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Catalog No.
Product Name
Application
Product Information
Citations
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RNA polymerase inhibitor
Rifabutin is a bactericidal antibiotic drug primarily used in the treatment of tuberculosis. Its effect is based on blocking the DNA-dependent RNA-polymerase of the bacteria.- Matt D Johansen, .et al. , Antimicrob Agents Chemother, 2020, Aug 17;AAC.00363-20 PMID: 32816730
- Meikle V, .et al. , Antimicrob Agents Chemother, 2018, Nov 12. pii: AAC.01846-18 PMID: 30420480
- Dinah Binte Aziz, .et al. , Antimicrob Agents Chemother, 2017, Jun; 61(6): e00155-17 PMID: 28396540
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RNA polymerase inhibitor
Antibiotic; inhibits bacterial RNA polymerase. Prototypical activator of the pregnane X receptor (PXR).- Meikle V, .et al. , Antimicrob Agents Chemother, 2018, Nov 12. pii: AAC.01846-18 PMID: 30420480
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HIV reverse transcriptase inhibitor
Tenofovir is in a class of medications called nucleoside reverse transcriptase inhibitors (NRTIs). It works by decreasing the amount of HIV in the blood. -
Transcriptase inhibitor
Abacavir sulfate is a nucleoside analog reverse transcriptase inhibitor (NRTI); guanosine analog used to treat HIV and AIDS. -
Polymerase inhibitor
Balapiravir (R1626, RG1626) is the prodrug of a nucleoside analogue inhibitor of the hepatitis C virus (HCV) RNA-dependent RNA polymerase (R1479, RG1479). -
HCV NS5B polymerase inhibitor
Mericitabine (RG 7128; R-7128) is a nucleoside inhibitor of the HCV NS5B polymerase that acts as an RNA chain terminator and prevents elongation of RNA transcripts during replication. -
NS5B polymerase inhibitor
Tegobuvir (GS-9190 is a non-nucleoside NS5B polymerase inhibitor. -
viral RNA polymerase inhibitor
T-705, a substituted pyrazine compound, has been found to exhibit potent anti-influenza virus activity in vitro and in vivo.
- Dylan M Johnson, .et al. , Viruses, 2024, Jul 9;16(7):1101 PMID: 39066263
- Steven B Tillis, .et al. , Microorganisms, 2023, May 24;11(6):1371 PMID: 37374873
- Hyeon-Min Cha, .et al. , ACS Infect Dis, 2023, Apr 14;9(4):1033-1045 PMID: 36912867
- Satoko Yamaoka, .et al. , Antiviral Res, 2022, Apr;200:105291 PMID: 35296419
- Crystal A Mendoza, .et al. , Antiviral Res, 2021, Jan;185:104993 PMID: 33296695
- Liva Checkmahomed, .et al. , Viruses, 2020, Oct; 12(10): 1139 PMID: 33049959
- JE Comer, .et al. , Viruses, 2019, Feb 3;11(2). pii: E137 PMID: 30717492
- Ma J, .et al. , Antiviral Res, 2018, Feb;150:112-122 PMID: 29253498
- Ji-Ae Kim, .et al. , Viruses, 2018, Feb; 10(2): 72 PMID: 29425176
- Haejin Chun, .et al. , Polym Chem, 2018, 9: 2116-2123
- Baz M, .et al. , Viruses, 2018, Nov 3;10(11) PMID: 30400276
- Sehee Park, .et al. , PLoS One., 2014, 9(7): e101325 PMID: 24992479
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HCV Polymerase Inhibitor
Setrobuvir (ANA-598) is a direct-acting antiviral or DAA, is a non-nucleoside inhibitor of the HCV RNA polymerase -
NNRT inhibitor
Delavirdine is a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT). -
HCV NS5B polymerase inhibitor
Deleobuvir (BI207127) was a non-nucleoside hepatitis C virus NS5B polymerase inhibitor for the treatment of hepatitis C
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RNA polymerase inhibitor
BMH-21 is a potent small molecule DNA intercalator. BMH-21 binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription.- Jun Kumai, .et al. , Exp Cell Res, 2025, Jul 15;450(2):114629 PMID: 40466802
- Masahiko Okuda, .et al. , Nucleic Acids Res, 2021, Jul 16 PMID: 34268577
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DNA polymerase Inhibitor
Valacyclovir is an antiviral drug used in the management of herpes simplex, herpes zoster, and herpes B. -
RNA polymerase II inhibitor
Oncrasin 1 is a proapoptotic substance. Induces abnormal nuclear aggregation of PKCι and suppressing RNA transcription. -
DNA/RNA polymerase Inhibitor
Mithramycin A is an antibiotic DNA/RNA polymerase and DNA binding transcriptional inhibitor observed to facilitate TNF-?? and Fas-ligand induced apoptosis. -
HCV Polymerase Inhibitor
VCH-759 is a non-nucleoside inhibitor of HCV RNA-dependent polymerase with sub-micromolar IC50 values versus genotype 1a/1b replicons.- Hassan GS, .et al. , Eur J Med Chem, 2019, Oct 1;184:111747 PMID: 31604164
