Catalog No.
Product Name
Application
Product Information
Citations
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Anti-inflammatory Agent
Militarine is an anti-inflammatory agent that primarily targets the NF-κB signaling pathway. It demonstrates significant biological activity by alleviating PM2.5-induced inflammatory injury and inhibiting cell migration in human alveolar epithelial A549 cells. Additionally, Militarine functions as a plant growth inhibitor, affecting the elongation of radicles and hypocotyls in various plant species. This compound is suitable for research applications related to PM2.5-induced pulmonary diseases and plant physiology studies. -
Anti-inflammatory Agent
Regaloside B is a phenylpropanoid with significant anti-inflammatory activity. Isolated from Lilium longiflorum, it effectively inhibits the expression of key inflammatory markers including VCAM-1, iNOS, and COX-2, as well as modulating the mRNA levels of various chemokines and angiogenic factors such as CXCL9, CXCL10, and IL8. Regaloside B is a useful reagent for research applications focused on osteogenic differentiation and inflammation-related studies. -
Anti-inflammatory agent
Hesperetin 7-O-glucoside is an anti-inflammatory flavonoid monoglucoside that exhibits orally active antihypertensive properties. It inhibits human intestinal maltase and HMG-CoA reductase with Ki values of 1.8 mM and 9.8 μM, respectively. Additionally, Hesperetin 7-O-glucoside demonstrates antibacterial activity and has been shown to regulate intestinal flora and support metabolic homeostasis in murine models. This compound is valuable for research applications in inflammation, metabolic regulation, and gut microbiota studies. -
Anti-neuroinflammatory Agent
Murrayafoline A is a carbazole alkaloid that functions as an anti-neuroinflammatory agent by directly targeting Specificity protein 1 (Sp1) and inhibiting the NF-κB and MAPK signaling pathways. This compound induces G0/G1-phase cell cycle arrest in PDGF-stimulated vascular smooth muscle cells and promotes the degradation of β-catenin, thereby attenuating the Wnt/β-catenin pathway. Additionally, Murrayafoline A enhances contractility in rat ventricular myocytes and activates L-type calcium currents through protein kinase C activation. Researchers can utilize Murrayafoline A to investigate inflammation, vascular complications, and colon cancer. -
Anti-inflammatory
Eupafolin, also known as Nepetin or 6-Methoxyluteolin, is a natural flavonoid derived from Eupatorium ballotaefolium HBK, recognized for its potent anti-inflammatory properties. It effectively inhibits the secretion of pro-inflammatory cytokines IL-6, IL-8, and MCP-1, exhibiting IC50 values of 4.43 μM, 3.42 μM, and 4.17 μM, respectively, in ARPE-19 cells. Eupafolin serves as a valuable research compound for studying inflammation and related pathways in various biological contexts. -
Anti-inflammatory Agent
Noreugenin is a phenolic compound that serves as an anti-inflammatory agent by inhibiting myeloperoxidase activity and reducing proinflammatory cytokines IL-1β and IL-17A in LPS-induced murine pleurisy. Additionally, it diminishes apoptosis and necrosis while lowering lipid peroxidation and modulating antioxidant enzyme activities (CAT, SOD, GST). With its anti-inflammatory and antioxidant properties, Noreugenin is valuable for investigating various inflammatory conditions, including pleurisy. -
Anti-inflammatory Agent
(±)-Lisofylline is an anti-inflammatory agent that acts by inhibiting the generation of phosphatidic acid and free fatty acids. It effectively blocks the release of pro-inflammatory cytokines, making it relevant for research in oxidative tissue injury, cancer chemotherapy responses, and experimental sepsis. Additionally, (±)-Lisofylline has applications in studies related to Type 1 diabetes. -
Anti-Inflammatory Compound
12-Oxo phytodienoic acid (12-OPDA) is an anti-inflammatory compound derived from plant lipids. It effectively suppresses neuroinflammation by inhibiting the nuclear factor kappa-light-chain-enhancer of activated B cells (Nf-κB) and p38 mitogen-activated protein kinase (MAPK) pathways in lipopolysaccharide (LPS)-activated cells. This compound is valuable for research related to neurodegenerative diseases, enabling the exploration of therapeutic strategies targeting inflammatory responses. -
Anti-inflammatory Agents
