Catalog No.
Product Name
Application
Product Information
Citations
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DNA Polymerase β Inhibitor
Prunasin is a specific inhibitor of DNA Polymerase β, showing an IC50 value of 98 μM in rat models. As an orally active cyanogenic glucoside and a principal metabolite of Amygdalin, Prunasin exhibits notable anti-inflammatory and anti-fibrotic properties. This compound is valuable for research into conditions such as liver fibrosis, facilitating investigations into therapeutic strategies targeting DNA repair and fibrotic processes. -
Thermostable DNA Polymerase
Taq DNA polymerase is a thermostable DNA polymerase that plays a crucial role in polymerase chain reaction (PCR) amplification. Its inherent heat resistance allows for the efficient synthesis of DNA at elevated temperatures, making it ideal for applications requiring robust amplification of nucleic acids. Taq DNA polymerase is widely utilized in molecular biology research, including cloning, gene expression analysis, and genetic fingerprinting, due to its high fidelity and activity. -
DNA Polymerase Inhibitor
3,4-Dihydroxybenzylamine hydrobromide is a DNA polymerase inhibitor that exhibits cytotoxic effects in melanoma cells. This compound demonstrates significant growth inhibitory activity across various melanoma cell lines, with efficacy correlated to the levels of tyrosinase activity. Its unique mechanism makes it a valuable tool for investigating cellular processes related to DNA replication and repair in cancer research. -
DNA Polymerases Sustrate
5-Propargylamino-dCTP is a substrate for DNA polymerases, enabling the synthesis of labeled nucleic acids. This reagent facilitates conjugation to molecular markers, enhancing applications in nucleic acid labeling and sequencing analysis. Featuring an alkyne group, 5-Propargylamino-dCTP is suitable for click chemistry, allowing for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. -
T7 RNA Polymerase
T7 RNA polymerase is a highly specific enzyme derived from the T7 bacteriophage, facilitating in vitro transcription (IVT) of mRNA in research applications. This enzyme utilizes single-stranded or double-stranded DNA templates containing the T7 promoter sequence in the presence of Mg2+, catalyzing the synthesis of RNA complementary to the DNA downstream of the promoter. Its precise activity makes T7 RNA polymerase an essential tool for RNA synthesis in molecular biology and genetic studies. -
Viral DNA Polymerase Inhibitor
Foscarnet trisodium hexahydrate is a viral DNA polymerase inhibitor that reversibly suppresses viral replication. It is primarily utilized as an antiherpesvirus agent, demonstrating efficacy in the treatment of cytomegalovirus retinitis. This compound is valuable for researchers studying viral infections and developing antiviral therapies. -
Poly(A) polymerase Inhibitor
2'-Deoxyadenosine 5'-diphosphate disodium (dADP disodium) acts as an inhibitor of bacterial poly(A) polymerase. This compound is particularly useful in the synthesis of deoxyadenosine oligonucleotides when utilized with Escherichia coli polynucleotide phosphorylase and other related enzymes. Its role in inhibiting poly(A) polymerase makes it valuable for studies in RNA metabolism and gene regulation research. -
DNA Polymerase Inhibitor
ddATP trisodium solution (100 mM) serves as a chain-elongating inhibitor of DNA polymerase. As an active metabolite of 2',3'-dideoxyinosine, it is primarily utilized in the Sanger method for DNA sequencing. Additionally, this reagent is valuable for studying viral infections and other applications in molecular biology research. -
DENV Polymerase Inhibitor
NITD-2 is a selective inhibitor of dengue virus (DENV) polymerase, specifically targeting the RNA-dependent RNA polymerase (RdRp) to impede RNA elongation. This compound exhibits potent antiviral activity against DENV, making it a valuable tool for research focused on understanding dengue virus replication and developing therapeutic strategies. Its limited ability to penetrate cell membranes can be an important consideration for in vitro experimental design. -
DNA Polymerase α Inhibitor
NSC639828 is a potent inhibitor of DNA polymerase α, exhibiting an IC50 of 70 μM. This compound demonstrates significant antitumor activity, making it a valuable tool for cancer research. NSC639828 can be utilized to investigate the role of DNA polymerase α in tumorigenesis and to explore potential therapeutic strategies in cancer treatment. -
DNA Polymerase Inhibtior
