Catalog No.
Product Name
Application
Product Information
Citations
-
Purine Nucleoside Analog
1-Methyl-2'-O-methylinosine is a purine nucleoside analog that exhibits broad antitumor activity. This compound primarily targets indolent lymphoid malignancies and functions by inhibiting DNA synthesis and inducing apoptosis. It serves as a valuable tool in cancer research, aiding in the exploration of therapeutic approaches to treat various malignancies. -
Purine Nucleoside Analog
3’-Deoxy-3’-fluoro-5-methoxyluridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis, which can lead to the induction of apoptosis in cancer cells. This compound is valuable for research applications focused on cancer therapeutics and elucidating the molecular mechanisms underlying tumorigenesis. -
Purine Nucleoside Analog
3',5'-Di-O-benzoyl fialuridine is a purine nucleoside analog that exhibits potent antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis, leading to cell cycle arrest and subsequent induction of apoptosis. This compound is valuable for research into therapeutic strategies targeting malignancies and understanding nucleoside analog mechanisms in cancer treatment. -
Purine Nucleoside Analog
3’-O-Levulinyl-2’-deoxyadenosine is a purine nucleoside analog that serves as an effective agent in anticancer research. It possesses significant antitumor activity, particularly against indolent lymphoid malignancies, through mechanisms that include DNA synthesis inhibition and apoptosis induction. This compound is valuable for studies focused on cancer therapeutics and mechanisms of action in malignant cell lines. -
Purine Nucleoside Analog
2'-Bromo-2'-deoxy-5-methyluridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This compound can be utilized to explore therapeutic strategies and pathways associated with tumorigenesis and cellular proliferation. -
Purine Nucleoside Analog
5’(R)-C-Methyladenosine is a purine nucleoside analogue that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This compound serves as a useful reagent for studying the effects of nucleoside analogs in therapeutic contexts. -
Purine Nucleoside Analog
2-Chloro-3′-deoxyadenosine is a purine nucleoside analog that primarily targets DNA synthesis. It exhibits significant antitumor activity, particularly against indolent lymphoid malignancies, by inhibiting cellular proliferation and inducing apoptosis. This compound serves as an important tool in cancer research, providing insights into therapeutic approaches for hematologic malignancies. -
Purine Nucleoside Analog
2′-Deoxy-6-thioinosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism of action includes the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research. This compound is useful for investigating the pathways involved in tumor cell proliferation and survival. -
Purine Nucleoside Analog
8-Benzyloxy-3’-deoxy-3’-fluoroguanosine is a purine nucleoside analog that exerts notable antitumor activity against indolent lymphoid malignancies. Its mechanism of action involves the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound is valuable for research focused on oncological studies, particularly in understanding the pathways of cancer cell proliferation and response to nucleoside-based therapies. -
Purine Nucleoside Analog
3’-Deoxy-3’-α-C-methylguanosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound is valuable for research applications focused on cancer biology and therapeutic development targeting purine metabolism. -
Purine Nucleoside Analog
3’-Deoxy-5’-O-(4,4’-dimethoxytrityl)-3’-fluorouridine is a purine nucleoside analog with significant potential in cancer research. It exhibits broad antitumor activity, particularly against indolent lymphoid malignancies, by inhibiting DNA synthesis and inducing apoptotic pathways. This compound can be utilized in studies focused on cancer therapeutics and the mechanisms underlying nucleoside analog efficacy in oncological contexts. -
Purine Nucleoside Analog
2'-Deoxy-2'-fluoro-N4-benzoyl-5-methylcytidine is a purine nucleoside analog that showcases significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis, leading to apoptosis in cancerous cells. This compound serves as an essential tool for research in oncology, aiding in the exploration of novel therapeutic strategies targeting nucleic acid synthesis pathways. -
Purine Nucleoside Analog
1,3-Dimethyl pseudouridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanisms include the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable reagent for cancer research. This compound is utilized in studies aimed at understanding cancer therapies and developing new treatments targeting nucleoside pathways. -
Purine Nucleoside Analog
7,8-Dihydro-8-oxo-7-propargyl guanosine is a purine nucleoside analog known for its antitumor activity, particularly against indolent lymphoid malignancies. This compound exerts its anticancer effects through mechanisms such as DNA synthesis inhibition and apoptosis induction. Additionally, it serves as a click chemistry reagent due to its alkyne group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, facilitating advanced bioconjugation applications. -