Xanthomicrol is a monoamine oxidase (MAO) inhibitor derived from the resin of the Chinese bellflower (Scrophulariaceae family). It exhibits significant anti-inflammatory and anti-tumor activities, with IC50 values of 0.88 and 1.69 μg/mL in HL60 and K562 cells, respectively. Xanthomicrol has been shown to reduce both iNOS protein and mRNA levels, as well as COX-2 protein levels. Additionally, it diminishes the production of the pro-inflammatory cytokine IL-1β and upregulates the antioxidant enzyme HO-1, making it a valuable tool for research in inflammatory and cancer-related studies. -
Anti-inflammatory agent
Docosahexaenoyl serotonin (DHA-5-HT) functions as an anti-inflammatory agent through its inhibition of interleukin-17 (IL-17). This endogenous conjugate of n-3 fatty acid and serotonin exhibits significant anti-inflammatory properties. It is utilized in research to explore mechanisms related to inflammation and potential therapeutic applications for inflammatory diseases. -
Anti-inflammatory Agent
Anti-inflammatory Agent 42 (Compound 10j) is designed to inhibit pro-inflammatory cytokines, specifically targeting tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6). This compound demonstrates significant efficacy in reducing cytokine expression in lipopolysaccharide (LPS)-stimulated macrophages, making it a valuable tool for research in inflammation and immune response studies. Its application extends to investigations aimed at understanding chronic inflammatory diseases and exploring therapeutic interventions. -
Anti-Inflammatory Compound
Cynandione A is an acetophenone compound with anti-inflammatory properties. It has been shown to protect hepatocytes and cortical neurons from toxicity, as well as improve neurological deficits in a rat model of cerebral ischemia. Additionally, Cynandione A exerts significant anti-inflammatory effects through the activation of macrophage α7 nAChR and the expression of IL-10, making it a valuable tool for research in neuroprotection and inflammation. -
Anti-inflammatory Agent
Hydrocortisone hemisuccinate hydrate serves as an orally active glucocorticoid anti-inflammatory agent, primarily targeting and inhibiting pro-inflammatory cytokines such as IL-6 and IL-3 with IC50 values of 6.7 μM and 21.4 μM, respectively. This compound exhibits significant anti-inflammatory and immunomodulatory activities, making it valuable in research applications related to ulcerative colitis and recurrent oral ulcers. Its ability to modulate inflammation positions it as a key reagent for studies in inflammatory disease pathways. -
Anti-inflammatory Agent
4-Ethoxybenzaldehyde is an anti-inflammatory agent that serves as a derivative of benzaldehyde. This compound effectively inhibits the production of key inflammatory mediators, including prostaglandin E2 (PGE2), IL-6, and IL-8, induced by ultraviolet radiation (UVR). Its demonstrated efficacy and safety profile make it valuable for reducing facial redness in topical formulations, notably in oil-in-water emulsions at a concentration of 1%. 4-Ethoxybenzaldehyde is suitable for research on chronic inflammatory skin diseases. -
Anti-inflammatory Agent
Arvelexin is an anti-inflammatory agent that primarily acts by inhibiting NF-κB activation. Isolated from Brassica rapa L. (Brassicaceae), Arvelexin also downregulates the expression of IL-8, making it a valuable compound for research into colonic inflammation. This compound is of interest for studies focused on inflammatory pathways and potential therapeutic applications in inflammatory bowel disease and related disorders. -
Oxidative Stress Modulator/Anti-inflammatory Agent
Guluronic acid is an oxidative stress modulator and anti-inflammatory agent. It functions by down-regulating pro-inflammatory genes such as TLR4, NF-κB, and iNOS, while inhibiting COX-2, MMPs, and VEGF activity. This compound promotes the up-regulation of immunoregulatory genes including SHIP1 and SOCS1, thereby mitigating cancer-related inflammation, tumor angiogenesis, cell adhesion, and metastasis, while decreasing immunosuppressive cell accumulation. Guluronic acid has demonstrated potential in extending survival times in tumor-bearing hosts within a non-cytotoxic concentration range and has applications in research related to multiple sclerosis, ankylosing spondylitis, breast cancer, and other inflammatory diseases. -
Anti-inflammatory Agent
