Immunology & Inflammation

TH1020 is a potent and selective toll-like receptor 5 (TLR5)/flagellin complex antagonist with an IC50 of 0.85 μM.

J14 is a reversible sulfiredoxin inhibitor with an IC50 of 8.1 μM. J14 induces oxidative stress (intracellular ROS accumulation) by inhibiting sulfiredoxin, leading to cytotoxicity and cancer cell death.

CTLA-4 (CD152), Hamster Anti-Mouse

Galectin-13 Human Recombinant

Galectin-7 Human Recombinant

Galectin-8 Human Recombinant

Galectin-2 Mouse Recombinant

Galectin-7 Mouse Recombinant

Galectin-8 Mouse Recombinant

Galectin-1 Mouse Recombinant

Galectin-4 Mouse Recombinant

Galectin-3 Mouse Recombinant

Galectin-1 Human Recombinant

Galectin-9 Mouse Recombinant

Galectin-3 Human Recombinant

Galectin-7 Human Recombinant, His Tag

Galectin-4 Human Recombinant

Galectin-3 Human Recombinant, His Tag

Galectin-9 Human Recombinant

Galectin-2 Human Recombinant

Galectin-8 Human Recombinant, His Tag

Galectin-16 Human Recombinant

Charcot-Leyden Crystal Protein Human Recombinant

Thrombopoietin Human Recombinant, HEK

Thrombopoietin Human Recombinant

Thrombopoietin Mouse Recombinant

ThrombopoietinHuman Recombinant, His Tag

Polyinosinic-polycytidylic acid (Poly(I:C)) is a synthetic analog of double-stranded RNA that serves as an agonist for toll-like receptor 3 (TLR3) and RIG-I-like receptors, including RIG-I and MDA5. This compound enhances both innate and adaptive immune responses, making it valuable in vaccine development as an adjuvant. Additionally, Poly(I:C) influences the tumor microenvironment and can directly induce apoptosis in cancer cells, highlighting its potential applications in cancer immunotherapy and research.

FAPI-4 is a potent inhibitor of fibroblast activation protein (FAP), targeting FAP with high specificity. This compound demonstrates significant potential in cancer research, particularly in improving diagnostic imaging. The use of 68Ga-FAPI-4 in PET/CT scans offers enhanced tumor-to-background contrast ratios, making it an effective tool for visualizing various types of tumors.

MGD-28 is a potent IKAROS protein degrader that functions through Cereblon (CRBN)-dependent mechanisms. It effectively degrades IKZF1 (DC50=3.8 nM), IKZF2 (DC50=56.3 nM), and IKZF3 (DC50=7.1 nM), along with CK1α (DC50=7.8 nM), in a dose-dependent manner. MGD-28 exhibits significant antiproliferative activity, making it a valuable tool for research in multiple myeloma and related hematological malignancies.

PROTAC STING Degrader-1 is a PROTAC degrader designed to target the STING (Stimulator of Interferon Genes) pathway, demonstrating a DC50 value of 3.2 μM. It exhibits pronounced anti-inflammatory effects, making it a valuable tool for investigating conditions such as acute kidney injury and inflammatory bowel diseases (IBDs). This compound can facilitate research into STING-mediated signaling and its role in various inflammatory processes.

ARV-393 is a potent BCL6 PROTAC degrader that facilitates the ubiquitination and subsequent proteasomal degradation of BCL6. This compound exhibits significant biological activity and is particularly relevant for research focused on advanced non-Hodgkin lymphoma. Its ability to modulate protein levels through targeted degradation makes it a valuable tool for elucidating BCL6-related pathways in cancer biology.

PROTAC PD-1/PD-L1 degrader-1 is a bifunctional degrader that targets the PD-1/PD-L1 immune checkpoint interaction by utilizing a Cereblon E3 ligase ligand. It demonstrates potent inhibitory activity with an IC50 of 39.2 nM, effectively restoring immune function in co-culture models involving liver cancer cells and CD3 T cells. Additionally, this compound reduces PD-L1 protein levels through a lysosome-dependent degradation pathway, making it a valuable tool for research in cancer immunotherapy and immune modulation.

FKBP12 PROTAC RC32 is a targeted protein degrader utilizing PROTAC technology to selectively degrade FKBP12. This compound combines Rapamycin, a well-characterized immunosuppressant, with a Cereblon E3 ubiquitin ligase ligand derived from Pomalidomide, facilitating the ubiquitination and subsequent proteasomal degradation of FKBP12. It serves as an important tool in research applications aimed at investigating the modulation of protein levels and the functional consequences of targeted degradation in various biological contexts.

dTAGV-1 hydrochloride is a highly selective degrader targeting FKBP12F36V-tagged proteins through the PROTAC mechanism. This compound effectively induces the degradation of FKBP12F36V-Nluc in vivo, making it a valuable tool for studies involving targeted protein degradation. Its application in research facilitates the investigation of protein function, dynamics, and the development of therapies that exploit the proteolysis pathway.

