecular biology applications, particularly in studies focused on RNA stability and function. -
Nucleoside Analog
2'-F-Bz-A (N6-Benzoyl-2'-Fluoro-2'-deoxyadenosine) is a nucleoside analog designed for the synthesis of oligoribonucleotides. Its structural modification enhances thermal stability and can influence hybridization properties. This reagent is valuable in nucleic acid research, particularly in studies involving RNA synthesis and modification. -
Nucleoside Analogue
2',3'-O-Isopropylideneadenosine is a nucleoside analogue that functions as a Golgi-targeting moiety. Exhibiting cyclization at the O (2') and O (3') atoms, it features a furanose ribose group, enabling its incorporation into fluorescent probes. As a key element of the fluorescent probe TPE-Ade, this compound facilitates specific Golgi localization for fluorescence imaging applications. Additionally, 2',3'-O-Isopropylideneadenosine plays a role in the development of aggregation-induced emission (AIE) fluorescent probes, contributing to advancements in biochemical research and imaging technologies. -
Adenosine Analog
2-Iodoadenosine is an adenosine analog known for its vasodilatory properties, primarily acting through smooth muscle relaxation. In addition to promoting vascular function, it exhibits potential in inhibiting cancer progression, making it a valuable tool for various research applications in oncology and cardiovascular studies. Its unique structural modifications enable investigations into adenosine's receptor interactions and biological effects, supporting its use in exploring therapeutic avenues. -
Adenosine Analog
N-Propargyladenosine is an adenosine analogue that primarily acts as a vasodilator by targeting adenosine receptors. This compound exhibits significant biological activity, demonstrating potential in inhibiting cancer progression. Additionally, N-Propargyladenosine functions as a click chemistry reagent, containing an alkyne group that allows it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, making it valuable for various chemical biology applications. -
Purine Nucleoside Analog
2-Methylthioadenosine is a purine nucleoside analog with significant antitumor activity, primarily targeting indolent lymphoid malignancies. Its mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research. This compound is used to explore therapeutic strategies for lymphoid malignancies and understand the underlying biochemical pathways involved in tumor development and progression. -
Purine Nucleoside Analog
2',3'-Dideoxyuridine is a purine nucleoside analog that primarily targets nucleic acid synthesis. It exhibits significant anticancer activity, particularly against indolent lymphoid malignancies, through mechanisms such as the inhibition of DNA synthesis and the induction of apoptosis. This compound is utilized in research to explore therapeutic strategies for cancer treatment. -
Purine Nucleoside Analog
3'-Deoxyinosine is a purine nucleoside analog that exhibits broad antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound serves as a valuable tool for researchers investigating cancer biology and therapeutic strategies. -
Purine Nucleoside Analog
8-Bromo-2'-deoxyadenosine is a purine nucleoside analog that exerts anticancer effects primarily through the inhibition of DNA synthesis and the induction of apoptosis. This compound has demonstrated broad antitumor activity, particularly against indolent lymphoid malignancies. It serves as a valuable tool for research applications related to cancer biology and therapeutic development. -
Adenosine Analog
2-Aminoadenosine is an adenosine analog and a modified adenine base that enhances the stability of RNA duplexes. By forming three hydrogen bonds with uracil, 2-Aminoadenosine increases the melting temperature of hybrid strands, making it a valuable tool for stabilizing uracil-containing RNA structures. This compound is widely utilized in biochemical research, particularly in studies involving RNA structure and function, template-directed nucleotide condensation reactions, and nucleic acid hybridization. -
Purine Nucleoside Analog
3’-Azido-3’-deoxyuridine is a purine nucleoside analog that exhibits broad antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis. Additionally, this compound acts as a click chemistry reagent, featuring an azide functional group that enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing molecules. This versatility makes it valuable for various applications in chemical biology and medicinal chemistry. -
Adenosine Analog
2-Methyladenosine is an adenosine analog that primarily functions as a smooth muscle vasodilator. This compound exhibits significant biological activity, including the potential to inhibit cancer progression. Its applications in research include studies focused on vasodilation, cancer biology, and the broader field of nucleotide signaling pathways. -
Adenosine Analog
3′-O-Methyladenosine is an adenosine analogue that primarily targets adenosine receptors. This compound exhibits significant biological activity as a smooth muscle vasodilator and has also demonstrated potential in inhibiting cancer progression. Its applications extend to various research fields, including cardiovascular studies and oncology, making it a valuable tool for investigating adenosine-related pathways and therapeutic targets. -
Purine Nucleoside Analog
Nebularine is a purine nucleoside analog that exerts its effects primarily through the inhibition of DNA synthesis. This compound demonstrates significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include the induction of apoptosis and disruption of cellular replication, making it a valuable tool for cancer research and therapeutic applications. -
Purine Nucleoside Analog