Anti-inflammatory agent 64 targets the inhibition of pro-inflammatory cytokines, specifically IL-6 and TNF-α. This compound exhibits both antioxidant and anti-inflammatory activity in vitro and in vivo, making it a valuable tool for studying inflammatory processes. Additionally, it has been shown to significantly reduce paw edema, highlighting its potential utility in therapeutic research for inflammatory diseases. -
Pro-Inflammatory Peptide
C5a Anaphylatoxin (human) is a pro-inflammatory peptide that functions as a potent leukocyte chemoattractant. It plays a significant role in mediating inflammatory responses and can be employed in research related to various immune system disorders, including allergic asthma. This reagent is ideal for studies investigating the mechanisms of inflammation and the effects of immune modulation. -
Anti-inflammatory Agent
Tiopropamine is an anti-inflammatory agent primarily targeting histamine receptors. It exhibits significant potential in modulating inflammatory responses, making it a valuable tool for studying various inflammatory conditions. Its ability to influence histamine activity facilitates research into novel therapeutic strategies for related diseases. -
Anti-inflammatory Agent
Pibaxizine is an orally active anti-inflammatory agent that functions as a histamine receptor antagonist. It effectively mitigates bronchoconstriction induced by histamine, making it a valuable tool for studies related to inflammation and immunology. Pibaxizine is particularly relevant in research focused on respiratory conditions, including asthma, where it can aid in understanding inflammatory pathways and potential therapeutic interventions. -
Anti-inflammatory Agent
Dimephosphon is an anti-inflammatory agent that exhibits antihistamine and antiserotonin activity. It is effective in preserving spinal cord conduction and decreasing the excitability of spinal motor neurons near lesions. Additionally, Dimephosphon activates lymphatic vessel movement, thereby enhancing lymphatic circulation. This compound is useful in research focused on inflammatory edema, acute spinal cord injury, and lymphatic circulation disorders. -
Anti-Inflammatory Agent
Cicloprofen is a non-steroidal anti-inflammatory drug (NSAID) that primarily targets cyclooxygenase (COX) enzymes, inhibiting prostaglandin synthesis. This compound demonstrates significant anti-inflammatory and analgesic activities, making it effective for alleviating pain and inflammation in various conditions. Its applications in biochemical research include studies on pain pathways and the mechanism of action of NSAIDs in inflammation management. -
Inflammatory Cell Activation Inhibitor
CI-959 is an inhibitor of inflammatory cell activation, primarily targeting signaling pathways involved in immune response modulation. It demonstrates significant anti-inflammatory and anti-allergic properties by reducing the production of reactive oxygen species in neutrophils, inhibiting neutrophil adhesion, and blocking histamine release from mast cells. CI-959 also effectively suppresses the release of inflammatory mediators, including histamine, leukotrienes, and thromboxane, from guinea pig and human lung tissues. This compound is valuable for research focused on inflammatory and allergic diseases, particularly asthma. -
Anti-Inflammatory Agent/Anti-Tumor Agent
AHR-1911 is a thiourea derivative characterized by its anti-inflammatory and anti-tumor properties, primarily functioning through inhibition of protein synthesis. This compound demonstrates potential in enhancing healing in burned skin and exhibits histamine-like effects upon intradermal administration. Research has shown that AHR-1911 can effectively inhibit tumor growth and may also lower arterial pressure in certain animal models, making it valuable for investigations into inflammation and oncology. -
Anti-inflammatory Agent
β-Eudesmol is a sesquiterpene compound known for its anti-inflammatory and anticancer properties. It functions as a neostigmine antagonist, effectively countering neostigmine-induced neuromuscular failure and promoting apoptosis in various cell types. This compound is particularly useful in research applications focused on sepsis and related inflammatory conditions, enabling a deeper understanding of therapeutic interventions. Isolated from the rhizome of Atractylodes lancea, β-Eudesmol offers significant potential for the development of novel anti-inflammatory strategies. -