3′-Deoxythymidine, also known as 2′,3′-dideoxythymidine, serves as a potent inhibitor of eukaryotic cellular and viral DNA polymerases. This nucleoside analog demonstrates significant antiviral activity, particularly against retroviruses, making it a valuable tool in the study of viral replication and infection mechanisms. Its application extends to research targeting antiviral therapies and understanding the biochemical pathways of DNA synthesis. -
DNA Polymerase Substrate
7-Deaza-2'-deoxyadenosine is a structural analog of 2'-deoxyadenosine that serves as a substrate for various DNA polymerases. Its unique chemical properties facilitate incorporation into DNA strands, enabling site-specific labeling through a bioorthogonal inverse electron demand Diels-Alder reaction with tetrazine-modified molecules. This reagent has shown to influence DNA curvature and reduce the stability of DNA/RNA double helices, with implications for decreasing antisense activity against SV40 T Antigen. 7-Deaza-2'-deoxyadenosine is particularly useful in the study of cancers related to SV40 T Antigen. -
DNA Polymerase Inhibitor
Acyclovir triphosphate sodium is a potent inhibitor of viral DNA polymerase, functioning as a competitive analogue of deoxyguanosine triphosphate (dGTP). This compound also exhibits inhibitory activity against HIV-1 reverse transcriptase, leading to the termination of viral DNA synthesis. Acyclovir triphosphate sodium is valuable for research applications in virology and the study of antiviral mechanisms. -
DNA Polymerase Substrate
2'-Deoxyadenosine-5'-triphosphate (dATP) serves as a critical substrate for DNA polymerase during DNA synthesis and replication. This nucleotide plays a vital role in the formation of DNA molecules by providing the necessary building blocks for polymerization. dATP is essential for various molecular biology applications, including DNA amplification, sequencing, and cloning, making it a valuable reagent for biochemical and genetic research. -
RNA Polymerase I Transcription Inhibitor
BMH-22 is a selective inhibitor of RNA polymerase I transcription, functioning independently of p53 pathways. This benzonaphthyridin compound induces reorganization of nucleolar marker proteins, indicative of nucleolar segregation, and destabilizes RPA194 through a proteasome-dependent mechanism. Additionally, BMH-22 effectively inhibits the synthesis of nascent rRNA and the expression of the 45S rRNA precursor. Its potent anticancer properties make it a valuable tool for studying cancer biology and RNA transcription regulation in various tumor models. -
RNA Polymerase Inhibitor
MMV688845 is an RNA polymerase inhibitor targeting nontuberculous mycobacteria (NTM) with demonstrated bactericidal activity against Mycobacterium abscessus. This compound exhibits potential anti-tuberculosis efficacy, making it a valuable tool for research in tackling mycobacterial infections. Its selective mechanism positions MMV688845 as a promising candidate for further exploration in antimicrobial studies and drug development. -
NS5B Polymerase/RdRp Inhibitor
Lomibuvir is a selective non-nucleoside inhibitor of the NS5B RNA-dependent RNA polymerase (RdRp) associated with Hepatitis C Virus (HCV). It targets the thumb pocket 2 of the NS5B polymerase with a binding affinity (Kd) of 17 nM and effectively inhibits HCV replication, demonstrated by an EC50 value of 5.2 nM in the 1b/Con1 subgenomic replicon model. Lomibuvir primarily interferes with the elongation phase of RNA synthesis, making it a valuable tool for studying HCV replication mechanisms and developing antiviral therapies. -
RNA Polymerases Inhibitor
3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is a nucleotide analogue that serves as an inhibitor of DNA-dependent RNA polymerases I and II. It competitively inhibits the incorporation of UTP into RNA, demonstrating potent biological activity with a Ki value of 2.0 μM. This compound is valuable for research applications involving transcription regulation and the study of RNA synthesis mechanisms. -
DNA Polymerase
Pfu DNA Polymerase is a thermostable DNA polymerase sourced from Pyrococcus furiosus, known for its high fidelity during DNA amplification. This enzyme is essential for polymerase chain reaction (PCR) applications, particularly in generating accurate and reliable DNA products. Its robustness at elevated temperatures makes it ideal for amplifying complex templates and minimizing errors in nucleotide incorporation. -
RNA Polymerase Inhibitor