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RNA polymerase inhibitor
Pseudouridimycin (PUM), an antibiotic, is a selective bacterial RNA polymerase (RNAP) inhibitor. Pseudouridimycin is a C-nucleoside analogue that is effective against both Gram-negative and Gram-positive bacteria. -
DNA polymerase IIIC inhibitor
ACX-362E is an orally available DNA polymerase IIIC (pol IIIC) inhibitor, acts as an antimicrobial agent to treat Gram-positive infections, with a MIC50 of 2 μg/mL for C. difficile. ACX-362E displays very potent in vitro and in vivo activities against broad spectrum of C. difficile pathogens. -
DNA polymerase-beta inhibitor
5-Methoxyflavone, belonged to Flavonoid family, is a DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity. -
HCV NS5B RNA-dependent RNA polymerase inhibitor
Beclabuvir is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase, and inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 with IC50 of < 28 nM. -
HCV NS5B polymerase inhibitor
PSI-6206 13CD3 is the deuterium labeled PSI-6206. PSI-6206 is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. -
eukaryotic DNA polymerase α inhibitor
Dehydroaltenusin is a small molecule selective inhibitor of eukaryotic DNA polymerase α, a type of antibiotic produced by a fungus with an IC50 value of 0.68 μM. -
RSV polymerase inhibitor
Lumicitabine (ALS-008176) is an inhibitor of the respiratory syncytial virus (RSV) polymerase. -
polymerase inhibitor
ERDRP-0519 is an orally available inhibitor of polymerase that shows efficacy against a lethal morbillivirus infection in a large animal model. -
DNA polymerase theta (Polθ) inhibitor
RP-6685 is a potent, selective, and orally active inhibitor of DNA polymerase theta (Polθ), with an IC50 of 5.8 nM as measured by the PicoGreen assay. It exhibits significant antitumor efficacy in mouse xenograft models. Additionally, RP-6685 contains an alkyne functional group, making it a useful click chemistry reagent capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAC) with azide-containing molecules, enabling its application in chemical biology and drug discovery research. -
Polθ DNA polymerase inhibitor
ART899 is a highly specific allosteric inhibitor of the DNA polymerase domain of polymerase theta (Polθ). It effectively enhances the radiosensitivity of tumor cells and demonstrates good tolerability when combined with fractionated radiation therapy. ART899 significantly reduces tumor growth compared to radiation alone, making it a promising candidate for combination cancer radiotherapy strategies. -
DNA polymerase inhibitor
Aphidicolin is a tetracyclic diterpenoid antibiotic produced by the mold Cephalosporium aphidicola, known for its potent and selective inhibition of DNA polymerase α and δ. By interfering with these polymerases, Aphidicolin blocks DNA synthesis and prevents mitotic cell division, making it a valuable tool for studying cell cycle regulation and DNA replication. In addition to its antiproliferative properties, Aphidicolin inhibits viral DNA synthesis and demonstrates antiviral activity against herpes simplex virus and orthopoxviruses. It also enhances apoptosis induced by arabinosyl nucleosides in human promyelocytic leukemia cells, suggesting potential in combination therapies for cancer and viral infections. Aphidicolin is widely used in research involving DNA replication stress, antiviral mechanisms, and cell cycle synchronization. -
Poly(ADP-ribose) Polymerase Inhibitor
PD128763 is a selective inhibitor of poly(ADP-ribose) polymerase (PARP). This compound enhances the cytotoxic effects of Streptozotocin, making it a valuable tool for studying cellular mechanisms in leukemia. PD128763 is suitable for research applications focused on PARP-related pathways and therapeutic strategies in cancer treatment. -
Viral DNA Polymerase Inhibitor
Foscarnet sodium, a viral DNA polymerase inhibitor, effectively suppresses viral replication through the reversible inhibition of polymerase activity. This compound is primarily utilized as an antiviral agent against herpesviruses, particularly in the treatment of cytomegalovirus retinitis. Its mechanism of action makes it a valuable tool for studying viral replication and evaluating therapeutic strategies against herpesvirus infections. -