Non-steroidal Anti-inflammatory Agent
Gaultherin is an orally active non-steroidal anti-inflammatory agent that selectively inhibits key inflammatory pathways, including NF-κB, MAPK, COX-2 (IC50 = 0.35 mg/mL), LOX (IC50 = 0.56 mg/mL), and HYAL (IC50 = 28.58 μg/mL). This compound demonstrates anti-inflammatory, antipyretic, and analgesic activities, making it suitable for research into inflammation-related conditions. Additionally, Gaultherin exhibits modest direct antioxidant capacity, particularly in cell-based models, while sparing COX-1, thus reducing the likelihood of gastrointestinal side effects commonly associated with traditional non-steroidal anti-inflammatory drugs. -
Anti-inflammatory Agent
Darutoside is an orally active diterpene compound that functions primarily as an anti-inflammatory agent. It exhibits notable analgesic properties and enhances wound healing by inhibiting COX-2 expression and the migration of inflammatory cells. Additionally, Darutoside modulates macrophage polarization towards the M2 phenotype through NF-κB pathway inhibition, thereby reducing inflammation. This compound has been shown to significantly alleviate acute gouty arthritis by regulating metabolic networks involved in inflammatory responses. -
Anti-inflammatory Agent
Methyl palmitate is a naturally occurring fatty acid ester that serves as a potent inhibitor of ΙκB phosphorylation. This compound exhibits significant anti-inflammatory properties by modulating macrophage activity and down-regulating pro-inflammatory mediators, including TNF-α and nitric oxide. Methyl palmitate has demonstrated the ability to inhibit LPS-induced activation in Kupffer cells and rat peritoneal macrophages while also reducing phagocytic function in RAW cells. Additionally, it displays cardioprotective effects in models of ischemia/reperfusion injury and shows high toxicity against the pest species T. cinnabarinus, providing valuable insights for both therapeutic and ecological applications. -
Anti-inflammatory Agent
Calcein Blue AM is a fluorescent cellular dye that targets and labels live cells, providing valuable insights into cell viability and health. It exhibits anti-inflammatory properties, making it a useful reagent for research applications involving inflammatory processes. This compound is commonly employed in studies related to cell proliferation, apoptosis, and cellular responses to therapeutic agents in various disease models. -
Anti-Inflammatory Agent
LM-021 is a coumarin-chalcone derivative that functions as an anti-inflammatory agent through its ability to suppress the production of nitric oxide (NO), IL-1β, IL-6, and TNF-α, along with the expression of CD68 antigen and histocompatibility-2 (MHCII). Additionally, it attenuates caspase 1 activity, lactate dehydrogenase release, and levels of reactive oxygen species (ROS). This compound is suitable for applications in neurological research, highlighting its potential in studies related to neuroinflammation and related pathways. -
Anti-inflammatory Agents
(±)-Naringenin is an orally bioavailable anti-inflammatory agent that modulates both acute and chronic inflammatory responses. Its biological activities include antioxidant, neuroprotective, hepatoprotective, and potential anti-cancer effects. (±)-Naringenin enhances vasodilation in endothelial cells via the activation of BKCa channels and demonstrates protective effects against experimental colitis by inhibiting the Toll-like receptor 4/NF-κB signaling pathway. This compound is relevant for research applications in sepsis, fulminant hepatitis, fibrosis, and cancer. -
Anti-inflammatory/Anti-tumor/Anti-fungal/Neuroprotective Agent
(+)–Magnoflorine chloride is an aporphine alkaloid that exhibits potent anti-inflammatory, anti-tumor, anti-fungal, and neuroprotective properties. This compound facilitates Parkin/PINK1-mediated mitochondrial autophagy and modulates the NLRP3/Caspase-1 pathway, demonstrating essential immunomodulatory effects. Additionally, it inhibits the JNK and TLR4/NF-κB signaling pathways while activating the Sirt1/AMPK pathway to reduce neuronal oxidative stress and apoptosis. The ability to regulate miR-410-3p and suppress HMGB1/NF-κB signaling further underscores its potential in therapeutic applications across various diseases. -