MRL-436 is an RNA polymerase inhibitor that exhibits significant antibacterial activity against Rifampicin-resistant strains. Its mechanism of action involves targeting residue 622 of the RNA polymerase β' subunit and the RNAP ω subunit. This compound is particularly valuable for research involving antibiotic resistance and the study of bacterial transcription mechanisms. -
Poly (ADP-ribose) Polymerase Inhibitor
8-NH2-ATP is an inhibitor of poly (ADP-ribose) polymerase (PARP), acting as a critical tool in research on cell apoptosis. This compound is derived from 8-NH2-Ado and exhibits potent effects by inducing apoptotic cleavage of PARP, making it useful for studying mechanisms of cell death, DNA repair, and cancer therapeutics. Its applications extend to exploring PARP's role in various biological pathways and assessing the therapeutic potential of PARP inhibition in disease models. -
T4 DNA Polymerase Inhibitor
3'-Fluorothymidine-5'-triphosphate tetrasodium is a competitive inhibitor of T4 DNA polymerase, functioning as an analog of dTTP. By inhibiting T4 DNA polymerases, including wild-type, L98, and CB121 variants, it effectively disrupts DNA synthesis processes. This compound is valuable for research applications involving DNA replication studies and exploration of polymerase inhibition mechanisms. -
DNA polymerase θ Inhibitor
RTx-303 is a selective inhibitor of DNA polymerase θ (Polθ), with an IC50 value of 5.1 nM. This compound demonstrates potent cellular activity and enhances the efficacy of PARP inhibitors in BRCA1/2 mutant cells and patient-derived xenograft models. RTx-303 is utilized in research focused on BRCA2-mutated breast cancer, providing valuable insights into therapeutic strategies targeting DNA repair mechanisms. -
HCV Polymerase Inhibitor
Dasabuvir sodium is a non-nucleoside inhibitor of hepatitis C virus (HCV) polymerase, specifically targeting the RNA-dependent RNA polymerase encoded by the HCV NS5B gene. It demonstrates potent antiviral activity against HCV genotype 1a (strain H77) and 1b (strain Con1) replicons, with EC50 values of 7.7 nM and 1.8 nM, respectively. Dasabuvir sodium is primarily utilized in research focused on HCV replication and the development of antiviral therapies. -
RNA Polymerase Activities Inhibitor
Thio-ITP (6-Thioinosine 5'-triphosphate) is a competitive inhibitor of RNA polymerase activities. It exhibits a high apparent affinity for RNA polymerases, with inhibition constants of 40.9 μM for RNA polymerase I and 38.0 μM for RNA polymerase II. Thio-ITP is useful in research applications aimed at understanding transcriptional regulation and dissection of RNA polymerase mechanisms. -
RNA polymerase II Inhibitor
Dideoxy-amanitin is an allosteric inhibitor of RNA polymerase II, demonstrating potent selectivity with an IC50 of 74.2 nM. This compound is particularly valuable for research applications focused on transcriptional regulation and RNA synthesis inhibition. Its ability to selectively hinder RNA polymerase II makes it a crucial tool for investigating gene expression and related pathways in various biological contexts. -
DNA Polymerase
Tth DNA polymerase is a thermostable DNA polymerase derived from Thermus thermophilus, primarily targeting DNA synthesis. It exhibits high fidelity and robust activity at elevated temperatures, making it ideal for applications such as PCR and DNA sequencing. This enzyme is essential for researchers requiring efficient amplification and accurate DNA replication in challenging experimental conditions. -
RNA Polymerase Inhibitor
2'-Deoxy-2'-fluoro-l-uridine is an L-nucleoside that serves as a selective inhibitor of viral RNA polymerase. It effectively inhibits the replication of RNA viruses, making it a valuable tool for research focused on viral replication mechanisms and the development of antiviral therapies. This compound is instrumental for studies investigating RNA virus pathogenesis and potential therapeutic interventions. -
RNA Polymerase II Inhibitor
ε-Amanitin is a cyclic peptide that specifically inhibits RNA polymerase II activity by binding to the enzyme's active site. This potent inhibitor disrupts transcription elongation, making it a valuable tool for investigating gene expression mechanisms. ε-Amanitin is commonly utilized in research focused on transcription regulation, RNA processing, and studying the effects of transcriptional inhibition in various biological systems. -
DNA Polymerase Inhibitor
ddhCTP is a nucleoside analog that acts as a selective inhibitor of DNA polymerase. It effectively disrupts DNA synthesis with Ki values of 1.32 μM for DNA polymerase beta and 0.034 μM for DNA polymerase gamma. This compound is valuable for research applications involving the study of DNA replication and polymerase-specific pathways, providing insights into cellular mechanisms and potential therapeutic targets. -