2'-Deoxy-N1-methylguanosine is a purine nucleoside analog that primarily interferes with DNA synthesis. This compound exhibits significant antitumor activity, particularly in indolent lymphoid malignancies, through mechanisms such as apoptosis induction. Its properties make it a valuable tool for research in cancer biology and therapeutic development. -
Purine Nucleoside Analog
3'-Deoxy-3'-fluoroadenosine is a purine nucleoside analogue that targets DNA synthesis in cells. This compound exhibits broad antitumor activity, particularly against indolent lymphoid malignancies, by inhibiting cellular proliferation and inducing apoptosis. Its role in cancer research makes it a valuable tool for studying mechanisms of tumorigenesis and therapeutic response. -
Purine Nucleoside Analog
5-Iodo-cytidine is a purine nucleoside analog that exhibits notable antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This compound is essential for studies focused on understanding cancer biology and developing novel therapeutic strategies. -
Purine Nucleoside Analog
5-Hydroxyuridine (OHUrd) is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms are primarily attributed to the inhibition of DNA synthesis and the induction of apoptosis. This compound is valuable for research applications aimed at exploring therapeutic strategies in cancer treatment and understanding the molecular mechanisms underlying tumor growth and proliferation. -
Purine Nucleoside Analog
6-O-Methyldeoxyguanosine is a purine nucleoside analog that functions as a DNA adduct. This compound demonstrates significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms include inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for research in cancer biology and therapeutic development. -
Purine Nucleoside Analog
N-Acetyl-2′-deoxycytidine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis, leading to subsequent induction of apoptosis in cancer cells. This compound is valuable for research applications focused on cancer biology and therapeutic development in oncology. -
Purine Nucleoside Analog
2'-Chloro-2'-deoxyadenosine is a purine nucleoside analog that exerts significant antitumor activity, particularly against indolent lymphoid malignancies. This compound mainly functions by inhibiting DNA synthesis and inducing apoptosis in cancer cells, making it a valuable tool for cancer research and therapeutic studies. It is commonly utilized in investigations focused on the mechanisms of tumor growth and the development of novel treatment strategies. -
Purine Nucleoside Analog
5-Methyl-2-thiouridine is a purine nucleoside analogue known for its significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound is valuable for research applications focusing on cancer biology and the development of therapeutic strategies targeting nucleic acid metabolism. -
Nucleoside Analog
N4-Benzoyl-2'-fluoro-2'-deoxycytidine is a nucleoside analog that serves as a building block for nucleic acid synthesis. It exhibits important structural modifications that enhance its utility in the development of nucleotide-based therapeutics and molecular probes. This compound is valuable for research in areas such as antiviral drug design and studies on DNA/RNA interactions. -
Purine Nucleoside Analog
1,3,5-Tri-O-benzoyl-a-D-ribofuranose serves as a purine nucleoside analog, exhibiting significant antitumor activity particularly against indolent lymphoid malignancies. Its primary mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research and therapeutic applications. This compound is crucial for studies aimed at understanding the molecular pathways involved in lymphoid malignancies and developing targeted treatments. -
Purine Nucleoside Analog
2′-Deoxy-N-methylguanosine is a purine nucleoside analog primarily targeting DNA synthesis pathways. This compound exhibits significant antitumor activity, particularly in the context of indolent lymphoid malignancies. Its anticancer mechanisms include the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research and therapeutic applications. -
Purine Nucleoside Analog
6-Methylmercaptopurine riboside is a purine nucleoside analog that exhibits significant antitumor activity, primarily effective against indolent lymphoid malignancies. Its anticancer mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis. This compound is valuable for research into therapeutic strategies targeting various malignancies. -
Purine Nucleoside Analog
2,3,5-Tri-O-benzyl-D-ribono-1,4-lactone is a purine nucleoside analog known for its potential antitumor activity. This compound exhibits biological effects such as inhibition of DNA synthesis and induction of apoptosis, making it relevant for research into the treatment of indolent lymphoid malignancies. It can be synthesized from D-ribose through Fischer glycosylation with methanol, providing a useful tool in anticancer studies aimed at understanding and combating lymphoid malignancies. -
Purine Nucleoside Analog
L-Threonolactone, a purine nucleoside analog, exhibits significant antitumor activity, particularly effective against indolent lymphoid malignancies. Its biological activity is attributed to mechanisms such as inhibition of DNA synthesis and the induction of apoptosis. This compound serves as a valuable tool in cancer research, allowing for the exploration of therapeutic strategies targeting nucleoside metabolism and cancer cell proliferation. -
Purine Nucleoside
8-Hydroxyadenosine is a modified purine nucleoside that serves as a marker for oxidative stress in nucleic acids. It plays a crucial role in cellular processes and is involved in the regulation of various biological activities, including gene expression and DNA repair mechanisms. This compound is commonly utilized in research studies focused on oxidative damage, cellular response to stress, and the examination of RNA modifications. -