Purine Nucleoside Analog
6-Chloro-2-iodo-9-(2’,3’,5’-tri-O-acetyl-β-D-ribofuranosyl)purine is a purine nucleoside analog that exerts significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis and the induction of apoptosis, contributing to its potential as an effective therapeutic agent in cancer research. This compound can be utilized in studies investigating the molecular pathways of cancer progression and treatment efficacy. -
Purine Nucleoside Analog
1,3'-Dimethylguanosine is a purine nucleoside analog that exhibits significant anticancer properties. This compound primarily targets indolent lymphoid malignancies through mechanisms such as the inhibition of DNA synthesis and the induction of apoptosis. It serves as a valuable tool in cancer research and therapeutic development, contributing to the understanding of purine metabolism and its implications in tumorigenesis. -
Purine Nucleoside Analog
3,4-Dihydro-3-oxo-4-β-D-ribofuranosyl-2-pyrazinecarboxamide functions as a purine nucleoside analog. This compound exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its biological effects are primarily attributed to the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research and therapeutic development. -
Purine Nucleoside Analog
5’-Deoxy-5’-iodo-2’-O-(2-methoxyethyl)uridine is a purine nucleoside analog known for its antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis and the induction of apoptosis. This compound is useful in cancer research for investigating cellular responses to nucleoside analog treatment and exploring therapeutic strategies in hematological malignancies. -
Purine Nucleoside Analog
2'-Deoxy-2'-fluoroarabino inosine is a purine nucleoside analog that exhibits potent antitumor activity through its ability to inhibit DNA synthesis and induce apoptosis. This compound is particularly relevant in the investigation of indolent lymphoid malignancies. Its mechanism of action makes it a valuable tool in cancer research and therapeutic development. -
Pyrimidine Nucleoside Analog
4-Chloro-7-(2-deoxy-β-D-erythro-pentofuranosyl)-5-iodo-7H-pyrrolo[2,3-d]pyrimidine is a pyrimidine nucleoside analog known for its ability to inhibit both DNA and RNA synthesis. This compound exhibits significant biological activity, making it a valuable tool in anticancer research, antiviral studies, and immunomodulation investigations. Its diverse applications in biochemical assays contribute to the understanding of nucleic acid metabolism and therapeutic development. -
Adenosine Analog
2-(4-Methylbenzyl)thioadenosine is an adenosine analog that primarily targets adenosine receptors. It is recognized for its vasodilatory effects on smooth muscle and demonstrates potential in inhibiting cancer progression. This compound serves as a valuable tool in researching adenosine receptor signaling, cardiovascular function, and cancer biology. -
Cytidine Analog
2'-Deoxy-5'-O-DMT-N4-Fmoc-5-methylcytidine is a cytidine analog that targets DNA methyltransferases. By inhibiting these enzymes, this compound demonstrates potential anti-metabolic and anti-tumor activities, making it a valuable tool for epigenetic research. Its unique chemical structure allows for specific modifications in nucleoside studies and provides insight into cellular processes related to DNA methylation. -
Purine Nucleoside Analog
N1-Methyl-arabinoadenosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly in indolent lymphoid malignancies. Its primary biological mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound serves as a valuable tool for researchers investigating targeted therapies and mechanisms of action in cancer treatment. -
Purine Nucleoside Analog
4'-Methylguanosine is a purine nucleoside analogue that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound is valuable in research applications focused on understanding and targeting malignant lymphoproliferative disorders. -
Purine Nucleoside Analog
N4-Benzoyl-3’-deoxycytidine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. This compound functions by inhibiting DNA synthesis and inducing apoptosis, making it a valuable tool in cancer research. Its biological properties offer potential for exploring therapeutic strategies in oncology and studying mechanisms of cell cycle regulation. -
Purine Nucleoside Analog
2′-Deoxy-8-(methylthio)adenosine is a purine nucleoside analog known for its broad antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This compound is utilized in various studies aimed at understanding the mechanisms of tumor growth and potential therapeutic interventions. -
Purine Nucleoside Analog