Anti-inflammatory Agent
Forsythoside I is a caffeoyl phenylethanoid glycoside (CPG) known for its anti-inflammatory properties. Isolated from Forsythia suspense (Thunb.) Vahl, this compound demonstrates the capacity to provide protective effects in models of acute lung injury. Its biological activity makes it a valuable reagent for research in inflammation and respiratory health. -
Anti-inflammatory/Anti-tumor/Anti-fungal/Neuroprotective Agent
(+)-Magnoflorine is an orally active aporphine alkaloid that serves as an anti-inflammatory, anti-tumor, anti-fungal, and neuroprotective agent. It promotes mitochondrial autophagy through Parkin/PINK1 mechanisms and inhibits the NLRP3/caspase-1 signaling pathway, demonstrating significant immunomodulatory effects. Additionally, (+)-Magnoflorine modulates JNK and TLR4/NF-κB pathways, activates Sirt1/AMPK, and alleviates oxidative stress and apoptosis in neuronal cells. Its capacity to upregulate miR-410-3p and inhibit the HMGB1/NF-κB pathway further supports its anti-tumor activity. Furthermore, (+)-Magnoflorine exhibits marked antifungal properties, making it a versatile reagent in chemical research. -
Inflammatory Lipid Mediator
2-Chlorohexadecanoic acid is an inflammatory lipid mediator that interferes with protein palmitoylation, thereby inducing ER-stress markers and reducing ER ATP content. This compound activates the transcription and secretion of pro-inflammatory cytokines, such as IL-6 and IL-8. Additionally, 2-Chlorohexadecanoic acid disrupts mitochondrial membrane potential, leading to the cleavage of procaspase-3 and PARP. Notably, it can cross the blood-brain barrier, impacting ER and mitochondrial functions in human brain endothelial cells. -
Anti-inflammatory Agent
Kamebakaurin is an orally active diterpenoid that functions as an anti-inflammatory agent by inhibiting NF-κB activation through direct interference with the DNA-binding activity of p50. This compound exhibits significant biological activity, including the induction of apoptosis and cell cycle arrest in tumor cells. Kamebakaurin is relevant for research applications focused on inflammation and cancer therapeutics. -
Anti-inflammatory/Antiviral Agent
Mulberrofuran G is a potent NOX inhibitor (IC50: 6.9 μM) and effective tyrosinase inhibitor. This compound demonstrates significant anti-inflammatory, antioxidant, antiviral, antitumor, and neuroprotective activities. Mulberrofuran G is valuable for research applications related to tumor biology, neurodegenerative diseases, and various inflammatory conditions. -
Anti-inflammatory Agent
Brazilein is an anti-inflammatory agent that targets Na+,K+-ATPase with an IC50 of 500 μM. It exhibits potent neuroprotective activities by reducing iNOS mRNA expression, thereby inhibiting nitric oxide production in immune cells and modulating inflammatory cytokines such as TNF-α and IL-6. Brazilein has been shown to decrease cerebral infarction volume and enhance neurological function in models of cerebral ischemia-reperfusion injury. Additionally, it induces apoptosis in splenic lymphocytes and can affect immune responses and organ weights, making it valuable for research in neurobiology, cardiovascular health, and inflammatory disorders. -
Anti-inflammatory Agent
(-)-Pinoresinol is a plant-derived tetrahydrofuran lignan that serves as an anti-inflammatory agent through the inhibition of α-glucosidase. This compound exhibits hypoglycemic properties and demonstrates chemopreventive potential by inducing apoptosis and causing G2/M phase cell cycle arrest. Its biological activities make it a valuable tool for research in inflammation and metabolic disorders. -
Anti-inflammatory Agent
Taurodeoxycholate-d6 sodium is an anionic detergent derived from bile salts, functioning primarily as an anti-inflammatory agent. This compound promotes the isolation of membrane proteins, particularly in the inner mitochondrial membrane, making it essential for studies in cellular biology. Furthermore, Taurodeoxycholate-d6 demonstrates notable anti-inflammatory and neuroprotective properties, positioning it as a valuable tool for research applications focused on inflammation and neuroprotection pathways. -
Anti-inflammatory Agent