Nrf2 Degrader 1 is a potent PROTAC that targets and degrades Nrf2, a key regulator of antioxidant response and cell survival. This compound demonstrates significant anticancer activity, effectively inhibiting the growth of A549 and LK-2 cancer cell lines with IC50 values of 100 nM and 40 nM, respectively. It is a valuable tool for studying the role of Nrf2 in cancer biology and has potential applications in therapeutic development.

KB02-SLF is a PROTAC-based nuclear FKBP12 degrader designed to facilitate targeted protein degradation. It achieves this by covalently modifying DCAF16, an E3 ligase, thereby enhancing the stability of FKBP12 degradation within biological systems. The compound consists of a molecular glue linking the ubiquitin E3 ligase ligand KB02 with SLF, enabling efficient degradation of FKBP12 for various research applications in protein regulation and degradation pathways.

Ergothioneine is an endogenous metabolite that acts as a potent antioxidant. It functions primarily as a specific inhibitor of p38 MAPK and Akt, which are critical signaling pathways involved in cellular stress responses. Ergothioneine is utilized in research focused on neuroprotection, cell apoptosis, and oxidative stress, making it a valuable compound for investigations into cellular resilience and health.

Nexinhib20 is a selective inhibitor of the Rab27a-JFC1 interaction (IC50: 2.6 μM) and Rac-1-GTP signaling. This compound effectively inhibits neutrophil exocytosis, adhesion, and β2 integrin activation, demonstrating significant anti-inflammatory properties. Nexinhib20 is suitable for research applications focused on systemic inflammation and myocardial ischemia-reperfusion injury.

dTAGV-1-NEG is a diastereomer that acts as a heterobifunctional negative control for dTAGV-1, specifically targeted at FKBP12(F36V). This compound is utilized in research to study the selectivity and efficacy of FKBP12(F36V) degraders, helping to elucidate cellular mechanisms and pathways influenced by FKBP12 modulation. Its role as a control reagent makes it essential for validating experimental results in protein degradation studies.

DB-3-291 is a potent and selective PROTAC degrader targeting the protein CSK, exhibiting a Kd of 1 nM. This compound facilitates the degradation of CSK through its specific interaction with the E3 ligase, enabling in-depth studies of CSK-related biological pathways and providing insights into potential therapeutic strategies. It is valuable for researchers investigating targeted protein degradation and cancer biology.

DB1113 is a bifunctional compound designed for targeted protein degradation of various kinases. It effectively induces degradation of ABL1, ABL2, BLK, CDK4, CDK11B, EPHA3, MAPK7, RIPK1, and others, facilitating the investigation of kinase-related signaling pathways. DB1113 is suitable for research focusing on diseases or disorders associated with dysregulated kinase activity, providing a valuable tool for exploring therapeutic interventions in cancer and other conditions.

dTAG-13-NEG serves as a negative control for dTAG-13, a PROTAC-based bifunctional degrader that selectively targets FKBP12F36V in the presence of a protein of interest. While dTAG-13 promotes the degradation of FKBP12F36V, dTAG-13-NEG allows for the assessment of specificity and background in experimental setups involving this pathway. This compound is essential for validating experimental results when studying protein degradation mechanisms and their implications in cellular biology.

PROTAC FKBP Degrader-3 is a proteolysis-targeting chimera that utilizes a FKBP ligand binding group and a von Hippel-Lindau (VHL) E3 ligase recruiting moiety linked by a flexible linker. This compound effectively induces the degradation of FKBP12, demonstrating potent biological activity in targeted protein degradation. It is primarily used in research applications related to protein homeostasis, cellular signaling mechanisms, and therapeutic development strategies for modulating protein levels.

Lucigenin is a chemiluminescence probe primarily utilized for the detection of the endogenous superoxide anion radical (O2-). This compound exhibits high sensitivity and can also function as a chloride indicator, as its fluorescence is quenched in the presence of chloride ions. With excitation and emission wavelengths of 455 nm and 505 nm, respectively, Lucigenin serves as a valuable tool in studies involving reactive oxygen species and chloride ion interactions.

2′,7′-Dichlorofluorescein diacetate (DCFH2-DA) is a cell-permeable fluorescent probe utilized for the detection of reactive oxygen species (ROS). It becomes fluorescent upon cleavage by intracellular esterases and subsequent oxidation, allowing for the assessment of oxidative stress levels in biological systems. This reagent is essential for studies in toxicology and cellular signaling, enabling researchers to monitor and evaluate oxidative phenomena in various experimental contexts.

Berberine (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine (Natural Yellow 18) induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Berberine (Natural Yellow 18) has antineoplastic properties. 

L-NAME hydrochloride inhibits NOS with an IC50 of 70 μM. L-NAME is a precursor to NOS inhibitor L-NOARG which has an IC50 value of 1.4 μM.

Nigericin is an antibiotic derived from Streptomyces hygroscopicus that act as a K+/H+ ionophore, promoting K+/H+ exchange across mitochondrial membranes. Nigericin is a NLRP3 activator. Nigericin shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin induces pyroptosis through caspase 1/GSDMD in TNBC.

Deferoxamine (Deferoxamine B) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine upregulates HIF-1α levels with good antioxidant activity. Deferoxamine also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. Deferoxamine can be used in studies of diabetes, neurodegenerative diseases as well as anti-cancer and anti-COVID-19.