5-O-(tert-Butyldiphenylsilyl)-2,3-isopropylidene-D-ribonolactone is a purine nucleoside analog known for its antitumor properties. This compound exhibits significant biological activity by inhibiting DNA synthesis and inducing apoptosis, making it a valuable tool in the research of indolent lymphoid malignancies. Its application in cancer research enhances understanding of cellular mechanisms and therapeutic strategies. -
Purine Nucleoside Analog
8-Chloro-2'-beta-C-methyl inosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include inhibition of DNA synthesis and the induction of apoptosis, making it a valuable compound for cancer research. This reagent is utilized in studies focused on exploring novel therapeutic strategies for malignancies involving purine metabolism. -
Purine Nucleoside Analog
2’-Deoxy-2’-fluoro-N1-methyl inosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research. This compound is suited for studies exploring the biochemical pathways of purine metabolism and the therapeutic potential of nucleoside analogs in oncology. -
Ribonucleoside Analog
4-Thiouridine is a ribonucleoside analog that serves as a valuable tool in RNA analysis and mRNA labeling. It effectively inhibits rRNA synthesis, leading to a nucleolar stress response, which can be utilized to study cellular stress mechanisms and RNA processing pathways. This compound is essential for researchers investigating RNA dynamics and the regulation of gene expression. -
Adenine Nucleoside Analogue
N-6-Methyl-2-deoxyadenosine (m6dA) is an adenine nucleoside analogue that targets nuclear processes and DNA replication machinery. It functions as a multifaceted epigenetic regulator, influencing transcription, DNA damage response, cell cycle progression, transposon silencing, and nucleosome organization in both prokaryotic and eukaryotic systems. Additionally, m6dA plays a crucial role in mitochondrial epigenetic inheritance and is implicated in fear extinction memory in murine models. Dysregulated levels of N-6-Methyl-2-deoxyadenosine have been associated with various cancers, making it a valuable reagent for research into glioblastoma, triple-negative breast cancer, and conditioned fear responses. -
Purine Nucleoside Analog
4-Thiothymidine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanisms include the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable compound for cancer research. This analog is essential for studies focused on the development of targeted therapies and the understanding of cellular responses to nucleoside analogs in oncological contexts. -
Purine Nucleoside Analog
5-Bromouridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer effects are primarily attributed to the inhibition of DNA synthesis and the induction of apoptosis. This compound is an important tool for research applications in cancer biology and therapeutic development. -
Nucleoside Analog
Bz-OMe-rA is a nucleoside analog that primarily targets cellular nucleoside metabolism. It exhibits potential biological activity as an inhibitor of nucleoside transporters and may influence RNA synthesis and processing. Bz-OMe-rA is utilized in research to study nucleoside analogs in therapeutic applications, including antiviral and anticancer strategies. -
Purine Nucleoside Analog
2'-Deoxy-2'-fluoro-5-iodouridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism of action involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This compound is relevant in studies focused on cancer therapeutics and the development of novel treatment strategies targeting nucleoside metabolism. -
Cytidine Analog
2’-Fluoro-2’-deoxy-ara-C(Bz)-3’-phosphoramidite is a cytidine analog that inhibits DNA methyltransferases, thereby influencing gene expression and cellular metabolism. This compound demonstrates significant anti-metabolic and anti-tumor activities, making it a valuable tool in cancer research and epigenetic studies. Its unique structure allows for incorporation into nucleic acids, facilitating investigations into gene regulation and therapeutic development. -
Nucleoside Analog
5'(E)-VP-2'-OMe-U phosphoramidite is a nucleoside analog utilized as a monomer in oligonucleotide synthesis. This reagent is instrumental in generating modified nucleic acids, enabling the study of RNA structure and function. Its unique properties make it suitable for applications in biological research, including probe design and therapeutic development. -
Nucleoside Antimetabolite/Analog
2′-Deoxy-2′-fluoroadenosine is a fluorinated nucleoside analog that functions as an antimetabolite, displaying significant antitumor and antiviral properties. It disrupts DNA replication in cancer and viral cells upon incorporation, hindering their proliferation. This compound is particularly valuable for synthesizing 2′-Deoxy-2′-fluoro-modified oligonucleotides hybridized with RNA. Additionally, 2′-Deoxy-2′-fluoroadenosine can be converted by E. coli purine nucleoside phosphorylase (PNP) into the cytotoxic agent 2-fluoroadenine (FAde), demonstrating promising in vivo efficacy against tumors with E. coli PNP expression. -