Lactucin is a recognized anti-inflammatory agent that promotes apoptosis in cancer cells. Additionally, it exhibits analgesic, anticancer, and antimalarial properties, making it a versatile compound for various biological research applications. Its multifaceted activity provides valuable insights into potential therapeutic interventions for inflammatory diseases and cancer. -
Anticancer/Anti-inflammatory Agent
Isoangustone A is an effective anticancer and anti-inflammatory agent that promotes apoptosis and autophagic cell death in cancer cells. This compound is of interest for research applications aimed at understanding cancer biology and developing potential therapeutic strategies. Its dual action highlights its relevance in the study of cancer progression and inflammation-mediated diseases. -
Anti-Inflammatory Agent
Stephanine ((-)-Stephanine) is an isoquinoline aporphine-type alkaloid known for its anti-inflammatory properties. It induces apoptosis via the reversal of mitotic exit, demonstrating significant antiplasmodial activity. This compound is valuable for research applications related to gastrointestinal disorders, inflammatory conditions such as arthritis, and various cancer types. -
Anti-inflammatory Agent
Taurodeoxycholic acid is an anionic bile salt with anti-inflammatory properties, primarily targeting inflammation pathways. It demonstrates significant neuroprotective effects and is utilized in the isolation of membrane proteins, including those from the inner mitochondrial membrane. This compound is valuable for research applications involving membrane biochemistry and neuroinflammation studies. -
Anti-inflammatory Drug
Taurochenodeoxycholic acid sodium is a bile acid derivative that exhibits anti-inflammatory properties through the modulation of immune responses. This compound has been shown to induce apoptosis and plays a significant role in reducing inflammation. Its biological activities make it a valuable reagent for research applications focused on understanding inflammatory diseases and potential therapeutic strategies. -
Anti-inflammatory Agent
Lonicerin, also known as Veronicastroside, is a flavonoid recognized for its anti-inflammatory properties. It inhibits xanthine oxidase with an IC50 of 37.4 µg/mL and suppresses alginate secretion protein (AlgE). Lonicerin demonstrates a broad spectrum of biological activities, including antimicrobial effects against Pseudomonas aeruginosa and Candida albicans, as well as antioxidant and neuroprotective effects. Its diverse applications make it valuable in research focused on inflammation, infection, and oxidative stress. -
Anti-inflammatory agent
Hederacoside C is a potent anti-inflammatory agent that targets the MAPK/NF-κB signaling pathway. It exerts its biological activity by inhibiting the activation of this pathway, resulting in a reduction of inflammation. In addition to its anti-inflammatory properties, Hederacoside C also demonstrates antibacterial activity, making it a valuable compound for research applications focused on inflammatory diseases and infections. -
Anti-inflammatory Agent
Balanophonin is an anti-inflammatory agent that effectively inhibits microglial activation and subsequent neurodegeneration. This compound plays a crucial role in preventing activated microglia-induced apoptosis, making it a valuable tool for research in neuroinflammation and neurodegenerative disorders. Its applications extend to investigations of inflammatory pathways and potential cancer therapies. -
Anti-inflammatory Agent
Siegeskaurolic acid is an orally active anti-inflammatory agent that targets multiple inflammatory pathways. It effectively inhibits the production of nitric oxide (NO), prostaglandin E2 (PGE2), and tumor necrosis factor-alpha (TNF-alpha), along with the activation of nuclear factor-kappaB (NF-kB). This compound is valuable for research applications focused on inflammation and associated disease models. -
Anti-inflammatory Agent
Berkeleyacetal C is a meroterpenoid compound that acts as an anti-inflammatory agent by inhibiting the NF-κB, ERK1/2, and IRF3 signaling pathways. It effectively reduces the expression of inducible nitric oxide synthase (iNOS) and subsequent nitric oxide production in macrophages. Additionally, Berkeleyacetal C suppresses the expression and secretion of key pro-inflammatory cytokines and chemokines, including TNF-α, IL-6, IL-1β, MIP-1α, and MCP-1, while also inhibiting neutrophil activation and reactive oxygen species (ROS) production. This compound is valuable for research into inflammatory disorders.