DNA Polymerase
DNA polymerase-IN-1 is a selective inhibitor of DNA polymerase with an IC50 of 20.7 μM. This compound exhibits significant antiproliferative activity against tumor cells, making it a valuable tool in cancer research. Its ability to disrupt DNA synthesis may provide insights into tumorigenesis and potential therapeutic strategies for cancer treatment. -
EV71 3D Polymerase Inhibitor
DTriP-22 is a potent inhibitor of the enterovirus 71 (EV71) 3D polymerase, characterized by low toxicity. It demonstrates broad-spectrum antiviral activity against RNA viruses, particularly within the picornavirus family, while exhibiting no effects on DNA viruses. By targeting and inhibiting viral RNA synthesis during the early stages of replication, DTriP-22 serves as a valuable reagent in anti-enterovirus research applications. -
DNA Polymerase λ Inhibitor
Procaspase-IN-5 is a selective inhibitor of human DNA polymerase λ, with significant implications for cancer research. It exhibits a potent inhibitory effect on DNA polymerization and terminal deoxynucleotidyl transferase (TdT) activities, with IC50 values of 5.9 μM and 4.5 μM, respectively. This compound serves as a valuable tool for studying the mechanisms of DNA replication and repair in cancer cells. -
Polymerase
DNA polymerase is a crucial enzyme that targets DNA templates, facilitating the polymerization of deoxyribonucleotides (dNTPs) to synthesize and extend DNA strands with high fidelity and processivity. This enzyme is widely used in molecular biology applications, including DNA amplification, cloning, and sequencing. Its reliability and precision make DNA polymerase an essential tool in cancer research and various genomic studies. -
NS5B Polymerase Inhibitor
A-837093 sodium is a potent inhibitor of the hepatitis C virus (HCV) nonstructural protein 5B (NS5B) polymerase, exhibiting high selectivity and oral bioavailability. It demonstrates strong inhibitory activity against HCV genotypes 1a (IC50 = 1.25 nM) and 1b (IC50 = 0.33 nM). A-837093 sodium has shown antiviral efficacy in in vivo studies involving HCV-infected chimpanzees, making it a valuable tool for research focused on HCV infection and therapeutic development. -
RNA Polymerase Inhibitor
Adafosbuvir is a uridine-based nucleotide analog that serves as a potent RNA polymerase inhibitor targeting the NS5B protein of Hepatitis C virus (HCV). It exhibits significant antiviral activity by effectively inhibiting HCV replication. This compound is primarily utilized in research applications aimed at understanding HCV biology and developing antiviral therapies. -
Polθ Polymerase Inhibitor
Polθ-IN-9 is a selective inhibitor of Pol θ polymerase, demonstrating an IC50 value of 9.6 nM and a Kd of 47.5 nM, with no significant inhibitory effects on other human DNA polymerases such as Pol α, Pol ε, Pol γ, Pol λ, and Pol μ. This compound exhibits potent antiproliferative activity in DLD1 BRCA2 knockout cells (IC50 = 2.9 μM) and MDA-MB-436 cells (IC50 = 4.9 μM), while also increasing DNA damage and γH2AX levels. In addition, Polθ-IN-9 has shown to inhibit tumor growth in conjunction with Olaparib in the MDA-MB-436 xenograft model, making it a valuable tool for studying homologous recombination-deficient cancers, including breast cancer. -
Bacterial RNA Polymerase Inhibitor
Tirandamycin A is a potent bacterial RNA polymerase inhibitor. It exhibits significant antibacterial and antiamoebic activity, making it a valuable tool for research into bacterial inhibition mechanisms. This compound is useful for studies examining bacterial resistance and the development of new antibiotics. -
Topoisomerase II/DNA Polymerase Inhibitor
Epolactaene is a potent inhibitor of Topoisomerase II and DNA Polymerases, exhibiting IC50 values of 10 µM for Topoisomerase II, 25 µM for DNA Polymerase α, and 94 µM for DNA Polymerase β. Its ability to interfere with these key enzymes makes Epolactaene valuable for studying DNA replication and repair mechanisms. This compound is suitable for research applications involving cancer biology and the investigation of DNA-targeting therapies. -
Strand-displacement Activity Of DNA Polymerase Inhibitor
NSC666715 is a specific inhibitor of the strand-displacement activity of DNA polymerase. This compound enhances the effects of Temozolomide by inducing DNA damage, promoting cell senescence, and triggering apoptosis. NSC666715 serves as a valuable tool for research in colorectal cancer, aiding in the investigation of DNA repair mechanisms and therapeutic responses. -