Purine Nucleoside Analog
5-Methoxyuridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms primarily involve the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This compound can be utilized in studies focusing on nucleoside metabolism and the therapeutic potential of nucleoside analogs in oncology. -
Purine Nucleoside Analog
5-(Hydroxymethyl)cytidine is a purine nucleoside analog that serves as a valuable reagent in oligonucleotide synthesis. This compound exhibits significant antitumor activity, particularly against indolent lymphoid malignancies, by inhibiting DNA synthesis and inducing apoptosis in cancer cells. Its mechanism of action makes it a critical tool for research focused on cancer therapeutics and genetic studies. -
Nucleoside Analog
Bz-dA (N6-Benzoyl-2'-deoxyadenosine) is a nucleoside analog that serves as a versatile building block for the synthesis of oligoribonucleotides. Its structural modifications facilitate the incorporation into RNA sequences, providing insights into RNA biology and function. Bz-dA is valuable for applications in molecular biology, including studies on RNA folding, stability, and interactions. -
Purine Nucleoside Analog
5'-Amino-5'-deoxyadenosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism of action includes inhibition of DNA synthesis and induction of apoptosis, making it a valuable tool for cancer research. This compound is suitable for studies focused on understanding the cellular and molecular effects of nucleoside analogs in therapeutic applications. -
Cytidine Analog
N4-Methylcytidine is a cytidine nucleoside analog that functions by inhibiting DNA methyltransferases. This compound exhibits potential anti-metabolic and anti-tumor activities, making it a valuable reagent in cancer research. Its ability to modulate DNA methylation patterns allows for exploration in epigenetic studies and therapeutic applications targeting methyltransferase-related pathways. -
Nucleoside Analog
1,2-Dideoxy-D-ribofuranose is a nucleoside analog that serves as a critical building block for the synthesis of nucleic acids. This compound is instrumental in the development of antiviral and anticancer agents, facilitating research in molecular biology and genetics. Its unique structural properties offer significant potential for the creation of modified nucleotides in various therapeutic applications. -
Purine Nucleoside Analog
2'-Deoxy-N4-methylcytidine is a purine nucleoside analog that exerts antitumor effects primarily by inhibiting DNA synthesis and inducing apoptosis. This compound has shown promise in targeting indolent lymphoid malignancies, making it a valuable tool in cancer research. Its biological activity in modulating cellular processes supports its potential applications in exploring treatment strategies for various malignancies. -
Cytidine Analog
N4-Benzoyl-2’-O-methylcytidine is a cytidine analog that functions primarily as an inhibitor of DNA methyltransferase. This compound exhibits potential antimetabolite and antitumor activities, making it a valuable tool in cancer research. Its mechanism of action contributes to the modulation of epigenetic regulation, offering insights into therapeutic strategies for various malignancies. Research applications include studying gene expression, DNA methylation patterns, and the biochemical pathways involved in tumorigenesis. -
Purine Nucleoside Analog
2-Thiocytidine is a purine nucleoside analog that demonstrates significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms are attributed to the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable compound for research in cancer therapeutics. This reagent can be utilized in various studies focused on understanding the molecular mechanisms underlying tumor growth and treatment resistance. -
Purine Nucleoside Analog
2'-O-Methylinosine, a purine nucleoside analog, exhibits significant antitumor activity primarily against indolent lymphoid malignancies. Its mechanism of action includes the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound is valuable for research applications focused on cancer biology and the development of therapeutic strategies targeting nucleoside metabolism. -
Purine Nucleoside Analog
5-Azidomethyl-2'-deoxyuridine (5-AmdU) is a purine nucleoside analog that functions as a radiosensitizer, particularly effective in EMT6 tumor cell lines. This compound serves as a valuable reagent in click chemistry, possessing an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with compounds that possess DBCO or BCN reactive groups, making it a versatile tool for biochemical research and molecular labeling applications. -
Purine Nucleoside Analog
4,10-Dioxatri cyclo[5.2.1.02.6]dec-8-ene-3,5-dione is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism of action involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This compound is useful in studies aimed at understanding and targeting specific cancer pathways.