Purine Nucleoside Analog
2'-Deoxy-N3-methylcytidine hydriodide is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer effects are primarily mediated through the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound serves as a valuable research tool for investigating therapeutic strategies in oncology. -
Purine Nucleoside Analog
1-(a-D-ribofuranosyl)uracil is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable compound for research in cancer biology and therapeutic development. This reagent is suited for studies focusing on nucleic acid metabolism and the molecular pathways involved in tumor growth and progression. -
Purine Nucleoside Analog
Dideoxycytidinene, a purine nucleoside analog, primarily targets DNA synthesis processes. This compound exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for research in cancer therapeutics. -
Purine Nucleoside Analog
2'-Deoxy-2'-fluoro-β-D-arabinocytidine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its biological mechanisms include the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research. This compound holds promise for studies aimed at understanding and developing therapies for various hematological cancers. -
Purine Nucleoside Analog
6-Chloroguanineriboside is a purine nucleoside analog that serves as a substrate for various nucleoside kinases. It demonstrates low affinity for guanosine binding sites, with a Ki value of 253.1 μM in rat brain tissues. This compound can be utilized in research related to nucleoside metabolism and the pharmacological effects of purine analogs in neurological studies. -
Nucleoside Analog
3'-NH2-ddA (3'-Amino-2',3'-dideoxyadenosine) is a nucleoside analog that serves as an important building block for the synthesis of nucleic acids. Its structural features facilitate incorporation into DNA and RNA, making it valuable for studies involving genetic manipulation and molecular biology applications. This reagent is essential for developing advanced nucleic acid-based technologies such as antisense oligonucleotides and gene editing strategies. -
Cytidine Analogue
N-Benzoylcytidine is a cytidine analogue that acts as a substrate for uracil-cytidine kinases (UCK1 and UCK2). It is integral to the synthesis of 2-OH protective groups for solid-phase RNA synthesis and is utilized in the production of synthetic oligonucleotides. This compound has applications in UV induction and targeted gene silencing in zebrafish embryos, making it a valuable tool in molecular biology research. -
Purine Nucleoside Analog
2’-Azido-2’-deoxycytidine is a purine nucleoside analogue that exhibits significant anticancer properties by inhibiting DNA synthesis and inducing apoptosis, particularly in indolent lymphoid malignancies. This compound serves as a versatile click chemistry reagent, containing an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne, DBCO, or BCN-containing molecules. Additionally, 2’-Azido-2’-deoxycytidine requires dual phosphorylation to function as an inhibitor of ribonucleotide reductase, positioning it as a valuable tool in cancer research and therapeutic development. -
Purine Nucleoside Analog
6-Methylpurine riboside is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms include the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable reagent for cancer research. This compound is utilized in investigations focused on therapeutic strategies targeting nucleoside metabolism and cell proliferation. -
Purine Nucleoside Analog
3'-Azido-3'-deoxyadenosine is a purine nucleoside analog that exhibits potent antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer effects stem from mechanisms such as inhibition of DNA synthesis and induction of apoptosis. In addition to its biological applications, 3'-Azido-3'-deoxyadenosine functions as a click chemistry reagent, featuring an azide group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted azide-alkyne cycloaddition (SPAAC) with alkyne-containing molecules. This versatility makes it a valuable tool in chemical biology and medicinal chemistry research. -
Purine Nucleoside Analog
3′-Deoxy-3′-fluorouridine is a purine nucleoside analog that exhibits significant antitumor activity. This compound primarily acts by inhibiting DNA synthesis and inducing apoptosis in neoplastic cells. Its application in research includes studying therapeutic strategies against indolent lymphoid malignancies, making it a valuable tool for cancer research and drug development. -
Nucleoside Analog
(3R,5S)-5-O-DMT-3-pyrrolidinol is a nucleoside analog featuring a dimethoxytrityl (DMT) protecting group and a 3-pyrrolidinol framework. This compound plays a crucial role in the synthesis of nucleic acids, facilitating the development of oligonucleotides and other nucleic acid-based materials for research applications. Its unique structural properties make it a valuable reagent in chemical biology and molecular genetics studies. -
Adenosine Analog
2’,3’,5’-Tri-O-acetyl adenosine is an adenosine analog that primarily targets adenosine receptors, serving as a potent smooth muscle vasodilator. This compound has been shown to exert inhibitory effects on cancer progression, making it a valuable tool in oncology research. It is useful for studying adenosine signaling pathways and their implications in various biological processes. -
Purine Nucleoside Analog
5-Methyl-2′-O-methylcytidine is a purine nucleoside analog that exerts significant antitumor activity against indolent lymphoid malignancies. Its primary mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis. This compound is valuable for research applications focused on cancer biology and the development of therapeutic strategies targeting nucleoside metabolism.