RNA-dependent RNA-polymerases Inhibitor
GS-443902 trisodium is a potent inhibitor of RNA-dependent RNA polymerases (RdRp), specifically targeting respiratory syncytial virus (RSV) and hepatitis C virus (HCV) RdRp with IC50 values of 1.1 μM and 5 μM, respectively. As the active triphosphate metabolite of Remdesivir (GS-5734), this compound is essential for research focused on viral replication mechanisms and the development of antiviral therapies. Its ability to effectively inhibit RdRp activity makes it a valuable tool for studies in virology and drug discovery. -
RNA Polymerase II/III Inhibitor
β-Amanitin is a cyclic peptide toxin that specifically targets and inhibits RNA Polymerase II and III, crucial enzymes in eukaryotic transcription. By obstructing these polymerases, β-Amanitin effectively halts protein synthesis, making it a valuable reagent in research focused on gene expression and transcription regulation. Additionally, its ability to induce cytotoxicity positions β-Amanitin as a potential component in antibody-drug conjugates (ADCs) for targeted therapeutic applications. -
RSV Polymerase Inhibitor
JNJ-8003 is a highly potent, orally active non-nucleoside inhibitor of respiratory syncytial virus (RSV) polymerase, exhibiting an IC50 of 0.29 nM. It specifically targets the L protein of the polymerase complex, effectively blocking the transcription and replication of the viral genome by inhibiting RNA-dependent RNA polymerase (RdRp) activity, with an IC50 of 0.67 nM. In vitro studies demonstrate subnanomolar efficacy, and it has shown significant effectiveness in mouse and neonatal lamb models. JNJ-8003 is a valuable reagent for investigating RSV biology and developing antiviral therapies. -
DNA Polymerase β Inhibitor
Prunasin is a specific inhibitor of DNA Polymerase β, showing an IC50 value of 98 μM in rat models. As an orally active cyanogenic glucoside and a principal metabolite of Amygdalin, Prunasin exhibits notable anti-inflammatory and anti-fibrotic properties. This compound is valuable for research into conditions such as liver fibrosis, facilitating investigations into therapeutic strategies targeting DNA repair and fibrotic processes. -
DNA Polymerase Inhibitor
3,4-Dihydroxybenzylamine hydrobromide is a DNA polymerase inhibitor that exhibits cytotoxic effects in melanoma cells. This compound demonstrates significant growth inhibitory activity across various melanoma cell lines, with efficacy correlated to the levels of tyrosinase activity. Its unique mechanism makes it a valuable tool for investigating cellular processes related to DNA replication and repair in cancer research. -
Viral DNA Polymerase Inhibitor
Foscarnet trisodium hexahydrate is a viral DNA polymerase inhibitor that reversibly suppresses viral replication. It is primarily utilized as an antiherpesvirus agent, demonstrating efficacy in the treatment of cytomegalovirus retinitis. This compound is valuable for researchers studying viral infections and developing antiviral therapies. -
Poly(A) polymerase Inhibitor
2'-Deoxyadenosine 5'-diphosphate disodium (dADP disodium) acts as an inhibitor of bacterial poly(A) polymerase. This compound is particularly useful in the synthesis of deoxyadenosine oligonucleotides when utilized with Escherichia coli polynucleotide phosphorylase and other related enzymes. Its role in inhibiting poly(A) polymerase makes it valuable for studies in RNA metabolism and gene regulation research. -
DNA Polymerase Inhibitor
ddATP trisodium solution (100 mM) serves as a chain-elongating inhibitor of DNA polymerase. As an active metabolite of 2',3'-dideoxyinosine, it is primarily utilized in the Sanger method for DNA sequencing. Additionally, this reagent is valuable for studying viral infections and other applications in molecular biology research. -
DENV Polymerase Inhibitor
NITD-2 is a selective inhibitor of dengue virus (DENV) polymerase, specifically targeting the RNA-dependent RNA polymerase (RdRp) to impede RNA elongation. This compound exhibits potent antiviral activity against DENV, making it a valuable tool for research focused on understanding dengue virus replication and developing therapeutic strategies. Its limited ability to penetrate cell membranes can be an important consideration for in vitro experimental design.