DNA Polymerase-α Inhibitor
PHYLPA-8 is a selective inhibitor of DNA polymerase-α, targeting the enzyme's active site to restrict its function. This compound demonstrates unique structural features that influence its binding efficacy, allowing it to modulate DNA replication processes. PHYLPA-8 is suitable for research applications involving the study of DNA synthesis, repair mechanisms, and the evaluation of polymerase activity in various biological systems. -
DNA Polymerase Inhibitor
Lucidenic acid O acts as a potent inhibitor of DNA polymerases, targeting calf DNA polymerase-α, rat DNA polymerase-β, and HIV-1 reverse transcriptase. Its inhibitory activity is characterized by IC50 values of 42 μM, 99 μM, and 69 μM, respectively. This compound is valuable for research applications focusing on DNA replication and viral infections, offering insights into the mechanisms of polymerase inhibition. -
HCV NS5B Polymerase Inhibitor
RG7109 is a potent inhibitor of hepatitis C virus (HCV) NS5B polymerase, demonstrating EC50 values of 1.1 nM for HCV genotype 1a (H77) and 1.0 nM for genotype 1b (Con1). This compound exhibits favorable pharmacokinetic properties, making it a valuable tool for anti-HCV research. RG7109 is applicable in studies aimed at understanding HCV replication and developing antiviral strategies. -
RNA Polymerase Inhibitor
Favipiravir sodium is a potent inhibitor of viral RNA polymerase, effectively converted to its active form, Favipiravir-ribofuranosyl-5′-triphosphate (RTP). Favipiravir-RTP demonstrates significant inhibition of influenza virus RNA-dependent RNA polymerase (RdRP) with an IC50 value of 341 nM. This compound is primarily utilized in research focused on antiviral mechanisms and the development of treatments against RNA virus infections. -
DNA Polymerase β Inhibitor
3′-Amino-2′,3′-dideoxy-CTP is a nucleoside triphosphate analogue that functions as a selective inhibitor of DNA polymerase β. This compound is particularly useful in studies related to DNA repair mechanisms and cellular responses to DNA damage. Its ability to inhibit polymerase activity makes it a valuable tool for researching the role of DNA polymerase β in various biological processes and cancer biology. -
RNA Polymerase Inhibitor
RNA polymerase-IN-4 is a potent inhibitor of RNA polymerase, exhibiting an EC50 of 22.81 nM. This compound demonstrates significant anti-influenza virus activity with an EC50 of 3.76 nM and displays relatively low cytotoxicity, with a CC50 of 29.91 μM. RNA polymerase-IN-4 is suitable for research applications focused on viral infections, particularly those related to influenza virus. -
RNA polymerase Inhibitor
RNA polymerase-IN-1 is a selective inhibitor of DNA-dependent RNA polymerase, which is crucial for the transcription process in cells. This compound has demonstrated effective inhibition of CYP isozymes, highlighting its potential in studying the role of RNA polymerase in transcription regulation and drug metabolism. RNA polymerase-IN-1 is valuable for research applications focused on gene expression and the modulation of metabolic pathways. -
DNA Polymerase Inhibitor
Lucidenic lactone is a terpene compound that serves as an effective inhibitor of DNA polymerase. This compound demonstrates significant inhibitory activity against calf DNA polymerase-α (IC50 = 42 μM), rat DNA polymerase-β (IC50 = 99 μM), and HIV-1 reverse transcriptase (IC50 = 69 μM). Lucidenic lactone is valuable for research in molecular biology and virology, particularly in studies investigating DNA replication and reverse transcription processes. -
DNA Polymerase α inhibitor
Aphidicolin 17-acetate is a selective inhibitor of eukaryotic DNA polymerase α. This compound significantly impairs in vivo DNA synthesis in model systems such as sea urchin embryos and HeLa cells while demonstrating no effect on RNA and protein synthesis. Its specificity for DNA polymerase α, without inhibition of polymerases β and γ, makes Aphidicolin 17-acetate a valuable tool for studying DNA replication processes and cellular responses to DNA damage. -
RNA polymerase Inhibitor
RNA polymerase-IN-2 is a potent inhibitor of DNA-dependent RNA polymerase, targeting the transcription processes in cells. This compound has been shown to effectively inhibit CYP isozymes, making it a valuable tool for studies investigating RNA synthesis and related metabolic pathways. Its applications extend to research in gene regulation and the development of potential therapeutic strategies targeting RNA polymerase activity.
